🎥 My graduate-level #Organometallics course is now live on @YouTube! #chemtwitter
Designed for PhD chemists, this series covers history, mechanisms, catalysis, ligand design & more. Offered once every 2 years—check it out anytime!
📺 tinyurl.com/5n9bjx5d
How much NaOMe is actually in that nice-looking bottle of solid 'NaOMe' on your bench? 🤔🧐 Hint: maybe not much. Read the details in our most recent @ChemRxiv pre-print w/ #BMSChemistry here: bit.ly/2ElbqMs. #RealTimeChem
One of the strangest reactions we've ever worked on is described today in @ChemRxiv, a redox-paired alkene addition process in which two useful products are produced within the same cycle.
bit.ly/3VAb9Hu@NiHuiqi w/ @houk1000@pengliu_group
What a great day to be @scrippsresearch (and to be up late writing a grant 😂). Barry becomes only the 2nd person in history to win the chemistry Nobel twice. Congrats to all laureates!
BREAKING NEWS:
The Royal Swedish Academy of Sciences has decided to award the 2022 #NobelPrize in Chemistry to Carolyn R. Bertozzi, Morten Meldal and K. Barry Sharpless “for the development of click chemistry and bioorthogonal chemistry.”
A year later, we've learned a lesson learned by many others: mechanistic work w/ Ni is hard! 🛠️
Nevertheless, we've made some progress and now share an updated @ChemRxiv pre-print shedding🔦 on how this stereodivergent isomerization works.
@Julien07tinyurl.com/kysaup5e
W(0)/W(II) redox catalysis for alkene isomerization/hydroboration, now online in @J_A_C_S. Fun transatlantic collaboration w/ @MartinLab_ICIQ led by @W0TangClan@TitoBraulio.
PS - Don't mind our subliminal messaging: W(0)/W(II)... [WOW]^2 🤩🤩
bit.ly/3hen8t2
The culmination of a long journey & the start of another. Our 1st report on alkene 1,2-difunctionalization via a transient directing group.
3 rxn components
2 stereocenters: C-F and C-C
1 resilient team led by @liu_zhonglin & Luke
🧢s off! @ChemRxivbit.ly/3sdUnAu
4+ years in the making: We’re excited to describe the first use of a chiral transient directing group in Heck-type alkene additions #JustAccepted@angew_chem. Nice work by Luke and the project team, and great as always collaborating with @pengliu_group. bit.ly/2Ut2OrS
Is my bisphosphine ligand oxidizing? How is it happening? Does it matter? 🤔
If these questions keep you up at night 🛌, you're not alone!
Happy to share 3+ years of learnings, led by G4 student Shenghua together w/ @DonnaBlackmond #BMSChemistry. tinyurl.com/vc8x9zhw
During the past year, the G4 students teamed up to write a 📖 chapter on π-bond difunctionalization for Comprehensive Organometallic Chemistry IV, online this week. Thanks to our fearless editor @ianatonks! @ELSchemistry bit.ly/3dbLBwO
Tungsten is known for its use in hard material, but here it offers a soft touch. Kinetic olefin transposition without over isomerization. bit.ly/3XhHFj4@ChemRxiv
Brought to you by Team W: @W0TangClan @CamZRub @TitoBraulio
Delighted to share the final version our asymmetric Pd-catalyzed alkene 1,2-arylfluorination w/ transient directing group #JustAccepted@J_A_C_S. Key step on a long TDG quest! Bravo @liu_zhonglin & team. bit.ly/3fKb1Uf
Second, if you're looking for ~20 years of metal-catalyzed directed C(sp3)-H activation in one stop, @Binzju@AndrewMRomine & @CamZRub have you covered in this colossal @ACSChemRev: bit.ly/3nHK0U4
Great pandemic collab w/ our friends in the @bfshi lab!
Slightly belated but all recordings/materials from last quarter's virtual @ScrippsGradPrgm 2021 Organometallics Grad Course are now updated and freely available. Experience it yourself, connection drops included!😎
Videos: bit.ly/3xnbEsg
Website: bit.ly/3jibBJw
A new mechanistic take on alkene 1,2-carbosulfenylation that proceeds w/ syn-stereoselectivity. Check out the final version of #TeamNickel's study in @J_A_C_S this week, led by @ZiqiLi0513. bit.ly/3rx3j5t
Prof. Keary Engle of the @EngleLab is the new Dean of Graduate and Postdoctoral Studies at Scripps Research, leading the @ScrippsGradPrgm. An alumnus, Engle brings personal experience and is committed to mentoring future researchers. More: ow.ly/FcHR50Su8l2
Starting Mon (Aug 3), OM Bootcamp @scrippsresearch is going virtual! This year we are opening it up to undergrads (esp those at PUIs!) who may have missed out on summer research. DM for details if you’d like to take part.
An academic, a process chemist, and a catalyst manufacturer walk into a pre-print...
tinyurl.com/4d8xfmy2
Take the plunge w/ us into the non-PGM catalyst pool!
#TeamNickel is already at it again in 2021! Together w/ #BMSChemistry colleagues, Nana, Van, and Omar describe Ni(COD)(DMFU), an all-in-one diarylation precatalyst bit.ly/3pUIe1J - part of the upcoming #Synlett@thiemechemistry Ni catalysis cluster.
2021 OM Bootcamp @scrippsresearch kicks off next week Mon (Aug 9) in virtual/hybrid format, open to all. We are hoping to beat last year's undergrad turnout (esp those at PUIs)!
Register here: forms.gle/Q8v9xnvpd6u4B5z28 ✅
In our lab's newest @ChemRxiv pre-print @sunjuntao1 & team craft C–N chiral axes through atroposelective C(heteroaryl)-H activation. Unique products that react fast & selectively in [4+2]s. tinyurl.com/47av296n
Synthesize Pd(COD)(DQ) together with the master (Wenji @HarryHe88239850) and the apprentice (Keary).
DM your shipping info for a free sample of the catalyst made by Keary himself.
Thanks to @avrlisboa for awesome filming and editing!
piped.video/watch?v=8UqbNgAm…
What can we say? We 🧡🖤🧡 making heterocycles. (Carbocycles aren't bad either.)
Happy to share the latest results from our collaboration w/ @pfizer led by @NiHuiqi on the Pd(II)/Pd(IV) anti-annulation of alkenes. @ChemRxivbit.ly/3Cdhy2F
A full account of our work on Ni(0)-cat directed Markovnikov hydroarylation and -alkenylation with RB(OH)2 is online today @ChemRxiv: 3 new protocols, >70 examples, and detailed mechanistic studies by #TeamNickel@ZiqiLi0513@omar__apolinar and Ruohan. bit.ly/3yDc7c0
After years of failures, frustration, and false starts... We are excited to share: chiral transient directing groups in Pd-cat alkene functionalization. Brilliant stuff by Luke and team @bamtran24@tugcegerbay@pengliu_group. The force is strong w/ this one! #RealTimeChem
A Transient Directing Group Strategy Enables Enantioselective Reductive Heck Hydroarylation of Alkenes by Keary Engle (@EngleLab) & co-workers
bit.ly/2kGI69O
Breaking bonds, taking names 😎Congrats to Van, John, and Kin on their Nat. Chem. paper describing a beta-X elimination approach to covalent bond activation. nature.com/articles/s41557-0…
New additions to the synthetic 🧰 enabled by co-catalytic transient directing groups (TDGs). Enantioselective hydroalkenylation / hydroalkynylation & non-aromatic alkenyl aldehydes. Led by @ASimlandy.
@ChemRxiv preprint: bit.ly/39gQUwr
Ni-quinone 📖 Part 2 is online @J_A_C_S. @Yeongyu_Hwang designed a quinone ligand to enable 1,2-carboamidation via nitrenoid transfer. Using DFT, he traced the origin of enhanced reactivity to hemilability & ⏫ electrophilicity during migratory insertion.
tinyurl.com/yus89484
By popular demand, we are happy to offer video recordings of all lectures for Organometallics 2019 @scrippsresearch@ScrippsGradPrgm via @YouTube. Tune in, and let us know how we can make your remote learning experience as valuable as possible. englelab.com/resources/
#4 After a technical delay at the end of 2023, we're finally ready to finish the countdown and share our lab's recent Ni review. The penultimate discovery to highlight comes from Knochel, who observed accelerated C(sp3)-C(sp3) coupling w/ an embedded EDO.
tinyurl.com/fmmnepkh
Sometimes dreams (and dream rxns) come true! One of our dreams since 2015 has been to use simple carboxylates to direct alkene difunctionalization. @JD_Chimico, Taeho, and #TeamNickel brought the dream to life. Another fun collaboration with @stevewiz06 and #BMSChemistry.
Nickel-Catalyzed 1,2-Diarylation of Alkenyl Carboxylates: A Gateway to 1,2,3-Trifunctionalized Building Blocks by Keary Engle (@EngleLab) & co-workers
bit.ly/2nReGHf
Fluorine meets its match 💪 in a sterically tuned directing auxiliary that can squeeze out pesky C(sp3)-F bonds from the metal center.
A fun new @ChemRxiv pre-print brought to you by @liu_zhonglin#BMSChemistry & team: bit.ly/36L74wO
Excited to offer samples of a new nickel(0) precatalyst from our collaboration with #BMSChemistry as part of today’s talk @StanfordUChem. Stop by at 4:30 pm to learn more. Air/water-stable ✅ Luggage-stable ✅ Pub coming soon! #TeamNickel @BurnsChemistry @du_bois_lab@YanXiaLab
Our latest installment in alkene carbosulfenylation now tolerates alkylzinc nucleophiles, allowing for simultaneous C(sp3)-C(sp3) and C(sp3)-S bond formation @ChemicalScience@ZiqiLi0513: rsc.li/3vFjKPI
Last year we celebrated Keary’s birthday 🎉 with the release of three chemrxiv preprints over three days 😎! This year we’re celebrating a month late due to the arrival of the newest and smolest Engle- baby Ollie 👶!
We congratulate our super 🌟🤩🌟 postdoc @SkylerMendoza2 for being awarded an @NSF#MPSAscend Postdoc Fellowship @scrippsresearch. Skyler is a @CaltechCCE @sarah_reisman lab alum who is applying his synthetic chops in organometallic catalysis. Bravo!
#1 As we count down⌛️ to publication of our forthcoming nickel(0) review, we highlight milestones from other labs that paved 🛣️ the way. First up: the original synthesis of Ni(CO)4 (caution: volatile and toxic).
tinyurl.com/mryfsr6n
A classical rxn with a lot left to teach us. Check out the #JustAccepted version of our mechanistic deep dive into catalytic E/Z isomerization of alkenes w/ Pd(II) led by @MatsuuraRei together w/ @DonnaBlackmond in @ACSCatalysis, formerly @ChemRxiv. bit.ly/2PlzZhO
Thrilled to start my independent career as Assistant Professor in the department of Chemical sciences at @IISER_BERHAMPUR. Really grateful to @LabMukherjee@KBrownLab@EngleLab for the training and tremendous support during this journey.
Engle lab students were rolling deep at #ACSSpring2022. @ZiqiLi0513 presented not 1 but 3 posters @NiHuiqi represented #teampalladium while Yilin and Taeho showed off their work with #teamnickel. Alena presented a talk as part of the cross coupling symposium. Great work everyone!
The final version of our @ASimlandy's olefin/nitroalkane coupling paper is now online @ACSCatalysis. Strikingly simple combination of PdI2, HFIP, and Na2CO3 enables this previously elusive addition w/ mechanistic details from @0iTurki@pengliu_group: bit.ly/3SIMCP1
*Ringing* in 2022 🍾🔔🎉 w/ the final version of collaborative alkene annulation paper w/ our neighbors @pfizer, now online in @angew_chem: bit.ly/3G9hAKR. Well done @NiHuiqi & team!
Translating catalytic three-component difunctionalizations from alkenes to alkynes has proven harder than it looks. Now together w/ the @bfshi and Lan labs, @MYNoblemetal & @sunjuntao1 blaze a path to tetrasubstituted olefins via oxyhalogenation. @ChemRxivbit.ly/3nwdwg5
#3 From the MPI-Kofo, the heart of the organonickel revolution, comes Wilke's 1960 synthesis of Ni(COD)2 and Ni(CDT). At <500 words, every sentence packs a punch.
tinyurl.com/y3j2p22etinyurl.com/4hm69uk3
The people have spoken 🗳️!Our lab’s pick for paper of the month 🏆, as presented by Wenzhuo, is the collab study on enantioselective Ni-cat couplings of unactivated alkenes from the Koh & Shi labs @NatureCatalysis. @MJKoh87nature.com/articles/s41929-0…
Very honored to be included in this super talented cohort of 2019 #SloanFellows. Grateful to work with an awesome group of students, postdocs, and colleagues @scrippsresearch - a great team makes great research possible!
Keepin’ 😎 while making 🟩s. In our latest pre-print w/ @pengliu_group and @pfizer we show how pi-stacking and other non-covalent interactions enable Cu-cat hydroboration of BCBs bit.ly/3gReTkn. Props to ⭐️ project leads @TaehoKang6 and @tugcegerbay!
Very happy😀 to share the final versions of 2 papers today, both a long time in the making. The 1st from @liu_zhonglin & team w/ #BMSChemistry describes a selective 1,2-carbofluorination of unactivated alkenes under Pd catalysis @angew_chem: bit.ly/3EDDJTE
The final version of @ASimlandy's study is now online in @angew_chem: bit.ly/3paBy4d.
New since the pre-print: @0iTurki's in-depth DFT study of the special feature of tert-leucine that make it such an effective TDG across different migrating groups (@pengliu_group).
New additions to the synthetic 🧰 enabled by co-catalytic transient directing groups (TDGs). Enantioselective hydroalkenylation / hydroalkynylation & non-aromatic alkenyl aldehydes. Led by @ASimlandy.
@ChemRxiv preprint: bit.ly/39gQUwr
Simple conditions, strange selectivity. Our newest alpha-selective hydroarylation work is online @ChemRxivbit.ly/39ZDlN4. Nice method + mechanism story from Alena, John, and #BMSChemistry.
“The science belongs to you, not to me.” -Coach Hans Renata @hanzyduzit
Stunning science by our treasured friend and colleague during his promotion talk @scrippsresearch. 🥅⚽️💨🏃