ALT A) (i) Photograph of trabecular bone structure and (ii) fluorescence micrograph of auxetic patch fabricated through CLEAR. Scale bars, 10 mm. (B) Multimaterial CLEAR printing through the switching of liquid resins and visualized with different fluorescent tracers (yellow and gray). Fluorescence micrographs of a multimaterial hydrogel in the shape of (i) a lattice (z direction) and (ii) an axial patch (xy direction). Scale bars, 5 mm. (C) Photograph of stiff hydrogels processed into porous, flexible patches that (i) conform to an underlying curved substrate and (ii and iii) are extensible. Scale bars, 30 mm. Shape recovery without permanent deformation demonstrated through (D) (i to iv) compression of auxetic octet-truss lattice and (E) (i to iv) stretching of 3D coil. Scale bars, 10 (D) and 5 mm (E).

ALT Fig.1. Engineering hydrogels to present extracellular signals to cells. Hydrogels consist of polymer networks in which polymer composition (natural, synthetic or hybrid polymers), polymer crosslinking (covalent or physical) and network degradation (user-mediated and cell-mediated) can be tuned. In addition, biological signals may be introduced as ligands to promote cell adhesion or as soluble factors. Cells interface with hydrogels either through seeding atop (2D) or being encapsulated within (3D).

ALT Overview of injectable granular composite system involving cell spheroids (purple) and microgels (green)

ALT Dr. Victoria Grace Muir stands behind a podium with the title slide of her thesis defense behind her. The slide reads Designing hyaluronic acid granular hydrogels for biomaterial applications.

ALT Graduates Maggie Prendergast (left) and Victoria Muir (right) with advisor Jason Burdick (middle)

ALT Dr. Maggie Prendergast stands behind a podium with the title slide of her thesis defense behind her. The slide reads fundamentals and applications of 3D suspension bath bioprinting for the engineering of menos al tissue

ALT Suspension bath printing of dynamic granular hydrogels to produce shape-morphing multi-material structures. a)Schematic of dynamic granular hydrogel design using temperature-responsive microgels. Temperature-responsive microgels reduce in volume when heated, resulting in macroscopic and microporous structure changes in granular hydrogels. b) Schematic of suspension bath printing using responsive granular ink and non-responsive granular bath to fabricate multi-material objects with programmed actuation. Printed structures are expected to actuate depending on the printed pattern design and bath shape.

ALT Burdick lab group photo - CU Boulder

ALT Schematic of embedded bioprinting processes to fabricate meniscal constructs.

ALT Figure 1. VAM printing of reactive macromers. Riffe et al Adv Mat 2024.

ALT Stepwise guide to digital light processing of hydrogels.

ALT Burdick Lab BMES presentations for Seattle Meeting - see online schedule for more details on the BMES website.

ALT In vivo study design and assessment of disc height index (DHI) in a goat model of disc degeneration. a) Overview of in vivo study design and outcome measures. b) Representative intra-operative images of percutaneous delivery of the injectable radiopaque granular hydrogel into goat cervical spinal discs using a syringe and 18G needle. c) Representative intra-operative fluoroscopic images in the sagittal, coronal, and axial planes depicting hydrogel positioning within the intradiscal space. d) Representative radiograph image of a goat cervical disc pre-injection of the hydrogel and subsequent images of the same disc 2, 4, 6, and 8 weeks after receiving the hydrogel injection. e) Quantification of the average disc height index (DHI, %) over the 12-week duration of the study, where the blue region indicates the 8-week period after hydrogel delivery in a subset of discs. Statistical significance compared to healthy controls at each time point is indicated (degenerative in gray; hydrogel-inj

ALT MEW scaffolds

ALT Burdick lab presentations at TERMIS 2024

ALT Graduates Maggie, Jon, Selen and Victoria with Jason in front of stage with Penn Engineering logo in background

ALT Photo of Irvine Auditorium with graduates and attendees in seats. On the stage are the stage guests, including faculty, with Penn Engineering logo behind stage guests

ALT Graduates Maggie, Jon, Selen and Victoria in front of stage with Penn Engineering logo in background

ALT Picture of the women in the Burdick lab at CU boulder for international women's day

ALT NSF GRFP awardee - Alysee DeFoe

ALT Burdick Lab presentations at BMES 2024 in Baltimore, MD.

ALT office watch party for Karen Xu's thesis defense

ALT Hydrolytically degradable NorHA (with addition of CA group), and DLP processing