PLOS Biology, the PLOS flagship journal in life sciences, is a highly selective open-access, peer-reviewed general biology journal @PLOSBiology@fediscience.org

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"Scooped"? We prefer to call it "complementary research," recognising its important role in reproducibility of science. Come to #PLOSBiology within 6 months of "scooping" and we'll consider it. See our new policy here: plos.io/2rRvTSA
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Cell tracking analysis made easier... @gomez_mariscal @JwPylvanainen @guijacquemet &co present #CellTracksColab, a transformative solution for #CellTracking analysis, combining cutting-edge computational methods with a user-friendly interface #PLOSBiology plos.io/3WEqOIr
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Super-fast, low-cost, low-tech prep of DNA or RNA from plants/animals/bugs in 30 seconds, using filter paper or paper towelling #PLOSBiology plos.io/2zbfNT0
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Floating life (#neuston) & trash cluster in the #GreatPacificGarbagePatch. High neuston abundance was only known in the #SargassoSea, but @this_fionachong @RebeccaRHelm &co reveal high densities of floating life in the plastic-rich GPGP #PLOSBiology plos.io/3LXY3CC
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The mysterious 'neuston' ecosystem at the ocean’s surface includes organisms like the seaweed Sargassum, floating barnacles, snails, nudibranchs & cnidarians; @RebeccaRHelm explores threats to its wellbeing and importance of further research #PLOSBiology plos.io/3uao06E
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Want to make your data look beautiful, but without learning coding skills? Try #PlotsOfData - an intuitive web-based tool for state-of-the-art #DataViz - Marten Postma & @joachimgoedhart in #PLOSBiology app: huygens.science.uva.nl/Plots… paper: plos.io/2V3I5Kk
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Do our #mitochondria run at 50 degrees? Temp-sensitive probe suggests they run 10 deg hotter than cells #PLOSBiology plos.io/2rE6cVx & read Nick Lane's take on the implications & problems: plos.io/2DGkL0j
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More secrets from the jellyfish that yielded GFP, transforming the study of living cells. @LABrechaun @NathanShaner &co reveal that A. victoria and its Aussie cousin encode a diverse set of fluorescent proteins, incl the brightest yet described PLOSBiology plos.io/35ZwQJl
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Which genes are hot... and which genes are not? Massive study of gene-specific bias in publication and funding shows that most human research is done on just 10% of genes, and predicts the most promising neglected gems #PLOSBiology plos.io/2Nl1TZR
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Nitrogen-fixing slime frees corn from fertilizer. Indigenous #Mexican maize produces slime on its aerial roots that hosts nitrogen-fixing #bacteria that provide up to 82% of the #plant’s nitrogen requirements #PLOSBiology plos.io/2OSUFcw
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In honor of #WorldOceanDay, we’re highlighting some of our most exciting research and commentary on #MarineBiology and #ocean research. This beautiful study from @RebeccaRHelm &co catalogues life in the North Pacific “Garbage Patch” plos.io/3LXY3CC
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What is the cost of science being conducted in English? @tatsuya_amano &co reveal that non-native English speakers spend more effort than native speakers in conducting scientific activities (reading, writing, preparing presentations...) #PLOSBiology plos.io/46Rfptc
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Editorial: We need leaders that believe in scientific evidence PLOS Biology cannot stand by in silence while trust is undermined by those elected to make decisions in the name of and for the benefit of society We urge you to vote wisely! plos.io/34lyl59
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The #phylogenetic tree has been a core conceptual tool for #EvolutionaryBiology for nearly 200 years. @RoliRoberts explores the role of the tree as a metaphor, discussing two new #PLOSBiology Essays (by @jlsteenwyk & @caseywdunn) that look to the future plos.io/3VjDSU8
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Most RNA #viruses cause acute infections, but phenomena such as #LongCovid suggest that viral #RNA can persist after recovery. In this Unsolved Mystery, Diane Griffin explores the meaning, origins and consequences of persistent viral RNA. @JohnsHopkinsSPH plos.io/3MfSPio
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#SARSCoV2 doesn't like it hot. #COVID19 involves onset of fever, raising body temp to 38-41°C; study shows that raising temp to 40°C limits replication of #SARSCoV2 in respiratory airway cultures, independently of interferon-mediated defences #PLOSBiology plos.io/3ec42C5
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A chromosome carrying a color patterning supergene has spread rapidly through a population of African monarch #butterflies by hitchhiking with a male-killing #endosymbiont (hitchhiking between unlinked genomes) @simonhmartin &co in #PLOSBiology plos.io/387mfuM
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Want to attract computational biologists to your project or to your department? @DrAnneCarpenter @FertigLab & 14 other #compbio folks explore solutions to problems faced in career advancement, publication & grant review #PLOSBiology plos.io/3iKmKn0
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Silkworms normally only eat mulberry leaves; can we make them love apples? A genetic study reveals that mutation of a single bitter gustatory receptor GR66 converts the #silkworm, a typical monophagous #insect, into a polyphagous species #PLOSBiology plos.io/2EhTxL3
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Ancestral immunity: @EnzoZ_P @AudeBer &co explore the concept of ancestral #immunity - the set of immune modules (domains & proteins) conserved between #prokaryotes & #eukaryotes - including a putative evolutionary scenario for its existence #PLOSBiology plos.io/4cJNLRm
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For junior researchers, the challenges of the #COVID19 pandemic extend beyond lost time and are career-threatening. @TLowePower @DrLouiseDyson & @ampolter argue that without intervention, academic science could lose a generation of talent #PLOSBiology plos.io/2RCDzGd
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Why spend €1000s on a #spectrophotometer when you can make one for <€5? Plans for 3D-printed cuvette holder with LED block, which with smartphone Ambient Light Sensor makes a high-performance, low-cost spectrophotometer. Also #Lego version! #PLOSBiology plos.io/2Xavjha
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Analysis of 36 million authors across >6000 journals reveals woeful #GenderGap across #STEMM disciplines, "likely to persist for generations, particularly in #surgery, #computerscience, #physics, and #maths" #PLOSBiology plos.io/2HN7e5W
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Pleiotropy has long been assumed to hinder adaptation. @EvolSys explores a #PLOSBiology study that instead suggests that regulatory networks may evolve to ensure mutations are beneficial in correlated environments. Primer: plos.io/4fby0D8 Paper: plos.io/4glXoXJ
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#Viruses infecting #bacteria & #archaea are often identified via metagenomics, but information regarding #phage hosts is lost. @simroux_virus &co present iPHoP, a new tool to maximize host prediction for #metagenome-assembled virus genomes #PLOSBiology plos.io/41A5QvG
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Many bacterial & archaeal defense systems are encoded by mobile genetic elements. @eprocha & @dbikard argue that this challenges our ideas of their role in cells: Who's defending? From what? And what's the role of the cellular genome in this?#PLOSBiology plos.io/3npRifQ
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The mysterious 'neuston' ecosystem at the ocean’s surface includes organisms like the seaweed Sargassum, floating barnacles, snails, nudibranchs & cnidarians; @RebeccaRHelm explores threats to its wellbeing and importance of further research #PLOSBiology plos.io/3uao06E
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Comparing #scRNAseq data across species: Sam Church, @jasminelmah & @caseywdunn argue that, by integrating #phylogenetic approaches into scRNA-seq analyses, hypotheses about gene & cell #evolution can be robustly tested #PLOSBiology plos.io/4bx61wx
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FYI that's exactly our attitude at @PLOSBiology - submit in any (reasonable) format!
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The mysterious 'neuston' ecosystem at the ocean’s surface includes organisms like the seaweed Sargassum, floating barnacles, snails, nudibranchs & cnidarians; @RebeccaRHelm explores threats to its wellbeing and importance of further research #PLOSBiology plos.io/3uao06E
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Statistical #PowerAnalysis currently dominates #ExperimentalDesign. In this Essay, @itchyshin &co argue that we should move away from the current focus on power analysis and instead encourage smaller scale studies & collaborative projects #PLOSBiology plos.io/48Gk8Og
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A single-cell transcriptomic study of the immune system of the cancer-resistant #NakedMoleRat reveals that it lacks natural killer (NK) cells, thought crucial for cancer resistance. Its genome lacks NKC expansion, and only has 2 MHC-I genes #PLOSBiology plos.io/33bZSlJ
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Why can #Toxoplasma only have sex in cats? #Cats are the only mammals to lack delta-6-desaturase enzyme, giving them high levels of linoleic acid. Inhibiting the enzyme in mice and feeding them linoleic acid allows Toxo to have sex in mice #PLOSBiology plos.io/2TRbk35
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#Bats are natural hosts for #viruses that cause higher case fatality rates in humans than do #zoonoses derived from any other source. @caraebrook @bootslab &co build a nested within-host, population-level model to explain this phenomenon #PLOSBiology plos.io/44Dri3y
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#Bacteria in lichens. @metalichen @robdfinn @tobyspribille &co reassemble 400 #lichen metagenomes; functional annotation of bacterial, fungal & algal assembled #genomes reveals a novel dimension to microbial cross-feeding #PLOSBiology plos.io/3UHFzu6
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Massive survey of >5k journals explores relationship between hyper-prolific authors & journal editorial teams, finding a subset of journals that show signs of nepotism @NaudetFlorian @IoanaA_Cristea @dmoher @deevybee @Clara_Locher &co #PLOSBiology plos.io/30Soh4m
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What is the cost of science being conducted in English? @tatsuya_amano &co reveal that non-native English speakers spend more effort than native speakers in conducting scientific activities (reading, writing, preparing presentations...) #PLOSBiology plos.io/46Rfptc
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Why are we still publishing complicated descriptions of #DNA constructs when they can be fully sequenced? @thuronyi @erika_alden_d & @barricklab suggest that outdated #methods narratives should be replaced with DNA #sequence files in publications. plos.io/47Ahg4Z
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Many #GenomeBrowsers only show one #genome assembly at a time. @NCBI presents a new visualization tool called the #ComparativeGenomeViewer (#CGV) that aids in pairwise comparison of whole-genome eukaryotic assembly-assembly alignments #PLOSBiology plos.io/3QYDtUP
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.@PeterHotez argues that #COVID19 has exposed how a rising tide of anti-science rhetoric & activities can exploit society's vulnerabilities to an infectious disease... has #AntiScience extremism become as big a threat as the virus itself? #PLOSBiology plos.io/2Yq3PTY
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Starvation turns some #fungi into #nematode-eating #predators. Study by @fungi_worms &co reveals increased DNA replication, translation & secretion as worm traps develop; DUF3129 proteins on trap surfaces are involved in worm #adhesion #PLOSBiology plos.io/40ShdiM
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Tetrapods are models for #biodiversity science. @mariormoura @walterjetz &co present #TetrapodTraits, a database of 33,281 #tetrapod species, integrating #taxonomic, spatial, #phylogenetic & attribute data through #phylogeny-based imputation #PLOSBiology plos.io/3WhkNm5
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Homeostatic plasticity in #neurons involves translation & degradation. Study reveals that RNA-dependent synergy between #translation, #degradation & #miRISC remodeling is needed for synaptic homeostasis during changes in network activity #PLOSBiology plos.io/3FN6fj7
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Cheaper, easier, safer: #OpenSource DNA/RNA purification & handling protocols based on functionalised magnetic beads, aiming to transform the practice & economics of life science research #PLOSBiology bomb.bio/ @teamBOMBbio plos.io/2RH6Kpf
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The ongoing #evolution inside all of us: pop'n genetic analysis of human gut #bacteria reveals short-term evolution within individual bacterial species, both within each human host & across the population @nanditagarud @benjaminhgood &co #PLOSBiology plos.io/2DwrZCv
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To what extent does #breathing modulate brain oscillations at rest? Human MEG study by @danlikesbrains & @Joachim__Gross identifies a widespread brain network of neural oscillations that are coupled to the respiratory rhythm #PLOSBiology plos.io/30gqYfr
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Plasmids manipulate host cells to their benefit. @catriona1392 @brockhurstlab &co describe a #plasmid-borne translational regulator that subverts ecological traits in #bacteria, inducing community organization & promoting plasmid transmission #PLOSBiology plos.io/3I4NES6
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Viruses are the most abundant biological entity in the #ocean. In this #PLOSBiology Essay, @vincentflora @vardilab discuss interactions between hosts and #viruses in the ocean and their relevance for global ocean ecosystem function in a changing climate. plos.io/3kJcjDY
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Female gametophytes of angiosperms contain cells with distinct functions (e.g. pollen tube attraction & fertilization). Live-cell imaging & transcriptomics of single female gametophyte cells reveal how cell fates are specified in Arabidopsis #PLOSBiology plos.io/31uUnjr
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No more paywalls for European scientific research: president of @ScienceEurope, @marcschiltz1, presents #cOAlitionS, mandating #OA publication from Jan 2020 (also pubbed @FrontNeurosci @PLOSMedicine) #PLOSBiology plos.io/2NOTQRf
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Nitrogen-fixing slime frees corn from fertilizer. Indigenous #Mexican maize produces slime on its aerial roots that hosts nitrogen-fixing #bacteria that provide up to 82% of the #plant’s nitrogen requirements #PLOSBiology plos.io/2OSUFcw
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"Scooped"? We prefer to call it "complementary research," recognising its important role in reproducibility of science. Come to #PLOSBiology within 6 months of "scooping" and we'll consider it. See our new policy here: plos.io/2rRvTSA
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Cells can counteract #aging by transmitting mitochondria asymmetrically. This study in #yeast shows how oxidatively damaged #mitochondria are selectively retained in the mother cell to prevent inheritance by the next generation. #PLOSBiology plos.io/48kAHQA
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As the legendary #LTEE baton is passed on to @barricklab, check out this conversation between @RELenski and @DynamicEcology published in @PLOSBiology back when the LTEE was a mere 27 years (or 60,000 generations) old... plos.io/1N6Jsgt
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How do birds position their feathers so accurately? New study reveals a spreading wave of ectodysplasin A, which triggers dense mesenchyme to begin feather patterning. Flightless birds have lost the EDA/cell density interaction #PLOSBiology plos.io/2XedfQs
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Many #GenomeBrowsers only show one #genome assembly at a time. @NCBI presents a new visualization tool called the #ComparativeGenomeViewer (#CGV) that aids in pairwise comparison of whole-genome eukaryotic assembly-assembly alignments #PLOSBiology plos.io/3QYDtUP
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Study of #SquashBug colonization by #bacterial #symbionts shows that heterogeneity & strain diversity in symbiotic microbial communities, within- & between-host, can be explained by stochastic colonization @thyreodon @NicoleGerardo @nicvega1 #PLOSBiology plos.io/4dceo21
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Jumping spiders can distinguish animate from inanimate objects based solely on visual motion characteristics ("biological motion" of a body comprising jointed segments) — previously known only in vertebrates @Massimo_De_Agro @RoesslerDaniela #PLOSBiology plos.io/2VFsJk8
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"I'll have what she's having!" Why do females choose particular mates? @EmilyHDuVal @servedio1 &co propose that mate choices rely on context-dependent social information, explaining major puzzles in the study of #SexualSelection. #PLOSBiology plos.io/46EHVgN
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Illustrating the pandemic. Molecular artist @dsgoodsell &co describe how visually striking illustrations of coronaviruses can capture our knowledge of the field and provide a touchstone for outreach & education about these pathogens #COVID19 #PLOSBiology plos.io/3km1RO4
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Neural oscillation... or not? Using a normal form oscillator model, @KeithD11 & @FlorAssaneo refute the most commonly held ideas of how an oscillator should behave, generating a series of cautionary examples to emphasize their findings #PLOSBiology plos.io/3umPcPA
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Which #COVID19 vaccination strategy? Two doses 3-4 weeks apart... or delay the 2nd dose? A modelling study by @Alison_Galvani &co shows that delaying the 2nd dose can maximize the benefits of vaccination programs under certain conditions #PLOSBiology plos.io/3gvyqcS
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Brewer's #yeast has been used to make fermented beverages for millennia. Genome analysis of #beer and other yeast strains shows that beer yeast have a polyploid admixed origin derived from European & Asian #wine populations @justinfay &co in #PLOSBiology plos.io/2XEQ6qF
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NLRs are the main class of disease resistance genes in plants. @JiorgosKourelis @KamounLab &co present #RefPlantNLR, a comprehensive reference dataset of 481 experimentally validated NLR immune receptors from 31 genera of flowering plants #PLOSBiology plos.io/2Zcrif6
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Replying to @arjunrajlab
For the record, @PLOSBiology do *not* do this. Reviewer exclusions will be respected if possible. If a large number of relevant experts are excluded, however, we'll ask the authors to rank those exclusions (and/or justify them), and may have to invite the "mildest."
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#Cryptosporidium is a leading global cause of #diarrhea. @elisetweetsbio @striepenlab &co reveal its program of asexual & sexual commitment & replication, requiring textbook-changing revision of the lifecycle of this important #parasite #PLOSBiology plos.io/3xKojt8
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A study of the relationship between antibiotic use & resistance shows that #AntibioticResistance peaks in the winter/spring and correlates most with use of penicillins & macrolides (antibiotics with winter-peaking use) @yhgrad @mlipsitch &co #PLOSBiology plos.io/3sXMu4E
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Surveillance for #SARSCoV2 variants is important, but sequencing is not always practical or affordable. @VogelsChantal @JosephFauver @NathanGrubaugh &co present a multiplex qPCR that can distinguish among current SARS-CoV-2 variants of concern #PLOSBiology plos.io/2RHU9DT
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Mammals have 6 conserved #actin isoforms with nonredundant functions. @koenvddries @syncellbiolab &co present IntAct, a tool to study actin isoform localization, dynamics & molecular interactions across species in fixed & living cells #PLOSBiology plos.io/3IA3YLo
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Seeing is feeling? Rod photoreceptors are mechanosensitive; study reveals that rod receptorss express mechanosensitive channels, that mechanosensitivity is crucial for phototransduction, and that outer segments shorten in response to light #PLOSBiology plos.io/2WqNAoV
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Cell tracking analysis made easier... @gomez_mariscal @JwPylvanainen @guijacquemet &co present #CellTracksColab, a transformative solution for #CellTracking analysis, combining cutting-edge computational methods with a user-friendly interface #PLOSBiology plos.io/3WEqOIr
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Which genes are hot... and which genes are not? Massive study of gene-specific bias in publication and funding shows that most human research is done on just 10% of genes, and predicts the most promising neglected gems #PLOSBiology plos.io/2Nl1TZR
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Using #monkeyflower genome sequences to reconstruct patterns of evolution over 1,000,000 years of divergence, @matt_streisfeld &co show that natural selection plays a key role in driving genetic differentiation between emerging species #PLOSBiology plos.io/2YjFrk8
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How are olfactory #cilia and sensory neuron differentiation regulated? This study of #zebrafish & mice shows that the #forkhead domain transcription factor Foxj1 is critical for #OlfactoryCilia and #SensoryNeuron differentiation #PLOSBiology plos.io/3SfsTbv
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Why is #LymeDisease common in the northern US, but rare in the south? Howard Ginsberg, @JTsao1 &co show that it's because the ticks attach mainly to rodents (good hosts for Lyme bacteria) in the north, and lizards (poor hosts) in the south #PLOSBiology plos.io/3t5xcZL
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Bar graphs hide the distribution of continuous data - time to kill them off! #PLOSBiology plos.io/1GlxeRL
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In all living organisms, cells must resist mechanical stress to survive. This study in #Arabidopsis reveals that the candidate cell wall #mechanoreceptor FERONIA and #microtubules independently contribute to this mechanical feedback @RDPlab #PLOSBiology plos.io/31SfDmG
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Combo of entry assays & live virus suggests #SARSCoV2 may have a broad host-range; its spike protein can use broad range of ACE2 receptors to enter cells, & sequence may have changed as it jumped to humans @Morbillivirus &co @Pirbright_Inst #PLOSBiology plos.io/3mFtrG6
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Brewer's #yeast has been used to make fermented beverages for millennia. Genome analysis of #beer and other yeast strains shows that beer yeast have a polyploid admixed origin derived from European & Asian #wine populations @justinfay &co in #PLOSBiology bit.ly/2ESqmjj
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Where do new genes come from? @HassanZaman91 @barricklab &co show that within the timescale of the #LTEE experiment, the co-option of #promoters, mainly from #TransposableElements, serves as the major source of raw material for #DeNovoGenes #PLOSBiology plos.io/4a8p6DT
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Movement proteins enable cell-to-cell transfer of #plant RNA & DNA viruses via #plasmodesmata. @Butkovic_A @mkrupovic &co show that 30K movement proteins originated from #virus #JellyRoll capsid proteins, emphasizing the key role of exaptation #PLOSBiology plos.io/3NxGsBX
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Super-fast, low-cost, low-tech prep of DNA or RNA from plants/animals/bugs in 30 seconds, using filter paper or paper towelling #PLOSBiology plos.io/2zbfNT0
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Employing optimal computational methodology in cryo-electron tomography is not always easy; @AlisterBurt &co (Gutsche lab) provide a set of tools and a complete guide to obtaining high-resolution structures from cryo-ET data #PLOSBiology plos.io/3kysz7b
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Teaching #reproducibility. New #graduate course highlighting essential methods for transparent & reproducible research - provides adaptable #OpenEducation resources for integration into graduate curricula #PLOSBiology plos.io/2LuPWj5
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In a new #PLOSBiology study, @teresa_omeara @microbialfaith &co show that healthy people are reservoirs for diverse strains of the yeast C. albicans, and that these commensal strains retain the capacity for virulence #microbiology plos.io/4207Rki
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Brain #connectivity: physical links between regions, synchronized activity, or molecular similarities? @JustineYHansen @misicbata &co integrate seven connectivity blueprints to characterize inter-regional relationships in the human #cortex. #PLOSBiology plos.io/3LBvQ3I
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Neural stem cells can transfer mitochondria via extracellular vesicles to target cells both in vitro & in vivo, suggesting a signaling mechanism used by NSCs to modulate physiology & metabolism of target cells @Dr_LPJ @Pluchinolab &co #PLOSBiology plos.io/31WMLGQ
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What made human gestation longer? An anthropoid-specific retroviral insertion regulates the expression of CRH, a placental protein associated with human birth timing; mice bearing this inertion have longer #gestation times #PLOSBiology plos.io/2Nsa1aG
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Making a new primate phylogeny, @farming_bugs @bq_minh @RobLanfear @3rdreviewer &co adapt a method for detecting ancient introgression to genome-scale data, revealing multiple previously unknown examples of hybridization between primate spp #PLOSBiology plos.io/39F9o7A
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Unifying statistical #genetics & #phylogenetics. @jgschraiber @DocEdge85 & @mwpen show that the distinct ways of mapping phenotypes while controlling for ancestry in these two fields are actually special cases of the same general approach #PLOSBiology plos.io/4eZvKiv
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Bees are a powerful system to probe host-gut #microbiota interactions. @a_chhun @PEngellab @YSchaerli &co engineer a native bacterial #symbiont of the #HoneyBee to non-invasively sense & report exposure to molecular cues inside the gut #PLOSBiology plos.io/3P8ioWJ
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#Plants use NLRs for #pathogen defense, but what do downstream "helper" #NLRs do? @M__Selvaraj @mpcontreras4 @KamounLab &co reveal that the helper NLR NRC2 flips from autoinhibited homodimer to active oligomeric resistosome upon activation #PLOSBiology plos.io/40e5fBU
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Why does #exercise reduce #appetite? Because the #hypothalamus heats up! Raised temperature in brain is detected by TRPV1-like thermoreceptors in proopiomelanocortin neurons in arcuate nucleus #PLOSBiology plos.io/2Jnslve
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60 yrs on: the legacy of #FrancisCrick's conceptual leap - the "Central Dogma" - by @matthewcobb in #PLOSBiology plos.io/2yarNmV
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Evidence suggests that some #insect species might feel #pain. @AndrewCrump94 @matilda_gibbons @Bee_Bytes @birchlse & @LChittka argue that researchers need to consider the welfare implications of these findings for insect experiments #PLOSBiology plos.io/3OQvwk0
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The #RequestAWomanScientist resource, launched Jan 2018 through @500womensci organization, represents an important step in increasing the diversity of voices represented as scientists in the public & scientific communities #PLOSBiology plos.io/2DugpHr
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Vampire bats meet for dinner. @SimonRipperger & Gerry Carter show that social bonds in #VampireBats typically defined by cooperative interactions within the roost also extend beyond the roost and may provide benefits when foraging for blood #PLOSBiology plos.io/3CHeAmR
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A spotters' guide to E. coli phages. This resource for the community is representative of natural #Ecoli #phage diversity and has been extensively characterized phenotypically & genomically @AHarms485 @phagemuffin @AisyluShaidull1 &co #PLOSBiology plos.io/2YXO4Ye
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How do intracellular pathogenic #bacteria scavenge host nutrients? @KMitosch @kiran_r_patil @TypasLab &co use 13C-mannitol to track #Salmonella's #metabolism when growing inside host cells, revealing its food sources & #MetabolicPathways #PLOSBiology plos.io/3OImjZh
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