They don't want you to know this but you can enroll at ASU for $20 and get a student discount to everything across America. We got a brand new Samsung fridge for $1200

Never been called rich before in my life, THANKS!

Cooking up something new A chrome extension that flags when the item you are looking at contains seed oils

Highest risk factor for Lung Cancer is cooking with Seed Oils wow

Called this in January. When the worlds largest polluter/CO2 producer stops working the environmental impact is crazy. bbc.com/news/world-asia-5169…

Got the course credit. Was told socioeconomic status is a larger driver than diet in the pathogenesis of diabetes which is great.

There's one in Denver

Lol moral courage - his company literally preys on insecure men

your life must be so empty to write this to a stranger.

This is terrifyiing

Someday we'll realise that ultimately the #1 reason startups fail is the founders run out of steam. On a long enough timeline you can figure it out

I think we all need to start leaving bad reviews for this stuff

Your body (fat) is polluted And reducing it dumps pollution in your blood One of my strongest-held beliefs that really kicked off my journey to try and decode obesity was the idea that hunger always exists for a reason. Our bodies are wildly intelligent machines...

this might be my fav new explainer/meme on MVPs and building new products don't build the complex one first - pick the small book problem and just build to get over that ignore the "ideal" solution and iterate until you overcomes the problem

Ray peat reddit seems to all be people who went peaty and got really fat

Is this what drives rebound/relentless hunger in weight loss? For every 2lbs you lose, persistent organic pollutants increase in your blood by 2-4% and remain elevated for over a year they "alter hormonal, immunological, reproductive, and metabolic systems of mammals" "POP are released from adipose tissue during weight loss, enabling blood levels to rise, for many POP by 2–4% per kilogram weight loss. This may lead to a total POP rise of 150–400% following a 40% body weight loss." "blood levels are reported to be continuously elevated after a period of 1 yr or more"

Lol which regulation worked so well that this was prevented

But who will know she stands with Ukraine if she closes it?

Good steal

Why Eating Linoleic Acid (Seed Oils) Is The Primary Driver in Obesity The Endocannabinoid system - explained

yup - institutional health rot i see it everywhere

lol - very rigorous research "I tweeted once to randos and they didn't give me an expert response"

sentiment against people who chose not to vaccinate has been disgusting the moral shaming was never warranted

asuonline.asu.edu/ Took a class for $20

Bought a tiny SAAS for $2500 a year ago based on 3.5x ARR Have made $2200 in 12 months. ARR is now $6000 Valuation should be $21,000 almost 10x We will win.

60% of the Hadza's calories come from honey in some months, but there's no diabetes, obesity or CVD I am increasingly convinced that nobody knows a damn thing about nutrition. Well except maybe me and the Hadza

Magic is real Here is my 2 year old reading

n of 10,000 is misleading It is one company so really n of 1

3rd world

Started reading this last night. Published in 2013 it lays out in immaculate detail how PUFAs are the driver of oxLDL and atherosclerosis I know we knew, but 10 years ago!?

Nocode is the future of software development. I've just watched a listed company spend $500k building something a nocode builder could do in an afternoon

It's been upsetting to see how intellectually dishonest people are just because the president takes issue with the CCP. Meanwhile they continue to commit atrocities that go ignored. Appreciate you raising even if you feel it was a small task.

This tweet, and the attached post have just opened you up to an enormous liability surely.

Not been. Menu includes well sourced heritage items - bison and nixtamalized corn, but most stuff is fried

apparently now I'm an antivaxxer because I don't believe the government should coerce you into health decisions ESPECIALLY when taking no position on weightloss as a society we should be ashamed of ourselves.

Building a startup is insanely hard.

So good for the female founders in the room

I've heard carnivore doctors say that its very hard to store dietary fat and carbs make you fat and Peaty PhDs say it's very hard to make fat from carbs, its dietary fat that makes you fat and like - i'm not saying either side is lying, but they can't both be right

We're British so we like our diet coke warm

I would imagine this is coming soon. Very easy to onshore this if you don't need chinese tech

I bend over backwards to empathize with everyone and am always shocked by how completely angry some people are Like guys - I'm here to give you a hug

You're right

I took a course lol.

no dogs?

Needed this

Absolutely mind blowing review of the state of health influencers' metabolisms

I don't disagree with this in any way. I'm confused - am I not allowed to buy a new freezer after running my 30 year old one into the ground?

BJs live forever matcha is hardcore poisonous when tested independently

Here's my New kid in the USA todo list: Set up gmail address Set up 539 college savings fund Apply for SSN Apply for Passport Add to will Add to benefits Add to credit card Freeze credit report Set up airline mileage accounts

Harper Mai Quinn 7lb 5oz Born today

If your english language country dropdown menu starts with Afghanistan and puts United States and United Kingdom at the bottom I immediately think your product is badly built

not correct.

Can this get a community note @elonmusk jfc

Many such cases My sister just said "I can't explain why but I know you're wrong" And kept feeding it to her ADHD kids

Linoleic acid nukes your microbiome it literally destroys the cell membrane of bacteria

💸

The best we have are from a time where people's base omega status was much better - but these trials rarely ran long enough to see the effect pubmed.ncbi.nlm.nih.gov/2338… pubmed.ncbi.nlm.nih.gov/2707…

This is the weirdest paper to cite Either you’re operating in very bad faith, or have no critical and analytical thinking skills

"cute 150-200k" holy santa clause shit

asu email > samsung education offer

I'm amazed she had earned it in the first place

Do you have an idea how unnecessary it is?

Kinda cringe that we're celebrating this as a society

Perplexity has become irreplaceable in my day to day

This is the shitposting I am here for Own it Steph

If you are following a protocol which "doesn't feel right" it would be silly to stick to the rules over how you feel

It can be done in safe ways like - fill your grandkids' 529s pay for annual education/experience passes (museums, tutors etc) Loan money at 0% interest

Would love to see warren respond to this one

Who do you think owns HuffPost, wapo, cnn etc

No wonder kids are so unwell @TuckerGoodrich

And we're LIVE A chrome extension that flags seed oils in the product you are looking at (link in next comment)

Fumes from "cooking"/seed oils. The mechanism will be - Seed oils > linoleic acid peroxidation > inhaling things like HNE. It is already well documented that 1 serving of mcdonalds fries has a higher carcinogen load than smoking a pack of cigarettes - that only happens in a PUFA environment

I've interviewed 8 teams that build on @bubble in the past 48 hours. I have never met such an evangelical, competent and excited group of builders. I feel like Bubble is the most unknown secret in tech. This name is going to be in every tech companies mouth by decade end.

between corn, and 1000 drug recalls a year I don't understand why people rely on the FDA

also - Faang engineers are nicely branded but not exactly inspiring

have you seen the inside of a big company?

I don't know what to say. I weighed in at the lowest weight in 2 months this morning (161.4) after 7 days of potassium maxxing. Need to extend this experiment another week. My working theories are: Potassium plays a key roll in energy mobilization - by maxxing, my body can take energy from stores rather than down regulate metabolism Potassium plays a key roll in detoxification - as I'm slightly out of energy balance, Potassium helps transport released toxins (inc pufa) out of my system (and kidneys) thus reducing my body fighting back.

Counting calories is such a stupid idea when you really think about it. I know so many people that go on a little diet and end up with completely disordered eating. We were all sold a lie.

A response to a response to A Chemical Hunger Preface: People in the west are getting fatter and fatter everyday. Whilst billions of dollars are spent researching the space, very few look at the actual root cause. Over and over again people cite Calories in Calories out, but fundamentally CICO is a resulting observation and not an actual cause. The question is this - what CAUSES people to spontaneously overeat for years on end. It wasn’t an issue for a millennia up until the past 100 years An anonymous research group that goes by the name Slime Mold Time Mold (SMTM) @mold_time , wrote a long set of papers on this in 2021 called “A chemical hunger” which broke obesity down into 8 mysteries and made a very strong case that the increased amount of Lithium in our environment is what may be driving obesity or dis-regulated hunger. A small note here to say, Obesity is a complex and barely understood issue. This post does not seek to blame or demonize people suffering with obesity. In the past month I have spoken to hundreds of them/you and will be publishing my best understanding of causes and solutions shortly. If you feel attacked or want to discuss any of this please reach out, I am all ears. Another internet anon, nutrition nerd and independent researcher that goes by the name of @exfatloss (E150) published a piece arguing that seed oils explains 7 of the 8 mysteries to which SMTM responded that there are now actually 10 mysteries. This post is my attempt to explain the 3 unanswered mysteries through the Seed oil (and really linoleic acid) lens. I highly recommend reading the original work: slimemoldtimemold.com/2021/0… Exfat150’s response: exfatloss.com/p/seed-oils-ex… And their response first: slimemoldtimemold.com/2023/0… My response Mystery 7 - Altitude ​ This is the original Mystery E150 couldn’t make fit, and is extra amusing to me because, well, I live in Colorado. If you look at the map - our great state has the lowest incidence of Obesity at a county level. Altitude may play a role, but there are enough paradoxes that it cannot wholly explain what is going on. This feeds into my point about complexity above. This map is the result of several compounding things. SMTM actually goes on in their rebuttal to say “The mountain ranges definitely stand out as less obese, but the distribution of obesity is not actually a great match with altitude. Low-lying areas of Florida, Massachusetts, and California, for example, also have very low rates of obesity. “ Which is why they prefer the length of watershed = more lithium in the water as the core arguments. Here’s some issues I take with that Irrigation in Southern California is fed almost exclusively by water from the Colorado river which, you guessed it, gets it start in Colorado. So does Arizona and Nevada (especially Las Vegas). If the watershed argument were valid, you would expect to see obesity rates change somewhat linearly along the Colorado river rather than spike in the metropolitan areas. At altitude you end up producing more red blood cells, that also live longer to compensate for the lower oxygen. This is why the kpi for diabetes HbA1c can be skewed up here. Our cells last longer and thus can accumulate more glycation - artificially increasing the number. We also know that lipid peroxidation products from eating seed oils are the number one source for oxidative stress in the human body in a modern context, and oxidative stress will reduce your bodies ability to produce energy from the substrate in your system. This paper showed that at higher altitudes "workers had lower levels of oxidative stress, and higher levels of antioxidant capacity, iron supply, and hemoglobin concentration as compared with altitude-naïve individuals" journals.physiology.org/doi/… So if we are eating seed oils up here (I can assure you those around me are), our environment is such that we can fight off more of the negative side effects naturally. The altitude map also gets really really weird when you break it down by race. Race is a real genetic factor that plays a role in cellular metabolism and how our bodies respond to the food we feed them. I for example have the ALDH2 mutation which causes “Asian glow”, and also means my body does not detoxify seed oil lipid peroxidation products very well. This gene makes east asians highly susceptible to seed oil damage (NAFLD, diabetes, cancer) whilst staying relatively lean, but in Caucasians it increases the risk of these illnesses whilst their fat cells grow. (researchsquare.com/article/r…) We also know that those with African originating genes can handle saturated fat much better (palm oil), than unsaturated fats (the !Kung fail glucose tolerance tests when Mongongo nuts are in season and become the diet staple which are high in PUFA). This is reflected in obesity to diabetes risk across races. These race differences and supposed altitude differences may also point to cultural differences. ​In SMTM rebuttal they say "We can’t see any reason why Charleston, WV would be eating more seed oils than Bridgeport, CT" But there is a pretty clear cultural difference here. Rural WV is much poorer than Connecticut but also - a northern coastal town would likely have culture of fresh seafood as opposed to a gloomy mining town where fried food would likely run rife. When I see the map and the Southern states have much higher rates of obesity, I immediately see a map of fried food culture. Fried food exists in Colorado, sure, but culturally it is a fairly gross thing to eat. I think this compounds, when you eat a lot of seed oils your sense of taste gets rewired, you can’t smell rancid oils and strong artificial flavors are usually needed to make statements in food more often (my anecdote). An additional anecdote - I also found this when I lived in Silicon Valley. Fried foods were not common and our increased incomes gave us access to better ingredients and healthier dining out options. (Maybe there’s something there, let’s read on). Charleston, SC however, a city I have visited over 20 times has a culture of fried food that I have never wrapped my head around. Fried shrimp, fried potatoes, fried fish etc. All this food is eaten and even celebrated. Another anecdote of mine is my trip to Alaska, my tour guide ran a salmon fishing boat as a side hustle, and despite hauling +100,000lbs of salmon out of the water every year, she laughingly told me her and her son like to mostly eat code red Mountain Dew and Flaming Hot Cheetos. They were both very obese. With modernization, access to Walmart, money and generations who didn’t eat this fiat food being long gone, Alaskans binge in seed oil rich foods, ignore the fresh stuff on their doorsteps and in turn suffer from higher rates of obesity that land locked Colorado. (side note: A discussion for another day is how Salmon is actually not great and is high in PUFA anyway) ​To be seed oil free you have to be militant with what you eat on a daily basis, that is how far they have infiltrated almost every food item in our lives here (in the US). The easiest way to load up on them is to eat fast food. Eating out is better but not good, I can assure you pretty much everyone is cooking with soybean oil, but for this final piece lets focus on fast food/junk food. What happens if we map the states with the highest fast food consumption to the obesity map? Some interesting trends appear with no slam dunks but something that does stand out to me is the difference in the income of these states. ​Whilst Colorado is this original glaring bastion, I know that Oklahoma, Nebraska, Kansas and Alabama all have much lower incomes. So maybe an additional complication to add to the mix is income. It’s all well and good as a Coloradan thinking our culture and elevation makes us superior but therein may lie the privilege that comes with higher incomes, the same goes for Silicon Valley. At higher incomes you have greater access to fresh food, restaurants that cook better food, expensive lesiurely activieis like Skiing & biking. This is proven in this study: The proportion of obese individuals in industrialized nations now correlates inversely with median household income - ​nature.com/articles/s41599-0… "​In 2015, the correlation between ln (income) and obesity rate across all 50 states was r = −0.697 [−0.816, −0.522], which is highly significant (p < 0.00001)" Mystery 9 - International variation In SMTM rebuttal to E150 they add that there are now 2 more mysteries. The first of which is international variation. This is capped off with "​if Kuwait loves seed oils in a way that Pakistan doesn’t, well, we haven’t heard about it" I’m here to tell you about it. ​Having visited Qatar, Bahrain & UAE I can tell you anecdotally that in the rich Arab nations, the citizens want westernized culture on steroids when they can afford it. ​Head in to the Dubai mall and you’ll find tables and tables of emiraty families gorging on Burger King and KFC. I think this phenomenon developed for a number of reasons, but what is true that cooking for yourself is seen as servant work, and the enlightened thing to do is eat take out/fast food. I remember vividly, being uncomfortable that getting KFC or another deep fried meal was a totally normal thing for my western friends' family to do for dinner in Abu Dhabi. As for those two countries - in 2021 Kuwait consumed 228kg of vegetable oils (marketing term for seed oils) per capita and Pakistan consumed 34kg per capita. (Data Source: Food and Agriculture Organization of the United Nations 2023) I found the UN data to be quite wobbly, but from a trend line perspective it clearly shows a difference. Mystery 10 - variation of obesity rates between professions ​​The final mystery that was added was that there is a variation in obesity rates across professions. "do we really think that mechanics consume that much more canola oil than lawyers?" And the answer is yes. Another Anecdote from me. In my career I have both worked in construction and in consulting (+3 year stint in both). Funny thing about the eating habits of my colleagues in both professions, they were totally different. In construction I was made fun of for trying to make and eat a chicken salad. In consulting, I was made fun of for suggesting Burger King as a legit lunch option. The reasons for this are again complicated I believe but there is very clearly different dietary patterns between the two. Some reasons - Mechanics/construction workers are likely paid by the hour and away from a set base, food options need to be quickly entertaining, tasty, quick - This is food trucks, grill top canteens, fried foods, foods in boxes. Professionals are likely paid more, by salary and work in constant environments. They will seek out healthier options that won’t slow them down or give brain fog, and can afford to buy more expensive ingredients. Many have the time & luxury to bring food from home. I guarantee you seed oil consumption across professions varies wildly. Beyond the mysteries - ​It doesn’t fit the case studies SMTM finishes off their position with the conclusion that the paradoxical case studies we have don’t fit the seed oil hypothesis. I actually think they might but my position raises many more questions than answers. Krinn & M I too have anecdotally mega dosed potassium and seen weight loss. And as Krinn describes, this isn’t through a reduction in appetite. I was eating more than normal actually. We know that PUFA's inhibit glucose metabolism (jci.org/articles/view/25256), and that when our bodies cannot produce more cellular energy, additional exercise steals energy from internal systems. We also know that stored PUFA, when released can create serious stress and inflammation in the body (ncbi.nlm.nih.gov/pmc/article…). My theory is that mega dosing potassium either: Restores the potassium-sodium pump and allows you to produce more energy from your existing energy stores. Helps blunt the negative effects of seed oil metabolites somehow "M was eating more potatoes but still consuming seed oils" Well the best seed oil detoxification protocols call for accelerating the saturation of your body fat. Animals can only produce saturated fat naturally, and this is done in de novo lipogenesis. When we eat any level of carbohydrate, this happens. Increasing potato consumption would create new saturated fat on the body and decrease stored PUFA. Pima Indians Yeah I have no idea. Maybe Lithium? Further down the river from the Pima, obesity rates are lower. Fattest and Leanest Places in America See Mystery 7 and wealth & culture. The Mechanism I’m not willing to discount the Lithium hypothesis, hell I think it could be a major contributor just not the major contributor. When we test out a substance to see if it is poisonous we typically test it in mice, then test it in humans then move forward with it. So here’s the kicker - in mouse models, Seed oils are disastrous and clearly have a compounding effect over time by impacting epigenetics. There are several other animal models this shows up in too: pubmed.ncbi.nlm.nih.gov/2136… nature.com/articles/srep0134… pubmed.ncbi.nlm.nih.gov/3414… pubmed.ncbi.nlm.nih.gov/1111… academic.oup.com/endo/articl… lipidworld.biomedcentral.com… nature.com/articles/s41598-0… ​pubmed.ncbi.nlm.nih.gov/8463… But Lithium in mouse models looks benign if not beneficial: sciencedirect.com/science/ar… ncbi.nlm.nih.gov/pmc/article… We should be testing lithium doses in humans and seeing what happens. Hunger signals at their core, are complex but seem to exist to get humans to eat the right nutrients (typically energy) as needed. Seed oils have been shown to work negatively on both sides of this equation. They both lower your energy metabolism through many pathways including inhibiting your ability to turn glucose/sugar into energy. And they make you hungrier by messing with your endocannabinoid system in exactly the same way that the munchies do when you ingest Marijuana. (pubmed.ncbi.nlm.nih.gov/3740…) Hmmm eating something that makes you hungrier and lowers your energy expenditure at the same time….sounds like a chemical hunger. And there ends my first foray into scientific writing. Again, obesity is complex. I actually think Lithium/heavy metals might play a role. Watch this space for further thoughts on causes and solutions.

Big @SeedOilDsrspctr energy

Living in Colorado is like living in a desktop background

Mike has no tan

99% of excellence is maintaining work through the boring bits.

Number of issues but I'll mention to obvious ones: No mention of n3n6 balance "Just don't use rancid oil" - but it goes rancid on contact with light or air or the human body....

same but my roomba, nest, simplisafe and ring how did I become this meme

You used this one - ea.asu.edu/ ?

It was sick. I just wish there was more health/medicine classes

Excited to announce that after countless LOIs and some bad faith negotiators I have finally bought my first SAAS! Thanks to @microacquire for the deal flow and @EyalToledano for the help!

Things I'm interested in: Being a better me Freedom & Independence Local enrichment Problem solving Diverse lived experiences Principled thinking Things I'm not interested in: Twitter's version of "what's happening" Here's my journey so far 👇👇👇

I live in a destination neighborhood and I hate it

This dude used to have a bmi of 30 GLP-1 + TRT has radically changed his life. HOWEVER - he knows the drugs are wearing off and he keeps upping the dose. When he tries to come off the food noise and ravenous hunger comes back almost immediately. Where does that leave him? Well that leaves him with total panic/anxiety about the future. He discussed the idea of taking 3,4,5x the recommended limit to keep it effective. He said he'd take any illegal drug available to never get food noise ever again. We discussed the work I've been doing and how I don't think it is fair to make any recommendations yet. After a back and forth he's convinced me to summarize what I think I know - it's all non invasive and if I can stop someone from killing themselves with drugs I will totally do it. So now I think it is only fair to share what I said to him, with you Right now key research has a few smells: As your fat cells expand - the blood vessels to and around them die. After you lose fat you need to re-vascularize. Ideas I have are massage where fat was, and bpc157. As your fat cells shrink they tear away from the ECM and become unstable, this will ramp up inflammatory response and hunger to gain fat so they become stable. You can remodel the ECM in cold plunge, sub 50F, 5 mins max, no more than every other day. Key hunger hormones are made by your commensal bacteria in the gut - need to make sure you have them (probiotics), and are feeding them i.e. red phenol foods, resistant starches etc Lipophilic chemicals we're exposed to our entire lives are sequestered into fat cells to protect your organs if your detox pathways are over loaded. As we lose fat and these get put back into circulation, our bodies signal to increase hunger, slow metabolism and gain fat to store them again. Can sequester them through deep sweat (sauna), dietary binders (charcoal/lecithin) and deep lipolysis (niacin rebound) There's more but it's too squishy to share with anyone. Have at it.

pay your dues

Less than 1,000,000,000 followers ?? Reply with your name, give a reason why to follow you. Let's goooooooo 🚀

Had a great call with another VC funded company looking to build on @bubble today It’s happening folks. Huge ROI for going no code. They we’re concerned VCs would avoid - Hell, funds should be encouraging this move!

I got called a bigot for posting this out earlier

Just finished Generative Energy Was surprised tbh that Ray was so anti beta-carotene I feel like no one talks about it.

Painfully true

Good for you Kyle. You got balls asking tough questions.