Eternally asking questions. Likes guts. Has guts, and a lab @TheCrick
London, England
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- Following 1,041
- Followers 3,047
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Testes are hungry; they want citrate. They talk to the gut and make it male. The male gut feeds citrate to the testes. Testes are happy. They make sperm. Lab’s latest and the filthiest of summer reads: cell.com/cell/fulltext/S0092…
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Eating for two? Blame your gut neurons! (or so say flies...). By the phenomenal @Drosostalis, our dream team and great collaborators @EnergyMemoryLab @deMendoza_Alex @aexbrown and Fengqiu Dia and Ben White
disq.us/t/3sjefbd
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Pleased, relieved, excited! Thank you @ERC_Research and those of you out there who believed in our idea. It couldn't have happened without a great team, past and present. Special mention to Laura Blackie and Pedro Gaspar, who were brave enough to take this on and make it fly!
📣 Amazing #News
Prof Miguel-Aliaga (@FlyGutLab) has been awarded with her 3rd grant from the @ERC_Research 🏅
Continuing her outstanding work at the LMS, she aims to interrogate further why organs have the shapes & positions they do.
👉lms.mrc.ac.uk/lms-professor-…
#ERCAdG
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Insulin signalling, intestinal interoception, sex differences and more: our review on how fruit flies lead to new discoveries in metabolism and metabolic disease is now out in @Cell_Metabolism cell.com/cell-metabolism/ful…
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Everything you always wanted to know about the fly gut (and almost certainly more!). Our 35-page #FlyBook chapter with Henri Jasper and Bruno Lemaitre is out: genetics.org/content/210/2/3…
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Who needs progenitors? Terminally differentiated skin cells continue splitting without replicating their DNA! disq.us/t/477853k
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Our lab’s latest, seven years in the making! #Zinc sensing in gut cells sustains #Tor signalling and promotes food intake. We got to name the sensor; #GameOfThrones fans will be pleased (I can’t say I am amongst them!) #Drosophila #Anopheles disq.us/t/3n0eb29
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If you're 35 or older and in the London area, we want your guts (well, images thereof, rather). Help us understand sex differences in the human GI tract. Retweets much appreciated!
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11 authors: 9 did the work in my @MRC_LMS lab, all EU citizens, only 1 UK citizen. Together = exciting discoveries for which UK institutions @The_MRC @imperialcollege get the credit. This is what "foreigners stealing our jobs" really looks like #Brexit
New research from @FlyGutLab and colleagues published today reveals how the testes talk to the gut to get the molecule that is needed for sperm production. Read more and check out some incredible images here: lms.mrc.ac.uk/testes-sweet-t…
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I wrote about the importance of including both sexes in your experiments, even as a molecular/cell biologist nature.com/articles/s41580-0… @NatRevMCB
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If you're in the London area, we want your guts (well, images thereof, rather). Help us understand sex differences in the human GI tract!
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Wow a segmentation clock in a bacterial community cell.com/cell/fulltext/S0092…
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Food, microbes, sex and old age: our thoughts on what gastrointestinal neurons do and how/why they change. Out today in Current Opinion in Neurobiology: doi.org/10.1016/j.conb.2019.…
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Our #Keystone symposium Metabolic Decisions in Development and Disease is around the corner! Abstract deadline for talks in a week. Great speakers including co-hosts @RJDLab and Marian Walhout. Come see how smart #metabolites can be! shorturl.at/twGT7 #VKSMetaDisease21
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Inter-organ and interactive: virtual get together @MRC_LMS hosted by our Genes & Metabolism Section. Short talks, longer discussions. Free registration. Book early to avoid disappointment ;) #LMSInterOrgan
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Cool lab day out yesterday, off the beaten track tour of the East End’s history and street art (and pub lunch of course). Thank you @AlternativeLdn!
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How to start a paper: "Our bodies are catacombs of spaces connected to the outside world and filled with fluid" (by Jared Diamond, in his first life as a physiologist). What can you possibly write after that?
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If anyone is left on Twitter, you might be interested in this review I contributed to - mainly the (good) work of @TrajkovskiMirko and Ozren Stojanovic. Comes with lots of pretty gut cartoons!
Did you know that the gut can grow and shrink? And that this intestinal remodelling impacts its capacity to take up calories?
Check out our latest paper (very nice collaboration with @FlyGutLab) on gut size just published in @NatMetabolism.
Read here: rdcu.be/cZT8F
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Looking forward to meeting you in 2D!
Join us on Monday, when the amazing Dr. Irene Miguel-Aliaga @FlyGutLab will tell us about the plasticity of the intestine in adult flies & mammals, gut-brain communication, and more. Register here: crowdcast.io/e/brainbody-mig… where you can also sign up for the Q&A afterwards.
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but looking forward to our new life in the brand new @MRC_LMS building, which is looking fabulous! (thanks @vaquerizas_lab for the picture). You will find us on the 4th floor.
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The RIKEN Center for Biosystems Dynamics Research @BDR_RIKEN is recruiting team leaders and hosting a cool symposium on biological transitions in March, deadline in Jan... make it your New Year's resolution! @MRC_LMS @vaquerizasjm and myself will be there.
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Very happy this special issue is out. Various articles showcase instructive roles of #metabolites in #development in a range of animal/plant systems. Plus a bunch of thoughtful, more conceptual reviews. Pleasure to put it together with @lydfinley, @RutterLab and Josh Gendron!
Special Issue #DevSImetabolism is now complete!
Cover image: During Stage 10B of Drosophila oogenesis, lipid droplets (green) accumulate at the same time as the actin cytoskeleton undergoes dynamic remodelling (magenta). See Research Article Giedt et al.
journals.biologists.com/dev/…
ALT Cover image of special issue
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Registration for the Physiology event of the year is now open. All animals welcome! Help us spread the word and join us in Heidelberg or from wherever you are in the world.
Are you interested in various aspects of vertebrate and invertebrate animal physiology? 🦠 Or want to know how recent developments in whole-organism physiology can pave the way to novel, adapted, and efficient therapies for multiple degenerative diseases? Then come join us for #EESPhysio! 🧬
💻 s.embl.org/ees24-05
📅 23 – 26 April 2024
🌍 EMBL Heidelberg and virtual
📥 Submit your abstract by 30 January
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For those struggling with the first line of an abstract, this article provides a versatile one jeb.biologists.org/content/2…
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Interested in the sex and geometry of organs? Come and do your PhD project with us at @TheCrick . Application deadline Nov 9!
crick.ac.uk/careers-study/va…
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REGISTRATION NOW OPEN. It is finally happening... in person or remotely! @embl Inter-organ communication in physiology and disease embl.org/about/info/course-a…
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I never expected to get excited about a new exon but this is a cool finding / clear paper science.sciencemag.org/conte…
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Postdoc, technician and PhD posts available in the lab. Gut-brain, sex differences, organ plasticity, flies, mice, intestinal organoids. Friendly and international environment, excellent facilities, ERC/MRC-funded, Brexit-proof! miguelaliagalab.com/news/lat…
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I couldn't agree more! A big thank you to all the organisers and helpers for all the fun and scientific excitement!
#EDRC2023 in a nutshell: Exciting Science, great people, full rooms and poster sessions, straws, boat trip, wine and cheese, great food and a superb party. The hearts of the organizing committee is very light after all the great feed backs we got. Thank you all. GO #EDRC2025 !!!
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Rotting bananas, organ stickers. Fly labs @imperialcollege @MRC_LMS bringing flies to the masses at #ImpFest
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Very clear and important piece, relevant to life scientists beyond neuroscience. Ditch your t tests and even your ANOVAs! cell.com/neuron/fulltext/S08…
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Great work from our next door neighbours @HirabayashiLab; muscle wasting feeds tumours with an amino acid, Holly and Susumu fixed the tumours with a drug! biorxiv.org/content/10.1101/…
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Looking forward to contributing! Please consider @Dev_journal for your submissions on instructive roles of metabolites in development and beyond
New @Dev_journal editorial from @katemmabrown1 & me
In which we welcome Associate Editors
@pf_mg
@TheLutolfLab
@FlyGutLab
@morris_lab
@Ken_Poss_Lab
Covering new & expanding areas of dev bio: modelling, engineering, metabolism, single cell, regeneration
dev.biologists.org/content/1…
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"My scientific hero is women who persevere through prejudice and raise children while doing research" R. Medzhitov goo.gl/uvNwxZ
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"If you took 30 steps from your front door, with each step twice as large as the last, how far could you get? It’s 26 times the Earth’s circumference. Our inability to appreciate how powerful exponential growth can be has concrete consequences" bit.ly/2xdQi7k
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The placenta is an absolutely amazing organ - placenta and mesentery are two inexplicably understudied organs in our body. If only flies had them...
The placenta's role in penis development - apparently not just a job for the testes. Human fetal masculinisation depends on #testosterone production by the testes and... on androsterone, made from placental precursors #PLOSBiology plos.io/2InMFBg
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I enjoyed this review's historical perspective. Good to know that the famous fathers of #Drosophila #cancer research had mothers. Plus references to Garcia-Marquez... what's not to like? dmm.biologists.org/content/1…
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Congratulations to our PhD student @AlvaroCastanoM for his award-winning large intestine!
Thanks to everyone who joined our imaging competition! It was an agonising decision for our judges 🧐but please congratulate our winners for their beautiful images!!!!
1st Prize: Anastasia Popwycz
2nd Prize: Morgane Le Dréan
3rd Prize: Álvaro Medina
🥳🥳🥳🙌🙌🙌
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Insect Christmas and a Gutsy New Year from us! (festive fly courtesy of former lab member Paola Cognigni)
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So no to no-deal, no to extension, no to the current deal and (EU says) no to amending the deal. Logically, that equals no Brexit. Except logic is nowhere to be found.
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Me, a medal! My sports teacher at school would be gobsmacked! Thanks to lab members past and present, our collaborators, scientific community, @MRC_LMS, and @AlexGouldLab and Petra Hajkova for nominating me.
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Gut-brain event of the week (year!) Gastronauts Global starting tomorrow! @Lauracells and I will be hosting the London session featuring great speakers @RMedzhitov @UlrikaKMarklund @nilyapici and Layla Kamareddine
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Sex in unexpected places: our new work on #stemcells, organ size and #tumours is out nature.com/nature/journal/v5…
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Congrats to all but particularly to our former lab member @Drosostalis, we are very proud!
🎉 The latest ERC Starting Grant competition results are out!
400 bright minds have been awarded over €628 million to fund ideas at the frontiers of science & scholarship.
Find out who, where and why 👉 erc.europa.eu/news-events/ne…
🇪🇺 #EUfunded #FrontierResearch #ERCStG @HorizonEU
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Pleased to announce that our inter-organ meeting has been postponed to 20-23 March 2022. Stay safe in the meantime...
Discovering inter-organ communications and illustrating the progress of molecular and genetic understanding of whole-organism physiology. #EESInterOrgan
Submit abstract by 6 January 2020⏳
15 - 18 March 2020, Heidelberg, Germany👉 embo-embl-symposia.org/sympo…
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And do get in touch if you're interested in inter-organ communication, 3D imaging, tissue geometry, tsetse flies or anything else we might not have thought of yet!
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Proud that we have achieved this. One small step for gender equality, one giant leap for a few people at work nitter.app/Athena_SWAN/status/100…
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Meta-Research: The need for more research into reproductive health and disease doi.org/10.7554/eLife.75061
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Immune cells as mediators of nutrient adaptability in the intestine. Beautiful study. Immune system increasingly looking like a broader "environment system"... science.sciencemag.org/conte…
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Our lab's latest: intestinal roles for the Ret neurotrophic receptor in flies/mice... but outside neurons! emboj.embopress.org/content/…
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Virtual but just as exciting and interactive, and with an amazing speaker lineup. Deadline for abstracts in 3 weeks... make this your New Year's resolution!
❗📣 'Inter-organ communication in physiology and disease' goes fully VIRTUAL - and there's still time to sign up! #EESInterOrgan 👩🏿🔬💬
New deadlines:
Abstracts➡️ 24 Jan
Registration➡️ 21 Feb
👉🏾 s.embl.org/ees22-02
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What our "control" flies have been up to...
1. The first paper from my lab became online @NatMetabolism. Our graduate student, Ayaka, mainly worked on this project. white, which should be the most famous fly gene, regulates aging-induced intestinal stem cell proliferation through folate metabolism.
nature.com/articles/s42255-0…
ALT Drawn by Hiroko Uchida @ucchy_v4.
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We've gone virtual... and global: six short and sweet sessions hosted live from six different locations: Adelaide – Australia, Doha – Qatar, Durham – USA, London – UK, Nantes – France, and Porto Alegre – Brazil. Our contributors remain stellar!
Interested in Gut-Brain axis with fantastic speakers?
Come to🇫🇷 for #Gastronauts2020🤯
👉34 days before early-bird registration ENDS !!!
Check out the program: thinkgastronauts.com/nantes/
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Enteroendocrine control of ovary physiology - the nice PhD work of our postdoc Tomo
How mating enhances egg production: gut-derived systemic factor, neuropeptide F, couples mating stimulus (sex peptide from sperm) to germline stem cell behavior through inter-organ communication in the #FruitFly #PLOSBiology plos.io/2IdJnNb
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High fat diet induces microbiota-dependent silencing of enteroendocrine cells doi.org/10.7554/eLife.48479
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Turning our #Brexit frustration into collaboration. First
@MRC_LMS @HelmholtzMunich @PioneerCampus @helmholtz_diabc #metabolism workshop starting this afternoon
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More power to micronutrients! Emily Strachan and I wrote about the latest work from the @PerrimonLab
PXo bodies are a new type of organelle discovered in fruit flies. Emily Strachan & Irene Miguel-Aliaga @FlyGutLab unpack the implications of this finding in a great N&V go.nature.com/40XzARX
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both sad and excited to vacate our current building. We will miss our neighbours in ICTEM @BorisLenhard @santiago_vernia @mikhailspivakov @tobias_warnecke!
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including our very own PhD student @AlvaroCastanoM @MRC_LMS @ImperialMed! Let's hope the prize is contagious ;)
Today, we invite 635 Young Scientists from all over the world to meet around 40 Nobel Laureates at the 72nd Lindau Nobel Laureate Meeting (25-30 June 2023 | #Physiology #Medicine | #LINO23) We can't wait to welcome you all to Lindau!
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"Suzanne possessed a grace and sweetness that one rarely encounters. She loved complicated things and was a master at many of them"
MPI-CBG remembers Suzanne Eaton: mpi-cbg.de/suzanne-eaton/ @mpicbg @csbdresden @BIOTEC_TUD @BIOTEC_TUD @maxplanckpress
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worms "see" colour without eyes! science.sciencemag.org/conte…
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50% female (and so far amazing) speakers at #2015SDB. Well done @___SDB___! #womeninscience
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We’re at #ExRdFest again today from noon - learn about how and why our organs grow and shrink, and try to make the longest gut on our Bungee Gut!
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Just updated our lab's website. 60% female miguelaliagalab.com/people/. Will do what I can to progress their careers equally and thus maintain the ratio #InternationalWomensDay
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Our lab is there! Go and watch Chris Amourda and Laura Blackie's talks today, in the Patterning/Morphogenesis/Organogenesis and Physiology/Metabolism sessions
A beautiful beginning to #Dros23 in Chicago! Your humble Fly Meeting organizers @SavrajGrewal @levine_lab @DePaceLab @Jenjemc & Lucy are excited to welcome you for 4 fab days of flies and community! @GeneticsGSA
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Thank you for another year of #SuffrageScience awards and very happy that one came back to us at the @MRC_LMS this time. Let's keep trying to make the voices of the underrepresented heard in science #womeninstem
Today marks the fifth #SuffrageScience awards for Life Sciences and we are celebrating the new recipients from Institutes and Universities around the world with the handing on of heirloom jewellery designed by students at @csm_news lms.mrc.ac.uk/suffrage-scien…
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8 months too late, but this is an important commentary on our relentless and ultimately pernicious mis-use of “necessary and sufficient”. I am a convert. But don't follow me for breaking news. tandfonline.com/doi/full/10.…
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"Inspired by organisms such as loaches that use intestinal air breathing"... power to comparative physiology! cell.com/med/fulltext/S2666-…
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Deadline for abstract submission Jan 24. We want to hear about YOUR ongoing work and new ideas. All animal models welcome! (even flies 😉) embl.org/about/info/course-a… #EESInterOrgan @EMBLEvents
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"In the most severe cases, the mutant flies consumed so much that they exploded, reminiscent of the scene in the Monty Python film The Meaning of Life in which a person’s stomach explodes because of gross overeating."
Visceral Mechano-sensing Neurons Control Drosophila Feeding by Using Piezo as a Sensor: Neuron disq.us/t/3rjux9i
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Somewhat unfortunate timing and almost certainly useless against COVID-19, but great team effort and collaborations @Sia_hai, @ClarePilgrim @Lena_Riab @GiesenLena @farah_dahalan @marakat @nikiwind @tobias_warnecke @LeulierFrancois
Our lab’s latest, seven years in the making! #Zinc sensing in gut cells sustains #Tor signalling and promotes food intake. We got to name the sensor; #GameOfThrones fans will be pleased (I can’t say I am amongst them!) #Drosophila #Anopheles disq.us/t/3n0eb29
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featuring the first Drosophila faecal transplants! nitter.app/LeulierLab/status/9464…
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Animal behaviour controls body size/shape. Perhaps also relevant to organs within bodies
What drives size and shape development in a soft-bodied animal? Our new preprint, led by the outstanding @EMBL PhD student, Anniek Stokkermans, in a prolific collaboration with @Prevedel_Lab/ Hiiragi lab/ @Mahadevan_Lab, solves this morphological mystery! biorxiv.org/content/10.1101/…
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Please spread the word: positions for scientists displaced by conflict
We have several opportunities for scientist refugees to join us.
These Fellowships are designed to facilitate the continuation of a research career for post-doctoral researchers who have been displaced by conflict.
Please share widely
👉 ow.ly/UpcP50J11KL
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Registration open for Drosophila Crete meeting goo.gl/p6iLUy. PIs only, but new/female PIs particularly welcome #EMBODrosophila
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"As long as there is stagnation in men’s roles, there will be an upper limit on the amount of change that can be achieved for women’s roles as well". Interesting perspective on gender bias including suggested actions cell.com/neuron/fulltext/S08…
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Join us for three short talks at the exciting interface between #development and #metabolism and consider submitting your work to this special issue I will be co-editing with @lydfinley @RutterLab and @GendronLab. All model (and non-model) organisms welcome!
We are delighted to announce that the topic of our next #Devpres webinar & our upcoming special issue is ‘Metabolic and Nutritional Control of Development and Regeneration’.
To register for #Devpres on Wed 7 Dec & for more on our call for papers: thenode.biologists.com/devel…
ALT Development presents... flier, advertising a webinar on Wed 7 Dec at 15:00 GMT, chaired by Irene Miguel-Aliaga Natalia López Anguita (PhD student in the Stem Cell Chromatin Group at the Max Planck Institute for Molecular Genetics) ‘Role of hypoxia in pluripotent cells and during differentiation via gastruloid formation’ Hannah Brunsdon (Postdoctoral Research Fellow in Liz Patton’s group at the IGC, University of Edinburgh) ‘Aldh2 is a metabolic gatekeeper in melanocyte stem cells’ Benjamin Jackson (MD-PhD Candidate in Lydia Finley‘s group at Memorial Sloan Kettering Cancer Center) ‘A non-canonical tricarboxylic acid cycle underlies cellular identity’
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Thanks to @Dev_journal for featuring our @KeystoneSymp meeting, and to @LlucMosteiro, @hanahariri and @Jellevda for writing about it!
Metabolic decisions in development and disease
A virtual @KeystoneSymp Meeting Review by @LlucMosteiro, @hanahariri & @Jellevda
journals.biologists.com/dev/…
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Happy to have contributed. Quoting T. Hiiragi "We need to know what we want to know. It will be the question, idea, and style that identify scientists—like an artist identifiable by their art. Be creative. Science will be once again closer to art." cell.com/developmental-cell/…
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Defend or reproduce? Muscle-derived glutamate determines an immune-reproductive energetic tradeoff cell.com/cell-metabolism/ful…
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Important virtual EMBL/EMBO/HHMI conference on gender and academia coming up embl.org/news/events/closing… via @embl
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Credit to many in the @FlyGutLab, our collaborators Thomas Preat and Pierre-Yves Placais and, especially, former postdoc Bruno Hudry who did most of the work and whose adventures from now on you may follow here ibv.unice.fr/research-team/h…
Testes are hungry; they want citrate. They talk to the gut and make it male. The male gut feeds citrate to the testes. Testes are happy. They make sperm. Lab’s latest and the filthiest of summer reads: cell.com/cell/fulltext/S0092…
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More Speed, More Haste, More Stress, More Waste. Assess quality rather than quantity, acknowledge teamwork cell.com/trends/cognitive-sc…
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What a stimulating couple of days #EESInterOrgan. Great discussions on gut-brain-microbe communication, immune-metabolic crosstalk and non canonical inter-organ crosstalk. Thanks to all speakers and attendees!
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Looking for a postdoc? Interested in splicing and/or metabolism? Santiago Vernia and I have a joint project for you! Apply here by Dec 7: ow.ly/LHmv30gC7Sl
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Happening tomorrow! Join us at 3pm GMT to hear about latest work at the interface of development and metabolism from the labs of @bulutkarslioglu @jvveenvliet @lydfinley @patton_lab. There is still time to register
Our #Devpres webinar on metabolism is happening next week on Wednesday 7 December, featuring talks from Natalia López Anguita @nata__93, Hannah Brunsdon and Benjamin Jackson @__btjackson, chaired by Irene Miguel-Aliaga.
Register here: us02web.zoom.us/webinar/regi…
ALT Promotion poster for Development presents... webinar, taking place on Wed 7 Dev 15:00 GMT
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Small, interactive symposium on inter-organ communication. Wider scope beyond the usual organs, signals and diseases
Discovering inter-organ communications and illustrating the progress of molecular and genetic understanding of whole-organism physiology. #EESInterOrgan
Submit abstract by 6 January 2020⏳
15 - 18 March 2020, Heidelberg, Germany👉 embo-embl-symposia.org/sympo…
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Lysosomal cystine mobilization shapes the response of TORC1 and tissue growth to fasting science.org/doi/10.1126/scie…
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A must on your Christmas list. Broader scope beyond usual organs/models. Brain, gut, pancreas, liver and beyond. Health and disease. Worms, flies, mice, humans. Abstract deadline coming up! #EESInterOrgan
Discovering inter-organ communications and illustrating the progress of molecular and genetic understanding of whole-organism physiology. #EESInterOrgan
Submit abstract by 6 January 2020⏳
15 - 18 March 2020, Heidelberg, Germany👉 embo-embl-symposia.org/sympo…
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the ancestor of complex cells may have been an extrovert... nice feature on tentacled archaea and the origin of eukaryotes nature.com/articles/d41586-0…
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From gut to brain... the neuropod way science.sciencemag.org/conte… by @gutsybrains
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