501(c)3 transforming how LongCovid, ME/CFS, Lyme+ and Alzheimer’s are studied, diagnosed, and treated. Leading the #LongCovid Research Consortium.
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From Crisis to Cure: PolyBio is supporting top HIV researchers to pivot into the study and treatment of Long COVID. Watch the full video to learn how this collaboration is being maximized & driving forward innovative research: piped.video/6kC1lyY6hPc?si=adTg…
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BREAKING: PolyBio-supported study reveals long-term immune and metabolic damage after COVID-19 infection
New preprint study reveals profound & long-lasting biological disruptions that can follow a SARS-CoV-2 infection, i.e. changes connected to altered metabolism & cancer-associated epigenetic changes
polybio.org/polybio-supporte…
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Breaking!: Research published today in Science Translational Medicine and supported by PolyBio Research Foundation shows that the #SARS-CoV-2 virus can chronically persist in the gut of patients with long COVID for over 2 years: polybio.org/chronic-virus-fo…
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Drs. Proal, VanElzakker, and Putrino yesterday at the Mount Sinai CoRE clinic. They reviewed autonomic, cognitive, endothelial & metabolic testing protocols that patients undergo as part of their medical care, or at certain stages of long COVID, ME/CFS, and chronic tick-borne/vector-borne illness clinical trials
ALT 3 people wearing N95 respirators in a hospital clinic. The woman on the left (Amy Proal) is wearing a black T-shirt with white polka dots and has long blonde hair. The man in the middle (Mike VanElzakker) wears a pink and purple checkered collar shirt and has close-cut hair. The man on the right (David Putrino) wears a black respirator and a dark purple long sleeved collar shirt.
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UCSF researcher Dr. Tim Henrich describes how the PolyBio-supported PASC tissue program is changing the game: “What we’ve really been finding is that SARS-CoV-2 is able to persist for a long period of time in various tissues across the body… the gut, the bone marrow, the brain, and other deeper tissues that are actually very difficult to sample. We’ve also been finding that there is profound changes in immune responses and inflammation in these tissues as well.”
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Dr. Amy Proal last week: “When people get an infection, there’s a huge assumption that it just clears after their symptoms go away… Little amounts of the pathogen [can persist] in parts of your tissue, parts of your nerves—where they can still drive inflammation and directly hijack the functioning of your mitochondria.”
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BREAKING: Cutting-edge Recommendations Provide Treatment Path for Millions of Long COVID patients 💊
In a new report global experts outline key considerations to address persistent SARS-CoV-2; provide a roadmap to test critical new long COVID therapies: polybio.org/cutting-edge-rec…
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Huge news! We received ~1.3M from Balvi (@VitalikButerin) for a study of #LongCovid intestinal tissue w/ @MehandruLab, @PutrinoLab & @drmfreire. We will use cutting-edge technologies to identify SARS-CoV-2 + immune/microbiome abnormalities in samples: polybio.org/portfolio/intest…
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We are excited to announce a 2nd series of collaborative projects & clinical trials supported via our LongCovid Research Consortium: polybio.org/new-longcovid-re…
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We are excited to announce an $800,000 donation to Mount Sinai to support a clinical trial of the drug rapamycin in patients with long COVID. The trial will be conducted at CoRE: a clinic directed by Dr. David Putrino and PolyBio's Dr. Amy Proal:
polybio.org/polybio-supports…
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We are excited to share that @MBVanElzakker & team at @MGHMartinos have published a preprint with the results of a high-resolution #LongCovid imaging study. They identified neuroinflammation across a wide range of brain regions in LongCovid patients: polybio.org/polybio-supporte…
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We're excited to announce the grand opening of CoRE: a new clinic at Mount Sinai providing innovative care for LongCovid, Lyme+ and related conditions, with @polybioRF's Dr. Amy Proal serving as Scientific Director. Read more here:
polybio.org/polybio-mount-si…
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BREAKING: Chan Soon-Shiong Family Foundation donation expands PolyBio Long COVID program
Funds will support exploration of SARS-CoV-2’s potential to drive cancer, as well as continued work delineating persistence of the virus in long COVID tissue & therapies to clear persistent virus
ALT Two scientists look at imaging on a computer in a dark clinic room at UCSF. They are both wearing black respirators. Photo credits Noah Berger.
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We are excited to have supported this new study via our #LongCovid Research Consortium. The project team are our incredible @CUBoulderBN colleagues at the University of Colorado Boulder: polybio.org/multiple-hit-mod…
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PolyBio is excited to be leading the LongCovid Research Consortium (LCRC): a global scientific collaboration to rapidly & comprehensively study #LongCovid disease mechanisms, with a focus on SARS-CoV-2 reservoir (polybio.org/longcovid). LCRC projects we are supporting include:
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1/ “When you have persistent pathogens & chronic inflammation associated with that, you have a lot of reactive oxygen species. The mitochondria are trying to create energy in a hostile environment…the more that you do, the harder it is to [function].”
-Dr. Putrino of @CoRESinai
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Tim Hendrich's team is using multimodal PET imaging to measure T cell activation post-COVID: "We saw significant increases in activated T-cell signalling in [the brain stem and spinal cord], that shouldn't have activated T-cells in them."
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“To get rid of HIV, we need to go after the virus, we need to go after the inflammation, we need the immune system to work better,” says Dr. Steve Deeks. “Over the last 20 years we have built up all these collaborations with industry, funders, and other academic groups trying to target those pathways. And those are the exact same pathways that we’re now targeting with Long COVID.”
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We are very excited to annouce that thanks to the generous support of 3 private donors, we are able to begin our CCI and Structural 7-Tesla Imaging Project in patients w/ complex chronic illness (#ME/CFS, #LongCovid, #EDS etc)
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PolyBio Research Foundation is excited to announce a $1M donation to UCSF. The donation will allow the UCSF LIINC team to study #ME/CFS patients with advanced technologies, several of which have never yet been used in the field: polybio.org/1m-polybio-donat…
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Now recruiting: Long COVID patients in NYC—consider joining the @CoRESinai clinical trial of repurposed antivirals Truvada & Maraviroc. These repurposed HIV antivirals may have activity against SARS-CoV-2 reservoirs and reactivated EBV. Email coreresearch@mountsinai.org to apply!
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BREAKING: Development of a spike protein-specific radiolabeled antibody used with PET imaging shows presence of spike in brain & lungs of macaque monkeys 3 months post-COVID; provides new viral reservoir detection opportunity for long COVID: nature.com/articles/s41467-0…
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We are excited to announce a $15M gift from Kanro: a philanthropic fund to support scientific research established by Vitalik Buterin, co-founder of Ethereum: finance.yahoo.com/news/polyb…
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PolyBio Research Foundation is excited to be leading the #LongCovid Research Consortium: a scientific collaboration between top global research teams to rapidly & comprensively study LongCovid, with a focus on the topic of SARS-CoV-2 persistence in tissue: polybio.org/longcovid
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At PolyBio we are supporting two autopsy studies underway - a study of SARS-CoV-2 persistence, inflammation and other forms of dysfunction in victims of sudden cardiac death, plus this pilot LC autopsy program in Washington DC w/ Dan Chertow’s NIH team: polybio.org/projects/develop…
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We are proud to have supported this new paper published in @BrainBehavImm.
Led by @MBVanElzakker & team at @MGHMartinos, it is the is first study to document neuroinflammation in the long COVID brain along with evidence of vascular problems: polybio.org/longcovid-brain-…
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2/ The findings suggest that multiple infectious “hits” (#viral and #bacterial) may amplify long-term neuroinflammatory or neuroimmune symptoms in patients with #LongCovid.
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Dr. Akiko Iwasaki, who has led work on the role of human endogenous retroviruses (HERVs) in chronic diseases i.e. lupus, is now investigating the role of HERVs in Long Covid. “We’re now collaborating to understand whether antibodies specific to Epstein Barr Virus can engage a pathological impact [in LC] when bound to this [HERV] cognate antigen.”
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Dr. Shannon Stott is leading a team using a novel microfluidics approach to identify SARS-CoV-2. A ‘Herringbone’ chip is coated with ACE-2, to pull out SARS-CoV-2 from blood: in acute COVID, “when we looked at basic plasma testing, we saw that no virus was found… but those same samples when used with our microfluidic capture, we saw 30,000 copies of SARS-CoV-2.”
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BREAKING: PolyBio and WE&ME-supported study identifies two distinct ME/CFS subtypes
🧪Collaborative research uncovers immune and biomarker patterns that could help subclassify ME/CFS and guide future treatments.
polybio.org/polybio-and-weme…
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1. Icahn School of Medicine Mount Sinai: “A clinical trial of repurposed HIV antivirals in LongCOVID” 👉 Learn more here: polybio.org/projects/a-clini…
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BREAKING: Invivyd and lead researchers Dr. Amy Proal, Dr. David Putrino & Dr. Michael Peluso form SPEAR (Spike Protein Elimination and Recovery) study group to assess the effects of Monoclonal Antibody Therapy for Long COVID & COVID-19 Post-Vaccination Syndrome
investors.adagiotx.com/news-…
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Good article in Bloomberg on our PolyBio/Sinai/Yale trial of repurposed HIV antivirals in LongCovid: bloomberg.com/news/newslette…
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“At least 2/3 of individuals with Long COVID contained [SARS-CoV-2] infected megakaryocytes,” says Dr. Morgane Bomsel. “This suggests that megakaryocytes form reservoirs in LC patients—which may produce platelets sheltering infectious SCV2.”
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At yesterday’s symposium, PolyBio’s Dr. Amy Proal introduced a new interactive module on our website.
It facilitates knowledge of our research and therapeutic projects, technologies, and findings across international institutions.
Check it out here! polybio.org/consortium-proje…
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Breaking: PolyBio-supported researchers at MGH/Harvard have developed a microfluidic device that quantitatively measures fibrinaloid clots (microclots): tiny, abnormal clumps in the blood that may play a key role in the biology of Long COVID: polybio.org/new-microfluidic…
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Polybio is supporting several trials of potential #LongCovid treatments. Working with @PutrinoLab & @CoRESinai, Polybio President Dr. Amy Proal is spearheading an investigation of repurposed HIV antivirals Truvada & Maraviroc for treatment of LC, targeting viral reservoirs
Since my episode with the wonderful @longcovidanswer has been released highlighting viral persistence as a major driver of some #LongCOVID pathology, I’ve been asked repeatedly, “what should we do about it?” - totally fair question. Here is my proposed roadmap: 1/
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We recognize the urgent need to trial more antivirals in #LongCovid. We are working w/ @PutrinoLab + @VirusesImmunity on this Truvada/Maraviroc trial. The drugs will be trialed individually first: polybio.org/projects/a-clini…
The trial is not yet enrolling but we will keep you posted
Just met with a doctor who's prescribing me multiple antivirals for #longcovid. Beyond disgusted with our govt for providing no warning and no treatments.
Honestly I urge anyone considering antivirals to start now. My doc said I might have made things worse by waiting.
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2/ New research published by scientists from the University of California San Francisco reveals that COVID-19 can lead to significant and enduring alterations in the immune and metabolic systems of impacted individuals.
ALT Preprint data showing measures of inflammasome activity and oxidative stress in monocytes from participants with and without prior COVID-19.
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“Our results have now clearly documented that Bartonella, Babesia, and the relapsing fever Borrelias… can certainly persist in human blood for long periods of time,” said Dr. Ed Breitschwerdt, an expert on tick-borne disease. “If you’re infected with one of these 3 genera, and COVID comes along, you might have a very aberrant immune response that persists.”
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“We have a number of studies underway trying to figure out which form of [SARS-CoV-2] persistence might be occurring in some patients,” said Dr. Amy Proal.
These include:
1. Inert RNA persistence
2. Active translation of viral proteins
3. Active replication of virions, resulting in infection of new cells
“All of [these persistence types] could be happening in Long Covid.”
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Polybio is partnering with a team of researchers out of Harvard Medical School to assess the role of fibrin accumulation in the lungs, hearts & brains of #LongCovid patients. Pictured below, the team is analyzing PET imaging that uses a novel radiotracer [64Cu]-FBP8.
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We’re excited that Dr. Akiko Iwasaki—a member of our long COVID consortium—gave such an excellent AMA talk on recent developments in #LongCovid. She refers to several RCTs underway, including the PolyBio-supported trial of Miraviroc & Truvada at @CoRESinai.
piped.video/ilIOh4cZiNI?si=cFqo…
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Breaking! This new PolyBio-supported study is the first to report reduced percentages of cytotoxic natural killer cells in people with #LongCovid. The immune dysfunction might facilitate #SARS-CoV-2 persistence in patients w/ the condition.
More here:
polybio.org/study-first-to-d…
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Since #COVID19 came on the scene, prevalence of cardiovascular disease & fatal heart conditions have risen drastically. That’s why we’re supporting a Post-Mortem study on sudden cardiac death victims—which will elucidate the role of COVID in the condition:
polybio.org/projects/covid-1…
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News 👉A new study published in Nature Communications has unveiled a crucial connection between chronic #infection with Cytomegalovirus (HCMV), and the development of #Alzheimer’s disease in certain individuals:
polybio.org/new-research-ill…
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Great article about the new UCSF #LongCovid monoclonal antibody clinical trial geared at clearing #SARS-CoV-2 reservoirs. We have committed funding to support the experimental medicine portion of the trial which includes key viral persistence measurements: sfchronicle.com/health/artic…
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#polybiofallsymposium2025 Marta Mirabent from Roan Lab at Gladstone Institutes: Long COVID tissue samples from the female reproductive tract & gut are positive for SARS-CoV-2 RNA more than 4 years after initial infection.
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Dr. Amy Proal, Scientific Director of @CoRESinai, discusses viral persistence as a driver of ME/CFS with Dr.s Raven Baxter & David Putrino: “[research] finds the RNA backbone & protein of enteroviruses in ME/CFS gut tissue.”
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At PolyBio, our Long COVID Research Consortium & related complex chronic illness projects are moving full speed ahead. On Friday May 16 we have planned an online Symposium where PolyBio-supported researchers will present updates on their projects. The symposium schedule is below!
Register here: us02web.zoom.us/webinar/regi…
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3/ More specifically, the team showed that brain exposure to a #SARS-CoV-2 spike protein subunit drove a long-term vulnerability not only to #neuroinflammation, but also to forms of autonomic dysregulation such as increased heart rate and core body temperature.
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PolyBio President Dr. Amy Proal joined Long Covid Clinic’s Dr. Binita Kane to discuss recent developments in SARS-CoV-2 viral persistence, the potential impact of co-infection with Tick-borne illness, and up-and-coming treatments for Long COVID.
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PolyBio’s Spring Symposium is tomorrow, May 16th 11-5 ET. The event will bring together scientists from several disciplines to cover the following topics:
Viral Persistence
Clinical Trials
Tissue Pipelines
Vascular & Clotting
Immune system function
Brain & Nervous system
Long Covid gut
Cardiovascular
Microbiome
Neurodegenerative disease
Tick-borne vector-borne illness
us02web.zoom.us/webinar/regi…
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Great to see this new piece in @ScienceMagazine highlighting LongCovid clinical trials working to target #SARS-CoV-2 persistence. We are proud to be supporting nearly all the teams/trials mentioned in the piece via our LongCovid Research Consortium: science.org/content/article/…
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13/ Mount Sinai’s Cohen Center for the Recovery from Complex Chronic #Illness (CoRE) will also add HEPA filters and germicidal UV devices to its building to clear airborne viruses & other aerosols from the air, and require N95 respirator use and COVID PCR testing from its staff.
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Dr. Amy Proal on the @foresightinst Existential Hope podcast highlights NK & T-cell activating therapy, Anktiva: “there are a growing number of companies… that are working on therapies that do not suppress the immune system, but support the immune system.”
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Viral reservoirs in megakaryocytes at #polybiofallsymposium2025: expansion to Dr. Morgane Bomsel’s research suggests platelets from Long Covid patients are sheltering infectious virus, which can begin new infectious cycles of both reporter cells and macrophages in vitro.
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“If someone gets COVID & the immune system goes down, and they have Bartonella they’ve been managing… it’s another [infection] that might become much more symptomatic. Bartonella infects the blood vessels… and if you get COVID, the Spike also hits BVs & that’s a terrible combination.”
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Great news! A generous donor has made a $250,000 donation to PolyBio. The funding will let us collect key early data for several of our projects 🙏 We are incredibly thankful + more motivated than ever to study root cause drivers of #MECFS, #LongCovid etc! polybio.org/#section-project…
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“We’re trialing a low dose of Rapamycin once a week… which may have an immune-supporting effect,” Dr. Proal explained last week for @CoRESinai. “There are a couple studies that show this low dose could improve signalling of interferons… used to control viral infections.”
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“Viruses, bacteria, fungi & even parasite pathogens directly hijack the mitochondria of people they infect, especially over time,” says Dr. Amy Proal. “There are different parts of the mitochondrial metabolism those viruses hack to benefit their own reproductive needs.”
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PolyBio is glad to have supported this Nature Immunology paper showing #LongCovid immune dysregulation connected to potential #SARS-CoV-2 tissue reservoirs. Learn more about the findings here: polybio.org/polybio-supporte…
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At today’s PolyBio symposium: Newly published study from Victoria Cortes Bastos found distinct ME/CFS cerebrospinal fluid subtypes—based on cytokine profiles & past CMV vs. SARS-CoV-2 infection.
“These patients are clinically the same. They are equally sick, but may have different causes.”
#polybiosymposium #mecfsresearch
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“The [vagus nerve] is immune privileged, but very microbially exposed… we haven’t begun to understand what those microbes are & what their byproducts might be,” said Dr. Melanie Walker. “We might be able to really narrow down our search for the origins & progression of [Alzheimer’s & Parkinson’s] if we understood the vagus nerve better.”
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BREAKING: Dr. Amy Proal’s participation in two recent major conferences on scientific innovation highlighted a growing interest in using cutting-edge scientific research to tackle persistent infection as a driver of chronic disease.
ALT A woman speaking in front of a crowd at a conference wearing a black T-shirt, black jeans, and a white and red name tag. She has long blonde hair. The projector screen behind her reads PolyBio and shows a collage of squares all showing different organ systems in white, blue, pink and purple.
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1/ PolyBio is excited to support the development of advanced diagnostics to identify the Babesia parasite.
Babesia is increasingly being identified in blood & tissue samples from patients with a range of chronic diseases, suggesting activity of the parasite may be contributing to more forms of chronic illness than previously understood.
polybio.org/projects/develop…
ALT A microscope image of red blood cells (stained in purple) on a white background. Babesia parasites at different stages of the life cycle are indicated with black arrows. Arrow 1 is in the middle of the screen pointing to a RBC with 2 oval shaped parasites. Arrow 2 is at the bottom right pointing to an RBC with a ring shaped parasite.
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Dr. David Putrino’s call for multi-drug combination therapies in Long Covid at #polybiofallsymposium2025: he describes plans for a 2026 “SHIELD” clinical trial of a 3-drug combination involving Valacyclovir, Celecoxib & Paxlovid. These medications in combination aim to address reactivations of herpesviruses, as well as the SCV2 reservoirs.
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How do #persistentpathogens affect brain function? @PutrinoLab , Nash Family CoRE director & PolyBio scientist, explains: “MCAS or chemokines from systemic infections affect everything. Inflammation causes mitochondrial dysfunction, which leads to energy crisis [in the brain].”
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Now recruiting! Lumbrokinase trial for Long Covid, ME/CFS and PTLD patients will “see how taking the enzyme impacts blood clotting, fibrin & other parameters over the course of the study… We should gain more info on which kind of patient Lumbrokinase can benefit.” Email coreresearch@mountsinai.org to apply now!
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5/ Neuroimmune ‘priming’ is an effect by which subsequent #immune challenges – such as several infections in a row – can cause increasingly profound and protracted #neuroinflammation,” said PolyBio co-founder and neuroimmunologist Dr. Michael VanElzakker.
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1/ BREAKING: Infections can be major drivers of Aging Processes, new PolyBio review paper delineates
A new scientific review written by PolyBio’s core team challenges the long-held assumption that human aging unfolds in a sterile environment. The authors argue that lifelong exposure to viruses, bacteria, fungi, and parasites—many of which persist in tissues and nerves—can directly accelerate aging processes.
sciencedirect.com/science/ar…
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Breaking: New grant expands Long COVID Lymph Node study
PolyBio Research Foundation and the Wallace Research Foundation announce a new grant to support continued research into the root causes of impaired antibody responses in some individuals with Long COVID.
polybio.org/new-grant-expand…
ALT A pink B cell surrounded by white antibodies in a blue circle, depicting a microscopic view. Two lines are coming out of the blue circle and meeting at a lymph node.
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2/ The findings, published by a UCSF team known for innovation in HIV research, also documented T cell immune activation across the bodies and brains of people after COVID. This T cell activation was particularly elevated in the spinal cord and gut wall of long COVID participants
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7/ These findings suggest that targeting lipid pathways through interventions like omega-3 supplementation or metformin may help mitigate symptoms and prevent further damage.
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13/ The authors note that persistent SARS-CoV-2 reservoirs, reactivation of latent viruses like Epstein-Barr virus, and damage to the gut barrier may all contribute to this pro-inflammatory and dysregulated metabolic cascade.
pubmed.ncbi.nlm.nih.gov/3994…
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Dr. Amy Proal last week: “More companies are creating broad-spectrum mAbs, and these are mAbs that have been designed to have activity against most variants. That’s exciting. There you wouldn’t have to think so much about ‘What reservoir is this? When did the person get infected?’ And maybe the broader spectrum mAbs will have activity against any form of reservoir.”
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5/ These included dramatically reduced levels of tryptophan (an essential amino acid important for immune and neurological health), persistent elevation of pro-inflammatory lipid mediators, and methylation changes in genes tied to metabolism.
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3/ Some of these changes may underlie the persistent symptoms experienced by many post-COVID-19 patients (Long COVID). The research was supported in part by PolyBio Research Foundation via the LIINC program.
polybio.org/projects/liinc-p…
ALT Researchers and staff members with UCSF’s Long-term Impact of Infection with Novel Coronavirus (LIINC) stand at Zuckerberg San Francisco General Hospital on Friday, Aug. 8, 2024, in San Francisco. (Photo by Noah Berger)
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PolyBio is excited to be supporting this new project by Nadia Roan & team at UCSF.
The study is analyzing endometrial biopsy tissue to improve our understanding of the mechanisms underlying long COVID in women: polybio.org/projects/sars-co…
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6/ This means that multiple inflammatory challenges can add up to be greater than the sum of their parts.
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Heads up long COVID patients in the NYC area: We need more participants for this PolyBio-supported trial👇
The trial is testing if repurposed HIV medications (either Truvada or Maraviroc) reduce symptom burden in long COVID. Learn more here:
polybio.org/projects/a-clini…
Long COVID and viral reactivation are linked. Our latest trial focuses on repurposing existing, broad spectrum antivirals to reduce symptoms in adults with #LongCOVID. Our clinical trial is currently recruiting! Email CoreResearch@mountsinai.org to inquire
ALT Volunteers Needed Long COVID Clinical Trial Icahn School of Medicine at Mount Sinai Do you have a confirmed diagnosis of Long Covid? You may be eligible for a 6 month drug clinical trial involving antiviral drugs You may qualify if: • You are over 18 • You have a diagnosis of Long Covid from a physician • You are HIV negative • You are able to commute to our office • Other criteria are considered as well | Participation Involves: • Being randomly assigned into one of three groups • Truvada (drug) • Selzentry (drug) • Placebo • Attend 6 in-person study visits • Blood and saliva samples • Completion of surveys online Study goal: We are investigating if antiviral medications have an effect on Long Covid symptoms IRB Approved Effective Date: 12/17/2024 End Date:7/22/2025 Please email CoreResearch@MountSinai.org for more information Location: 5 East 98th St, SB-18 Lead Researcher: David Putrino, PT, PhD STUDY- 24-00088 Participation will be compensated up to $300
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PolyBio is proud to have supported this new study by @MichaelPelusoMD & team. They identified tissue-based T cell activation in body sites such as brainstem/bone marrow + #SARS-CoV-2 RNA persistence in colorectal tissue up to 2 years post-COVID-19: medrxiv.org/content/10.1101/…
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Dr. Morgane Bomsel is studying SARS-CoV-2 persistence in Long Covid patients’ platelets and megakaryocytes. Thus far, their early data shows that spike protein and viral RNA “can be found in at least 2/3 of the Long Covid patients’ [megakaryocytes]… this research suggests MKs may form SARS-CoV-2 reservoirs in Long Covid patients, which may produce platelets sheltering infectious SCV2.”
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Michela Locci is leading the first study in the world that collects lymph node tissue from #LongCovid patients via Fine Needle Aspirate. Her team is investigating whether inefficient germinal center responses, which generate antibodies, lead to LC neurological symptoms.
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Together, these observations suggest that even clinically mild infection could have long-term consequences on tissue-based immune homeostasis and potentially result in an active viral reservoir in deeper tissues." 👇
sciencealert.com/covids-hidd…
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Excited to announce the PolyBio Spring Symposium. It will take place online May 17 from 12 -5 pm ET.
Join to hear PolyBio-supported investigators give short updates on their projects.
Register here: us02web.zoom.us/webinar/regi…
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Dr. Michael Peluso on LC therapies: “we need to move beyond single therapy treatments for Long COVID and begin to piece together combinations targeting the different biological mechanisms of Long COVID. Kind of hit this disease from multiple angles to try to get people feeling better.”
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We’re grateful to announce a new grant from the Wallace Research Foundation will support PolyBio’s multi-lab based study on coagulation, innate immune & vascular biomarkers for #LongCovid. The Harvard-based team can now integrate a targeted analysis for SCV2 proteins.
polybio.org/wallace-foundati…
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Yes enough already! These leads on #LongCovid disease mechanisms are HUGE, which is why we’re doing everything in our power to support the team moving forward
Enough already: T cell inflammation and SARS-CoV-2 virus persist in Long Covid.
Editor's choice in @ScienceMagazine Immunology from Friday.
science.org/doi/10.1126/scii…
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“Microclots, although present in many diseases, may have significance for clinical utility,” says Resia Pretorius. Using her team’s new “flow clotometry” method, they found “significant differences in [microclot counts] with ME/CFS slap in the middle of controls & LC.”
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4/ The study, conducted roughly four months after initial infection, identified widespread metabolic abnormalities in individuals with prior COVID-19.
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9/ They also show that problems like #autonomic dysfunction and #hormonal imbalances in long Covid can be directly connected to #environmental insults and exposures.
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16/ Post-COVID epigenetic changes and cancer risk
The study findings also raise concerns that COVID-19 may increase the long-term risk of cancer by disrupting the normal regulation of genes involved in tumor growth and immune function.
ALT A volcano plot from the preprint displaying the differentially methylated CpGs between study participants with prior COVID-19 infection and non-infected control participants.
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Last week’s PolyBio Spring Symposium featured updates on innovative research that is driving forward discoveries in infection-associated chronic illnesses. If you weren’t able to attend live, or want to watch a replay, the recording is now available:
polybio.org/spring-2025-symp…
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6/ Notably, potentially-harmful inflammatory lipids like arachidonic acid were elevated, while beneficial ones such as AEA and DHEA—linked to cardiovascular and brain health—were decreased.
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Dr. Peluso wraps-up the #polybiofallsymposium2025 by presenting INTERRUPT-LC, a trial of the IL-15 agonist Anktiva. “Improving coordination between T-cells and NK cells may lead to better clearing of the virus,” in Long Covid patients who have persistent viral antigens or whole pathogens in long-term reservoirs.
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1/ Interested in trying repurposed antivirals for your long COVID?
Join this NYC study of repurposed HIV antivirals Truvada & Maraviroc! 🦠💊
👉🏻The Cohen Center for Recovery from Complex Chronic Illness (CoRE) is seeking participants for their double-blinded RCT of repurposed HIV antivirals for Long Covid. If you meet eligibility, reach out to CoreResearch@MountSinai.org.
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PolyBio's Drs. Proal & VanElzakker today in front of a poster at the Harvard/MIT Martinos Center featuring sections from their 2021 paper on #LongCovid disease mechanisms.
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