A monthly journal at the forefront of stem cell science and policy. Posts & opinions from Editor-in-Chief, Dr. Sheila Chari
Cambridge, MA
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Metabolic regulation of the hallmarks of stem cell biology by Jackson (@__btjackson) and Finley (@lydfinley)
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Collection highlight from Cell Stem Cell
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Harnessing synthetic biology to engineer organoids and tissues dlvr.it/SgcNFF
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Online Now! Hallmarks of regeneration dlvr.it/TC64V6 #stemcells
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Decoding aging-dependent regenerative decline across tissues at single-cell resolution
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Open stem cell research from Cell Stem Cell.
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Exercise reprograms the inflammatory landscape of multiple stem cell compartments during mammalian aging by Ling Liu at @StanfordMed et al.
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Hallmarks of regeneration dlvr.it/TCw0CZ
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Hallmarks of totipotent and pluripotent stem cell states dlvr.it/T3pqPr
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Replacing microglia to treat Alzheimer’s disease dlvr.it/StCx2v
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New Review online now CellStemCell: Programming hydrogels to probe spatiotemporal cell biology zpr.io/EEnTD2rpNTNR
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Our May issue is live! Featuring a Reviews Focus on Biomaterials and their applications in #StemCell biology, #TissueEngineering, and #RegenerativeMedicine from @JenniferALewis1, @TejalADesai, @BurdickLab, & @fu_jianping. Cover art from @saratysonart cell.com/cell-stem-cell/curr…
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Hallmarks of stemness in mammalian tissues dlvr.it/T0z7hQ
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Our Jan 2023 issue is live! The cover features a gene therapy strategy from @Ken_Poss_Lab using zebrafish enhancers to target injury sites in small and large mammals & improve heart #regeneration. Read this & more here👉 cell.com/cell-stem-cell/curr…
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Metabolic regulation of the hallmarks of stem cell biology dlvr.it/T2BVsm
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New issue alert! See exciting studies including our cover article on gene-edited hypoimmune islets that can reverse diabetes on transplant in an allogeneic non-human primate from Shrepfer lab @Sana_Biotech. Plus, the latest in our Hallmarks series from @leo_jwu! cell.com/cell-stem-cell/curr…
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Over the past year, we've featured 71 early-career researchers who discussed their research and the COVID-19 pandemic's impact on their labs & lives. We mark the closing of this article series with interviews and essays from some of the participants. cell.com/cell-stem-cell/curr…
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Cancer stem cell mimicry for immune evasion and therapeutic resistance dlvr.it/TBN2Kj
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Our April installment of Mentoring the NextGen features Fiona Watt @Cambridge_Uni. Great suggestions on who to seek as alternative mentors, what you get from putting yourself in a mentor's shoes, managing failures and breaking through the old boys club. cell.com/cell-stem-cell/full…
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Sox9-coordinated cellular neighborhoods generate fibrosis dlvr.it/T6NR1m
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A mechanical niche promotes the rejuvenation of blood stem cells dlvr.it/Sm822K
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Online Now! Autofluorescence is a biomarker of neural stem cell activation state dlvr.it/T4Sgjd #stemcells
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New issue alert! cell.com/cell-stem-cell/curr… The cover paper reports generation of humanized mesonephros from hiPS in chimeric pigs.
Other highlights include blastoid models of human development (incl pre-implantation to early gastrulation), reconstitution of proximal and distal lung with PSCs, how adrenergic nerves & type 3 innate immune cells control gut regeneration, detecting splicing aberrations in clonal hematopoiesis, wnt control of cartilage identity, and a Perspective on chemical reprogramming.
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Trained immunity in the bone marrow: Hub of autoimmunity dlvr.it/TG4mqW
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A stem cell zoo uncovers intracellular scaling of developmental tempo across mammals by @JorgeLazaroF et al.
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High-quality paper handpicked by the @CellStemCell editorial team
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New paper alert: Mouse embryo model derived exclusively from embryonic stem cells undergoes neurulation and heart development. From @ZernickaGoetz @MZG_Lab and colleagues- cell.com/cell-stem-cell/full…
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Happy New Year! We're ringing in 2024 with lots of great papers and an exciting Reviews series on the Hallmarks of Stem Cells! Check out the flagship Review from @HansClevers & Joep Beumer on Hallmarks of stemness in mammalian tissues. More to come! cell.com/cell-stem-cell/curr…
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Our August issue is live! The cover features a Technology article from @milicaruoft lab. The authors create patent, stable and perfusable microvasculature in cardiac tissue for organ-on-chip by integrating hiPSC-macrophages into their system. cell.com/cell-stem-cell/curr…
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Making blood from iPSCs: Reaching for the most sought-after prize dlvr.it/TGdqgM
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Online Now! Hallmarks of totipotent and pluripotent stem cell states dlvr.it/T30xvJ #stemcells
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New Article online now CellStemCell: Dietary suppression of MHC class II expression in intestinal epithelial cells enhances intestinal tumorigenesis zpr.io/vhJVu93vjCxD
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Decoding aging-dependent regenerative decline across tissues at single-cell resolution dlvr.it/Szr7RZ
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A new Review from @iannisaifantis1, @DrStass & Co provides a "Cell-by-Cell Deconstruction of Stem Cell Niches" cell.com/cell-stem-cell/full…
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Dawn of development: Exploring early human embryogenesis using stem cells dlvr.it/StCZjg
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Getting physical: Material mechanics is an intrinsic cell cue dlvr.it/SqCFcr
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New Short Article online now CellStemCell: SARS-CoV-2 infects the brain choroid plexus and disrupts the blood-CSF-barrier in human brain organoids zpr.io/HKsg3
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Our March issue is live! The cover story is @Zhu_Lab's in vivo #CRISPR screen that ID's chromatin regulators as druggable targets for liver regeneration.The image depicts characters who represent ribosomes repairing a damaged liver with the help of BAZ2i. cell.com/cell-stem-cell/curr…
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Online Now! Decoding aging-dependent regenerative decline across tissues at single-cell resolution dlvr.it/Sy2Vml #stemcells
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Online Now! Genome-wide CRISPR activation screening in senescent cells reveals SOX5 as a driver and therapeutic target of rejuvenation dlvr.it/THdkPb #stemcells
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Genome-wide CRISPR activation screening in senescent cells reveals SOX5 as a driver and therapeutic target of rejuvenation dlvr.it/SyJ7vY
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Online Now! Modeling blood-brain barrier formation and cerebral cavernous malformations in human PSC-derived organoids dlvr.it/T6x8jJ #stemcells
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Our latest issue is out! Featured on the cover, two papers from the Tabar & Studer labs set the stage for clinical study of hPSC-derived dopaminergic neurons for Parkinson's disease patients in the US. cell.com/cell-stem-cell/curr…
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Online Now! Exercise reprograms the inflammatory landscape of multiple stem cell compartments during mammalian aging dlvr.it/SmlBNf #stemcells
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Online Now! Organoid cultures for cancer modeling #stemcells dlvr.it/SqcY08
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Alternative splicing of a chromatin modifier alters the transcriptional regulatory programs of stem cell maintenance and neuronal differentiation dlvr.it/T6Kxvl
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Online Now! Pre-existing stem cell heterogeneity dictates clonal responses to the acquisition of leukemic driver mutations dlvr.it/TJB3Z2 #stemcells
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TGFB1 induces fetal reprogramming and enhances intestinal regeneration dlvr.it/SyJbL2
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OurJune issue features several exciting studies on stem cell models of human development, showing hESCs make trophectoderm & can be used to create blastoids. The cover art by Misaki Ouchida plays on the etymology of "placenta" which is “cake” in Latin. cell.com/cell-stem-cell/curr…
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Online Now! An iron rheostat controls hematopoietic stem cell fate dlvr.it/T36Hpj #stemcells
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Online Now! A pancreatic cancer organoid platform identifies an inhibitor specific to mutant KRAS dlvr.it/T0cms4 #stemcells
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Online Now! Highly cooperative chimeric super-SOX induces naive pluripotency across species dlvr.it/T0V194 #stemcells
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New issue alert! The cover from @Goodell_Lab features their paper on SCRAP mutations in clonal hematopoiesis and how epigenetic dysregulation and DNA damage repair combine to "superpower" mutant HSC clones. Check this out and more: cell.com/cell-stem-cell/curr…
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Early human development and stem cell-based human embryo models dlvr.it/TF0jqV
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Spatial-temporal proliferation of hepatocytes during pregnancy revealed by genetic lineage tracing
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Open stem cell research from Cell Stem Cell
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New Short Article online now CellStemCell: A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids zpr.io/HPeQi
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CRISPRi/a screens in human iPSC-cardiomyocytes identify glycolytic activation as a druggable target for doxorubicin-induced cardiotoxicity dlvr.it/TGcpln
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Transitional cell states sculpt tissue topology during lung regeneration
@LeaElHaddad, @arvikonk, @Tatalab_Duke, @KonishiSatoshi, @TataAleksandra
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Open stem cell research from Cell Stem Cell.
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New Article online now CellStemCell: Loss of Extreme Long-Range Enhancers in Human Neural Crest Drives a Craniofacial Disorder zpr.io/HmEYj
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Transcription factor dynamics, oscillation, and functions in human enteroendocrine cell differentiation dlvr.it/T9CWW5
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Genetic reporter for live tracing fluid flow forces during cell fate segregation in mouse blastocyst development dlvr.it/St8htW
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Online Now! Inflammation-induced epigenetic imprinting regulates intestinal stem cells dlvr.it/TCmw37 #stemcells
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From stem cells to regulatory T cells: A tale of plasticity dlvr.it/T7zkc8
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Inflammation-induced epigenetic imprinting regulates intestinal stem cells dlvr.it/TDyjWv
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Pluripotent stem-cell-derived therapies in clinical trial: A 2025 update dlvr.it/TH8fhd
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Harnessing matrix stiffness to engineer a bone marrow niche for hematopoietic stem cell rejuvenation dlvr.it/SmHFw4
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Online Now! Phase I clinical trial of intracerebroventricular transplantation of allogeneic neural stem cells in people with progressive multiple sclerosis dlvr.it/SzNKjB #stemcells
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Online Now! Coordinated differentiation of human intestinal organoids with functional enteric neurons and vasculature dlvr.it/TJKM8L #stemcells
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Online Now! Single-cell multi-omics defines the cell-type-specific impact of splicing aberrations in human hematopoietic clonal outgrowths #stemcells dlvr.it/StdcSQ
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Online Now! Spatiotemporal single-cell roadmap of human skin wound healing dlvr.it/TH1HDC #stemcells
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Maintenance of high-turnover tissues during and beyond homeostasis dlvr.it/SmGrLF
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Human iPSCs offer an alternative for modeling vascular malformation dlvr.it/THvLRB
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New paper from Franklin Lab @SCICambridge: Metformin Restores CNS Remyelination Capacity by Rejuvenating Aged Stem Cells: Cell Stem Cell cell.com/cell-stem-cell/full…
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The KRAS tour: Studying metabolic reprogramming in isogenic pancreatic cancer organoids dlvr.it/T11BS7
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A mitochondrial NADPH-cholesterol axis regulates extracellular vesicle biogenesis to support hematopoietic stem cell fate dlvr.it/T3wwz3
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Chemical reprogramming takes the fast lane dlvr.it/SmJjZQ
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New Article online now CellStemCell: Chemical-induced chromatin remodeling reprograms mouse ESCs to totipotent-like stem cells zpr.io/ixV29SWdbcZg
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The third installment of our Mentoring the Next Generation series goes with our bioengineering theme! @MIT's Robert Langer shares his thoughts on the power of positive reinforcement, co-mentoring, and following your own mind and heart. cell.com/cell-stem-cell/full…
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Happy New Year! To start off 2019, our January issue has a Reviews feature on Stem Cell Mechanisms of Cancer. Access to the 5 reviews and perspectives are free through the end of the month. bit.ly/2SvBRS1
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Online Now! Modeling early gastrulation in human blastoids with DNA methylation patterns of natural blastocysts dlvr.it/THM1Yc #stemcells
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Online Now! Human pluripotent stem cell-derived organoids repair damaged bowel in vivo dlvr.it/TD8fT8 #stemcells
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Breast cancer-on-chip for patient-specific efficacy and safety testing of CAR-T cells dlvr.it/T9KDXW
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Online Now! Marmoset and human trophoblast stem cells differ in signaling requirements and recapitulate divergent modes of trophoblast invasion dlvr.it/TDdn2l #stemcells
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Maternal gut microbiota influence stem cell function in offspring dlvr.it/THqghT
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New Article online now CellStemCell: Multi-omic analysis reveals divergent molecular events in scarring and regenerative wound healing zpr.io/3S7C8GRmpWrA
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Genome-wide CRISPR activation screening in senescent cells reveals SOX5 as a driver and therapeutic target of rejuvenation dlvr.it/THv5lr
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Online Now! Bioengineered human colon organoids with in vivo-like cellular complexity and function dlvr.it/T8DkvK #stemcells
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November 2018 marks the 20th anniversary of the paper that reported the initial human embryonic stem cell derivations and launched the field of human pluripotent stem cell research. Ludwig et al reflect on the impact of this groundbreaking achievement. bit.ly/2Qhh9aJ
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Collection highlight from @CellStemCell: Biomaterials to enhance stem cell transplantation from Bhushan Kharbikar, Priya Mohindra & Tejal Desai @UCSF @GradDivision @UCSF_BTS
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Oscillation steers differentiation dlvr.it/T9QBkd
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Online Now! Mechano-oncogenic cytoskeletal remodeling drives leukemic transformation with mitochondrial vesicle-mediated STING activation dlvr.it/TJ6Ncy #stemcells
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Online Now! Long-term engraftment and maturation of autologous iPSC-derived cardiomyocytes in two rhesus macaques dlvr.it/T7szH2 #stemcells
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Extra (embryonic) dialogues: Keys to improved stem cell-based embryo models dlvr.it/T2BMjG
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Multilineage circuits of regenerative cell states dlvr.it/SyMCft
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Online Now! Analyzing embryo dormancy at single-cell resolution reveals dynamic transcriptional responses and activation of integrin-Yap/Taz prosurvival signaling dlvr.it/T9ywCW #stemcells
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Sustained NF-κB activation allows mutant alveolar stem cells to co-opt a regeneration program for tumor initiation dlvr.it/TJP2lt
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Promises and challenges of organoids: From humanized to human derived dlvr.it/T3zljp
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Online Now! Primitive macrophages enable long-term vascularization of human heart-on-a-chip platforms dlvr.it/T8bKVw #stemcells
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Selective advantage of mutant stem cells in human clonal hematopoiesis is associated with attenuated response to inflammation and aging dlvr.it/TBN8DX
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A new paper from @studerl Lab reports on
"A Multiplex Human Pluripotent Stem Cell Platform Defines Molecular and Functional Subclasses of Autism-Related Genes" cell.com/cell-stem-cell/full…
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New from @SeanM_Wu & Co: Wnt Activation and Reduced Cell-Cell Contact Synergistically Induce Massive Expansion of Functional Human iPSC-Derived Cardiomyocytes cell.com/cell-stem-cell/full…
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Collection highlight from @CellStemCell: Harnessing matrix stiffness to engineer a bone marrow niche for hematopoietic stem cell rejuvenation
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