Biocatalysis and complex molecule synthesis at the University of Michigan. Go BLUE! Go Chemistry! Now on bluesky @narayanlab.bsky.social
Ann Arbor, MI
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Check out our synthesis of enantioenriched atropisomers in Nature!
rdcu.be/e2Kc0
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Nine enzymes, three natural products synthesized, two NPs reassigned all in one JACS paper brought to you by @Summer_ABD @ScienceBey, Josh and collaborators Ren, @leoajoyce and the always fab Janet Smith
pubs.acs.org/doi/10.1021/jac…
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Thanks! We like to use this type of figure to concisely illustrate substrate scope. Figure guru @ScienceBey was the person in the group to pioneer this type of figure and it has spread like wildfire🔥
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And 🧁 & ☕️ to 🎉
Today, I am delighted to share work from @NarayanLab on biocatalytic oxidative cross-coupling reactions to form tetra-ortho-substituted biaryl bonds in @Nature
nature.com/articles/s41586-0…
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Excited to share the latest from the group! Congrats to April, Duncan and Meagan as well as collaborators Ryan and Justin (Du Bois Lab) and Sherwood Hall (FDA)!!
C–H Hydroxylation in Paralytic Shellfish Toxin Biosynthesis pubs.acs.org/doi/10.1021/jac…
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Old dog teaching old tricks 🐶@AlisonNarayanUM
#biocats
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Big day for Dr. Summer Baker Dockrey @Summer_ABD who wowed the crowd with an awesome thesis defense! Congrats, Summer!! It won’t be the same without you. #firstNarayanPhD #biocatalysis @MichiganChem @UMLifeSciences
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Grateful to @NatProdReports for recognizing the work of the group. I am lucky to work with a talented, creative, dedicated crew @NarayanLab @MichiganChem @UMLifeSciences
.@NarayanLab has received the 2020 @NatProdReports Emerging Investigator Lectureship, in recognition of her "significant contribution to a natural products-related area of the chemical sciences." Congratulations!
blogs.rsc.org/np/2019/12/18/…
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Go Biocatalysis Go! Congratulations to @EvanORomero, @AtsauSaucedo, @joserhern1, @DiYang33319166, and @purfectcatalyst on this perspective about the adoption of biocatalysis in organic chemistry! Make sure to check it out! pubs.acs.org/doi/10.1021/jac… #GoBlue #BioCats
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Congrats to Summer, April and Marc on their work out today in @NatureChemistry! @MichiganChem #UMLSI #biocatalysis #naturalproducts
Biocatalytic site- and enantioselective oxidative dearomatization of phenols nature.com/articles/nchem.28…
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Congrats to the non-heme team on their JACS paper demonstrating a chemoenzymatic synthetic strategy for making ortho-quinone methides @tyler_doyon @JCPerkins23 @Summer_ABD @EvanORomero @kevincsumich @ZimmermanUMich #biocatalysis @MichiganChem
pubs.acs.org/doi/10.1021/jac…
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Check out our new work led by the amazing Dr. Ye Wang in @J_A_C_S! We are so proud of this wonderful team and their investigation into the PLP radical!
pubs.acs.org/doi/10.1021/jac…
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Our newest paper on biocatalytic stereoselective oxidation of 2-Arylindoles is out! Congratulations to Sarah Champagne and the flavins team, @Chad46971777 , @ChemGemm, and @charleslbrooks! Go Champase, Go!
#BioCats #GoBlue
pubs.acs.org/doi/full/10.102…
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Thanks to the @SloanFoundation for their support, honored to be a part of this fantastic group of fellows! Congrats to all the other new #SloanFellows, including @EngleLab @basktastic @SongLinLab @MatsonLab @nagiblab @drcmwoo
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🎓🎓🎓Congrats to @ScienceBey @JYazarians and @Stephietoxin🎓🎓🎓 look at those doctors complete with their hoods! @umichgradschool
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Check out April's minireview on natural products known to bind to voltage-gated sodium channels: dx.doi.org/10.1002/cbic.2018…
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Our most recent chemoenzymatic synthesis story is out! Congratulations to @EvanORomero, @JCPerkins23 and collaborators from the @TheNelsonLab! Non hemes for the win! #BioCats Chemoenzymatic Synthesis of (+)-Xyloketal B pubs.acs.org/doi/10.1021/acs…
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Prospective postdocs: Do you love perfectly selective reactions? Are you into complex molecules? Are you intrigued by biocatalysis? If you answered yes to any of these questions, a postdoc in the Narayan Lab might be right for you! Check us out: narayanlab.com
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Congratulations to @UMich faculty member @AlisonNarayanUM, who has received the Arthur C. Cope Scholar Award for excellence in organic chemistry.
"The Narayan group has had an enormous impact at the nexus of synthetic chemistry and enzymology."
myumi.ch/lxOvD
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New paper just dropped! Congrats to the amazing @SAckenhusen, Dr. Ye Wang, and Dr. @Stephietoxin! #TeamPLP #BioCats
Understanding and Circumventing the Requirement for Native Thioester Substrates for α-Oxoamine Synthase Reactions pubs.acs.org/doi/10.1021/acs…
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Check out the cover artwork from the fabulous LSI Multimedia Designer, Stephanie King. Maize 'n Blue ortho-quinols never looked so good. @MichiganChem #UMLSI @NatureChemistry
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The amazing work of Dr. Ye Wang, @KatieJaneTorma5, and Dr. Josh Pyser in collaboration with the @ZimmermanUMich is finally published on ACS Central Science! Congratulations to the team! #BioCats #SubstrateSelectivity
pubs.acs.org/doi/10.1021/acs…
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Congrats to group members Carolyn Suh (undergraduate researcher) and Lara Zetzsche (PhD candidate) on an NSF GRFP award and an honorable mention! Well-deserved recognition for these talented scientists 👏👏👏 @ChemistryMIT you’re getting a good one next year @MichiganChem
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Congratulations to our newest PhD candidate!! We’re so excited for @EvanORomero for killing it in his online social-distanced candidacy :)
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Accepted! Photo shoot to capture the just accepted manuscript moment @tyler_doyon @JCPerkins23 👏👏👏
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Thanks to RCSA for recognizing Alison as a Cottrell Scholar and supporting our research 👍👏🙌
RCSA Announces 2019 Cottrell Scholars
Research Corporation for Science Advancement announces its 2019 Cottrell Scholar Awards. These Awards provide $100,000 to each recipient identified as a leader in integrating science teaching and research at a top... bit.ly/2BvXETf
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Thanks to @BalskusLab for writing a @NatureNews and views on our recent work published in @ChemicalBiology nature.com/articles/d41586-0…
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The latest from @AprilLukowski and Meagan and collaborators Nick, Lori (Isom Lab) and Sherwood (FDA) on the enzymatic elaboration of saxitoxin and the behavior of these molecules as ligands for VGSC, out today in @ChemicalBiology tinyurl.com/y3ohe4xj
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Our very own @AprilLukowski has begun her virtual thesis defense! We are so proud of all she’s done and to have the pleasure to work alongside her!
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Thanks for the shoutout @ChemBioChem and for recognizing the work of the talented @NarayanLab group members including @AprilLukowski, the first author of this review on natural products that bind to voltage-gated sodium channels...so many beautiful natural products 🥰
ChemBioChem #ChemBioTalents (bit.ly/ChemBioTalents): Alison Narayan (@UMLifeSciences) . The @NarayanLab focuses on biocatalysis and natural product biosynthesis. Read their recent paper here: onlinelibrary.wiley.com/doi/…
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Congrats to the new doctor, Dr. Jessica Yazarians!!! We’re not crying, you are 😭 Cheers to biocatalytic C-C bond formation and all of your accomplishments 👏👏👏👏 #biocatalysis @MichiganChem
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Congrats to Stephanie, Meagan and Meredith on our group's first paper elucidating the biosynthesis of saxitoxin!
#JustAccepted Biochemical characterization of enzyme involved in saxitoxin biosynthesis provides a new tool for the synthesis of alpha-amino ketones directly from amino acids acspubs.co/E0Qv30igmQP @NarayanLab
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It’s time to celebrate our second candidate of the year! The amazing @KatieJaneTorma5 just passed her Gateway exam, joining Gonzalo on the dream team of second year candidates.😎🙌🏼 #BioCats #GoBlue
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In our first 2022 paper, we report the structural features that control site-selectivity in a Reiske oxygenase C-H hydroxylation run. Working with @BridwellRabbLab is always a blast and takes our science in new directions!
@MichiganChem @UMLifeSciences
nature.com/articles/s41467-0…
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The latest from the group is out today in @ACSCentSci from
@Summer_ABD, Carolyn Suh and @AttabeyR! A fun project to tackle with collaborators Troy Wymore and @charleslbrooks. Think like a chemist to make enzymes work for you. pubs.acs.org/doi/10.1021/acs…
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Thanks for including us, @ChemBioChem!
#ChemBioTalents Rising Stars in Chemistry & Biology (bit.ly/ChemBioTalents) - We welcome our new Editorial Advisory Board Members @AChemSynBio @NarayanLab @Beatfierz @jenheemstra @junseoklee @kath_lab. Early-career scientists shaping the future of the journal!
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We are gearing up for a major event this week! @Summer_ABD defends Thursday at 2pm. Come cheer her on in the Rackham 4th floor west conference room @MichiganChem @UMLifeSciences
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Are you seeing double?! In the Narayan lab, Pride month is EVERY month. This year, we celebrated with the first Narayan Lab Gay Olympics! Congratulations to the #BlueTeam for winning first place and happy pride to all! 🌈🦄
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Starting out the semester with a BANG!💥Congratulations to @TessaEpstein7 and Dr. @c_b_roos on being awarded NIH-F31 and NIH-F32 fellowships! So proud of our #BioCats! @UMLifeSciences
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It’s still taking my breath away
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It was a special day for @MichiganChem as Melanie Sanford, @Sanford_Lab, was named a Distinguished University Professor. Congrats Melanie, and thanks for a wonderful seminar!
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We couldn't finish Pride month without highlighting our amazing LGBTQ+ chemists Sarah C., @joserhern1, @KatieJaneTorma5, Casey, @gonza_vr, @JCPerkins23, and @SAckenhusen!🌈Proud of you all and all of the amazing science you're doing! #PrideMonth #BioCats
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With more hours of daylight come more celebrations in our lab! ☀️🎊Congratulations to Sarah Champagne and @joserhern1 on being awarded NIH-F31 fellowships this spring! We’re extremely proud of their accomplishments! #BioCats #GoBlue @UMLifeSciences
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We’re going to miss @Summer_ABD as we send her off to her new job at Genetech. The lab won’t be the same without you. You’re the best and everyone else is garbage!
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The future of synthesis includes catalysts of all sizes! Congrats to Merck on this incredible biocatalytic cascade to accomplish the synthesis of an HIV drug, islatravir #MerckChemistry #biocatalysis #enzymesrule #efficientsynthesis
science.sciencemag.org/conte…
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Just another Sunday morning, talking science with @sirfrasersays at the Foresight Institute workshop
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What a fantastic experience to be be in a room with 700+ scientists passionate about biocatalysis #Biotrans2019
Alison Narayan @NarayanLab (@MichiganChem) #ChemBioTalents shows how to use biocatalysis to generate complex molecules and natural products, wonderful talk and amazing science!!!
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Our newest paper in collab with the @charleslbrooks and Smith labs is finally out! Check it out if you want to learn more about the evolution of flavins. Congrats to @Chad46971777, former lab member Dr. @ScienceBey and our collaborators!🎉🥳pnas.org/doi/10.1073/pnas.22…
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Being back on the Berkeley campus was fabulous. @UCB_Chemistry is a special place full of spectacular science. Thanks for your hospitality Richmond, @SarpongGroup @christhechang @AlannaSchepartz @HartwigGroup @Toste_Group and the rest of the faculty and students
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We are so proud of @Summer_ABD, congrats on being recognized with a WCC Merck Research Award! @MichiganChem @UMLifeSciences
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Four years ago, this crew of superstars started their grad school journeys at @UMich. Cheers to what we've built together @AprilLukowski @Summer_ABD @tyler_doyon and Stephanie, we are all officially 5th years now! #firstclass #allstars
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And finally, our last candidate of the year, the iconic @luke_schulert just passed his candidacy exam! Luke joins Katie Jane, Alex and Gonzalo in the running of becoming the Narayan Lab’s next PhD. 🙌🏼🥂Stay tuned… #BioCats #GoBlue
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We showed you that flavin-dependent enzymes are the most selective catalysts for oxidative dearomatization of phenols, now we explain the origin of this selectivity in the group’s first preprint @AttabeyR @Summer_ABD @AprilLukowski @charleslbrooks @ChemRxiv #votinglinereading
Structural Basis for Selectivity in Flavin-Dependent Monooxygenase-Catalyzed Oxidative Dearomatization by Alison Narayan (@NarayanLab) & co-workers
bit.ly/2qE334V
#biochempreprints
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On charting a course for chemistry, see what Alison @cathleencrudden @A_Aspuru_Guzik @leecronin @GloriusFrank @Chem_Diva @MaulideLab @anatmilo @NevadoLab @SarpongGroup @SchindlerLab and many others have to say in @NatureChemistry #10yearsofNatChem
nature.com/articles/s41557-0…
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Standing room only at the Merck Symposium women in chemistry session @MichiganChem @Merck #womeninSTEM #MerckChemistry
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The wonderful @KatieJaneTorma5 just gave an amazing 3rd year seminar on her work towards azaphilone natural product synthesis. We are so proud of our azaphilone QUEEN!👑
#Biocats #GoBlue
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Thanks @smjyoti at @cenmag for writing up our latest work on saxitoxin biosynthesis published in @ChemicalBiology cen.acs.org/content/cen/arti… via @cenmag
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Congratulations to @KatieJaneTorma5 for winning best poster for the Tuesday night poster session! Thank you @ACSorganic #NOS2022
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Introducing Dr. Lara Zetzsche!!! Congrats to twitterless Lara on an excellent defense 🥳🎉👏 we miss you already and are wishing you the best @Amgen
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Congratulations to our newest PhD, Dr. @JCPerkins23 (aka Dr. Jonny P Rex 🦖). We are so proud of you and can’t wait to see you do great things at @abbvie. We will miss you so much! Go Jonathan Go! #GoBlue #BioCats
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We have another PhD candidate! Congratulations to @katelynvbrown for an amazing job on your candidacy exam 🎉
#Biocats #GoBlue
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🎉👏🥳 Celebrating @joserhern1 who delivered a wonderful presentation and soared through his @MichiganChem gateway exam yesterday. Way to go José!!!
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Thanks for highlighting our work #SYNFORM
Our recent #SYNFORM article covers @NarayanLab who describe a biocatalytic, selective method for the oxidative #dearomatization of #phenols. fal.cn/V-2W @MichiganChem
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Check out the Nature highlight of our recent paper on saxitoxin biosynthesis. Thanks for featuring our work @nature! @MichiganChem #UMLSI nature.com/articles/d41586-0…
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Our collaborative work with @charleslbrooks, @ZimmermanUMich and @troy_wymore is out! Congrats to first author, Sara Tweedy, and coauthor @AttabeyR for revealing this hydroxyl radical coupled electron transfer mechanism #flavins #biocatalysis
pubs.acs.org/doi/10.1021/acs…
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It was fantastic to have Prof. Keary Engle @EngleLab back in Ann Arbor as a student-invited seminar speaker! Thanks for visiting and sharing the latest and greatest from your group! Go Blue 💙💛 @MichiganChem
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Congratulations to Dr. Sarah Ackenhusen! We are so proud of you and we can’t wait to see you excel in your ACS public policy fellowship 💛💙@SAckenhusen
#GoBlue #Biocats
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Thanks, @J_A_C_S for including our work in this week’s JACS Spotlight pubs.acs.org/doi/10.1021/jac…
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Our very own @gonza_vr showing off his pre- and post-gateway exam vibes! Congratulations to our first PhD candidate of the year! 🎉 #BioCats
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Congratulations to @BrookeDunnery for winning best poster for the Wednesday night poster session! We are so proud of you! Thank you @ACSorganic and @angierangeles #NOS2022
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Coming to broadway soon: Chemistry on ice! ❄️⛸️
@MichiganChem thank you for planning such a fun event!
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Congrats to @TessaEpstein7 on her @NSFGRFP honorable mention! Well deserved recognition! And shoutout to all the scientists that put themselves out there and applied- no small feat any year and in 2020, wow.
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Congratulations to @AlisonNarayanUM on being named a finalist for the 2023 Blavatnik National Award for Young Scientists!
These awards recognize "America’s most innovative, faculty-ranked scientists and engineers." @BlavatnikAwards @MichiganChem
blavatnikawards.org/news/ite…
ALT Photo of Alison Narayan with text: Congratulations, Alison! Alison Narayan has been named a Finalist of the 2023 Blavatnik National Awards for Young Scientists.
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Congratulations to the fabulous @nicemalovic for graduating today 🤩 We will miss you!
#GoBlue #Biocats
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Our favorite newscaster @tyler_doyon is presenting his dissertation work now! We're so proud of this amazing leader in our lab👍
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Happy international #WomenInScienceDay! Here in the Narayan lab, we’re half women, led by a kick butt woman PI 👩🔬
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Make sure to check out @KatieJaneTorma5 poster (number 37)! The session starts at 8pm! #NOS2022
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Considering adding this to your talk, @todd_hyster? @HysterLab #photobiocataylsis #Biotrans2019
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Oh no, we got phage!! 🙀 Watch out bacteria, @RogerDiehl5 is coming for you! Happy Halloween #ChemTwitter @UMLifeSciences
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Huge congratulations to @AprilLukowski and @Summer_ABD on being awarded prestigious Rackham (@umichgradschool) predoctoral fellowships!! @UMLifeSciences @MichiganChem #UMChembio
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