Student-run twitter account for the Hartwig Group at UC Berkeley. š§Ŗ
Berkeley, CA
- Tweets 881
- Following 505
- Followers 13,040
- Likes 1,599
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The group goes to Johnās house for good food and a great time! Tap to see a very proud John of his paella š„
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Is it possible to recycle a common waste plastic into useful chemical feedstocks? We are excited to share our new paper in @ScienceMagazine, where we show the conversion of waste PE into propylene. Congrats @rjconk13, @StevenH32137006 and coworkers! science.org/doi/10.1126/scieā¦
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Wouldn't it be great to take common waste plastics like PE and PP and break them back down to high value building blocks? We're excited to share our new method using base metal catalysts inĀ @ScienceMagazine!
science.org/doi/10.1126/scieā¦
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Copper catalyzed Ullmann couplings are one of the oldest ways to forge new bonds. Our new mechanistic study in @ScienceMagazine shows these reactions occur by a novel mechanism: leading to higher TONs, more stable catalysts, and air tolerant conditions! doi.org/10.1126/science.adi9ā¦
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Our research group, together with Alex Bell, Ji Su, Corine Scown, will be recruiting postdoc candidates to conduct research on aspects of the polymer deconstruction process that we recently published in Science (science.org/doi/10.1126/scieā¦).
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Check out our latest @NatureChemistry paper on the catalytic undirected borylation of tertiary CāH bonds, done in collaboration with @EnamineLtd and @JanssenUS! Congratulations @isaac_yu_ and @JanssenEMEA! nature.com/articles/s41557-0ā¦
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See how #catalytic CāH amination transforms polyethylene into new materials with versatile and tunable properties! Our new study in @ScienceMagazine highlights unique catalyst design to avoid common side reactions! science.org/doi/10.1126/scieā¦ @GroupHelms @BASF @MessersmithLab
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Check out our new @J_A_C_S article where we demonstrate an air-stable singe component precatalyst for the borylation of CāH bonds! Congrats Kyan, Chris and everyone involved! pubs.acs.org/doi/10.1021/jacā¦
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Congrats to John for winning the Arthur C. Cope award! cen.acs.org/content/cen/artiā¦
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Ever dreamt of reaching into the base cabinet and grabbing the aqueous ammonia and potassium hydroxide pellets to run your amination reactions? (1/4)
Palladium-Catalyzed Amination of Aryl Halides with Aqueous Ammonia and Hydroxide Base Enabled by Ligand Development | Journal of the American Chemical Society @HartwigGroup @UCBerkeley @UCB_Chemistry @TotalSyntheses #Pd #Amination #ArylHalides #Ammonia pubs.acs.org/doi/10.1021/jacā¦
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It was a pleasure to have @BuchwildGroup give the Heathcock lecture! Of course John had to have paella served at group lunch šš„
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Can a computer predict the site of borylation better than an expert can? Our new model predicted the major product correctly 100% of the time on pharmaceutical intermediates with better accuracy than any experts we compared to. Check it out on @ChemRxiv! doi.org/10.26434/chemrxiv-20ā¦
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Check out our new paper on Pd-catalyzed aryldifluoromethylation of aryl-halides on @angew_chem! Congratulations Kyoungmin, @FluoridaMan, Eric, and John! doi.org/10.1002/anie.2022082ā¦
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Check out this CE&N article on our recent @Nature paper in collaboration with @Keasling_Lab and the Clark Lab! cen.acs.org/synthesis/Carbenā¦
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Check out our latest @J_A_C_S paper where we demonstrate a Cu-mediated cyanodifluoromethylation of aryl halides. Congrats @woop_jer_it_is, Tommaso, Trevor, Sophie, and @EnamineLtd! pubs.acs.org/doi/10.1021/jacā¦
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Check out our new borylation preprint done in collaboration with @EnamineLtd! chemrxiv.org/engage/chemrxivā¦
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Our new report in @J_A_C_S shows how carefully selected organic reactions can access an array of functional polyethylenes from a common intermediate. These materials have enhanced properties and improved methods for recovery! pubs.acs.org/doi/10.1021/jacā¦ @GroupHelms @MessersmithLab
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Check out Yumeng and Jason's paper on asymmetric hydroamination of internal olefins, out in Nature!
nature.com/articles/s41586-0ā¦
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Check out our new paper on undirected alkyl C-H borylation, now with limiting substrate! Congrats to Raphael, Bo and Co.
In @ScienceMagazine this week, @HartwigGroup reports methylphenanthroline is the key to unlock rapid alkyl C-H borylation science.sciencemag.org/conteā¦
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Metal hydride reductions join the growing family of reactions catalyzed by metalloenzymes! Check out this paper on abiotic reactivity, achieved on a carbonic anhydrase platform.
Kudos to @Jipengfeium, Jeeyoung, and Yang! nature.com/articles/s41557-0ā¦
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Check our new paper on a chemoenzymatic hydroaminomethylation method to selectively form linear primary amines! Congrats to Jenna @jenna_manske, Jeremy @woop_jer_it_is, and Brandon! pubs.acs.org/doi/10.1021/acsā¦
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Huge congratulations to our fearless leader John and Prof. Buchwald on their tireless dedication to advancing organometallic chemistry! jpost.com//Israel-News/Wolf-ā¦
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Check out our latest mechanistic study in @NatureCatalysis where we peer into cyclopropanation catalyzed by an iridium-containing cytochromeāfeaturing a unique porphyrin flipping mechanism! Congrats Brandon! doi.org/10.1038/s41929-022-0ā¦
ALT This graphic contains an pictorial example of porphyrin flipping mechanism within an enzyme scaffold, producing a large induction period to carbene formation
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After two days of scanning (over shifts), all the chemicals in the group have been inventoried! Here's hoping everyone can find their desired chemical in 2021.
Shoutout to the @SarpongGroup for lending us these shiny new scanners!
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Nice writeup! Congratulations again John!
John Hartwig: The 2019 Wolf Prize and the importance of fundamental research in the discovery of synthetic catalysts. chemistry.berkeley.edu/news/ā¦ @HartwigGroup @UCBerkeley
ALT John Hartwig, UC Berkeley College of Chemistry
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Check out our latest work in @J_A_C_S where we selectively functionalize internal alkenes by remote hydroamination via fine tuning the NāH donor's electronics and developing a new DIP-Ad-SEGPHOS ligand. Congrats Jason, Haoyu, @TheCraigDay, and @yumengxi8! doi.org/10.1021/jacs.2c13054
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Check out our latest @ACSPublications Accounts of Chemical Research on #hydroamination of activated to unactivated alkenes catalyzed by late transition-metal complexes. Congrats Jason! pubs.acs.org/doi/10.1021/acsā¦
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Caleb's studies on the mechanism of the iridium-catalyzed silylation of C-H bonds was just accepted in JACS!
Read about how more hindered ligands form less hindered and more reactive complexes.
pubs.acs.org/doi/10.1021/jacā¦
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Can a computer predict the site of borylation better than an expert can? Our new model predicted the major product correctly 100% of the time on pharmaceutical intermediates with better accuracy than any experts we compared to. Try it out! @AmerChemSociety pubs.acs.org/doi/full/10.102ā¦
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Congratulations John and Prof. Buchwald!! What great news !
journals.elsevier.com/tetrahā¦
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Congratulations Zhitao!! This project has been a long time in the works; well deserved and impressive chemistry! @NatureChemistry nature.com/articles/s41557-0ā¦
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Check out our latest paper! Congrats @isaac_yu_, Kyan, and everyone!
2-Aminophenanthroline Ligands Enable Mild, Undirected, Iridium-Catalyzed Borylation of Alkyl CāH Bonds | JACS @HartwigGroup @UCB_Chemistry @UCBerkeley @TotalSyntheses @Boron_Chemistry #AminoPhenanthroline #Ir #Borylation #AlkylCH #CHFunctionalization pubs.acs.org/doi/10.1021/jacā¦
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Trevor and co's paper on the desymmetrization of difluoromethylene groups has just been accepted by Nature. Congrats Trevor, Johnathan, Willi, Nicholas, and Natalie!
nature.com/articles/s41586-0ā¦
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John and others of the @angew_chem International Advisory Board have resigned.
Eric and other members of the @angew_chem International Advisory Board have resigned their positions on the Board.
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Congratulations Masha! šš„³š We canāt wait to see the awesome research youāll be doing!
We are so excited to welcome our newest Assistant Professor, Dr. Masha Elkin, to the Department of Chemistry Faculty this July! Dr. Elkin joins us from the @HartwigGroup at @UCBerkeley.
chemistry.mit.edu/chemistry-ā¦
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John has been highlighted as one of the Citation Laureates 2020 in Chemistry!
clarivate.com/webofsciencegrā¦
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Check out Yehao's study on Ni-catalyzed C-H oxidation! Congrats! pubs.acs.org/doi/10.1021/jacā¦
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Super excited to welcome our new first years Madeline, Gloria, Clyde and Abbie! @UCB_Chemistry @UCBerkeley
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Congrats to Alex!
See his new paper on improving the selectivity of C-H chlorination!
onlinelibrary.wiley.com/doi/ā¦
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Check out our new method for the enantioselective hydroamination of unactivated alkenes! Congrats to Jason and co.
cell.com/chem/fulltext/S2451ā¦
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Weāre thrilled to share that our team at the University of California, Berkeley was selected through @ARPAE's Vision OPEN 2024 program, which creates groundbreaking solutions across the energy spectrum.
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Checkout Craig, Alex, and co's new paper on the mechanism of Iron-Catalyzed C-H azidation, now out in JACS! pubs.acs.org/doi/abs/10.1021ā¦
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Check out this new paper on Pd-catalyzed oxidation of Ī²-C-H bonds of alkylamines from the Hartwig group!
Congrats Bo, Ala, and Yehao!
doi.org/10.1021/jacs.0c01629
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Congrats to Yumeng, Bo, and Shayun! Check out their new paper on the hydroboration of disubstituted alkenes, with a new TMG-bisphosphine ligand.
pubs.acs.org/doi/10.1021/jacā¦
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Our student-hosted colloquium in organic chemistry this year was Prof. Abby Doyle! We enjoyed hearing about your work and are excited to speak with you through the rest of the day!
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Hartwig Group (and friends) says goodbye to Max Surke, our visiting scholar from Germany. Good luck with your PhD in the Ackermann Group @aztul cleaving C-H bonds!
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Caleb reveals that the most active catalysts for C-H silylation of arenes fail under traditional reaction set-ups but produce high yields of products when reactions are conducted in open systems. Our 1st @ChemRxiv paper to find a home in @J_A_C_S ! bit.ly/2KV4YyF
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In honor of Black History Month, each member of the Hartwig group presented a brief biography of a black chemist that inspired them. We wanted to do this to educate ourselves and each other about important chemists that may not have been recognized to the extent that their
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Huge congratulations to prior PhD student Dr. Zachary Litman on his work in @nature with cooperative photocatalysis and enzymatic catalysis!
nature.com/articles/s41586-0ā¦
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The Hartwig Group is officially now on twitter! We are excited to join the #RealTimeChem community
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Celebratory lunch at the faculty club in honor of of the Wolf prize award! Great talks by John and Bob Bergman about the history of the lab and some fun times
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Congratulations Yang and the rest of the BioBay on your recent paper on site-selective C-H functionalizations with Ir-containing artificial metalloenzymes (onlinelibrary.wiley.com/doi/ā¦)!!!
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Check this out! Featuring our very own @isaac_yu_ š§Ŗāļø
This week on Synthesis Workshop, Isaac Yu shares his work on catalytic borylation of tertiary CāH bonds in BCPs and BCHs @HartwigGroup with @EnamineLtd and @JanssenEMEA!
Episode: piped.video/Xz9yEr7toQM
@NatureChemistry 2023, 15, 685-693.
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Zhennan and Yang's work in collaboration with @Keasling_Lab is out today!
pubs.acs.org/doi/abs/10.1021ā¦
By the way, Happy New Year everyone!
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š„³ Congrats John!
šššCongratulations to Professor John Hartwig!!
@HartwigGroup He was recently awarded the
Emanuel Merck Lectureship. @merckgroup chemistry.berkeley.edu/news/ā¦
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Take a look at @AdrianT37126577's new paper on direct arylation of arenes with aryl bromides!
Congrats Adrian, Sarah, and Shu!
pubs.acs.org/doi/10.1021/acsā¦
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Zhennan and Brandon's work in collaboration with @Keasling_Lab is finally out in @NatureChemistry !
Check out our new paper in @NatureChemistry with @HartwigGroup where we report an engineered microbial cell expressing a heterologous biosynthetic pathway that produces an unnatural product.
@UCB_Chemistry @aindrilam
doi.org/10.1038/s41557-021-0ā¦
rdcu.be/czzFY
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Check out Steven, Tyler, and Trevor's new paper on Contra-Thermodynamic Olefin Isomerization, out in @ACSCatalysis!
pubs.acs.org/doi/10.1021/acsā¦
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Some good news during strange times.
Congrats Zhennan and Brandon!
Artificial Biosynthetic Pathway for an Unnatural Terpenoid with an Iridiumcontaining P450 by John Hartwig & co-workers
doi.org/10.26434/chemrxiv.11ā¦
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Officially saying goodbye as the Hartwig Group Tweeter!!! Please give a warm welcome to Isaac who is taking over!
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Hello all! In honor of #WomenScienceDay, this week we will be posting some profiles to honor and recognize women alumni from our group! All these new profiles can be found at our website hartwig.cchem.berkeley.edu under "Alumni Profiles" #WomenAndGirlsInScience #RealTimeChem
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Today Prof. Mary Watson (Delaware) gave an amazing talk on Ni-catalyzed cross-couplings with amines and alcohols!
We would like to thank her for taking the time to talk with us too ā she shared insight and truly gave us the pep talk we didn't know we needed.
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It's the first annual Hartwig Group mini-golf open!šļøā³Prizes include a golf ball balled signed by Bob Bergman himself! š„
ALT The Hartwig Group poses for a photo in a mini golf studio.
ALT This photo is a candid shot of group members playing.
ALT The last photo shows a golf ball signed by Robert Bergman.
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Understanding the difference in reactivity for Ir-catalyzed borylation of C-H bonds with different ligands! Congratulations Raphael, Matt, and @AlexBismuto pubs.acs.org/doi/10.1021/jacā¦
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Congrats to Trevor and Jonathan! Defluorination team strikes again: pubs.acs.org/doi/10.1021/acsā¦
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Wishing our amazingly talented administrative assistant Anneke (@jacknravi) a hearty and well deserved congratulations on finishing her degree (pictured w/her favorite professor)! The lab literally could not function without you!
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Congrats @EricKalkman! See his study on diastereomeric Pd-fluoroenolate complexes, out in @J_A_C_S !
Synthesis and characterization of a series of diphosphine-ligated arylpalladium fluoroenolate complexes, including complexes bearing a metal-bound, stereogenic carbon @HartwigGroup pubs.acs.org/doi/10.1021/jacā¦
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Starting this week, the @HartwigGroup is back in lab in shifts as part of the phased opening of @UCB_Chemistry.
Stay safe everyone!
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Amazing talk on cooperative catalysis by Professor Nakao!
John & Dean @Toste_Group having endless questions for the speaker.
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Checkout Shu, Trevor, and co's paper on gem-difluoroallylation, out in ACIE now!
onlinelibrary.wiley.com/doi/ā¦
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At our group meeting proposal session for the total synthesis of Neoabyssomicin D, Makoto and team 1 narrowly snagged the title of "Star Synthesis" and won an espresso break for their group. Sadly, Caleb and group 2 with their "Nicolaou-mimetic" lost points for originality!
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We were happy to get a chance to share our science with Prof. Denmark today and hear about his group's work! @ChemistryUIUC
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Make sure you don't miss out on Zhitao's latest work! Alpha-arylation of free aliphatic carboxylic acids and secondary amides is achieved with a traceless protecting strategy
pubs.acs.org/doi/10.1021/jacā¦
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Another paper on oxidative upcycling of polymers from Liye: selective and mild oxidation of Polyisobutene! Congrats to Liye, Katerina, and Adam!
pubs.acs.org/doi/10.1021/jacā¦
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Itās bittersweet as the group says goodbye to Julia Altarejos Salido, a visiting student from the Universidad de AlcalĆ”. Good luck with the rest of your studies!
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Today for #ShutDownSTEM, our group met in a Zoom meeting to discuss diversity in chemistry and our group. People shared experiences, both good and bad, we looked at the NSF data, and confronted some of our implicit biases.
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Congratulations Karl!!
pubs.acs.org/doi/10.1021/jacā¦
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Is posting pictures of tiny glassware still a thing people do? Pipette bulb shown for scale #RealTimeChem #scaleup
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Congrats to Masha (@NewhouseGroup alum) and Trevor, finalists of the #ReaxysPhDPrize!
elsevier.com/solutions/reaxyā¦
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Bob welcomes Prof Barry Carpenter to Berkeley and introduces the 2017-2018 Robert Bergman Lecture! Bob thanked all his prior students and colleagues who contributed to make this special lecture possible each year! Welcome Prof. Carpenter!
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John talked about polymer recycling for a general audience on Korean radio (Busan English Broadcasting)!
Have a listen at the link below:
befm.or.kr/program/template.ā¦
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Congrats Alex!
Congratulations to current and former PhD students, Steve and Alex (@HartwigGroup), for our latest @J_A_C_S on the modular and diastereoselective synthesis of borylated cyclobutanes (>60 examples) through the difunctionalization of CāC Ļ-bonds: pubs.acs.org/doi/pdf/10.1021ā¦
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Checkout Jason, Chris, and Casey's new paper on ruthenium-catalyzed hydroamination of olefins with stoichiometric substrate!
pubs.acs.org/doi/abs/10.1021ā¦
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Worth a read!
The Buchwald-Hartwig amination is one of the most-used reactions in drug discovery ā this month, we sat down with one of the people behind its development
chemistryworld.com/opinion/jā¦
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Copper mechanisms demystified! Lots of hard work put into this beast of an article! Nice job Ramesh, Andy, Konstantin, Justin, and Marc!
pubs.acs.org/doi/10.1021/jacā¦
#RealTimeChem
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Suggested reading:
African American Women Chemists
by Jeannette Brown
global.oup.com/academic/prodā¦
(also available on Amazon)
Thanks to Masha for the suggestion!
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