Moffitt Cancer Center President and CEO, @MoffittNews. Tumor immunologist. Inspired leader. Girl dad. #DocsWhoRock. Driven to save more lives from #cancer.
#ScienceSaturday
❓ Why do T cells sometimes fail to fight cancer?
➡️ A new study in Nature shows that when T cells are exposed to cancer or long-term infections, they can enter a state called exhaustion, where they lose their ability to eliminate harmful cells.
➡️ The researchers found that exhausted T cells develop a special type of stress response. Instead of reducing protein production, these cells increase it, leading to protein buildup and overworked “chaperone” proteins. This stress weakens the T cells and helps tumors evade the immune system.
➡️ By blocking certain stress-related proteins, the scientists were able to restore T cell activity and improve the effectiveness of cancer immunotherapy in preclinical models.
🌟 Congratulations to my good friend and senior author Zihai Li of The Ohio State University Comprehensive Cancer Center and collaborators at Johns Hopkins, Emory, Uppsala University and others for advancing this important research. @Zihai@OhioState@HopkinsMedicine@EmoryUniversity
🔗 Read more: doi.org/10.1038/s41586-025-0…
So many ways for an immune cell to kill (or not to kill) a #cancer cell! This is a nice review summarizing non-apoptotic regulated cell death pathways and their complex interactions with the antitumor #immune response. nature.com/articles/s41392-0…
Meet the first patient in the world to receive Tecelra, a groundbreaking engineered cell therapy for synovial #sarcoma. This is a powerful story of resilience and innovation—and I’m so proud of our team @MoffittNews for leading the way in this area!
moffitt.org/endeavor/archive…
#ScienceSaturday
❓ Why do some cancers resist immunotherapy?
➡️ A recent study in Nature found that certain cancers can “trick” the body’s immune system. They do this by changing how cells in the bone marrow develop. These changes cause more immune cells called macrophages to form — but these macrophages actually block the immune system from attacking the tumor.
➡️ Lung cancers cause this change by stressing cells in a way that activates a protein called NRF2. This reprogramming creates macrophages that protect the tumor instead of fighting it.
➡️ The researchers found that blocking NRF2, through drugs or genetic changes, lowered these protective macrophages, boosted immune cell activity and made immunotherapy work better. This suggests a new way to improve treatments for cancers that usually resist immunotherapy.
🌟 Congratulations to senior author Miriam Merad of the Icahn School of Medicine at Mount Sinai, and collaborators at Institut Gustave Roussy, Harvard Medical School and others for advancing this critical work. @MiriamMerad@SinaiImmunol@IcahnMountSinai
The Hwu Lab mourns the loss of one of our own, Dr. Deb Silverman @deb_silverman, who was so courageous in the face of breast cancer at such a young age. I’m so happy Deb was able to receive her Ph.D. and that she could visit from @MDAndersonNews to join our last lab team outing.
About 1/3 of all cancers diagnosed annually can be prevented, and more can be cured by early detection through screening. Do you know what #cancer screenings you should get? Check out the recommended screenings and prioritize your health this New Year! moffitt.org/endeavor/archive…
(1/2) Immune response against #cancer can be inhibited by myeloid derived suppressor cells (MDSCs). Defining and studying MDSCs has been challenging due to the lack of specific surface markers. science.org/doi/10.1126/scii…
So sad to hear about the passing of Jeff Weber, a giant in the field of oncology. He was involved in the early days of cytokine and cell therapy and most recently led studies of personalized vaccines for melanoma patients. I originally worked with Jeff @theNCI over 30 years ago. He was a great friend and colleague to many of us in the melanoma and immunotherapy field and we will remember him as a pioneer, thought leader and compassionate physician.
@sitcancer@DrJamesMule@BernardAFox
I've officially surpassed my first 100 days @MoffittNews and thought it was time to get connected to the world in a new way on Twitter. I'm looking forward to inspiration, collaboration and conversation. More on why I've joined moffitt.org/endeavor/archive…
It’s only appropriate that every few years our anniversary lands on #Thanksgiving. Grateful for 32 incredible years together and the best is yet to come! Happy Anniversary to my wife, Katie!
It was an honor to attend The @WhiteHouse Holiday Reception last night. We appreciate the commitment and support of @POTUS and @FLOTUS for cancer prevention, screening and research and to eliminate disparities in #cancer outcomes.
#ScienceSaturday
For #immunotherapy to be effective, T cells need to effectively infiltrate tumors. In this preclinical study, low molecular weight heparin was found to enhance T cell infiltration and anti-tumor efficacy for both adoptive T cell therapy and immune checkpoint blockade tumor models. jitc.bmj.com/content/11/8/e0…
What makes cancers regrow after therapy? Many cancers initially respond well to treatment but then progress due to resistant “persister cells”. nature.com/articles/d41586-0…
Happy Father’s Day to all the dads out there! Fatherhood is a humbling and fulfilling role and I have such unconditional love for my two girls who are so creative, compassionate and authentic. #FathersDay
How it started vs. how it's going! I've learned a lot over the last 50+ years, but the most important lesson is this: Action is what matters. Worrying produces nothing. #TransformationTuesday
It is such an honor to have @FLOTUS Dr. Jill Biden and @NCIDirector Dr. Ned Sharpless visiting Moffitt Cancer Center today. We are thrilled to share the important work our teams are doing here @MoffittNews to prevent and treat cancer. wfla.com/news/hillsborough-c…
I was honored to be officially inducted as a Fellow in the National Academy of Inventors today in Washington, D.C.! The NAI Fellow program has more than 1,700 Fellows worldwide who collectively hold more than 58,000 issued U.S. patents. @AcadofInventors
Most of you know that our Bichon Frisé, Maisy, was a beloved member of our family. I am sad to share the news that Maisy passed away today, after a long and wonderful 16 years with the Hwu family. We will dearly miss her and the companionship and unconditional love she brought to our family.
#ScienceSaturday
Dendritic cells (DCs) play a critical role in activating CD4 and CD8 positive T cells to mediate the immune response against cancers.
❓But which DCs are the most important in triggering cancer-specific T cells?
➡️ In a recent report published in @SciImmunology, investigators utilized single cell spatial transcriptomic analysis to identify a relatively small population of DCs characterized by IL-27 production and a hyperactivated phenotype critical for activation of tumor-specific T cells, which was amplified with CTLA-4 immune checkpoint blockade.
➡️ Characterizing this important population of DCs may inform novel strategies to activate these DCs in #cancer patients to potentiate #immunotherapy responses.
🔗 Here’s a link to the full study- science.org/doi/10.1126/scii…@victora_lab@ChudnovskiyLab
#ScienceSaturday
❓ Why do some cancers resist anti-PD-1 immunotherapy?
➡️ A new study in @Nature shows that cancer-induced nerve injury (CINI) drives resistance. Tumors that damage nearby nerves trigger chronic inflammation, creating an immune-suppressive environment that blunts checkpoint blockade.
➡️ Importantly, targeting nerve injury pathways — such as blocking IL-6 signaling — helped restore response in models, pointing to new strategies to overcome resistance.
🌟 Congratulations to co-corresponding author Dr. Ken Tsai (@KYTsaiLab) of @MoffittNews, collaborators @MDAndersonNews and others for advancing this critical field.
🔗 Read more: doi.org/10.1038/s41586-025-0…#CancerResearch#Immunotherapy#CheckpointBlockade#Neuroimmunology
Having a wonderful weekend with daughter Emily in Brooklyn, NY. Even got to see her perform with her band. She’s become quite the drummer in less than a year! #WeekendVibes
This hangs above my desk and is one of my major principles of #leadership. It’s by the ancient philosopher Lao Tsu. The best leaders are the ones who elevate others without them even knowing! #WednesdayWisdom
#ScienceSaturday
❓ How can we turn T-cells into cancer-fighting “soldiers” without changing their DNA?
➡️ A new study in Nature Biotechnology introduces an all-RNA platform that can turn T-cell genes on or off using epigenetic CRISPR tools called CRISPRoff and CRISPRon. Instead of cutting or rewriting DNA, this method “reprograms” genes by adding or removing chemical marks — allowing researchers to boost or silence key immune functions safely.
➡️ The team showed this can enhance CAR T-cell therapies, helping immune cells better recognize and attack tumors while reducing potential side effects linked to traditional gene editing.
🌟 Congratulations to senior authors Alex Marson, Luke Gilbert, Brian Shy, and Justin Eyquem of UCSF, Arc Institute, and Gladstone Institutes for this exciting advance — a big step toward the next generation of precise, safer immunotherapies.
🔗 Read more in Nature Biotechnology: doi.org/10.1038/s41587-025-0…@LukeGilbertSF@UCSF@UCSFCancer@UCSFMedicine@arcinstitute@GladstoneInst@j_eyquem
Dr. Anirban Maitra is a treasured friend and colleague who is a leader in #pancreaticcancer research and has served as a mentor to many young investigators throughout the world! Go give him a follow @Aiims1742! #FollowFriday
#ScienceSaturday How can we identify tumor reactive T cells circulating in the blood? Using single cell transcriptomic profiling of tumor infiltrating lymphocytes (TIL) and blood lymphocytes, researchers at @NCI_CCR_SB identified a phenotypic signature of circulating T cells capable of recognizing mutated antigens. Interestingly, these circulating T cells appear to be more functional than those found in the tumor. This approach may provide an important alternative source of T cells for immunotherapy for #cancer.
Here’s a link to the full article: cell.com/cancer-cell/pdfExte…
Saddened by the loss of a member of the @MoffittNews family, Dr. Robert Gillies. Bob was a cherished member of the team who made remarkable strides in molecular imaging and cancer research. He will be greatly missed. Our thoughts are with his family, friends and peers.
Reflecting on the groundbreaking research of 2024 @MoffittNews!
From innovative treatments to breakthrough discoveries, we continue to push boundaries in cancer care. Excited for what’s to come in 2025. 🎉 moffitt.org/endeavor/archive…
#ScienceSaturday
The combination of anti-CTLA-4 and anti-PD-1 antibodies is FDA approved for the treatment of advanced #melanoma. How does this combination work mechanistically? In a recently published study in @Cancer_Cell using both single cell TCR and RNA sequencing, Wang et al demonstrate that the combination results in higher numbers of clonal T cells capable of recognizing melanoma and that anti-CTLA-4 drives the expansion of exhausted T cells while anti-PD-1 reinvigorates them. These insights may help with future patient selection as well as enhanced combinations and treatment schedules.
Here’s a link to the full study- cell.com/cancer-cell/abstrac…
#ScienceSaturday Mutations in cancer cells look “foreign” to the immune system and are excellent targets for T-cells. However, patients with high levels of mutations in their cancers don’t always respond durably to #immunotherapy. @PeterMKWestcott, @LabJacks et al demonstrate that tumor heterogeneity may be the issue, and that mutations that are only in a small population of the #cancer cells (subclonal) are not as correlated with clinical responses compared to mutations that are in all the cancer cells within a tumor (clonal). nature.com/articles/s41588-0…
Snow Patrol, a Scottish and Irish alternative rock band, had their biggest hit with the release of "Chasing Cars" in 2006. It has since been used in countless movies, TV shows and more. Had a great time covering it with #TheReMissions@MoffittNews last week! #MusicMonday 🤘
Can you travel from Tampa to NYC and back in the same day? So glad I was able to watch daughter Emily’s band perform in Brooklyn today. She’s become quite the accomplished drummer!
#ScienceSaturday Can dietary nutrients help the immune system kill #cancer cells? In this study, researchers screened 255 circulating nutrients for the ability to enhance T cell activity and found that the long-chain fatty acid TVA (Trans-vaccenic acid) could enhance the activity of CD8-positive “killer” T cells against cancer. This impressive work has significant implications for cancer #immunotherapy and beyond.
Here’s a link to the full article. nature.com/articles/s41586-0…
#ScienceSaturday CD8+ T cells classically kill tumor cells by recognition of peptide antigens in the context of class I MHC molecules, and downregulation or loss of class I expression can lead to tumor escape. @EmilyCLerner et al have now shown that CD8+ T cells can kill class I negative tumor cells through the receptor NKG2D, paving the way for strategies to neutralize this escape mechanism.
nature.com/articles/s43018-0…
Who knew that our Chair of Radiation Oncology, @KOSJ12, could sing like this?
Fun fact, the piano I’m playing on is the one I grew up playing — it’s over 50 years old!
If you look at the data, it's not the ratio of doctors to patients that's correlated with survival, it's the ratio of nurses to patients. That speaks volumes. I can't thank ours enough for their dedication and commitment to our number one priority, our patients. #NursesWeek
Cancer care isn't what it was 10 or even 5 years ago. Hospital leaders shouldn't ask if outpatient treatment with immune and cell-based therapies will become standard, but when.
Thanks, @BeckersHR, for the opportunity to share my perspective!
beckershospitalreview.com/on…
The future of #cancer vaccines is bright! An important consideration is the type of antigen used in the vaccine. This review nicely summarizes the different types of antigens that are being investigated for #CancerVaccines. nature.com/articles/s43018-0…
#ScienceSaturday
❓ Why do some patients respond better to immunotherapy?
➡️ A new study in Nature found that tumors with mutations in PPP2R1A — a gene encoding a scaffold protein in the PP2A complex — were linked to much longer survival after immune checkpoint blockade (ICB).
➡️ In ovarian clear cell carcinoma and other cancers, PPP2R1A mutations were tied to stronger immune signals, more tumor-infiltrating T cells, and better tumor control. Preclinical models confirmed that altering or inhibiting PPP2R1A boosted the effectiveness of ICB and CAR-T therapies.
🌟 These findings suggest PPP2R1A mutations could serve as a predictive biomarker for immunotherapy success and highlight PP2A as a potential therapeutic target to make treatments more effective.
🔗 Read more in @Nature: doi.org/10.1038/s41586-025-0…@NaturePortfolio@MDAndersonNews#CancerResearch#Immunotherapy#Biomarkers#OvarianCancer#CheckpointBlockade
Thank you, @AmirJazaeri for your visit and lecture @MoffittNews this week!
#ScienceSaturday
The combination of anti-LAG-3 and anti-PD1 antibodies is @US_FDA approved for patients with advanced #melanoma. But how is this combination working mechanistically? In a recent issue of @CellCellPress, 3 manuscripts shed light and suggest that PD-1 blockade enhances T-cell proliferation while LAG-3 blockade enhances anti-tumor effector functions including cytotoxicity, cytokine production, and expression of activating NK receptors.
➡️ These insights may lead to the optimization of future therapeutic combinations for patients.
Here are links to the 3 articles as well as an excellent overview:
🔗 cell.com/cell/abstract/S0092…
🔗 cell.com/cell/abstract/S0092…
🔗 cell.com/cell/abstract/S0092…
🔗 cell.com/cell/abstract/S0092…
#ScienceSaturday
➡️ Immunotherapies targeting neoantigens can be effective in mediating long-term durable responses in advanced cancer patients. However, identifying these neoantigens from metastatic tumors can be logistically challenging.
🧬 In this study, investigators looked at whether archived, preserved primary tumor samples could be used for neoantigen discovery.
➡️ The study found that primary FFPE tumor samples could be used to discover most of the neoantigens present in metastatic tumors and even unique neoantigens not present in metastatic tumors.
🌟 This approach would reduce the need for additional, sometimes complicated resections and expedite the time to treatment! These promising findings could pave the way for more accessible and personalized therapies.
🔗Here's the link to the full study: jitc.bmj.com/content/13/1/e0…@NCICCR_SurgOnc@theNCI@jitcancer
Everyone knows that we have bacteria in our gut, but did you know that #cancer cells can be infected with #bacteria and this can suppress the immune response against them?science.org/content/article/…
Please join me in welcoming @karenluMD to @MoffittNews as our new Physician in Chief!
We are grateful to have a nationally recognized physician-scientist of Dr. Lu’s caliber coming onboard to lead our Moffitt Medical Group.
Welcome, Karen Lu, MD (@karenlumd), who will join Moffitt as our new Physician in Chief in June.
She has a proven track record of successfully leading clinical and translational teams, and we could not be more excited for her to join Moffitt at such a transformative time.
Please give Dr. Lu a very warm welcome.
Learn more about Dr. Lu: bit.ly/3ucLdKJ
The Rosenberg group has characterized RNA signatures of T cells in the tumor that recognize cancers. This may help in identifying immune cells and receptors that can be used for patient therapy and will help us understand the tumor immune microenvironment. science.org/doi/10.1126/scie…
The Moffitt Cancer Center "M" has officially been hoisted and positioned at the top of our new McKinley hospital. A sure sign of the incredible progress toward our opening this July! @MoffittNews
Also had the opportunity to meet former pro tennis star @Martina Navratilova at the @RepDWStweets Cancer Survivorship Summit, who was speaking on The Caregiver Experience.
Our @Moffittnews Physician in Chief, @KarenLuMD, has hit the ground running and been an extraordinary leader. Learn more about her work as a nationally recognized physician-scientist and her goals at Moffitt! moffitt.org/endeavor/archive…
Moffitt awarded $10.2 million grant from @theNCI to support team research focused on investigating lung cancer metabolism to help develop new therapies. Congrats @LabElsaFlores and team! moffitt.org/newsroom/press-r…
Honoring and remembering my former student, Dr. Deb Silverman, at @ACSCAN's 13th Annual Lights of Hope event in D.C. tonight. Our work continues for the patients of today, the patients of tomorrow and those taken too soon. 🕯💙 #MoffittDCFlyIn#LightsofHope@deb_silverman
Behind the scenes filming the band's rooftop music video. And the perfect time to announce our band name (drumroll, please...) "The Remissions!" Now for logo design ... 🤘 🎹 🎤 🎸
Dr. Dana Ataya is a subspecialty-trained breast radiologist, educator and researcher @MoffittNews. She’s also the rockstar lead vocalist in our band, #TheReMissions! Go give her a follow @DanaAtayaMD! #FollowFriday
As @SITCancer President, it was an honor to induct our first class of Fellows of the Academy of Immuno-Oncology (FAIO) last night. These impressive individuals helped get us where we are today, and mentored many of the leaders in the field. #SITC21sitcancer.org/funding/awards…
LIVE from #TheCheckPoints Party at #SITC24! 🎶 Here’s a behind-the-scenes look at us performing "Walking on Sunshine." So proud to be part of the @sitcancer band, playing to support early-career scientists!
So proud of Ally for her graduation from @ChapmanU this weekend! She’s demonstrated such determination and resilience over the past four years! #ProudDadMoment
Small molecule STING agonists can trigger innate immune cells which can lead to potent T-cell mediated antitumor immune responses. @NatalieArtzi and colleagues recently demonstrated that nanoparticle conjugation can enhance the antitumor potency of intravenously administered STING agonists by increasing half-life and stability. This has important translational potential for combination immunotherapies in #cancer patients. #ScienceSaturdaynature.com/articles/s41565-0…
#ScienceSaturday
➡️ T cells in the tumor microenvironment can become exhausted, limiting their ability to kill cancer cells.
❓ How can we prevent T cell exhaustion?
➡️ In a recent study, Ma et al found that the protein P4HA1 accumulated in activated CD8 T cells, interfering with mitochondrial function and promoting T cell exhaustion. Targeting P4HA1 improved T cell expansion, decreased exhaustion and improved antitumor responses in preclinical models.
🌟 This represents a promising approach to one day enhance T cell therapy in patients.
🔗 Here’s a link to the full study: cell.com/cancer-cell/abstrac…@Cancer_Cell
Ran into our hard working Environmental Services team preparing for #HurricaneIan by removing potential projectiles around campus. Our @MoffittNews team is well prepared to weather the storm! Please stay safe.
What an incredible ride it's been at #SITC23. It's true, California knows how to party! #TheCheckPoints hit the waves tonight for a special "Surfing for a Cure" event. Together, we're riding the tide towards a future without cancer. @SITCANCER
"What people may not know about me is that I'm an immunologist, and I've had a lab for over 30 years."
Come along for a video tour of @MoffittNews president and CEO @PatrickHwuMD's lab! 🔬
#ScienceSaturday
❓ Can engineered T cells target the mutations that cause cancer to eliminate solid tumors?
➡️ In a new study, @JOlweus and colleagues found that a common β-catenin driver mutation (CTNNB1-S37F) creates new “flags” (peptides) on cancer cells that the immune system can see.
➡️ Researchers built T cells with custom receptors (TCRs) that recognize these mutant flags. In lab and animal models, the engineered T cells completely wiped out tumors.
➡️ Because this mutation appears in thousands of new cancer cases each year in the U.S., it could become a powerful shared immunotherapy target.
🌟 This is a promising step toward harnessing “public” mutations as broad cancer treatments.
🔗 Read the full study in @NatImmunol: nature.com/articles/s41590-0…@CoE_PRIMA
Thrilled Moffitt Cancer Center has once again been named the #1 Cancer Hospital in Florida and the Southeast by @Newsweek. @MoffittNews has also been recognized on Newsweek’s list of the World's Best Oncology Hospitals. These recognitions are a testament to the quality of research, care and exceptional outcomes provided.
Congratulations, team!
Just landed in San Diego! Looking forward to an exciting week at the @sitcancer annual meeting and pre-program workshops! #SITC23
Also excited to be reunited with #TheCheckPoints for our West Coast concert on Saturday!
Happy National Doctors’ Day! Thank you to all of our incredible doctors @MoffittNews who dedicate so much to our patients and our mission. #NationalDoctorsDay
Congratulations to Dr. Ana Gomes (@Lab_Gomes) on receiving the @NIH New Innovator Award! This marks the first time a Moffitt faculty member has received this award and demonstrates the exceptional research of Dr. Gomes on aging and cancer development. moffitt.org/newsroom/press-r…
👨👩👧👧#FathersDay reflections...
So grateful to be a father to my two girls, Emily and Ally. Both bring such bright light to the world around them, and it's so fulfilling to see what compassionate young women they have become. 💕
Happy Father's Day!
#ScienceSaturday
Better treatments are needed when cancers spread to the brain, which can especially happen in #melanoma, lung and breast #cancer. The secret may lie in the blood vessels of these brain metastases. @BejaranoLeire, @Johanna_A_Joyce and colleagues performed an extensive molecular analysis of human and murine brain metastases and found a number of potential targets, including CD276 (B7-H3), that when blocked could increase the infiltration of cytotoxic CD8 positive T cells into brain mets and decrease tumor growth in preclinical models.
Here’s a link to the full study- cell.com/cancer-cell/fulltex…