Our mission is to end the threat of age-related disease for this and future generations
Novato, CA
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We knew they were great! Congrats to Buck professors @EricVerdin, Judith Campisi, Martin Brand and @HetzLab for being recognized by @Clarivate as being among the world’s most highly cited researchers! buckinstitute.org/news/four-…
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For the first time, Alpha-ketoglutarate has been shown to improve #healthspan in mice. Mice fed #AKG had 40% ↑ healthspan and some ↑ #lifespan, too. Congrats to Azar and the Lithgow lab on this major contribution to the field! #livebetterlonger buckinstitute.org/news/a-met…
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Judy Campisi published nearly 500 papers and had almost 105,000 citations. We are honored to share one very influential paper which describes the SASP (#senescence associated secretory phenotype). A new concept then, it is enshrined in modern #geroscience. journals.plos.org/plosbiolog…
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Could taurine be an anti-aging intervention in humans? Landmark study @ScienceMagazine shows restoring “youthful” levels of taurine hit several hallmarks of aging in worms, mice and monkeys. Buck researchers were involved in the work and talk about here: buckinstitute.org/blog/tauri…
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📢 time! Dr. Malene Hansen is joining Buck as our new Chief Scientific Officer! Buck CEO Eric Verdin sums it up: “She is an extraordinary scientist with the background, vision, and skills to enhance our leadership position and to accelerate our mission" buckinstitute.org/news/buck-…
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As we mourn loss of and celebrate life of Judy Campisi, enjoy listening to interview she did for our podcast. It’s great tutorial on #cellularsenescence and her comment on “failed experiments” is classic Judy. Details about memorial service are pending buckinstitute.org/podcasts/u…
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Both honored and sad to share obituary for Judy Campisi @Nature. Many thanks to Jan Vijg and Jan Hoeijmakers for recounting Judy’s pioneering work in cellular senescence and highlighting the personal attributes which made her beloved colleague and friend
nature.com/articles/d41586-0…
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We now know what drives #wrinkles and other signs of skin aging. Study @NatureAging reveals high levels of pro-inflammatory cytokine IL-17 are expressed in skin immune cells with aging. Inhibiting it temporarily in mice delayed appearance of aging in skin. eurekalert.org/news-releases…
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Our own Dr. Judy Campisi and former Buck scientist Dr. Chris Wiley take a deep dive into the metabolic roots of senescence @NatMetabolism. Their review also discuss mechanisms and opportunities for interventions. Great read! nature.com/articles/s42255-0…
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As we age, our cells are less likely to express longer genes. An editorial @TrendsGenetics posits that many aging phenotypes across multiple animals, including humans, could be occurring due to this phenomenon. Could this be main cause of systemic aging?
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Too good to be true? Study in @NatMetabolism finds that natural molecule found in coffee (trigonelline) boosts levels of #NAD+ and improves muscle function during #aging, providing target for #sarcopenia. Study was done in mice and worms. nature.com/articles/s42255-0…
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From bench to bedside in the biology of aging. Buck faculty @EricVerdin @GeriSciDoc #JudyCampisi #SimonMelov #GordonLithgow & #PankajKapahi publish Review in @nature chronicling 30 years of research on aging. #Livebetterlonger nature.com/articles/s41586-0…
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Cellular rejuvenation therapy using variations of the #Yamanaka factors safely reverses aging in healthy mice as they age - there was no increase in cancer or neurological problems. Study @NatureAging comes from @Salk and @genentech. eurekalert.org/news-releases…
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Yahoo!! Buck receives $3.5 million for first-ever clinical trial of #ketone supplementation to treat or prevent frailty. TAKEOFF asks: Can putting older adults into #ketosis stave off a key aspect of geriatric syndrome? buckinstitute.org/news/the-b…
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Huge study in @NatureAging from the Furman lab: creation of the immune clock #iAge using AI analysis of 1001 immunomes. "Using iAge it’s possible to predict 7 years in advance who is going to become frail. That leaves us lots of room for interventions.” buckinstitute.org/news/first…
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An analysis of the #metabolome and its interaction with the SASP has identified 25 metabolites that predict healthy agers regardless of gender and race. Study in @Aging_Cell details the Healthy Aging Metabolic Index. onlinelibrary.wiley.com/doi/…
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Join the BUCK, Tues. Nov.15th as @steveaoki hosts-BOWLING FOR BRAINS benefiting #brain #research. ✌️️ ow.ly/LRdp306408n
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Researchers @NYUniversity may have found fountain of youth–for ants. Study in @sciencemagazine shows queen ants exhibit high metabolism for reproduction without aging by generating anti-insulin protein that blocks only part of pathway responsible for aging nyu.edu/about/news-publicati…
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Restoring youthful levels of specific subunit of telomerase enzyme reverses multiple hallmarks of #aging in mice. Study in @CellPressNews shows maintaining TERT levels in aged animals reduced cellular senescence, improving memory & neuromuscular function cell.com/cell/abstract/S0092…
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Leaky #mitochondria are making us sick. Study in @NatureCellBio found inflammation-causing leaks are triggered by malfunction in #mtDNA replication. Targeting this process could help slow aging process and find treatments for #autoimmune diseases nature.com/articles/s41556-0…
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The Buck is proud and excited to bring #agingresearch to the fight against #Alzheimers. A $14 million grant builds on our expertise in #cellularsenescence, a major driver of aging. Congrats to PI’s Judy Campisi and Lisa Ellerby. buckinstitute.org/news/buck-…
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Bye, bye sarcopenia – at least in mice. Study @NatureAging identifies factor in young blood that helps rejuvenate aged mouse muscle. (It’s all about extracellular vesicles). eurekalert.org/news-releases…
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Big #biomarker news from Campisi lab! They found a lipid detectable when #senescent cells burst, the 1st non-invasive measure of #senolytic efficacy. "We are excited to bring this to the field and look forward to it being used in the clinic" -Dr. Campisi buckinstitute.org/news/the-f…
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Researchers at @UofR have successfully transferred a #longevity gene from naked mole rats to mice. The mice lived healthier, longer lives, with less inflammation and a healthier gut. Study in @Nature nature.com/articles/s41586-0…
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#Epigenetic alteration a known #hallmarkofaging, but that doesn’t mean we know much about it, until now! Data from multiple tissues at 7 different ages in mice is a treasure trove of both local and global transcriptional changes with age #livebetterlonger cell.com/cell-reports/fullte…
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The Buck’s “Senescence Day” is in full gear! Great talks. Exciting discussions. New collaborations in the air. Thanks o Judy Campisi who kicked off the event.
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Celebrating the grand opening of our student and postdoc lounge dedicated to the memory of Judy Campisi. She’d love the great science conversations that will happen there!
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Potential for a new therapeutic strategy against #herpes! Congrats to Buck CEO @EricVerdin and @mw_fr for their paper on designing a viral gene drive in #herpesviruses. #livebetterlonger biorxiv.org/content/10.1101/…
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Congratulations to our great students on receiving your PhD in the biology of aging from our USC-Buck joint program. So proud of you! @USCLeonardDavis
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Thrilled to be part of the #RejuvenomeProject with @AsteraInstitute. Unprecedented study of longevity interventions will be a game-changer for aging research buckinstitute.org/news/aster…
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Switching off an inflammatory protein increased healthy #lifespan of mice by almost 25%. Study in @Nature showed treatment with IL-11 antibody reduced #aging in several tissues. #Antibody is now in clinical trials for other conditions. Next step humans? nature.com/articles/s41586-0…
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Great work from the Zhou lab! Buck researchers have uncovered clues as to how aging starts to happen in #mitochondria, opening a completely different way to think about, measure, mitigate and reverse the process. Study is in @eLife buckinstitute.org/news/buck-…
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Destroying #senescent cells in the aging stem cell niche enhances #neurogenesis in the hippocampus and improves cognitive function in mice. Published in @StemCellReports, researchers say dormant stem cells “woke up” after treatment. eurekalert.org/news-releases…
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Congratulations to @buckinstitute Professor Gordon Lithgow for receiving prestigious award from @americanaging The Denham Harman Award recognizes lifetime achievement in research on aging. buckinstitute.org/news/buck-… #livebetterlonger
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Get your smarts on! The Buck has launched the first-ever #onlinecourse on the #biologyofaging. This is an opportunity for non-scientists to get an inside view of how research on aging can transform our health. And it’s free! buckinstitute.org/news/buck-…
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How are obesity, aging, and #anxiety related? A recent @Cell_Metabolism study shows that obesity drives #senescence in brain glial cells and is associated with anxiety-like behaviors, which were alleviated by senescence clearance in mice. #livebetterlonger cell.com/cell-metabolism/ful…
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Congrats @kapahi_pankaj & @ellerby_lisa labs! Study posted in @NatureComms ➡️how #dietaryrestriction slows brain aging and increases lifespan. Mechanism, involving OXR1, provides potential targets to slow aging and age-related #neurodegenerativediseases buckinstitute.org/news/buck-…
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Our own Prof Judy Campisi was officially inducted into the Nat Academy of Sciences tonight, joining 2,300 members who have been recognized for their distinguished & continuing achievements in original research. Huge congrats to Judy & her fellow inductees! nasonline.org/about-nas/even…
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We say “kudos” to a recent financial analysis published in @NatureAging, showing slowing aging process can offer much larger economic gains than chipping away at individual diseases. Our President & CEO @EricVerdin weighs in on extremely large numbers: buckinstitute.org/blog/targe…
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The Buck Institute for Research on Aging has an opening for a new faculty member at Assistant, Associate, or Full Professor. We are seeking an outstanding candidate who works on the Biology of Aging and/or Age-Related Diseases.
Job link: app.jobvite.com/j?cj=oCQ7ifw… #sciencejobs
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Buck has been awarded $12.7 million to join SenNet, the NIH-supported #CellularSenescence Network. Our scientists will identify and characterize senescent cells, recognized as driver of age-related disease in human ovaries, breast tissue & skeletal muscle buckinstitute.org/?post_type…
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Buck was well represented at the 52nd Annual AGE meeting in #madisonWI, presenting their work on aging research and getting to connect with beloved Buck alumni as well @americanaging #AGE2024
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A natural extract targets cellular #senescence, improving longevity and healthspan in mice. Study @NatureAging shows the flavonoid luteolin disrupted the P16-CDK6 interaction, lowering inflammation and fibrosis while increasing muscle strength. nature.com/articles/s43587-0…
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Join us for Buck webinar on Dec 9: Could taming cellular #senescence help stop the scourge of #Alzheimers, #cancer and other chronic diseases? Buck was recently awarded $27 Million to find out! Hear from 3 Buck scientists on our discovery process. buckinstitute.org/events/27-…
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Calorie restriction enhances #longevity in model organisms. A new @Cell_Metabolism study shows that the benefits also extend to people. Participants of this two-year trial, CALERIE, showed reduced oxidative stress. #NationalNutritionMonth #livebetterlonger eurekalert.org/pub_releases/…
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Tributes following the Jan 19th death of Judy Campisi keep coming in. Some of those tributes along with links to her Celebration of Life event and recent obit in Nature are included in our latest blog post. Please enjoy remembering our beloved colleague buckinstitute.org/blog/payin…
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Congrats to the Tracy lab! Great paper in @jclinicalinvest highlights promise of restoring synaptic resilience in the #brain. Boosting #KIBRA protein reversed memory impairment in mouse model of #Alzhheimers despite the presence of toxic #tau. Exciting! buckinstitute.org/news/buck-…
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Hot off the Buck Blog Press! Buck’s Chief Scientific Officer @thehansenlab is celebrating her 1 year anniversary at Buck! Our latest blog post has the scoop on her scientific background and lab focus, as well as info on her wicked beach volleyball skills! buckinstitute.org/blog/scien…
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We’re excited to welcome Ashley Webb, PhD to the Buck faculty. Her research focuses on the molecular mechanisms underlying #stemcells and #brainaging. Her portfolio of interests will add depth to our ongoing efforts to promote #brainhealth as we age.
buckinstitute.org/news/brain…
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Delighted to have @UCL Professor Dame Linda Partridge give the inaugural Arnold J. Kahn Memorial Lecture at the annual Buck Student Aging Symposium! #Livebetterlonger
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Given that health benefits from dietary restriction are not “one size fits all,” Buck researchers pitch a new sub-specialty: precision nutrigeroscience. The detailed primer in @cell_metabolism is a must read for those interested in aging and nutrition. buckinstitute.org/news/buck-…
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Congrats to @NBasisty on his prestigious K99 grant with cool translational potential for #senescent biomarkers of aging! buckinstitute.org/news/buck-…
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Congrats to @thehansenlab for study in @NatureAging that describes new roles for autophagy genes in cellular waste management and aging. Researchers show that #autophagy genes help extrude protein aggregates from neurons in #Celegans. buckinstitute.org/news/new-r…
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Buck Podcast: Episode 2 LIVE! Renowned researcher, author @davidasinclair joins Gordon to dive into startling insights from applying information theory to aging. Topics: #epigenetics, sirtuins, metabolism, and why we might not want to kill all the zombies. buckinstitute.org/podcasts/a…
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Keeping mitochondria happy prevents muscle loss during aging. Experiments in @AgingCell in mice and human tissues reveals an inflammatory process that causes muscle atrophy and shows an increase in #BNIP3 is linked to better muscle aging. eurekalert.org/news-releases…
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Another reason to delay #menopause. Study in @ScienceAdvances shows women’s higher risk for #Alzheimers may stem from harmful, chemically modified form of C3, an inflammatory immune protein. Estrogen, which drops at menopause, normally protects against it eurekalert.org/news-releases…
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Researchers in Sweden have developed a highly accurate blood test for #Alzheimers which could allow for early diagnosis before symptoms appear. Study in @NatureMedicine states test results are equivalent or superior to current tests requiring spinal tap nature.com/articles/s41591-0…
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Are #ketonebodies good for the #military? The Buck is proud to be partnering with @OhioState on a $10 million grant to see whether #ketones help active service members perform better in the field and help #veterans live better longer. buckinstitute.org/blog/keton…
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Buck Podcast: Episode 3 LIVE! Dr. Judy Campisi has been at the forefront of studying cellular senescence for decades, revealing the mysteries of these not-exactly-dead cells and their role in many diseases of aging. Listen on your favorite podcast app
buckinstitute.org/podcasts/u…
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Just published in @NatMetabolism from the @EricVerdin lab! A new link between declining #NAD+ and #senescence-activated #CD38+ macrophages. Supports the "leaky sink" rather than "blocked faucet" explanation. Congrats @ACovarrubiasPhD! buckinstitute.org/news/chron…
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Here's some motivation for getting good night’s sleep. Study @Cell_Metabolism analyzed gene expression in both short & long-lived mammals. Turns out “negative” #lifespan genes, involved in metabolism and inflammation, are controlled by #circadian networks eurekalert.org/news-releases…
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Our outstanding T32 postdoctoral training programming continues for another five years, thanks to $3.9 million from @NIH. We’ve helped train 110 postdocs in the field of research in aging over the past 25 years! buckinstitute.org/news/nih-r…
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Don’t miss Longevity Week! Dec 4 – 8. We’re proud to be hosting/participating in events focusing on biomarkers of aging, the longevity ecosystem and longevity clinics. And don’t forget BAAM @Stanford! Great speakers @agingbiomarkers @LongevityGL buckinstitute.org/events/
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We are excited to have the Biomarkers of Aging Symposium taking place at the @BuckInstitute today! Exciting and incredible talks happening *right now* on how to reproducibly measure the aging process that is ongoing in all of us. #BoAS2023
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Aging Is Not Optional. Or Is It? @BuckInstitute Professor and Geriatrician John Newman @GeriSciDoc explains how science could intervene in the aging process. (science fiction? not anymore!) ucsf.edu/magazine/aging-opti… #livebetterlonger
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The new SASP Atlas described in @PLOSBiology pushes forward the science of clinically relevant biomarkers of aging. We’re excited about a future of early detection and intervention! Congrats to the Buck’s Campisi and Schilling labs! buckinstitute.org/news/stage… #livebetterlonger
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Ketone bodies are produced by fatty acid metabolism during intermittent fasting and are central to the ketogenic diet. @GeriSciDoc discusses why ketone bodies are rising players in #longevity and what happens to mice on a ketogenic diet. #livebetterlonger lifeapps.io/fasting/ketones-…
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Take a look! Nicole Shanahan and the Buck’s @jenngarrison spoke at the recent CNN Life Itself Conference. Find out what these two “reproductive longevity warriors” have to say about aging and fertility. cnn.com/videos/health/2022/0… @GCRLE1 #reproductivehealth
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Really great to see #biologyofaging getting more attention in the mainstream press! Two great reads: thehill.com/opinion/healthca… from @mkaeberlein and weforum.org/agenda/2021/07/a… from
@davidasinclair and others.
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#Metformin is favorite among scientists looking for interventions to slow aging process and prevent age-related diseases. Our new blog describes upcoming TAME clinical trial and highlights need to take genetic diversity among participants into account. buckinstitute.org/blog/the-p…
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We are very excited to be hosting biology of aging pioneers from both academia and industry at the Longevity Summit 2022 The Future of Medicine: Eliminating the Disease of Aging, 6th-7th December. For registration and a full list of speakers visit: longevitysummit.io/
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Data is in on humans. Fasting-like diet lowers risk factors for disease and reduces biological age. Study in @NatureComms shows that cycles of the diet reduce immune system aging, insulin resistance and liver fat. Study involved randomized clinical trial. nature.com/articles/s41467-0…
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Your hypothalamus probably has lot to do with how you age. Our latest blog delves into small, but incredibly active structure that lives deep in our brain and covers research in @TheWebbLab focused on understanding why it becomes less sensitive with age buckinstitute.org/blog/meet-…
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Improving a broccoli-related compound yields a possible treatment for macular degeneration ow.ly/n1hD301ZFkE
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No surprise to us, but great to have it validated in a clinical trial: #caloricrestriction slows the pace of aging in healthy adults! Study in @NatureAging details 3 measures of DNA methylation used as epigenetic biomarkers in the trial. eurekalert.org/news-releases…
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New study @NatureAging shows that just a slight increase in #mTORC1 activity is enough to set off early #aging and shorten #lifespan in mice. Malfunctions in pancreas, liver and kidneys are linked to #inflammation; reducing it increased survival. nature.com/articles/s43587-0…
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Just published in @cellreports! Buck establishes the connection between cellular senescence and age-related blood clots. Researchers were able to implicate 44 specific senescent markers out more than 300! #livebetterlonger buckinstitute.org/news/cellu…
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Big new #caloricresctriction study published in @CellCellPress finds tons of changes in single-cell transcriptomics of 40 cell types related to #inflammation, #immunity, #lipidmetabolism, and others. Good thing we’re posting after lunch! #livebetterlonger zcu.io/DT9H
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#intermittent + #rapamycin? Buzzword city! Mice experienced improved #heartfunction even 8 weeks AFTER ending rapamycin. Maybe an intermittent dose is a way to get the good and minimize any side effects? #livebetterlonger onlinelibrary.wiley.com/doi/…
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When #telomeres become short they communicate with #mitochondria, triggering complex signaling, initiates inflammation, destroys potentially cancerous cells. Study in @Nature opens new possibilities for preventing & treating cancer & intervening in aging eurekalert.org/news-releases…
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We’re loving the focus on #senescence as a target for improving #healthspan! This article gives great background on how our own Judy Campisi’s work has been foundational in moving the science closer to the clinic #livebetterlonger zcu.io/Firl
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Study in @NatureAging identifies two blood proteins that could be the key to a long, healthy life. Both proteins are linked to clotting and heart health. New targets for drug development! eurekalert.org/news-releases…
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Have researchers @Yale unlocked the blood-brain barrier? Study in @NatureComms describes an antibody that can open the barrier for a couple of hours, allowing for the delivery of drugs to a diseased brain. eurekalert.org/news-releases…
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Buck researchers show MANF is a rejuvenating factor in parabiosis. Publishing in @NatMetabolism, the Jasper lab harnesses the innate repair mechanism to protect against liver damage in aged mice and extend lifespan in flies. #livebetterlonger buckinstitute.org/news/manf-…
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The Buck is thrilled to announce that we have received nearly $10M in funding from the @NIH for a #geroscience approach to developing treatments for #Alzheimers buckinstitute.org/news/the-b…
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The science of ovarian aging is so important and so under-studied. Buck professor @JennGarrison will be talking about it on the @BioAgePodcast Translating Aging next week. Click here to subscribe so you can get it hot in your eardrums @GCRLE1 bioage.captivate.fm/
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So proud of our very own Malene Hansen @thehansenlab who will receive @AFARorg prestigious Irving S. Wright Award of Distinction this Friday at the @GeronSociety Scientific Meeting. Register to hear her lecture on role of #autophagy in aging and disease. gsa2021.org/Registration
On 11/12, at 3:30pm ET, four AFAR Scientific Award of Distinction recipients will present lectures on their respective research at the @geronsociety 2021 Annual Meeting online. Learn more about all awardees & register here: bit.ly/3BmLGr9 #gsa2021
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The Today Show is working on a story about biological clocks. We’re thrilled that the Buck, and our CEO @EricVerdin will be part of it. We’ll announce when it’s airing so you don’t miss it!
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Why must we age and what can we do to slow it? Buck CEO @EricVerdin and Professor Judy Campisi unite with 14 global luminaries in research on aging toward making breakthroughs in longevity accelerated and accessible. #livebetterlonger eurekalert.org/pub_releases/…
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Congrats to all the students presenters who won awards today!! 🏆🏆🏆#buckstudentagingsymposium #bsas2023
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New light has been shed on how #obesity dismantles #mitochondria, reducing their capacity for burning fat. Study in mice in @NatMetabolism shows the process is controlled by a single gene with processes that are analogous in humans. nature.com/articles/s42255-0…
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Buck Podcast: Episode 6 LIVE! Can we study genetics of long-lived people to learn how to delay or reverse aging? @GordonLithgow talks with @NirBarzilaiMD about his research on #centenarians, insulin signaling pathways, and moving aging interventions out of lab and into clinic.
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Will #folate become a new key word in #agingresearch? New work in Nature Communications from @CECAD_ and @MPIAGE identifies folate metabolism regulation as a driver of #longevity eurekalert.org/pub_releases/…
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Our very own John Newman is featured in @UCSF Magazine, forecasting the future of healthcare in light of progress in research on aging. (FYI: The outlook is pretty darn sunny). magazine.ucsf.edu/aging-not-…
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Live from the Lab! Here's what Brendan Hughes is up to in the Campisi lab. He's turning skin cells into brain cells to study #cellularsenescence, #Alzheimers disease and other related #dementias. He's working to extend the healthy years of life to enable us all live better longer
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29th Annual NIA Training Course, hosted by Buck: Oct 16-21. App deadline: Aug 1. Intense exposure to experimental aging research. Open to research scientists w/ min 2 yrs postdoc experience in cell or molecular biology or related field. For more info: buckinstitute.org/wp-content…
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Neurons get involved in housekeeping while we sleep; findings could lead to new approaches for #Alzheimers. Study in @Nature shows #braincells produce bursts of electrical pulses during #sleep, becoming miniature pumps that push out metabolic waste. nature.com/articles/s41586-0…
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#Aging pathways #IIS and #TOR in C. elegans synergistically extend #lifespan by 500%! Paper just published in @cellreports with contributions from Dr. Pankaj Kapahi's lab at the Buck #Livebetterlonger sciencedaily.com/releases/20…
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Can’t resist those donuts? Blame it on a one-two punch delivered in the gut. Study in @Cell_Metabolism has identified two vagus nerve pathways; one for fat, another for sugar. Activating both can be a death knell for dieting. New targets for therapeutics!
cell.com/cell-metabolism/ful…
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