Director, Immunology Institute @SinaiImmunol @IcahnMountSinai | Harnessing the innate immune system for novel therapies against cancer & inflammatory diseases.

Manhattan, NY
Very sad to hear that UMass is rescinding all PhD admissions for Fall 2025. This means there will be no new PhD cohort, and UMass will not have a graduating class that year. This is just unprecedented and I am so very sorry for all the affected students.
Community note
This is incorrect. UMass is NOT rescinding all PhD admissions for Fall 2025. Only the Morningside Graduate School has done this. Other UMass programs have not. Read here for details: masslive.com/worcester/2025… “applicants to UMass other graduate schools …. are not impacted” boston.com/news/health/20
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Congratulations to Magdalena Skipper for being the first Woman editor- in chief at Nature- what a great statement for all women scientists !! Nature announces new editor-in-chief nature.com/articles/d41586-0…
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Beautiful picture with all my fellows’ babies born in the lab recently and one on the way ! Scientists don’t hesitate to have kids if you want one ! parenthood often increases productivity, focus and happiness !
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Very proud to be inducted today along incredible scientists @theNASciences and very grateful to many people and institutions that led me here. Starting with my Med school mentors in Algiers including my parents who taught me intellectual engagement , discipline & rigor (1/x)
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25 years ago, I came to Stanford on a J1 visa and worked so hard to be worthy of that privilege. Today, I lead Immunology at Mount Sinai and I am the one who feel privileged when brilliant international students chose to join us.
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One family spent their entire vacation budget on these tests. On my way back I saw that in Paris’ airport, antigen tests were free! Antigen tests cost max 15$! @JFKairport should forbid test centers that make disgraceful profits out of people misfortune!
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Very excited by our results @Nature showing that IL4R signaling is strongly enriched in myeloid cells that infiltrate mice and lung cancer lesions nature.com/articles/s41586-0…
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Excited to share our new paper in @NatImmunol on how TREM2+ monocyte-derived macrophages in lung cancer reduce activity of natural killer cells that fight tumors. We provide potential dual targeting strategies to improve antitumor immunity. Read here: rdcu.be/damS8
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Our lab picnic home country cooking competition today : 16 nationalities, 5 religions , extraordinary food & fantastic debates : the american’s lab spirit we all emigrated for ! why would someone want to destroy that ?
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Our paper on the effect of fasting on innate immunity was published today alongside a beautiful study on the role of fasting on memory T cells by my very close friend and compatriote Yasmine Belkaid ! hate chauvinism but a bit happier than usual today ! cell.com/cell/fulltext/S0092…
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We started a large effort to review all COVID19 studies posted BioRxiv. Our goal help highlight relevant new data . Trainees screen and write short reviews and faculty review and post on BioRxiv. Thank you very much Sinai Immunol for the effort. @SinaiImmunol #COVID19
Given the accumulation of #COVID19 literature posted in preprint servers, we have started an institutional effort to provide critical reviews on articles posted on @biorxivpreprint and @medrxivpreprint. Direct links to these reviews will be updated in this thread ⬇️
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Immunology takes center stage again at the #NobelPrize! Congratulations to Mary Brunkow, Fred Ramsdell & Shimon Sakaguchi for uncovering how regulatory T cells maintain immune tolerance—a discovery that transformed our understanding of autoimmunity and cancer immunotherapy
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I travelled this week to paris from @JFKairport . @Delta did not ask for vaccine passports but I saw several families in tears because they were forced to get an antigen test before boarding regardless of vaccine history-cost of the tests were 200$ per person ( adult& kids)
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Our paper describing a cytokine signature of COVID19 disease severity is now online. here we describe how we developed a rapid test to profile 4 cytokines in 1,484 COVID patients one the day of hospitalization and followed them for 49 days. 1/2 medrxiv.org/content/10.1101/…
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Thrilled to begin my tenure as the new president of @iuis_online! We are working toward demystifying immunology research, fostering global collaborations & bringing new immunotherapies to patients everywhere 🤝 Read more here: iuis.org/about/who-we-are/ed…
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As anticipated a more careful study comparing rate or severity of COVID19 between age matched patients who were either vaccinated or not vaccinated at birth against BCG did not reveal any differences between the groups- ja.ma/2zaxKpX
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Welcome Back America !
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Excited by our study @ImmunityCP showing that senescent monocyte-derived macs (driven by MAPK mutations) which we showed lead to macs prolonged survival and cytokine release breakdown the BBB, infiltrate the brain and promote neurodegeneration sciencedirect.com/science/ar…
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Honored to be awarded the Griffuel prize tonight from the @FondationARC an extraordinary french cancer foundation that funded my PhD work at @Stanford more than 25 years ago- most touched to be surrounded by former fellows @FGinhoux @HelftJulie Jerome Martin
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Strong article from Tom Maniatis, head of the NY Genome Center, on the history of the NIH and its role in maintaining U.S. scientific leadership. Safeguarding the future of biomedical science in the United States: Cell cell.com/cell/fulltext/S0092…
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Great panel of editors from Cell, Nat Med, Nat Immunol. Nat Biotech, JEM ⁦⁩ @SinaiImmunol⁩ retreat today talking about Twitter’s impact on publishing. the good news is that editors solicit papers based on Tweets-feeds so please keep tweeting about the science you like!
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In my acceptance speech for the griffuel prize, I wore a silver dress to symbolize the “LIGHT” that science and advocates bring to humanity. I called on political leaders worldwide to be inspired by scientists’ commitment to a better and united world (1 out of 2)
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Tomorrow, I’ll be standing for science with my lab in NYC. Come learn what we do, why we need support to continue, and how this impacts everyone—because no one is immune to disease. Hope to see many New Yorkers, not just scientists, standing with us. standupforscience2025.org
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My 13 yo son tired of hearing me complain about funding organized a bake sale to fundraise for my lab and raised few hundred $$!! Was thinking using the funding towards organizing a think-tank on how to bring back boldness and conceptual thinking on study section ?
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Very honored to receive the International @Inserm Prize today at the French Embassy in DC. Great evening with @Inserm CEO Didier Samuel, Ambassador Lilli, and wonderful colleagues, celebrating France/US partnerships and our shared commitment to advancing science across borders.
Replying to @Inserm
Bravo à @MiriamMerad chercheuse à l’Ecole de médecine du @MountSinaiNYC qui reçoit le #prixinternational 2024 de l’Inserm ! Il salue son travail exceptionnel en immunologie du #cancer et des maladies inflammatoires, symbole de la collaboration scientifique franco-américaine.
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Great review about the need to expand understanding of human immune diseases and how this requires a change in academic culture that further recognizes and award team efforts without detracting from the enormous value of individual creativity. #TeamScience science.sciencemag.org/conte…
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What a beautiful and inspiring article ! A mandatory read to young and older scientists. I have rarely felt so aligned with an opinion piece ! Congrats Ron for your price and thank you for the inspiration ! cell.com/cell/fulltext/S0092…
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Beautiful story on the discovery of integrins by the fantastic 2022 Lasker awardee Immunologist Tim Springer and cancer biologists Erkki Ruoslahti & Richard Hynes. Incredible how many transformative discoveries were made during my adult life. cell.com/cell/fulltext/S0092…
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Postmortem analysis of COVID19 patients showing that spleen and LN macrophages express ACE2 and CoV2 nucleoprotein (NP) associated with profound lymphocyte apoptosis. Intriguing as steady state macs lack ACE2 !NP+ could reflect uptake of infected cells! Need to explore further!
This In-Brief highlights one of several studies pointing to the role that inflammatory macrophages may play in COVID-19-associated cytokine release syndrome. Thanks to @SinaiImmunol @MiriamMerad for the opportunity to contribute to an ongoing effort!
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Today we celebrated the 80th Bday of Irv Weissman ! An incredible mentor who taught us to think big, enjoy the journey and be generous! The symposium’s talks given mostly by Irv’s progeny was a great tribute to his enormous legacy ! Happy Bday Irv !
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I had the most extraordinary celebration of my Lab 20th anniversary this weekend in the Poconos (aka 'Mykonos' to the labbies !) Thanks to @JessLeBerichel for the extraordinary organization and @samhegde2006 and @jboumelha for the scientific leadership (1x)
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Thank you Cancer World for the fun interview and for your interest in cancer immunology !
📣 🏆 The prestigious 2025 #SjöbergPrize ($1,000,000) has been awarded to Dr. @MiriamMerad , for her pioneering research on tissue-resident macrophages and their role in #CancerImmunity. 🔬🧬 Her work has unveiled new targets for #cancer therapies, offering hope for more effective treatments. Her enthusiasm for #oncology is palpable. Her passion is not merely intellectual—it is deeply personal, rooted in years of observation, hands-on research, and an unwavering drive to find better cancer treatments. When asked about her passion for her work, she simply laughs and responds with an undeniable truth: “I love these cells. That’s true. I love these cells.” Read the full article to explore her early career journey, the challenges she overcame as a #WomanScientist, the clinical translation of her #discovery, gain insights from Prof. Urban Lendahl, Secretary of the Prize Committee, on the significance of her work, and much more 👇 cancerworld.net/miriam-merad… @IcahnMountSinai @SinaiImmunol @ScienceAcad_swe @oncodaily #CancerResearch #Immunotherapy #MiriamMerad #OncologyInnovation #MacrophageResearch #WomenInScience #CancerInnovation
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Excited to speak @broadinstitute next week about how macrophages & dendritic cells in tumors affect cancer outcomes & responses to immunotherapy, as well as the need for better spatial profiling technologies to identify new therapeutic targets for cancer & inflammatory diseases.
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Honored to be elected to @theNAMedicine today as a physician-scientist committed to bringing basic science to medicine. This election recognizes the work of an extraordinary group of post-doctoral fellows, students & colleagues for almost 20 years. 📰 > loom.ly/qd3JrUk
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Happy #DayofImmunology to all immunologists across the world and especially to my relentless lab. Thank you @JessLeBerichel for the beautiful T-shirts - let's bring them all to Cape Town! #immunotherapy #iuis2023 @iuis_online
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I'm thrilled to celebrate launching @IcahnMountSinai's first Dept. of Immunology & Immunotherapy with Vice-Chair Brian Brown, faculty and friends. Read more about the DII’s mission to elevate fundamental explorations of how the immune system works here: loom.ly/xbXC8Ho
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Great picture of my lab picnic in central parc today showing a beautiful mix of scientists from all 5 continents and many religious and non religious background that share the same interest in immunotherapy ! So fun and powerful to be different and yet share the sale purpose !
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Amidst all the craziness, 2020 has been a great year for women immunologists in my lab, with @Casanova_Acebes starting her lab @CNIOStopCancer ; @dendriticBabs starting her lab @CeMM_News and @meravcohen8 starting her lab @TelAvivUni. You made me very proud ladies #WomenInSTEM
Replying to @StacieDodgson
More interested in innate immunity or tumor immunology? Another brand-new PI, María Casanova-Acebes, former postdoc with @MiriamMerad @IcahnMountSinai, now at @CNIOStopCancer will talk about the pro-tumorigenic role of tissue resident macrophages in lung cancer
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On my way to ⁦@AlaciOrg⁩ immunology congress organized by the fantastic Emilio Malchiodi. By the time I come back, we will have a new US president- hopefully one who will bring prosperity, peace, decency and an ambitious NIH budget to enhance our fight against major illnesses
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The power of a bipartisan America—that refuses to dismantle science, cares about patients, and understands that medical academic research is also an economic engine. Thank you to the senators who stood up for NIH and the future of American health. science.org/content/article/….
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Macron just won the reelection in France against the far-right populist, anti-European, anti-Immigrant Marine Le Pen- But the score of the far-right (42%) is historically the highest in France.Populism & Xenophobia are dangerously spreading #FightAgainstPopulism #MacronPresident
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Very inspired that Yaghi, a Palestinian refugee who came to the U.S. at 15 received the 2025 chemistry #NobelPrize . A reminder of the power of education to unleash talent, a testament to U.S. capacity to attract/ enable talent, and how much progress a we lose to incessant wars
This year’s chemistry laureate Omar Yaghi was born in Amman, Jordan, in 1965 to parents who were refugees from Palestine. When we spoke to him he shared his story: “I grew up in a very humble home, we were a dozen of us in one room, sharing it with the cattle that we used to raise. I was born in a family of refugees, and my parents could barely read or write. My father finished sixth grade and my mother couldn’t read or write. It’s quite a journey. Science allows you to do it. Science is the greatest equalising force in the world. Smart people, talented people, skilled people exist everywhere. That’s why we really should focus on unleashing their potential through providing them with opportunity.” Today Yaghi shared the 2025 Nobel Prize in Chemistry with Susumu Kitagawa and Richard Robson for their work developing metal–organic frameworks. Learn more about the prize: nobelprize.org/prizes/chemis…
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In a 2015 correspondence to Nature, my colleague Brian Brown and I have stressed that equal-authorship details are missing from indexing sites or citations and called on PubMed to reflect shared authorship- Unfortunately co-first authors remain insufficiently acknowledged !
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Happy Mother's Day to all the mothers @SinaiImmunol and in the world. I am sharing a piece I wrote sometime ago to describe my struggle of becoming a mother while building my lab and the critical need for affordable childcare. rdcu.be/cM7nf
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Thrilled to receive the Coley Award and thrilled to be an immunologist !
2018 William B. Coley Award honoree @MiriamMerad of @IcahnMountSinai shares the roles of myeloid cells in the tumor microenvironment. #CICON18
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I am quite excited by the quality of the images we are obtaining with the Orion - a cyclic-IF technology that enables the imaging of 20 proteins at a time ! This is just the beginning but more hopeful than with most multiplex imaging instruments we have tried so far !
Exciting news! 📢HIMC has implemented @RareCyte Orion high-plex immunofluorescence imaging instrument to investigate the local tissuemicroenvironment! Check out the solid tumor tissue images for various immune infiltrates and CAR-T targets in Multiple myeloma 👇
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Very excited to celebrate ⁦@AACR⁩ fellows with close friends and colleagues ⁦@PamSharmaMDPhD⁩ ⁦@JimAllisonPhD⁩ SangeetaBhatia ⁦@MIT⁩, @ Tak Mak, ⁦@wolchokj⁩ , ⁦@BhardwajLab⁩ @ Robert Schreiber and many more
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Sinai Immunol trainees in addition to reviewing COVID19 preprints are now helping process COVID samples in BSL2+facility Working in several shifts per day to profile PBMC and sera ! @SinaiImmunol Thank you all for stepping up to help ! Very proud of you all !
Proud of our scientists, busy processing blood from COVID19 patients samples so we can measure their immune response #COVID19 #Priism
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Happy Women’s day to all Women out there that are fighting for human rights and special thoughts today to Iranian women who have inspired the world with their extraordinary courage, resilience and leadership #WomensDay
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What’s the purpose of getting rid of foreign students who have been vetted and admitted to US schools ? a disgraceful law once more ! cnn.com/2020/07/06/politics/…
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Very honored to give the Ballantyne Lecture at MD Anderson. I enjoyed the discussions on pre-cancer modeling and targeting inflammation as a major strategy for cancer prevention "esp. in aging" areas becoming a major focus of my lab. @SinaiImmunol #inflammation #cancerprevention
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We are facing a war that could have been avoided if NIH budget was not constantly trimmed ! Time to reflect as a society on budget allocation to research ! Let’s make sure that NIH budget significantly increases not only during a pandemic !! #NIH #COVID19 @NCIDirector
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⁦The best Thanksgiving gift: 4 former super star post docs now leading their own labs in Europe hanging out together with former student at a European myeloid meeting organized by them @FGinhoux⁩, @HelftJulie⁩, Melanie Greter, Jerome Martin. I miss you guys #ProudPI
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Another powerful study highlighting that macrophages are an untapped source of therapeutic targets with new data showing the role of macrophages atrial fibrillation science.org/doi/10.1126/scie…
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Excellent study showing the key protective role of tissue resident macrophages in hypertension. This is important as hypertension is a major public health issue in much need of better treatment #macrophages (1/x) sciencedirect.com/science/ar…
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Relieved to see our review on host déterminants of tumor immunity published ! This was a difficult review to write as published data on the topic are sparse but we believed it was an important and timely topic to discuss ! Thanks to @HeleneSalmon et al. for all the efforts
NEW Review by @MiriamMerad @HeleneSalmon & colleagues discusses how differences in tissue sites may influence the antitumour immune response, with potential implications for novel therapeutics. #immunotherapy @NatResCancer @IcahnMountSinai @institut_curie go.nature.com/2Ux0heV
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Today instead of mining new data or writing a grant application due soon, or reading science I spent many hrs attending a town hall addressing the immigrant Visa Ban and calming scientists’ anxiety! What a distraction from our core mission #ImmigrationBan #ImmigrantScience
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Some of us ⁦@SinaiImmunol⁩ gathered today to watch the « inauguration » which felt more like a « liberation » of the United States from a bunch of imposters !
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Calling all immunologists! Registration & abstract submission for this year's @iuis_online Congress is NOW OPEN! Hope to see you later this year in Cape Town, South Africa for #IUIS2023! Register & submit abstracts: iuis2023.org
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Voted yesterday under pouring rain in NYC quite confident that American across the board will chose light over darkness as this presidency never once represented American values #VoteAmerica
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urging them to find political solutions to current conflicts that uplift all communities & ensure sustained peace. I called for increased science's funding and imagined the extraordinary discoveries we could achieve if the budget for science was only half that of the military’s.
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This is so absolutely true ! Failure is so much part of the science journey : we need to acknowledge failure, understand why we failed and have the courage and stamina to try another path! economist.com/graphic-detail…
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Our deep mapping study of Crohn's lesions is out- we highlight the limitations of current diagnostics & the power of sc profiling to identify molecular disease patters. Currently measuring molecular responses to biologics in naive lesions so stay tuned ! cell.com/cell/fulltext/S0092…
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Honored to receive the Sjöberg Prize today from the Royal Swedish Academy of Science and very Inspired by Bengt Sjöberg, a very successful industrialist who, after cancer diagnosis, turned to academic science as the only path to a cure.
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Wow what a beautiful paper ! if this really works, it will be a game changer for all immune drug discovery efforts ! sciencedirect.com/science/ar…
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Today SinaiImmunol. joined their colleagues to observe 9 minutes of silence to stand with our black community. It is hurtful to realize that while Sinai has been fighting days and nights to save lives for months some trivialize death #BlackLivesMatter
Today we show support for our community; support for our Black colleagues, family, friends, and neighbors; and support for those who are peacefully protesting the killing of George Floyd, and so many others before him ✊🏾
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Celebrating the inaugural awardee of the Menarini Prize for outstanding woman Immunologist : Pr. Diane Mathis ⁦@harvardmed⁩ - congratulation Diane
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Celebrating the Nobel price with Jim Allison Pam Sharma and Drew Pardoll
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Today we celebrate the defense of a very special MD PhD student Seven Chen. A great immunologist who abandoned his promising IO project to work on COVID. Thank you Steven for everything you did for the field- Good luck on the clinical floors and come back soon #ProudPI
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A pleasure to host ⁦@danmucida⁩ at ⁦@SinaiImmunol⁩ who presented this nice immunology analogy to human emigration emphasizing that most foreign antigens like human foreigners are beneficial to the host !! Thanks Daniel for the quote !
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Exciting to have full house for Lab meeting this morning #VaccineWorks@SinaiImmunol
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A nice tribute to Paul Frenette, a very special friend and colleague who left us much too soon ! I will very dearly miss you ! einsteinmed.org/features/261…
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I am debating if I should keep the wand in lab meetings for some time and report if the magic happens! Happy Halloween !
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Hope you can join @MaxKrummel and I at the keystone meeting we have organized on Myeloid Targeting Strategies for Cancer Treatment, this May in Killarney! keysym.us/KSMyeloidTargets24 #KSMyeloidTargets24
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To celebrate #DayOfImmunology@SinaiImmunol⁩ started a T-shirt campaign to educate the community about the power of vaccines to educate the immune system to fight COVID 19 ! #VaccineSaveLives #ThankYouImmunology
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Excited to share our review highlighting how loss/dysregulation of resident tissue macrophages drives tissue damage in aging. Together with enhanced myelopoiesis & reduced lymphopoiesis, this creates a vicious cycle we aim to target to promote healthier aging. @SinaiImmunol
🎉Immune aging focus🎉@MatthewD_Park et al discuss dysregulation of resident tissue macrophages in immune aging as a contributor to age-related diseases including cancer @MiriamMerad nature.com/articles/s43587-0… rdcu.be/eARAd
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Beautiful study from fantastic former fellow ⁦@nkg2d1⁩ showing how a gut commensal protozoan, he identified in my lab to improve gut infection outcome, now is shown to shape lung immunity and tune response to infection and allergens. Fascinating ! cell.com/cell/abstract/S0092…
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Exciting to chair the myeloid session today #AACR22 - The room was super packed highlighting how much myeloid cell biology is now at the center of cancer therapeutic discovery
V interesting myeloid cell session this morning @ #AACR22 ft. 4 stellar @CancerResearch scientists: Brian Brown, @MiriamMerad, Ira Mellman, & @RayArja. As Mellman noted, “Although we focus predominantly on T cells in IO, they would be nowhere were it not for the myeloid cells.”
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Even if temporary, this order could significantly alter America’s stance in science by damaging the image of the safe American laboratories that have welcomed, embraced, benefitted but also empowered foreign scientists across the nation for generations. whitehouse.gov/presidential-…
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Looking forward to giving a global immunotalk this Wednesday ! Thank you Carla Rothlin and @ZunigaLab for your effort to connect scientists across the world at a time when the pandemics and politics is enforcing isolationism #ScienceWithoutBorders
Looking forward to our next #globalimmuno talk this Wednesday 9/2/20 at 9am PST noon EST 4pm GMT by Dr. Miriam Merad. "Pathogenic inflammation in COVID19 patients" LINK: ucsd.zoom.us/j/91053505061 Meanwhile catch up with the amazing previous talks at: piped.video/channel/UCXn0yDm…
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Today ⁦⁦@SinaiImmunol⁩ we celebrated a future where diversity, science and rational thinking will be respected again #ScienceMatters #DiversityandInclusion
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We've launched two new programs @IcahnMountSinai @SinaiImmunol designed to foster collaboration among physicians & researchers, hasten progress & expand access to immunotherapy. Discover the transformative potential of INTERACT & TARGET: reports.mountsinai.org/artic…
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What an honor to be listed among these talents. I came to America in 1998 with a J Visa after living in 2 continents. America taught me the power of diversity and empowerment. The true basis of America's exceptionalism and the America I love. @carnegiecorp carnegie.io/2VwZ21X
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This study claims to measure the effect of IL6R blockade therapy on PBMC inflammatory programs - yet there are no pretreatment measurement ! I understand the urgency to share COVID 19 data but ininterpretable data are never useful even « or especially» during a pandemic !
Tocilizumab treatment in severe COVID-19 patients attenuates the inflammatory storm incited by monocyte centric immune interactions revealed by single-cell analysis biorxiv.org/cgi/content/shor… #bioRxiv
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Celebrating the Nobel price with Jim Allison, Jim’s son Robert Allison, Nina Bhardwaj, Dan Littman , Phil Greenberg, Sacha Gnjatic and many more phenomenal immunologists ! What a day !
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I use to have chocolates for my lab in my office, now I store face shields and N95 to make sure they will be able to keep analyzing COVID samples ! ⁦@SinaiImmunol#COVIDー19
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Beautiful line of scientists from all over the world queuing after ⁦@JimAllisonPhD⁩ phenomenal keynote address #iuis2023 to take pictures with him
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Well Dr Conley: you should be telling people that they should be afraid of COVID because in contrast to the president, they are not being tested everyday and they won't be airlifted to a hospital and treated in the hrs following a positive test #CovidKills #MasksSaveLives
“Don’t be afraid of Covid,” Trump tweeted of the virus that's infected more than 7.4 million Americans, killed nearly 210,000 and resulted in the president getting airlifted to a hospital. Asked about the tweet, Dr. Sean Conley declined to comment politi.co/33ziwr0
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