News from the editors of Nature Biomedical Engineering, a journal for researchers, engineers and clinicians interested in human health. Launched in Jan 2017.
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Predicting pathogenicity from non-coding mutations
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A swallowable X-ray dosimeter detects the absolute absorbed radiation dose alongside changes in pH and temperature in the gastrointestinal tract of rabbits.
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Tips for constructing an effective title
(Deliberate practice will, however, get you further.)
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Biomedical research needs upgraded standards for the monitoring, control and reporting of the environmental conditions of cells in culture.
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Application of prime editing to the correction of mutations and phenotypes in adult mice with liver and eye diseases
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In tendon cells under shear stress, the induction of an influx of calcium by the mechanosensitive ion channel PIEZO1 upregulates collagen crosslinking, which increases tendon stiffness.
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Extracellular vesicles encapsulating mRNA encoding for extracellular-matrix collagen and delivered intradermally via microneedles led to the replacement of collagen in the dermis of mice with photoaged skin.
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Graph neural networks and transformers taking advantage of contextual information and large unannotated multimodal datasets are redefining what is possible in computational medicine.
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We have done a first round of internal checks and have contacted the authors. Thank you, @MicrobiomDigest.
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The most-read Review Articles and Perspective in 2022 (1/2)
1. The evolution of commercial drug delivery technologies
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2. CRISPR-based diagnostics
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3. Artificial intelligence in healthcare
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A machine-learning pipeline identifies potent antimicrobial peptides by gradually narrowing down the search space of polypeptide chain sequences.
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The repertoire of new preclinical strategies for fighting tumours that resist or evade immunotherapy drugs and cellular immunotherapies is widening.
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The November cover illustrates a wearable electrochemical biosensor for the continuous detection of trace levels of metabolites and nutrients in sweat.
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Whole-body tracking of single cells via positron emission tomography
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Inhibition of post-surgery tumour recurrence via a hydrogel releasing CAR-T cells and anti-PDL1-conjugated platelets
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Enhanced tendon healing by a tough hydrogel with an adhesive side and high drug-loading capacity
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A wearable electrochemical biosensor for the monitoring of metabolites and nutrients
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A wearable electrochemical biosensor can continuously detect, in sweat during physical exercise and at rest, trace levels of multiple metabolites and nutrients, including all essential amino acids and vitamins.
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Cancer cells enriched in cholesterol in their plasma membrane impair T-cell-mediated cytotoxicity, which can be augmented by stiffening the cancer cells via cholesterol depletion, as shown in mouse models of adoptive T-cell immunotherapy.
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A deeper understanding of the myriad ways that the mechanics of cellular and tissue microenvironments trigger or exacerbate disease will open up pathways for new interventions.
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A machine-learning model identifies cell-type-specific predictors of the pathogenic effects of promoter and enhancer mutations in the human genome.
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The June cover illustrates a wireless and battery-free millimetric endovascular implant for the stimulation of peripheral nerves that are difficult to reach by surgery.
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Durable antitumour responses can be triggered by maximizing the cooperative phagocytic potency of macrophages through the disruption of the CD47–SIRPα macrophage checkpoint and by delivering a tumour-opsonizing monoclonal antibody.
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Peptide-encoding mRNA barcodes for the high-throughput in vivo screening of libraries of lipid nanoparticles for mRNA delivery
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Many drug-delivery systems and strategies have been overengineered.
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Biomaterial structures can be printed with near-infrared light within the tissues of living animals by using photosensitive polymer hydrogels.
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A machine-learning pipeline identifies potent antimicrobial peptides by gradually narrowing down the search space of polypeptide chain sequences.
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In scientific storytelling, the punch line should not be left to the end, and hinting at or hiding key elements should not be used as a way to keep the reader’s attention.
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A polymer patch that rapidly and robustly adheres to diabetic wounds and contracts in a pre-programmed manner
promotes wound closure and re-epithelialization, as shown in mouse and human skin, in mini-pigs and in humanized
mice.
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Inflamed heart tissue after myocardial infarction can be repaired via an intravascularly infusible degradable matrix that binds to leaky vasculature.
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A patient with microtia has had their ear reconstructed with a 3D-printed scaffold of collagen and autologous cartilage cells. nytimes.com/2022/06/02/healt…
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The November cover illustrates that the viscoelasticity of extracellular matrices can be altered to generate functionally distinct T-cell populations from T cells that received the same stimulation.
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High-throughput automated organoid culture via stem-cell aggregation in microcavity arrays
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The May cover illustrates that a peptide identified via screening aids the delivery of CRISPR ribonucleoprotein into cells, increasing the yield of edited primary human lymphocytes.
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An integrated wearable microneedle array for the continuous monitoring of multiple biomarkers in interstitial fluid
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Genetically engineered and enucleated human mesenchymal stromal cells for the targeted delivery of therapeutics to diseased tissue
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Amphiphilic peptides can aid the delivery of CRISPR ribonucleoproteins into primary human lymphocytes at low toxicity, boosting editing yields with respect to the use of electroporation.
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A high-throughput method leveraging peptide-encoding mRNA barcodes for the in vivo screening of libraries of nanoparticle formulations allows for the rapid optimization of a lipid nanoparticle for the delivery of mRNA to the liver.
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Graph deep learning for the characterization of tumour microenvironments from spatial protein profiles in tissue specimens
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A wireless millimetric magnetoelectric implant for the endovascular stimulation of peripheral nerves
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In tendon cells under shear stress, the induction of an influx of calcium by the mechanosensitive ion channel PIEZO1 upregulates collagen crosslinking.
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The April cover illustrates tissue chips with matured human heart, liver, bone and skin tissue niches linked by recirculating vascular flow.
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The July cover illustrates a prototype ultrasonic phased array for the monitoring of blood flows in deep tissues.
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Amphiphilic peptides can aid the delivery of CRISPR ribonucleoproteins into primary human lymphocytes at low toxicity, boosting editing yields with respect to the use of electroporation.
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A machine-learning pipeline identifies potent antimicrobial peptides by gradually narrowing down the search space of polypeptide chain sequences.
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Transcranial ultrafast ultrasound localization microscopy of brain vasculature in patients
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Wirelessly operated bioelectronic sutures for the monitoring of deep surgical wounds
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Mechanobiological conditioning of mesenchymal stem cells for enhanced vascular regeneration
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A wearable electrochemical patch for the real-time monitoring of the biomarker C-reactive protein in sweat detects elevated concentrations of the protein in patients with acute or chronic inflammation.
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A machine-learning pipeline identifies potent antimicrobial peptides by gradually narrowing down the search space of polypeptide chain sequences.
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The December cover illustrates that graph deep learning applied to whole-slide images of tumours can leverage information in the tumour microenvironment to derive histopathological features with prognostic value.
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This Perspective highlights notable milestones from the past two decades of research in cardiac tissue engineering, and outlines opportunities and challenges for further advancement.
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Classification of T-cell activation via autofluorescence lifetime imaging
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Gelling hypotonic polymer solution for extended topical drug delivery to the eye
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Detection of ovarian cancer via the spectral fingerprinting of quantum-defect-modified carbon nanotubes in serum by machine learning
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Glucose-responsive insulin patch for the regulation of blood glucose in mice and minipigs
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Patterned organoids and bioprinted tissues can be generated by simultaneously co-differentiating pluripotent stem cells into distinct cell types via the forced overexpression of transcription factors, independently of culture-media composition.
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Regardless of whether they are labelled as ‘delivery problems’ or ‘delivery opportunities’, strategies to overcome the biological barriers to drug delivery should be at the forefront of basic and translational nanomedicine. [Editorial]
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“In clearing drugs for human trials the agency should rely more heavily on computer modeling, “organ chips,” and other nonanimal methods that have been developed over the past 10 to 15 years.” science.org/content/article/…
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Nuclear mechanosensing drives chromatin remodelling in persistently activated fibroblasts
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Optimization of therapeutic antibodies by predicting antigen specificity from antibody sequence via deep learning
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The September cover illustrates that the tagging of tumour cells with an amphiphilic ligand for a chimaeric antigen receptor on T cells allows for the universal redirection of the cells against solid tumours.
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"A two-sided biomaterial can firmly attach to injured tendons with one of its surfaces, while allowing for normal gliding of regenerating tendons on its opposite low friction surface."
#BehindThePaper
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Bone-matrix mineralization dampens integrin-mediated mechanosignalling and metastatic progression in breast cancer
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Rapid reprogramming of tumour cells into cancer stem cells on double-network hydrogels
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Ovarian cancer can be predicted with high sensitivity and specificity via a fingerprint obtained, via machine learning, from near-infrared fluorescence emissions of an array of carbon nanotube sensors in serum samples.
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This Review Article discusses how delivery challenges associated with small molecules, nucleic acids, peptides, proteins and cells led to the development of commercial products and are now informing the delivery of live-cell therapeutics.
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Strain maps of cardiomyocyte nuclei during contraction indicate that, by integrating environmental mechanical cues, the nuclei of cardiomyocytes stabilize the fate of the cells through the reorganization of epigenetically marked chromatin.
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A rapid one-pot isothermal assay that leverages rolling-circle amplification and the endonuclease Cas12a can accurately detect specific miRNAs in extracellular vesicles in patient plasma.
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Extracellular vesicles encapsulating mRNA encoding for extracellular-matrix collagen and delivered intradermally via microneedles led to the replacement of collagen in the dermis of mice with photoaged skin.
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A soft neuroprosthetic hand providing simultaneous myoelectric control and tactile feedback
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Transdermal microneedles for the programmable burst release of multiple vaccine payloads
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Amphiphilic peptides can aid the delivery of CRISPR ribonucleoproteins into primary human lymphocytes at low toxicity, boosting editing yields with respect to the use of electroporation.
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Research on disease mechanisms will increasingly be supported by progressively more sophisticated engineered tissues serving as in vitro models of human disease. [Editorial]
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Durable antitumour responses can be triggered by maximizing the cooperative phagocytic potency of macrophages through the disruption of the CD47–SIRPα macrophage checkpoint and by delivering a tumour-opsonizing monoclonal antibody.
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An epidermal patch for the simultaneous monitoring of haemodynamic and metabolic biomarkers
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Extracellular vesicles encapsulating mRNA encoding for extracellular-matrix collagen and delivered intradermally via microneedles led to the replacement of collagen in the dermis of mice with photoaged skin.
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Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation
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RNA-binding proteins acting as decoys for pathogenic expanded CUG RNA repeats reverse the toxicity of the mutant transcripts in muscle cells derived from a patient with myotonic dystrophy type 1 and in a mice with the disease.
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Nanoparticle-encapsulated siRNAs for gene silencing in the haematopoietic stem-cell niche
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The editing of single DNA bases in the genome is being optimized for higher editing precision and versatility. [Editorial highlighting three papers by @davidrliu’s team and collaborators]
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A microfluidic cell-migration assay for the prediction of progression-free survival and recurrence time of patients with glioblastoma
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Physician-scientist who pioneered molecular imaging for the early detection of cancer.
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A fluorescence sandwich immunoassay for the real-time continuous detection of glucose and insulin in live animals
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