Nature Reviews Cancer is a monthly review journal for researchers working on cancer. We, the editors, highlight the most exciting topics in cancer research.
London, UK
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Our JULY issue is now live!🌞 🏖️🍉
It features #REVIEWS on:
- AI for integrating cancer multi-omics & clinical data
- Targeting cancer dormancy
- Context-dependent synthetic lethality
- Microbiota in immune-related adverse events
📖 👇
dlvr.it/TTGZKc
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Our 1st Roadmap asking why do patients with cancer die? is now FREE to access for 1 month starting today! The precise causes of mortality in patients with cancer remains poorly understood & this piece starts to highlight areas of unmet need for targeting go.nature.com/3RDKlao
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Our August issue is live now! ☀️🍑
It features articles on:
- why patients with cancer die
- cancer #organoids for modelling the #TiME
- #immunecheckpointinhibitor-mediated #myocarditis
- targeting the breast #TiME
Check it out now 👇
go.nature.com/46iyQv3
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NEW content online! Tertiary lymphoid structures in anticancer immunity dlvr.it/TBh6fM
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Our latest POSTER with @NatRevImmunol explores rationale combinations of #immunecheckpointblockade of #PD1-#PDL1, with other therapies aimed at targeting effector T cells, innate immune + regulatory T cells, the #TME & cancer cells.
Check it out now!
go.nature.com/3WLcCh5
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NEW content online! Exploiting temporal aspects of cancer immunotherapy dlvr.it/T8Q0kd
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NEW content online! Mechanisms driving the immunoregulatory function of cancer cells dlvr.it/Shh53m
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Don´t miss this Review summarizing the different antibody-based approaches for targeting cancer cells including #CheckpointInhibitors, bispecific antibodies and #AntibodyDrugConjugates, as well as strategies that improve efficacy and reduce toxicities.
go.nature.com/3wWetGE
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And the moment you've all been waiting for... Our top downloaded article in 2023: Mechanisms driving the immunoregulatory function of cancer cells
by Antoinette van Weverwijk & @deVisserKarin go.nature.com/3HoMqBk @NatResCancer @NKI_nl @oncodeinstitute #NRCtop10of2023 nitter.app/NatureRevCancer/status…
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Cancer organoids 2.0: modelling the complexity of the tumour immune microenvironment dlvr.it/T9N1S4
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Our 2nd most downloaded article in 2023: Cancers make their own luck: theories of cancer origins by @RJG3062 & colleagues go.nature.com/3SwbXiF @NatResCancer @Gilbertson_Lab #NRCtop10of2023 nitter.app/NatureRevCancer/status…
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And the moment you've all been waiting for... Our top downloaded article in 2022: CRISPR in cancer biology and therapy by @alynakatti @biancaaadiaz @cmcaragine @nevillesanjana & @dow_lab go.nature.com/33Rgp4Y @NatResCancer #CRISPR #NRCtop10of2022 nitter.app/NatureRevCancer/status…
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NEW content online! Cross-priming in cancer immunology and immunotherapy bit.ly/4ayN6lv
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NEW content online! Mastering the use of cellular barcoding to explore cancer heterogeneity dlvr.it/SWrjQw
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NEW content online! Hallmarks of sex bias in immuno-oncology: mechanisms and therapeutic implications dlvr.it/T5Fz27
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NEW content online! Bacteria in cancer initiation, promotion and progression dlvr.it/SrcBZ0
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#singlecell epigenomic technologies are redefining our understanding of cancer evolution.
Now, @MartheLaisne, @MatLupien & @VallotCeline explain how epigenomic heterogeneity drives tumor cell state diversity through reprogramming and selection.
go.nature.com/3NyflWN
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NEW content online! Emerging strategies to investigate the biology of early cancer go.nature.com/48i8han
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NEW content online! Acquired resistance in cancer: towards targeted therapeutic strategies bit.ly/3SABwye
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NEW content online! Targeting the DNA damage response in immuno-oncology: developments and opportunities dlvr.it/S5NMp2
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NEW content online! Macrophages and T cells in metabolic disorder-associated cancers go.nature.com/4duhbCv
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NEW content online! Decoding the basis of histological variation in human cancer dlvr.it/T0TsJw
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NEW content online! Cancer organoids 2.0: modelling the complexity of the tumour immune microenvironment dlvr.it/TB0ftH
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Our 6th most downloaded article of 2021: Antigen presentation in cancer: insights into tumour immunogenicity and immune evasion
by S Jhunjhunwala, C Hammer & L Delamarre
go.nature.com/3bt1Yor
#ImmuneEvasion #ImmuneCheckpointInhibition
@genentech
@NatResCancer
#NRCtop10of2021
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NEW content online! Defining clinically useful biomarkers of immune checkpoint inhibitors in solid tumours dlvr.it/T8BcW3
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NEW Review! @deVisserKarin and A. van Weverwijk outline how inter-tumoural #heterogeneity in tumour #immunelandscapes is shaped by cancer cell-intrinsic alterations and how their crosstalk impacts #Immunotherapy
go.nature.com/3IcnU7C
@natrescancer @NKI_nl @oncodeinstitute nitter.app/NatureRevCancer/status…
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NEW content online! A guide to artificial intelligence for cancer researchers dlvr.it/T723G9
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NEW Review! @alynakatti @biancaaadiaz @cmcaragine @nevillesanjana & @dow_lab outline the ENORMOUS progress that has been made in the application of #CRISPR tools to the study of #cancer & describe their potential use in diagnosis & treatment go.nature.com/33Rgp4Y
@natrescancer
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NEW content online! Metabolic networks in mutant KRAS-driven tumours: tissue specificities and the microenvironment dlvr.it/S3NxMh
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NEW content online! Beyond genetics: driving cancer with the tumour microenvironment behind the wheel dlvr.it/T2hjdj
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FINALLY 🥁.. our top most downloaded article of the year is…. 🥁 🥁🥁
Why do patients with cancer die? By @thomasrcox, Eric Sahai and colleagues
bit.ly/42SREkL
@crick.ac.uk @natrescancer @GarvanInstitute @UNSW @TheCrick
@NatResCancer #NRCtop10of2024
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2019 #NobelPrize winner William Kaelin @kaelin_lab wrote a Perspective article for the journal in 2017 on Common pitfalls in preclinical cancer target validation that many have said should be 'required reading'. Access it for free here: go.nature.com/33eeO3c
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Our 3rd most downloaded article of 2021: The metabolism of cancer cells during metastasis
by G Bergers @BergersLab
& S-M Fendt @FendtLab
go.nature.com/38TYN87
#cancermetabolism
#metastasis
#NRCtop10of2021
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NEW content online! Compressive stresses in cancer: characterization and implications for tumour progression and treatment go.nature.com/4eXaIRD
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NEW content online! Immunobiology of high-grade serous ovarian cancer: lessons for clinical translation dlvr.it/SYN9tv
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NEW content online! Towards targeting of shared mechanisms of cancer metastasis and therapy resistance dlvr.it/SGsmRN
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NEW content online! Epigenomic heterogeneity as a source of tumour evolution go.nature.com/4dKLSUg
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NEW content online! Cancer stem cell–immune cell crosstalk in tumour progression dlvr.it/S1Jl85
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In case you missed it, out NOW @ElaineFuchsLab @greatysp & @almagro_jorge discuss the non-genetic drivers of tumorigenesis & progression – it’s not all about mutations! #tumourmicroenvironment go.nature.com/3UTAcsF
@natrescancer @RockefellerUniv @HHMINEWS nitter.app/NatureRevCancer/status…
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NEW content online! Cancer-induced systemic pre-conditioning of distant organs: building a niche for metastatic cells go.nature.com/3YkwcCs
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New Perspective! Marine, Dawson & Dawson discuss how therapeutic #resistance in cancer is not only driven by genetic evolution but often involves nongenetic adaptive mechanisms that are intimately linked.
go.nature.com/3iKHEQ7
@NatResCancer @lab_marine @TheDawsonLab @MAFD110
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NEW content online! Stress and cancer: mechanisms, significance and future directions dlvr.it/S7JrxM
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NEW content online! The immunological and metabolic landscape in primary and metastatic liver cancer dlvr.it/S4gVsp
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And the moment you've all been waiting for...
Our top downloaded article in 2021: Systemic immunity in cancer
by K Hiam-Galvez @InflammatoryDC, B Allen @ballen1725 & M Spitzer @SpitzerLab
go.nature.com/3sa8qWH
@UCSFCancer
@UCSF
#NRCtop10of2021
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NEW content online! Mechanisms of immune activation and regulation: lessons from melanoma dlvr.it/SJBBB5
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NEW content online! Glial and myeloid heterogeneity in the brain tumour microenvironment dlvr.it/S8VRRf
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NEW content online! Linking cell mechanical memory and cancer metastasis dlvr.it/T1ZZK4
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NEW content online! The evolutionary theory of cancer: challenges and potential solutions dlvr.it/TD3X00
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NEW Review! @zervanto & colleagues discuss mechanisms by which tumour ecosystems adapt to therapeutic stresses and how adaptive responses could be targeted to overcome cancer therapy resistance.
go.nature.com/36jXlx7
@natrescancer @UPMCHillmanCC @OHSUNews @harvardmed
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NEW content online! Cancer drug-tolerant persister cells: from biological questions to clinical opportunities dlvr.it/TCljVQ
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NEW content online! Immunogenic cell death in cancer: targeting necroptosis to induce antitumour immunity dlvr.it/T3n7lG
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NEW content online! Synthetic biomarkers: a twenty-first century path to early cancer detection dlvr.it/S71z5C
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NEW content online! Fcγ receptors and immunomodulatory antibodies in cancer dlvr.it/SzqnNR
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Our 6th most downloaded article in 2022: Towards targeting of shared mechanisms of cancer metastasis and therapy resistance by Peter Friedl & colleagues go.nature.com/3r5I2yI @NatResCancer @MDAndersonNews @radboudumc @radboudumc_weet #Metastasis #NRCtop10of2022 nitter.app/NatureRevCancer/status…
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NEW Perspective! Friedl et al outline how exploitation of signalling pathways shared between those enabling #Metastasis and those in #TherapyResistance might result in better therapies.
go.nature.com/3r5I2yI
@natrescancer @MDAndersonNews @Radboudumc @Radboudumc_weet
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Our 2nd most downloaded article in 2022: Natural killer cells in antitumour adoptive cell immunotherapy by Katy Rezvani @lab_rezvani & colleagues go.nature.com/3XCAtyh @NatResCancer #NRCtop10of2022 nitter.app/NatureRevCancer/status…
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NEW content online! Genomic and fragmentomic landscapes of cell-free DNA for early cancer detection bit.ly/4ioP7Dr
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Tumour-associated lymphatic growth & remodeling were once viewed as passive means for lymphatic spread. In this #Review, @theLundLab provide a working framework for the role of the lymphatic system in tumour progression & response to immunotherapy.
go.nature.com/442H4GG nitter.app/NatureRevCancer/status…
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In our September issue: The immunological and metabolic landscape in primary and metastatic liver cancer, by M Heikenwalder @CancerInflam et al.
go.nature.com/3rV8xHj
@natrescancer #livercancer #immunology #metabolism @DKFZ
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Attending Ton Schumacher's talk at #AACR2022? Have a look at his @NatureRevCancer Review: #CD8+ T cell states in human cancer: insights from single-cell analysis; bit.ly/CD8T_TNS
@NatResCancer @NKI_nl
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Our 8th most downloaded article in 2023: The neural addiction of cancer by Claire Magnon & Hubert Hondermarck go.nature.com/3SmNmg3 @NatResCancer @inserm #NRCtop10of2023 nitter.app/NatureRevCancer/status…
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NEW content online! Lymphatic vessels in the age of cancer immunotherapy dlvr.it/T5MqCc
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In the March issue of @NatureRevCancer | Towards targeting of shared mechanisms of #cancer #metastasis & #therapyresistance by F Weiss, D Lauffenburger & P Friedl
go.nature.com/3r5I2yI
@natrescancer @MDAndersonNews @radboudumc @radboudumc_weet #CancerTherapy
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NEW Review! GG Wang & co discuss the many connections between #chromatin modifications and #cancer, going into recent advances and highlighting options for therapeutic targeting.
go.nature.com/3u9YKww
@NatresCancer @UNC_SOM @UNC_Lineberger
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NEW content online! How chemokines organize the tumour microenvironment dlvr.it/SzwHGb
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🥳 Our 6th most downloaded article in 2024:
The evolutionary theory of cancer: challenges and potential solutions by @LucieLaplane & @cmaley
bit.ly/4gCc5FL
#cancermodels #evolutionarybiology
@NatResCancer #NRCtop10of2024
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In our August issue | Metabolic networks in mutant KRAS-driven tumours: tissue specificities and the microenvironment, by Costas Lyssiotis @LyssiotisLab et al.
go.nature.com/3hUSzbo
@UMRogelCancer @YatrikShahLab @ThalesPapaG
#KRAS #cancermetabolism #NSCLC #CRC #PDAC
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NEW content online! The present and future of the Cancer Dependency Map go.nature.com/4fiZ6sw
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NEW content online! Defining precancer: a grand challenge for the cancer community go.nature.com/3XH0wWo
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In our August issue | Cancer stem cell–immune cell crosstalk in tumour progression, by Defne Bayik & Justin D. Lathia
go.nature.com/3gf2nfy
@d_bayik @JustinLathia @caseccc @CCLRI @NatResCancer
#tumorimmunology #tumormicroenvironment #cancerstemcell #CSC #immunecell
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Tertiary lymphoid structures (TLS) are found in many solid tumours. In this Review, the Dieu-Nosjean group (@Sorbonne_Univ_), highlight the unique biology of TLS & their potential for therapeutic targeting to orchestrate immune responses.
📖it➡️go.nature.com/3YFus7s
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NEW content online! Tumour hypoxia in driving genomic instability and tumour evolution bit.ly/4aCU3SL
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NEW content online! Liquid–liquid phase separation drives cellular function and dysfunction in cancer dlvr.it/SJpLLg
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Our 6th most downloaded article in 2023: Dynamics and specificities of T cells in cancer immunotherapy by Giacomo Oliveira & Cathy J. Wu go.nature.com/3tYex7s @NatResCancer @DanaFarberNews
@harvardmed #NRCtop10of2023 nitter.app/NatureRevCancer/status…
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Towards targeting the breast cancer immune microenvironment dlvr.it/T9C7GF
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NEW content online! Endoplasmic reticulum stress responses in anticancer immunity bit.ly/4ei3dFN
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Our NEW Review by @AshaniTW and @FaneMitchell discusses the interplay between ageing cell types in the #microenvironment and cancer cells and how this is likely to impact tumour #metastasis and #cancertherapy response. go.nature.com/2LSHPLk @NatResCancer
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#REVIEW 🚨
Amit et al. outline the reciprocal interactions among neurons, immune cells and tumour cells that regulate peripheral antitumour immune responses and discuss how these mechanisms could be leveraged to enhance immunotherapy.
📖 ⬇️
bit.ly/4kLWyGq
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