Cell Reports@CellReports

Cell Reports is an open-access journal at Cell Press, publishing weekly. Tweets by Cell Reports editors.

 Cambridge, MA, USA
cell.com/cell-reports/home
Joined July 2011
Activated dormant stem cells recover spermatogenesis in chemoradiotherapy-induced infertility dlvr.it/TBWJ4g
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Dead cells do tell tales, or at least they keep making cytokines to tell the immune system to clean up the mess #necroptosis #zombies bit.ly/2Uomo7T
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Lactic acid induces transcriptional repression of macrophage inflammatory response via histone acetylation dlvr.it/T2TbnV

Lactic acid induces transcriptional repression of macrophage inflammatory response via histone...

Lactic acid is emerging as a prominent immunosuppressive metabolite. Shi et al. reveal that lactic acid acts as a primary fuel source for the TCA cycle to promote H3K27 acetylation. This histone...

cell.com
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SARS-CoV-2 escapes direct NK cell killing through Nsp1-mediated downregulation of ligands for NKG2D dlvr.it/Sg14L6

SARS-CoV-2 escapes direct NK cell killing through Nsp1-mediated downregulation of ligands for NKG2D

Natural killer (NK) cells are designed to kill virally infected cells. Lee et al. demonstrate that healthy NK cells are unable to efficiently lyse SARS-CoV-2-infected cells, likely due to their loss...

cell.com
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The deubiquitinase BAP1 and E3 ligase UBE3C sequentially target IRF3 to activate and resolve the antiviral innate immune response dlvr.it/TBk62d

The deubiquitinase BAP1 and E3 ligase UBE3C sequentially target IRF3 to activate and resolve the...

In brief, Liu et al. report that BAP1 and UBE3C sequentially control IRF3 ubiquitination and degradation during viral infection. In the early phase, BAP1 predominates and prevents IRF3 ubiquitination...

cell.com
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Absolute deconvolution of human immune cell types from RNAseq data bit.ly/2WMxMvc
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Genome-guided discovery of cancer therapeutic targets dlvr.it/Stl2kg

Genome-guided discovery of cancer therapeutic targets

Precision oncology is an approach to cancer treatment that aims to match the right therapy to the right patient based on molecular features. Konda et al. review how recent advances in genomics and...

cell.com
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The PD-1 pathway regulates development and function of memory CD8+ T cells following respiratory viral infection bit.ly/38HXcR0
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Tumor-induced metabolic immunosuppression: Mechanisms and therapeutic targets dlvr.it/THlVvL

Tumor-induced metabolic immunosuppression: Mechanisms and therapeutic targets

This review explores how metabolic reprogramming in cancer and immune cells impacts antitumor responses. It highlights how altered metabolism affects immune function and cancer progression, discusses...

cell.com
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Microglial identity and inflammatory responses are controlled by the combined effects of neurons and astrocytes bit.ly/39ki02M
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No evidence of human genome integration of SARS-CoV-2 found by long-read DNA sequencing dlvr.it/S5vBWn

No evidence of human genome integration of SARS-CoV-2 found by long-read DNA sequencing

In response to a recent claim that SARS-CoV-2 can be incorporated into human DNA by LINE-1 retrotransposon proteins, Smits et al. apply long-read DNA sequencing to cultured HEK293T cells infected...

cell.com
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165
HIF-1α drives resistance to ferroptosis in solid tumors by promoting lactate production and activating SLC1A1 dlvr.it/StNcHS
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Pyruvate metabolism controls chromatin remodeling during CD4+ T cell activation dlvr.it/Sq3tHC
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28,569
Proline restores mitochondrial function and reverses aging hallmarks in senescent cells dlvr.it/T2jSD0

Proline restores mitochondrial function and reverses aging hallmarks in senescent cells

Choudhury et al. report that senescent cells exhibit diminished proline biosynthesis and benefit from proline supplementation. Proline promotes mitophagy by activating AMPKα and upregulating Parkin,...

cell.com
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22,647
Elephants lowered their cancer risk by resurrecting a zombie pro-apoptotic pseudogene bit.ly/2nPag0w
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Neurotransmitter release progressively desynchronizes in induced human neurons during synapse maturation and aging dlvr.it/ShTCtp

Neurotransmitter release progressively desynchronizes in induced human neurons during synapse...

Uzay et al. show that long-term disruption of excitation-inhibition balance results in progressive desynchronization of excitatory neurotransmission in human synapses. In a purely excitatory human...

cell.com
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40,464
A comparative analysis of microglial inducible Cre lines dlvr.it/SvLFNk

A comparative analysis of microglial inducible Cre lines

Microglia are key regulators of neural circuits and neuroinflammation. Tools to specifically manipulate their function in vivo are critical. Faust et al. show that recombination efficiency and...

cell.com
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131
36,087
Maternal obesity impairs fetal brown adipogenesis by attenuating fetal FGF21 signaling dlvr.it/TLgQRS

Maternal obesity impairs fetal brown adipogenesis by attenuating fetal FGF21 signaling

Hua et al. demonstrate that maternal obesity impairs fetal brown adipogenesis by attenuating fetal FGF21 signaling. Meanwhile, postnatal FGF21 supplementation could counteract the adverse effects of...

cell.com
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10,984
Microglia degrade Alzheimer’s amyloid-beta deposits extracellularly via digestive exophagy dlvr.it/TGgtjm

Microglia degrade Alzheimer’s amyloid-beta deposits extracellularly via digestive exophagy

Jacquet et al. shows that microglia use digestive exophagy to engage large Aβ deposits that cannot be phagocytosed, forming acidic extracellular compartments on the aggregates into which lysosomal...

cell.com
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BCL-xL inhibition potentiates cancer therapies by redirecting the outcome of p53 activation from senescence to apoptosis dlvr.it/SfyW91
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Mitochondrial damage-associated molecular patterns trigger arginase-dependent lymphocyte immunoregulation dlvr.it/SR6tcy

Mitochondrial damage-associated molecular patterns trigger arginase-dependent lymphocyte immunore...

Westhaver et al. demonstrate that damage-associated molecular patterns released from the mitochondria during cell death induce a dominant and rapid regulatory program in natural killer and T cells....

cell.com
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A pan-cancer metabolic atlas of the tumor microenvironment dlvr.it/SQJlPg

A pan-cancer metabolic atlas of the tumor microenvironment

Rohatgi et al. profile the metabolic phenotypes of cancer and stromal/immune cells across 20 tumor types, identifying cancer- and stromal-cell-specific metabolic pathways. They find recurrent...

cell.com
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The pro-inflammatory cytokine IL6 suppresses mitochondrial function via the gp130-JAK1/STAT1/3-HIF1α/ERRα axis dlvr.it/TJP5X0

The pro-inflammatory cytokine IL6 suppresses mitochondrial function via the gp130-JAK1/STAT1/3-HI...

Xu et al. show that IL6, not TNF-α, suppresses mitochondrial function. When PGC1 is low, IL6 increases HIF1A transcription and stabilizes HIF1α protein via ERRα. HIF1α reciprocally suppresses ERRα,...

cell.com
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Chromatin landscape instructs precise transcription factor regulome during embryonic lineage specification dlvr.it/T5rMLW

Chromatin landscape instructs precise transcription factor regulome during embryonic lineage...

Wang et al. reveal highly adaptable TFAP2C-centered transcription factor (TF) regulomes during murine peri-implantation and provide a perspective of plastic chromatin environment in designating the...

cell.com
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21,633
Triglyceride metabolism controls inflammation and microglial phenotypes associated with APOE4 dlvr.it/TLsnf0

Triglyceride metabolism controls inflammation and microglial phenotypes associated with APOE4

Neuroinflammation is central to Alzheimer’s disease pathogenesis. Stephenson et al. establish that neutral lipid accumulation is necessary for microglial activation and that microglia expressing an...

cell.com
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Cancer cells reprogram to metastatic state through the acquisition of platelet mitochondria dlvr.it/SzkPNs

Cancer cells reprogram to metastatic state through the acquisition of platelet mitochondria

(Cell Reports 42, 113147, September 26, 2023)

cell.com
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YAP mediates apoptosis through failed integrin adhesion reinforcement dlvr.it/T38dDZ

YAP mediates apoptosis through failed integrin adhesion reinforcement

Shi et al. reveal that apoptosis on soft matrices depends on YAP Tyr357 phosphorylation and its accumulation in small adhesions, followed by its nuclear translocation. This process is blocked upon...

cell.com
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HIF1α-dependent uncoupling of glycolysis suppresses tumor cell proliferation dlvr.it/T5Zbcr

HIF1α-dependent uncoupling of glycolysis suppresses tumor cell proliferation

In this article, Urrutia et al. explain the metabolic pattern of ccRCC tumors characterized by the suppression of lower glycolysis and constitutive HIF1α activation. Urrutia et al. show that HIF1α...

cell.com
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The Hippo signaling pathway in development and regeneration dlvr.it/T3zKT3
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21,631
mTORC1 activity oscillates throughout the cell cycle, promoting mitotic entry and differentially influencing autophagy induction dlvr.it/TB6WJQ

mTORC1 activity oscillates throughout the cell cycle, promoting mitotic entry and differentially...

mTORC1 is a master metabolic regulator that stimulates anabolic cell growth and proliferation and suppresses catabolic processes such as autophagy. Joshi et al. find that mTORC1 activity oscillates...

cell.com
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18,405
Gain-of-Function p53 protein transferred via small extracellular vesicles promotes conversion of fibroblasts to a cancer-associated phenotype bit.ly/3jRtcaV
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Impact of eIF2α phosphorylation on the translational landscape of mouse embryonic stem cells dlvr.it/T0kpP2

Impact of eIF2α phosphorylation on the translational landscape of mouse embryonic stem cells

mRNA translation is the final step of the central dogma of molecular biology. A key translational control mechanism is the phosphorylation of the alpha subunit of eukaryotic translation initiation...

cell.com
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Rescue of Alzheimer’s disease phenotype in a mouse model by transplantation of wild-type hematopoietic stem and progenitor cells dlvr.it/StdfT1

Rescue of Alzheimer’s disease phenotype in a mouse model by transplantation of wild-type hematopo...

Mishra et al. demonstrate that single systemic wild-type hematopoietic stem and progenitor cell transplantation leads to complete preservation of the neurocognitive performance, partial preservation...

cell.com
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Astrocytic Slc4a4 regulates blood-brain barrier integrity in healthy and stroke brains via a CCL2-CCR2 pathway and NO dysregulation dlvr.it/T6VDC5

Astrocytic Slc4a4 regulates blood-brain barrier integrity in healthy and stroke brains via a...

Ye et al. highlight astrocytic Slc4a4’s role in astrocyte and BBB function under both normal and stroke conditions. Their study further emphasizes the significance of the Slc4a4-CCL2-CCR2 axis in BBB...

cell.com
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Irreversible cell cycle exit associated with senescence is mediated by constitutive MYC degradation dlvr.it/SvSPbC

Irreversible cell cycle exit associated with senescence is mediated by constitutive MYC degradation

Afifi et al. use time-lapse imaging, high-throughput single-cell analyses, and quantitative measurements to investigate the irreversibility of cellular senescence. Senescent cells enter and maintain...

cell.com
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12,978
Amino acids in cancer: Understanding metabolic plasticity and divergence for better therapeutic approaches dlvr.it/TK1KCg
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MHC class II regulation of CD8+ T cell tolerance and implications in autoimmunity and cancer immunotherapy dlvr.it/Sz5XsQ

MHC class II regulation of CD8+ T cell tolerance and implications in autoimmunity and cancer...

Zhou et al. discover a group of MHC class I and II dual-specific CD8+ T cells in MHC class II-deficient animals. Those CD8+ T cells cause autoimmunity when encountering MHC class II molecules in the...

cell.com
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Histone H3.1 is a chromatin-embedded redox sensor triggered by tumor cells developing adaptive phenotypic plasticity and multidrug resistance dlvr.it/T4LbSV

Histone H3.1 is a chromatin-embedded redox sensor triggered by tumor cells developing adaptive...

Palma et al. report that H3.1Cys96 oxidation is a functional posttranslational modification involved in the regulation of gene expression. In breast cancer, H3.1Cys96 oxidation promotes resistance to...

cell.com
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Perturbations in 3D genome organization can promote acquired drug resistance dlvr.it/SwQlG2
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Sex differences in gene expression and regulatory networks across twenty-nine human tissues bit.ly/3ezm2or
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106
Two-pore channel-2 and inositol trisphosphate receptors coordinate Ca2+ signals between lysosomes and the endoplasmic reticulum dlvr.it/T0rPjf

Two-pore channel-2 and inositol trisphosphate receptors coordinate Ca2+ signals between lysosomes...

Yuan et al. investigate organelle crosstalk in the genesis of cytosolic Ca2+ signals. They resolve a continuum of Ca2+ transients from local elementary events driven by lysosomal TPC2 channels,...

cell.com
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19,816
Dendrite architecture determines mitochondrial distribution patterns in vivo dlvr.it/T6Xj4k

Dendrite architecture determines mitochondrial distribution patterns in vivo

Donovan et al. combine mathematical modeling with in vivo measurements of mitochondrial transport and neuronal architecture in Drosophila HS (horizontal system) neurons to demonstrate that global,...

cell.com
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26
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23,883
Single-cell spatial transcriptomic and translatomic profiling of dopaminergic neurons in health, aging, and disease dlvr.it/T363px

Single-cell spatial transcriptomic and translatomic profiling of dopaminergic neurons in health,...

Kilfeather et al. showcase a single-cell spatial transcriptomic study of mouse brain spanning 29 cell types. They describe gene expression changes in health, age, and a model of Parkinson’s disease....

cell.com
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The RNA-binding protein EIF4A3 promotes axon development by direct control of the cytoskeleton dlvr.it/TCP0Zy

The RNA-binding protein EIF4A3 promotes axon development by direct control of the cytoskeleton

The exon junction complex (EJC) is critical for the mRNA life cycle in eukaryotic cells. Alsina et al. report that the nucleating component of this complex, EIF4A3, acts non-canonically as a microt...

cell.com
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Brain capillary pericytes are metabolic sentinels that control blood flow through a KATP channel-dependent energy switch dlvr.it/Sg31xp
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A role of cytoplasmic p53 in the regulation of metabolism shown by bat-mimicking p53 NLS mutant mice dlvr.it/SgGHb1
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Single-cell spatial multiomics reveals tumor microenvironment vulnerabilities in cancer resistance to immunotherapy dlvr.it/T93wkf

Single-cell spatial multiomics reveals tumor microenvironment vulnerabilities in cancer resistance...

Quek et al. characterize the longitudinal multiomic features of melanoma using multimodal single-cell and spatial integration. Their comprehensive analysis reveals the spatially resolved cell...

cell.com
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Topography of mutational signatures in human cancer dlvr.it/StNLjx

Topography of mutational signatures in human cancer

Comprehensive topography analysis of mutational signatures encompassing 82,890,857 somatic mutations in 5,120 whole-genome-sequenced tumors across 40 cancer types. Otlu et al. provide an online...

cell.com
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Acetyl-CoA synthesis in the skin is a key determinant of systemic lipid homeostasis dlvr.it/THvGdF

Acetyl-CoA synthesis in the skin is a key determinant of systemic lipid homeostasis

Nguyen et al. demonstrate that loss of acetyl-CoA synthesis enzymes in mouse skin depletes key epidermal barrier lipids, disrupts the skin barrier, and causes rapid fat loss. Sebum production is...

cell.com
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SWI/SNF-dependent genes are defined by their chromatin landscape dlvr.it/T3f6hR

SWI/SNF-dependent genes are defined by their chromatin landscape

Despite the importance of SWI/SNF complexes for disease, it is unclear what determines that the expression of a gene is SWI/SNF dependent. By using a small-molecule inhibitor, Basurto-Cayuela et al....

cell.com
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SSRI antidepressant citalopram reverses the Warburg effect to inhibit hepatocellular carcinoma by directly targeting GLUT1 dlvr.it/TFCH8d

SSRI antidepressant citalopram reverses the Warburg effect to inhibit hepatocellular carcinoma by...

Dong et al. find that commonly prescribed antidepressants, SSRIs, have significant anti-tumor effects in HCC. SSRIs, including citalopram, target GLUT1 instead of their classical target, SERT,...

cell.com
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10,798
Butyrate and propionate are microbial danger signals that activate the NLRP3 inflammasome in human macrophages upon TLR stimulation dlvr.it/TDL5VW

Butyrate and propionate are microbial danger signals that activate the NLRP3 inflammasome in human...

Latz et al. show that the bacterially derived metabolites short-chain fatty acids (SCFAs) are sensed as danger signals under inflammatory conditions through the NLRP3 inflammasome. Mechanistically,...

cell.com
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13,866
Different cancers that form brain metastases share common transcriptomic hallmarks bit.ly/2URROqR
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A tool for investigating isoform-specific function, expression, localization, and signaling of endogenous proteins in select cells bit.ly/38HOhRD

isoTarget: A Genetic Method for Analyzing the Functional Diversity of Splicing Isoforms In Vivo

Liu et al. develop a genetic method that enables the investigation of isoform-specific function, expression, localization, and signaling of endogenous proteins in select cells. Using this method,...

cell.com
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97
Astrocytes produce nitric oxide via nitrite reduction in mitochondria to regulate cerebral blood flow during brain hypoxia dlvr.it/SzZ7Xw

Astrocytes produce nitric oxide via nitrite reduction in mitochondria to regulate cerebral blood...

How does the brain maintain its oxygen supply during hypoxia? Christie, Theparambil et al. show that in response to hypoxia, brain astrocytes produce nitric oxide (NO) via nitrite reduction in...

cell.com
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A mouse model for investigating mitochondrial ribosome composition and mitochondrial translation in vivo bit.ly/2NCaiGR
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IL-7 promotes integrated glucose and amino acid sensing during homeostatic CD4+ T cell proliferation dlvr.it/THlh1s
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25
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6,732
Tumor microenvironment-associated oxidative stress impairs SIRT1 secretion to suppress anti-tumor immune response dlvr.it/TKfqY3

Tumor microenvironment-associated oxidative stress impairs SIRT1 secretion to suppress anti-tumor...

Wang et al. show that SIRT1 secretion into the TME suppresses tumor growth by regulating immune cell interactions. The study reveals that TME stress-induced methylation hinders SIRT1 secretion,...

cell.com
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Macrophage memories of early-life injury drive neonatal nociceptive priming dlvr.it/T5khDm

Macrophage memories of early-life injury drive neonatal nociceptive priming

Dourson et al. investigate the effects of injury on peripheral macrophages and how they contribute to neonatal nociceptive priming. Macrophages are essential regulators of this phenomenon through...

cell.com
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16,978
NF-κB activation enhances STING signaling by altering microtubule-mediated STING trafficking dlvr.it/SkG026

NF-κB activation enhances STING signaling by altering microtubule-mediated STING trafficking

Zhang et al. find that activation of a wide range of NF-κB pathways enhances STING-mediated immune responses. NF-κB activation blocks STING degradation by inhibiting microtubule-mediated STING...

cell.com
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12,020
Regulatory architecture of housekeeping genes is driven by promoter assemblies dlvr.it/Sp3nFq

Regulatory architecture of housekeeping genes is driven by promoter assemblies

Using mouse embryonic stem cells, Dejosez et al. describe how Ronin enables promoter-promoter interactions to regulate housekeeping gene expression, bypassing distal enhancers. This mechanism is...

cell.com
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22,934
Nutrient deprivation causes an inflammatory response that reduces protein synthesis bit.ly/2npJ5sW

Nutrient Deprivation Elicits a Transcriptional and Translational Inflammatory Response Coupled to...

Deprivation of some nutrients may impose more constraints on mRNA translation than others. Gameiro and Struhl describe a relationship between translational repression and pro-inflammatory gene...

cell.com
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Biotin controls intestinal stem cell mitosis and host-microbiome interactions dlvr.it/SLXV9s
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Oct4 is a gatekeeper of epithelial identity by regulating cytoskeletal organization in skin keratinocytes dlvr.it/T3V5Tf

Oct4 is a gatekeeper of epithelial identity by regulating cytoskeletal organization in skin...

Christofidou et al. generate OCT4 knockout clonal cell lines in human immortalized skin keratinocytes to investigate the function of the protein in somatic cells. Absence of Oct4 increased migratory...

cell.com
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15,745
The malate-aspartate shuttle is important for de novo serine biosynthesis dlvr.it/SvNGCv

The malate-aspartate shuttle is important for de novo serine biosynthesis

Broeks et al. find that disruption of the malate-aspartate shuttle reduces de novo serine biosynthesis. Using 13C6-glucose tracer analysis in a comprehensive panel of knockout cell lines, they show...

cell.com
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13,204
Organoids as models of immune-organ interaction dlvr.it/TMs6gK

Organoids as models of immune-organ interaction

Introducing an immune compartment into organoids to model organ immune processes is a major challenge. Harter et al. survey the current state of the field and provide an overview of the opportunities...

cell.com
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7,872
A trio of ubiquitin ligases sequentially drives ubiquitylation and autophagic degradation of dysfunctional yeast proteasomes dlvr.it/SLyVWf
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Oxidative stress triggers selective tRNA retrograde transport bit.ly/2FrQ5xS
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Principles of 3D chromosome folding and evolutionary genome reshuffling in mammals dlvr.it/SfzKNC

Principles of 3D chromosome folding and evolutionary genome reshuffling in mammals

A major challenge in genome research is to determine why some species have stable genomes whereas others have undergone extensive rearrangement. Álvarez-González et al. describe fundamental princip...

cell.com
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17,783
Anti-inflammatory effects of hunger are transmitted to the periphery via projection-specific AgRP circuits dlvr.it/SyGK22

Anti-inflammatory effects of hunger are transmitted to the periphery via projection-specific AgRP...

Klima et al. describe a neural mechanism underlying hunger’s potent anti-inflammatory effects. AgRP neurons projecting to the paraventricular hypothalamus inhibit peripheral inflammation through...

cell.com
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90
32,485
TGF-β in the microenvironment induces a physiologically occurring immune-suppressive senescent state dlvr.it/SjyZq3

TGF-β in the microenvironment induces a physiologically occurring immune-suppressive senescent state

Using cell culture and mouse tumor models, Matsuda et al. show that the TGF-β-hypoxic tumor microenvironment induces a physiological deep senescent state with a 14-gene immune-suppressive SASP....

cell.com
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12,930
Inflammation in distant parts of the body affects microglia in the brain bit.ly/2UG8ajs
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Dopamine and serotonin interplay for valence-based spatial learning dlvr.it/SNdjz8
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Skeletal muscle TFEB signaling promotes central nervous system function and reduces neuroinflammation during aging and neurodegenerative disease dlvr.it/SyqBvv

Skeletal muscle TFEB signaling promotes central nervous system function and reduces neuroinflamma...

Matthews et al. demonstrate that activation of the muscle-to-brain axis in vivo promotes robust neuroprotective effects during aging and neurodegenerative disease. These benefits are associated with...

cell.com
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25
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40,708
Cellular senescence is associated with the spatial evolution toward a higher metastatic phenotype in colorectal cancer dlvr.it/T3vywz

Cellular senescence is associated with the spatial evolution toward a higher metastatic phenotype...

Park et al. unravel the spatial heterogeneity of colorectal cancer and gradual phenotypic transition from the center to the invasive front. They demonstrated that cellular senescence is associated...

cell.com
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14,893
In obese adipose tissue adipocytes- and macrophages-derived proteoglycans induce inflammation and insulin resistance bit.ly/3gQCUaV

Adipocyte-Derived Versican and Macrophage-Derived Biglycan Control Adipose Tissue Inflammation in...

Proteoglycans have many functions, including providing a scaffold and regulating the inflammatory response. In this study, Han et al. show that adipose tissue proteoglycans affect inflammation and...

cell.com
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METTL3-mediated m6A mRNA methylation regulates neutrophil activation through targeting TLR4 signaling dlvr.it/T0rFRQ

METTL3-mediated m6A mRNA methylation regulates neutrophil activation through targeting TLR4...

(Cell Reports 42, 112259; March 28, 2023)

cell.com
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24,355
Age-associated accumulation of B cells promotes macrophage inflammation and inhibits lipolysis in adipose tissue during sepsis dlvr.it/T4JlVJ
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mTOR inhibition reprograms cellular proteostasis by regulating eIF3D-mediated selective mRNA translation and promotes cell phenotype switching dlvr.it/SstVsm

mTOR inhibition reprograms cellular proteostasis by regulating eIF3D-mediated selective mRNA...

mTOR is the primary regulator of the cellular proteome, thereby governing cell growth and proliferation. Shin et al. reveal that cells dynamically change their proteome in response to mTOR inhibition...

cell.com
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Different mechanisms of synapsin-induced vesicle clustering at inhibitory and excitatory synapses dlvr.it/Sv4xyz

Different mechanisms of synapsin-induced vesicle clustering at inhibitory and excitatory synapses

Song and Augustine examine how synaptic vesicles cluster in presynaptic terminals. They find that different types of synapses employ the same protein in different ways: at inhibitory synapses,...

cell.com
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18,886
Decoupling astrocytes in adult mice impairs synaptic plasticity and spatial learning dlvr.it/SLRBNw
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Astrocyte-neuron crosstalk through Hedgehog signaling mediates cortical synapse development dlvr.it/SKdjtL

Astrocyte-neuron crosstalk through Hedgehog signaling mediates cortical synapse development

Xie et al. show that Sonic hedgehog expressed by cortical layer V neurons signals to Ptch1-expressing astrocytes where it is necessary to promote the expression of layer-enriched astrocyte gene...

cell.com
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Mammalian circular RNAs result largely from splicing errors dlvr.it/S4y2LD

Mammalian circular RNAs result largely from splicing errors

Circular RNAs (circRNAs) comprise a large class of mostly non-coding RNAs generated through back-splicing of pre-mRNAs, but the biological functions of circRNAs are largely unknown. Xu and Zhang...

cell.com
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Platelets tune fear memory in mice dlvr.it/THnxfR

Platelets tune fear memory in mice

Garofalo et al. identify serotonin as a platelet-derived factor that modulates fear behaviors in mice through the control of inhibitory neurotransmission and plasticity in the hippocampus. Further,...

cell.com
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11,868
Lipid accumulation-mediated histone hypoacetylation drives persistent NK cell dysfunction in anti-tumor immunity dlvr.it/T0NdNr

Lipid accumulation-mediated histone hypoacetylation drives persistent NK cell dysfunction in...

(Cell Reports 42, 113211, October 31, 2023)

cell.com
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Deletion of AMP-activated protein kinase impairs metastasis and is rescued by ROS scavenging or ectopic CD36 expression dlvr.it/THjWX9

Deletion of AMP-activated protein kinase impairs metastasis and is rescued by ROS scavenging or...

Ramakrishnan et al. deleted AMPK in a spontaneous breast cancer metastasis mouse model and metastatic cell lines and showed that it is required for breast cancer metastasis. AMPK is required to...

cell.com
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8,332
Reprogramming of microglia through extracellular vesicles shed by glioma cells. #ERCC #exRNA bit.ly/2MbVjBp

Glioblastoma-Associated Microglia Reprogramming Is Mediated by Functional Transfer of Extracellular...

Abels et al. show miR-21 transfer from glioma to microglia by palmitoylated GFP-labeled extracellular vesicles in vivo. This transfer results in miR-21 target-specific mRNA downregulation. Following...

cell.com
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Upregulation of exosome secretion from tumor-associated macrophages plays a key role in the suppression of anti-tumor immunity dlvr.it/SxBwtS

Upregulation of exosome secretion from tumor-associated macrophages plays a key role in the...

Zhong and colleagues report that tumor-associated macrophages secrete a large amount of small extracellular vesicles that carry PD-L1, which actively inhibit the proliferation and function of CD8...

cell.com
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Immune suppression by human thymus-derived effector Tregs relies on glucose/lactate-fueled fatty acid synthesis dlvr.it/TCHbMw

Immune suppression by human thymus-derived effector Tregs relies on glucose/lactate-fueled fatty...

de Kivit et al. reveal discerning lipidomes of conventional T cells (Tconvs) versus thymus-derived regulatory T cells (tTreg). Effector tTregs can use either glucose or lactate to synthesize long and...

cell.com
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6,730
Metabolic reprogramming, sensing, and cancer therapy dlvr.it/TGml1r
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7,394
Ornithine lipid is a partial TLR4 agonist and NLRP3 activator dlvr.it/TDlKJF

Ornithine lipid is a partial TLR4 agonist and NLRP3 activator

Pizzuto et al. reveal the dual role of the bacterial ionizable lipid, ornithine lipid (OL), in modulating immune responses via TLR4 and NLRP3. This study clarifies conflicting reports on OL inflamm...

cell.com
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10,096
Hypoxia and inflammation induce synergistic transcriptome turnover in macrophages dlvr.it/T9CdXb
1
29
86
9,022
A tripartite circRNA/mRNA/miRNA interaction regulates glutamatergic signaling in the mouse brain dlvr.it/TDfwkv

A tripartite circRNA/mRNA/miRNA interaction regulates glutamatergic signaling in the mouse brain

Silenzi et al. report that the loss of circDlc1(2) in a KO mouse model upregulates glutamatergic genes, enhances synaptic transmission, and causes hyperactivity. circDlc1(2) interacts with gluRNA and...

cell.com
1
21
83
10,815
Methods for accessing inhibitory neuron subclasses in the mammalian forebrain bit.ly/2tWDwoY
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80
Adipose mitochondrial metabolism controls body growth by modulating systemic cytokine and insulin signaling dlvr.it/SQ6y5f
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Hippocampus-to-amygdala pathway drives the separation of remote memories of related events dlvr.it/T5xph3

Hippocampus-to-amygdala pathway drives the separation of remote memories of related events

Remembering closely related events poses a brain challenge. Each memory must retain its uniqueness while commonalities are recalled. Concina et al. found that hippocampal neurons guide amygdala...

cell.com
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10,271
­­­Natural killer cells suppress T cell-associated tumor immune evasion bit.ly/2LvsOiY

Natural Killer Cells Suppress T Cell-Associated Tumor Immune Evasion

Freeman et al. use a series of genome-wide loss-of-function genetic screens to identify genes that limit tumor sensitivity to killing by natural killer cells. The findings highlight that natural...

cell.com
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Schwann cell promotes macrophage recruitment through IL-17B/IL-17RB pathway in injured peripheral nerves dlvr.it/T2fXtQ

Schwann cell promotes macrophage recruitment through IL-17B/IL-17RB pathway in injured peripheral...

Huang et al. discover the activation of IL-17B/IL-17RB signaling in Schwann cells following peripheral nerve injury. This activation triggers an upregulation of several chemokines involved in...

cell.com
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11,394
Fibroblasts repair blood-brain barrier damage and hemorrhagic brain injury via TIMP2 dlvr.it/SdF9Wh
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Dissecting gene activation and chromatin remodeling dynamics in single human cells undergoing reprogramming dlvr.it/T6KrQR
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13,630