Institute of Human Biology (IHB), Roche, Basel, Switzerland. Institute of Bioengineering, EPFL, Switzerland. #organoids, #tumoroids, #stemcells, #bioengineering
Lausanne, Switzerland
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- Following 360
- Followers 6,065
- Likes 524
Imagine growing a miniature version of the human intestine in the lab to study gut biology in great detail and test medicines before clinical trials? We are happy to share our latest publication on bioengineered human mini-intestines: authors.elsevier.com/sd/arti… Let’s dive in!
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Have you ever seen real-time footage of a tumor developing outside a living organism? We are thrilled to announce a new paradigm in ex vivo cancer modelling rdcu.be/dFD2v. Let’s have a quick look!
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What a great way to start the new year!!! Check out our recent paper in Science showing how
tissue geometry drives intestinal organoid patterning. Great work by @ngjorevski,
@mike_nikolaev
et al. and collaboration with @priscaliberali
@AnsethGroup
science.org/doi/10.1126/scie…
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The beauty of intestinal organoids à la @HansClevers, Toshiro Sato and colleagues! Emergence of de novo 'crypts' from 3D-bioprinted intestinal stem cells forming an 'organoid tube'. rdcu.be/b7vHu #organoids #bioprinting
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Our paper on homeostatic organoids is finally out! nature.com/articles/s41586-0… Heroic effort by @mike_nikolaev who unified two important cell culture concepts, organoids and organs-on-chips. Thanks to all the co-authors, especially @olga_mitrofan and @NicoBroguiere!
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Another step toward replacing Matrigel? Excited to see this paper published! nature.com/articles/s41563-0… Great work by PhD students @AChrisnandy & Delphine Blondel👏 Thanks to co-authors @RezakhaniSaba @NicoBroguiere & support from @NCCRbioinspired & @epflSV #LowonMatrigelhighonPEG
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Check out our preprint on #tumoroids: A robust and scalable microwell assay to measure how T cells can kill #tumoroids - patient-derived and fully autologous. biorxiv.org/cgi/content/shor… Nice work by #tumoroid team @Dj1987Devanjali, Francois Rivest, @LFranciscoLM, @NicoBroguiere.
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Following our recent breakthrough on mouse mini-intestines for ex vivo tumor development, we asked ourselves: can this technology be applied to cells from cancer patients? We are excited to announce the answer to this question in our latest publication: rdcu.be/dMuAr
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Very excited to see the our paper on ‘Organoid Arrays’ featured on the cover! nature.com/articles/s41551-0…
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From gastruloids to organoids: our study on modelling cardiogenesis with ESCs just published @CellStemCell! Check it out: authors.elsevier.com/a/1c2sX… Fantastic work by @Giuliana_Rossi_ and collaborators! #gastruloids #embryoids #organoids
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Happy to see JiSoo Park’s work on mouse neural tube organoids published journals.biologists.com/dev/… 👏🎉!! Not quite a #SyntheticEmbryo… but still impressive display of the self-organization capacity of stem cells. Check out the neural crest cells that emerge from these organoids!
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We have several vacancies for junior group leaders @IHB_Research! Join us and conduct groundbreaking research in a unique institute that seamlessly integrates academic and pharmaceutical research in the vibrant city of Basel. Please RT if you know someone who should apply!
We’re seeking Early Career Scientists to establish their own independent #research program, with competitive funding, across three key focal areas. Open to mature #scientists with PhD or Postdoctoral training in #HumanModelSystems.
Apply to #TeamIHB here: bit.ly/3NyRjul
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Super excited to share that we will be expanding our ambitions to advance #organoid research with a translational goal at @IHB_Research! Stay tuned for our latest discoveries in the exciting fields of human model systems and human biology.
👉Learn more: institutehumanbiology.com/
Welcome to the #IHBResearch Twitter channel 👋
We’re excited to be sharing news of the latest research into #Organoids and connecting with all those interested in this scientific field 🧫
Find out more about our work here ➡️ bit.ly/41VsvTe
#Science #HumanModelSystems
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Excited to see this published!! Great effort by hugely talented @TheLutolfLab PhD student @MoritzHofer_ 👍🙏
Engineering organoids by @TheLutolfLab @EPFL! In this Review, @TheLutolfLab argues that many limitations of #organoid cultures can be addressed by engineering approaches. From engineering the cell and niche, to engineering the organism-level context go.nature.com/3pvn2yF
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Tumorigenic transformation can be spatiotemporally controlled by directing oncogenic activation through blue-light exposure, and emergent colon tumors can be tracked in real-time with single-cell resolution for several weeks without breaking the culture.
By integrating microfabrication, optogenetics and tissue engineering, we have developed topobiologically complex mini-colons able to undergo tumorigenesis ex vivo.
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Check out our latest preprint on bone marrow #organoids generated from aggregates of endothelial & mesenchymal cells biorxiv.org/content/10.1101/… Nice effort by @sonja_giger @MoritzHofer_ and collaborators 👏! Another application of hydrogel microcavity arrays nature.com/articles/s41551-0…
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How can 3D-bioprinting be used to control the shape and size of organoids? Check our paper in @NatureMaterials! nature.com/articles/s41563-0…
Fantastic team work by @BrassardJon, @mike_nikolaev, @TaniaHubscher and @MoritzHofer_! #organoids #bioprinting #tissueengineering
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Excited to share our latest preprint on human mini-guts! biorxiv.org/content/10.1101/… Great work by @olga_mitrofan 🙌🎉
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New synthetic hydrogel formations for 3D organoid culture. These matrices are much simpler and cheaper than those we reported on earlier, and yet they work just as well. Great work by @RezakhaniSaba! onlinelibrary.wiley.com/doi/…
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Formation of #gastruloids with anterior neural tissues by inhibition of WNT signaling
Congrats to @muggi_ @NicoBroguiere!
sciencedirect.com/science/ar…
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These organoids maintain thymus functionality and mediate physiological T cell development upon reaggregation with T cell progenitors. Huge thanks to all collaborators @LFranciscoLM, @JakobJLanger, Thomas Bartlott, Lucie Tillard, Paul Rouse, Clare Blackburn and Georg Holländer!
Check-out our latest preprint on thymic epithelial organoids! biorxiv.org/content/10.1101/… Fabulous work by @TaniaHubscher 👏🥳!!
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The Roche ITB has a brand new website: ritb.roche.com! Super excited to be able to shape the ITB together with an exceptional group of scientists & engineers. A unique institute at the industry-academia interface to unlock the potential of #organoids for drug development
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Are you interested in cancer organoids/tumoroids and their application in drug discovery and development as well as in personalized medicine? Check out this open postdoctoral position at the Roche Institute for Translational Bioengineering (ITB)!
careers.roche.com/global/en/…
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Check out our latest preprint on next-gen. #embryoids that combine features of #gastruloids and ETS embryos. Generation of brain-like tissues from epithelialized aggregates. Great work by @muggi_ @NicoBroguiere and thanks for collaboration @AMartinezArias. biorxiv.org/content/10.1101/…
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Excited to see that our paper on synthetic gels for 3D organoid culture is featured on the cover of Advanced Functional Materials onlinelibrary.wiley.com/toc/… Congrats to @RezakhaniSaba!
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The GRC on Engineered Extracellular Matrices will be held July 24-29, 2022. Fantastic speakers and program, focus on #organoids, #AdvancedECMs, #biofabrication, #mechanobiology, #immunoengineering and more. Still some spots available:
grc.org/signal-transduction-…
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Very happy that we could contribute to this work from Hiiragi lab with our organoid engineering tools! A uterus-like substrate for ex vivo mouse development and mechanistic studies of embryo-uterus interactions. Outstanding collaborative work by @vlad_bndk and @mike_nikolaev👏🎉!
1/n Thrilled to share my Ph.D. study, an amazing team effort with @TheLutolfLab, @MicroEos, @ErzbergerGroup, @ilastik_team, where we combined bioengineering, #LSFM, and theory to model embryo-uterus interaction ex vivo and study mechanisms of embryogenesis during implantation
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Check-out our latest preprint on thymic epithelial organoids! biorxiv.org/content/10.1101/… Fabulous work by @TaniaHubscher 👏🥳!!
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As co-director and head of translational bioengineering, I will continue to push the biotech aspects of human model systems, addressing key translational challenges and expanding IHB's network ties to academia.
Great news today for IHB. I warmly welcome Juergen Knoblich as new director and head of the institute. Thrilled to see the next step of our strategic evolution come to fruition and our ambitions to expand into basic biology realised. See you soon in Basel @Knoblich_lab!
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Great news today for IHB. I warmly welcome Juergen Knoblich as new director and head of the institute. Thrilled to see the next step of our strategic evolution come to fruition and our ambitions to expand into basic biology realised. See you soon in Basel @Knoblich_lab!
🎇Big news! Prof Juergen Knoblich @IMBA_Vienna @oeaw @MedUni_Wien joins #TeamIHB as its new Head. Bringing extensive leadership experience, he is also a pioneer in #organoids biology. His lab was 1st to develop an organoid model for a human brain disorder. Welcome @Knoblich_lab!
ALT A picture of Juergen Knoblich, Directo and Head of IHB, with his quote: “I am honoured to join IHB as its new head and build upon its already impressive successes. Together with the outstanding scientists at the institute and Roche, we will trailblaze towards a future where our basic research translates to profound impact on patients.”
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Exciting organoid meeting in Basel!
📢Sign up now! Registration is open until 7 April 2023 for the 2nd annual #BaCell3D meeting on 8–9 May 2023 in Basel🇨🇭!
The meeting will focus on the latest developments in #organoid and #3D model research! For more information visit our website! fmi.ch/bacell3d/
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Check out our latest preprint on gastruloids! We describe a new gastruloid model that could generate anterior neural tissues. We identify inhibition of WNT signaling to be crucial for the expanded axial patterning ⬇️
biorxiv.org/content/10.1101/…
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Amazing #gastruloids!! Excited to release our 1st preprint to reveal how self-organising mouse embryonic stem cells can undergo key steps of early heart organogenesis. Magenta=cardiac troponin T. Thanks for the collaboration @IBDMmarseille @ViventisMicro! biorxiv.org/content/10.1101/…
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Check out our just updated preprint on endoderm emergence in #gastruloids: biorxiv.org/content/10.1101/… Beautiful work by the one and only Stefano Vianello who now sheds light on the dynamics and anterior-posterior patterning of the gut tubes that can emerge in gastruloids!
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Very happy to see this published! Huge effort by Nathalie Brandenberg and Sylke Hoehnel who will take the technology to the next level @sunbioscience. Thanks much to our collaborators Fabien Kuttler, Gerardo Turcatti, Krisztian Homicsko, @tillringel, @schwanklab and George Coukos
A recent breakthrough from @TheLutolfLab laboratory and published in @natBME will enable mass production of standardized #organoids for the first time. This was achieved thanks to a customized guidance system that ensures homogenous cell culturing @epflSV actu.epfl.ch/news/standardiz…
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Wonder how much colorectal cancer organoids could be improved by reconstructing the tumor microenvironment? Check out our latest pre-print and opus magnum by @NicoBroguiere and colleagues!
Dissection and reconstruction of the colorectal cancer tumor microenvironment biorxiv.org/cgi/content/shor… #bioRxiv
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Modelling embryonic blood development in #gastruloids? We think it looks promising: biorxiv.org/content/10.1101/… Follow-up study from our recent cardiogenesis work (cell.com/cell-stem-cell/pdf/…). Nice team effort by @Giuliana_Rossi_ @sonja_giger @TaniaHubscher 👏👍!
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Fantastic paper that exemplifies the credo and mission of @IHB_Research: bold and creative young scientists as hands-on leads + projects combining biology, engineering, computation and drug development + extremely close collaboration between multiple research groups! Congrats!!
Exciting new inroads into human biology and therapy development: Human intestinal organoids with an autologous tissue-resident immune compartment! #Gjorevski #Cabon #IHB @Nature @IHB_Research nature.com/articles/s41586-0…
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By integrating microfabrication, optogenetics and tissue engineering, we have developed topobiologically complex mini-colons able to undergo tumorigenesis ex vivo.
Have you ever seen real-time footage of a tumor developing outside a living organism? We are thrilled to announce a new paradigm in ex vivo cancer modelling rdcu.be/dFD2v. Let’s have a quick look!
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This work was spearheaded by the hugely talented @LFranciscoLM and @TaniaHubscher, and supported by our collaborators Amber Bowler, @NicoBroguiere, @JakobJLanger, Lucie Tillard, @mike_nikolaev, and @isrec_radtke. Thank you all!!
This opens up exciting prospects for cancer research as it provides a powerful tool for mechanistic studies and testing of potential therapies, especially when applied to human patient-derived organoids - stay tuned for follow-up work also from the @IHB_Research!
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We begin the conference with @priscaliberali talking about design principles in multicellular systems #BaCell3D it’s a full house!
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This opens up exciting prospects for cancer research as it provides a powerful tool for mechanistic studies and testing of potential therapies, especially when applied to human patient-derived organoids - stay tuned for follow-up work also from the @IHB_Research!
Mini-colons display rich intra- and inter-tumoral diversity and recapitulate key pathophysiological hallmarks displayed by colorectal tumors in vivo. By fine-tuning cell-intrinsic and -extrinsic parameters, these mini-colons can be leveraged to unveil tumorigenic determinants.
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Beautiful work by Nikolce Gjorevski's group of #TeamIHB. Congrats!!
Patient-derived intestinal organoids predict immunotherapy toxicities of T-cell-engaging bispecific antibodies, which may guide safer cancer treatments in future. 👏to authors at #TeamIHB @Roche #pRED @UnivParisSaclay & @DepBiomedicine for the @natBME📰!
nature.com/articles/s41551-0…
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Incredibly exciting science and so much fun, despite losing against Ovijit @theChaudhurilab 😁 A privilege to organise this conference with Dave Schaffer. Thanks to all the speakers, discussion leaders and participants!! Also looking fwd to the next one @peytonlab & @kumarlabucb!
Great time learning new science & re-living fun dorm life w/ friends, colleagues, & trainees! Thanks Matthias @TheLutolfLab & Dave Schaffer for organizing a fantastic Engineered Extracellular Matrix meeting! Looking fwd to the next one w/ Shelly @peytonlab & Sanjay @kumarlabucb!
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Exciting collaboration with the @PetrovaLab, thanks for involving us! Great potential for modelling nutrition with next-gen organoids.
❣️❣️Just published ❣️❣️
c-Maf sustains zonation, lipid handing and tuft cells in small #intestinal #villi
fbm.unil.ch/go/d6220642
Great collaboration with @JakobJLanger @TheLutolfLab to study lipid uptake in cool “mini-guts”🤩
👍Ale, @IrenaRoci, @JbernierLatmani+collaborators!
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Really excited to have such a distinguished scientist as a new colleague at the IHB!
Join us in giving a warm welcome to our newest team member, Prof Michael N Hall!
He augments #TeamIHB's basic biology expertise via his new lab on adipose tissue biology
while he leads his @biozentrum lab in parallel. A true bridge between academia and industry. @UniBasel_en
ALT A portrait of Prof Hall in his lab. Overlaid a quote from him "I've always been curious and it is a big component of my approach to basic research. I'm thrilled to bring my curiosity and decades of experience to the IHB to help strengthen their foundation for translation." And a banner that reads: Prof. Michael N Hall, Metabolic Homeostasis group
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Excellent review on how to "engineer self-organization" from Jonathan Brassard! Thank you @sonstance95 for the beautiful figures!
#bioengineering #selforganization #organoids
cell.com/cell-stem-cell/full…
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Have a look at our recent review! 🧫🧪
Progress and potential in organoid research go.nature.com/2xkcgD0 #Review by Giuliana Rossi, Andrea Manfrin & Matthias P. Lutolf
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Check out our recent paper on next-generation #gastruloids. Congrats to @muggi_ 👏🎉🥳 and thanks to @NicoBroguiere @AMartinezArias @sunbioscience!
It feels good to see this one out in @NatureComms! Have a look at how we attempt to engineer mouse embryos 🔧🐭
Exciting findings on the link between epithelial architecture of the post-implantation epiblast and formation of brain-like tissues⬇️
nature.com/articles/s41467-0…
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Thrilled to announce that our #preprint in collaboration with Schoonjans lab is out now! We engineered clinical grade #hydrogels to design #bioinspired synthetic niches for mouse and human #liver #stem cells and #organoids for regenerative medicine and tissue mechanics modeling.
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Check out our beautiful review on "Bioinspired Hydrogels for 3D Organoid Culture" from Delphine Blondel #3D #syntheticmatrices
ingentaconnect.com/content/s…
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Follow-up paper with an application of the microcavity array technology to the derivation of mouse ESC-derived optic-cups, a beautiful self-organising system developed by THE pioneer, Yoshiki Sasai. Nice collaboration with the lab of Ivan Arsenijevic. nature.com/articles/s41598-0…
Very happy to see this published! Huge effort by Nathalie Brandenberg and Sylke Hoehnel who will take the technology to the next level @sunbioscience. Thanks much to our collaborators Fabien Kuttler, Gerardo Turcatti, Krisztian Homicsko, @tillringel, @schwanklab and George Coukos
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Check out some cool #micropatterns from @ManuelTHERY @ekass11 and @manf1984 @TheLutolfLab
cell.com/pictureshow/micropa…
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Engineering organoids 🔧🔬
Matthias Lutolf talked about our approaches to tackle current challanges in intestinal organoid development! @ISSCR #ISSCR2019 #Amsterdam
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Exploring and illustrating the mouse embryo: virtual objects to think and create with
biorxiv.org/content/10.1101/…
New cool article by @sonstance95 on visual representation in mouse #devbio! A guide+resource on using @emouseatlas volume models for illustration, exploration, outreach
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Check out our new @IHB_Research PhD program with @ETH_BSSE!! 👇
Exciting times at @IHB_Research! A new PhD program with @ETH_BSSE -> next-gen-bioengineers.ethz.c…. A search for new group leaders (early career) -> institutehumanbiology.com/ab…. It is a very interesting intersection at the moment: Exploration, Engineering, Translation! #Organoids #Basel
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Mini-colons display rich intra- and inter-tumoral diversity and recapitulate key pathophysiological hallmarks displayed by colorectal tumors in vivo. By fine-tuning cell-intrinsic and -extrinsic parameters, these mini-colons can be leveraged to unveil tumorigenic determinants.
Tumorigenic transformation can be spatiotemporally controlled by directing oncogenic activation through blue-light exposure, and emergent colon tumors can be tracked in real-time with single-cell resolution for several weeks without breaking the culture.
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Great piece on cancer organoids from @metricausa 👇
And @metricausa asked cancer researchers about what they find most useful about using cancer organoids in their research. nature.com/articles/s41592-0…
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Great chance to join an energetic team! Our new Sci Ops Director will champion #TeamIHB's collaboration with academic and clinical institutions and strategically manage our institute's operations. Please share with your network!
Exciting opportunity to become #TeamIHB's Scientific Operations Director! Help us drive IHB’s positioning in the scientific community and ensure the operational efficiency of the institute and its integration within the Roche ecosystem. Pls RT & details at bit.ly/ihbopsdir
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super interesting review, congrats @BeumerJoep @HansClevers !!
1. Adult stem cells (ASCs) compensate for cell loss during daily wear and tear. Evolution has created a variety of stem cell designs. In this review, @HansClevers and I define six hallmarks that are key enabling features of the basic function of ASCs, replacing lost tissue.
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It was indeed a lot of fun doing this together with @WarmflashLab and Jianping! Thanks a lot to @sonstance95 for designing the beautiful figures👍🙏!
Happy to have this review out @NatureMaterials. Hope this provides a useful intro to stem cell based embryo models for engineering audiences. Fun writing this with @TheLutolfLab and Jianping Fu nature.com/articles/s41563-0…
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Very excited to be involved in this... please consider submitting your papers at the interface of bioengineering, stem cells and developmental biology!
New @Dev_journal editorial from @katemmabrown1 & me
In which we welcome Associate Editors
@pf_mg
@TheLutolfLab
@FlyGutLab
@morris_lab
@Ken_Poss_Lab
Covering new & expanding areas of dev bio: modelling, engineering, metabolism, single cell, regeneration
dev.biologists.org/content/1…
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If you want to know more about the mechanobiology of early mouse embryos, have a look at Stefano's (@sonstance95) recent perspective! 🐭👨🏽🔧👩🏽🔧
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Very nice review by @heilshornlab @bauerlesavage 👍👏! Thanks much for involving us in this effort, was great fun!
Excited to share another recent review, out in @NatureMaterials! Learn about challenges and advancements in #cancer #organoids for disease modeling.
Congrats to @bauerlesavage for leading this effort and many thanks to our co-authors at @TheLutolfLab!
nature.com/articles/s41563-0…
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The 3D-printed intestinal organoid tubes recapitulate several features of the architecture and function of native tissue! Check out how Paneth cells can be stimulated to release secretory granules and how tubes can be perfused to remove dead cells: piped.video/JP-9bspZ0xU
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Special thanks @NicoBroguiere @boniandr @mkmiyamoto @ChulanKwonLab @romainGuiet @muggi_ @IBDMmarseille (Robert Kelly) @ViventisMicro who made this possible!
From gastruloids to organoids: our study on modelling cardiogenesis with ESCs just published @CellStemCell! Check it out: authors.elsevier.com/a/1c2sX… Fantastic work by @Giuliana_Rossi_ and collaborators! #gastruloids #embryoids #organoids
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In collaboration with @AMA_lab and @Duboule, we describe how mouse embryonic stem cells can self-organise into embryo-like structures ⬇️
#InHoxWeTrust #Gastruloids
A recent study in Nature reveals an unanticipated self-organizing capacity of aggregated embryonic stem cells and suggests that gastruloids could be used as a complementary system to study early developmental events in the mammalian embryo. go.nature.com/2RvCqLs
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20 countries have been represented in #LSCB so far!#scienceacrossborders
🇪🇸🇰🇷🇹🇷🇨🇭🇨🇦🇬🇷🇩🇪🇯🇵🇲🇦🇹🇼🇮🇳🇮🇩🇮🇷🇮🇹🇫🇷🇲🇽🇲🇰🇺🇸🇵🇹🇷🇺
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@GrayCampLab at #TeamIHB, @TreutleinLab & @lucaspelkmans have unveiled #CuttingEdgeResearch: a detailed image of the human retina. Unlocking new possibilities in eye disease diagnosis and treatment.
Witness the marvels of science 👁️ ethz.ch/en/news-and-events/e…
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Thanks @ab_meier for highlighting our preprint!
There will be blood – Gastruloids recapitulate early hematopoiesis in vitro
preLight by @ab_meier highlighting a preprint by @Giuliana_Rossi_ and @sonja_giger at @TheLutolfLab
prelights.biologists.com/?p=…
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Great team work!
biorxiv.org/content/10.1101/…
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Fantastic, congrats!!!
I still can’t believe it!! Phenotypic landscape of 400k intestinal organoids. The 3k compound fingerprints allowed us to infer the first map of functional interactions and to translate our findings into intestinal regeneration in vivo
nature.com/articles/s41586-0…
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Fantastic meeting, thanks a lot for having me!!
#BioEng24 is history - many new, many renewed bonds 🎇 #scienceprevails
THANKS @manoliskellis for documenting kindly (beside giving one-of many- stellar science talks we have been privileged to hear🙏👏🎉
THANKs to ALL attendees - check back for more coverage✅👍 @HelmholtzMunich
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These mini-colons mimic the cellular diversity, maturity and patterning of the natural colon. They show #stemcells proliferation restricted to the crypt, the development of highly mature colonocytes, and a thick mucus layer.
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👍👏!!!
🎬Bioprinted intestine 🎬 by @MoritzHofer_ and @TaniaHubscher #VoirEstSavoir2020 - Vote 05
Full scientific image exhibition 👉 go.epfl.ch/VES-online
@LeBIOP @EPFL_Imaging @EPFLevents @TheLutolfLab @EPFLculture
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Congrats Bart and team!! Great to see it published and glad we were able to make a small contribution.
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These bioengineered mini-intestines are a powerful tool for exploratory and translational research. They enable advanced modeling of the intestinal #epithelial barrier for drug testing and capturing the multicellular complexity of gastrointestinal diseases.
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Integrating #bioengineering with advancements in #organoids culture, we have generated human #minicolons simulating anatomical architecture of the natural colon with deep crypts and polarized columnar epithelia, exhibiting homeostatic epithelial cell turnover and longevity.
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LSCB wine tasting with guests from Cambridge! @AMartinezArias and Susan.
Congrats to 🇮🇹 (@Giuliana_Rossi_ ) and 🇨🇭(Moritz) for winning the competition! 🍷
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This approach enabled the creation of small intestinal tissues and the study of colon function in real time. Mini-colons effectively captured stem cell-targeted cytotoxicity and the rapid epithelial barrier disruption caused by anti-tumor drugs.
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was fun working on this with you and @HughesLabPenn!
The current issue of @stemcellreports is a special issue on stem cell-based embryo models edited by @fu_jianping and @NRivron. With @HughesLabPenn and @TheLutolfLab we have contributed a review on bioengineering of embryo-like models: cell.com/stem-cell-reports/f…
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Exciting positions in a fantastic lab, check it out!
PhD-and Post-doctoral positions in the field of neural stem cell metabolism available in my lab!
Check here for more details and how to apply:
wp.unil.ch/knobloch-lab/peop…
Looking forward to meeting highly motivated candidates, please spread the word! #lipiddroplets #braindevelopment
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Thanks, this was a lot of fun!!
🤩The first Swiss Gut Workshop was a success! So exciting to dive into the latest gut research from organoids to the gut-brain axis, all set against the stunning Lavaux landscape🤩
🙏 to all participants for sharing amazing science and @UNIL for support!
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We’ve generated long-lived human ‘mini-colons’ that stably integrate cancer cells and their native tumor microenvironment. These are optimized for real-time, high-resolution evaluation of cellular dynamics.
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Beautiful, congrats!!!
We’re really proud that our efforts to induce embryo-like architecture in #gastruloids, resulting in the generation of trunk-like-structures (#TLS), are now out in @ScienceMagazine - with @adrianobolondi @MPI_MolGen - A tweetorial (1/17) science.sciencemag.org/conte…
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This system unlocks exciting experimental possibilities, such as the multi-faceted evaluation of drug efficacy, toxicity and resistance in anti-cancer therapies,
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Upon 3D-bioprinting in permissive matrices, mouse intestinal stem cells fuse and self-organize, forming a centimeter-scale organoid ‘tube’ with crypts and villus-like domains!
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and the identification of immunomodulatory interactions among different components of the tumor microenvironment.
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This project was spearheaded by @olga_mitrofan and supported by co-authors @mike_nikolaev, @_xuquan, @NicoBroguiere, Irineja Cubela, @GrayCampLab and Michael Bscheider as a collaborative effort between IHB, Roche pRED and EPFL. Huge thanks to all!!
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the discovery of a cancer associated fibroblast (CAF)-triggered mechanism driving colorectal cancer invasion,
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Thanks a lot to our collaborators @sunbioscience, Krisztian Homicsko and George Coukos!
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Congrats and thanks for involving us a little bit in this great work!
A functional genetic toolbox for human tissue-derived organoids doi.org/10.7554/eLife.67886
Congratulations @sundakao @GurdonInstitute ! Thanks @eLife for posting so quickly! And many thanks to all of our lovely collaborators! 😍
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Check out @sonstance95 beautiful jellyfish-like endoderm 'tube' emerging in gastruloids!! 👇
🎬Deep see jellyfish 🎬 by @sonstance95 #VoirEstSavoir2020 - Vote 14
Full scientific image exhibition 👉 go.epfl.ch/VES-online
@TheLutolfLab @LeBIOP @EPFL_Imaging @EPFLevents @EPFL @EPFLculture
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