Professor @UCSF. Molecular/cellular mechanisms of neurodegeneration. Functional Genomics. Diversity & Inclusion. 🏳️🌈 he/him. kampmann on bsky.social
San Francisco, CA
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I'm no longer actively using Twitter/X. Follow me on blue sky: bsky.app/profile/kampmann.bs…
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Came into the lab today for the first time in quite a while, and found that our lab bays are now all named after strong women! ♥️ my lab. #WomenInSTEM @KampmannLab
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Our paper “Genome-wide CRISPRi/a screens in human neurons link lysosomal failure to ferroptosis“ is finally out in @NatureNeuro today! First genome-wide CRISPRi and CRISPRa screen in human neurons, and introducing the @CRISPRbrain data commons. (1/4) nature.com/articles/s41593-0…
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How do human mitochondria signal stress to the rest of the cell? Our paper is now out in @nature, led by postdoc
@XiaoyanGuo99 with contributions from @kampmannlab @gio_av, @blueboytrl, and our collaborator labs @UCSF Correia, @apwiita & @UCBerkeley Xu! nature.com/articles/s41586-0…
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Yay - Our paper is out in @NatureNeuro today:
A #CRISPR i/a platform in iPSC-derived human #microglia uncovers regulators of disease states.
Great collaboration with @LiGanLab, led by @KampmannLab @DraegerNina & @sydsat and @LiGanLab Cindy Huang.
(1/3) nature.com/articles/s41593-0…
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My lab is funded by @cziscience & @czbiohub, awesome organizations whose values I share. Many CZI-funded scientists are concerned about the spread of misinformation & incendiary statements on @Facebook. We wrote an open letter to Mark Zuckerberg:
washingtonpost.com/technolog…
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I'm humbled to accept the Rainwater Prize for Innovative Early Career Scientist on behalf of my entire lab @UCSF @KampmannLab.
I am very grateful to @RCFNeuro and everyone in the Tau Consortium for their support, collegiality and friendship!
Congratulations Dr. Martin Kampmann @MartinUCSF for winning the 2022 Rainwater Prize for Innovative Early Career Scientists! #Tau2022
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Excited that our work, led by @KunLeng2, is out today in @NatureNeuro today:
CRISPRi screens in human iPSC-derived #astrocytes elucidate regulators of distinct inflammatory reactive states
nature.com/articles/s41593-0…
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Excited to share this review on one of my favorite biological problems:
Selective vulnerability in neurodegenerative disease, and how recent technologies are yielding new insights into the underlying mechanisms.
Out in @NatRevNeurosci today!
nature.com/articles/s41583-0…
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Are you interested in "skipping the postdoc" and starting your independent lab in biomedical research as a fellow?
Check out the @UCSF Sandler Fellows Program!
Nominations are due 1/10/2025 - more info below.
fellows.ucsf.edu/
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Excited to launch @CRISPRbrain today: Data commons for functional genomics screens in differentiated human cell types. Great team effort with @KampmannLab @blueboytrl and @DataTecnica @actuallyHadi @FarazFaghri @mike_nalls. Check it out:
crisprbrain.org/
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I'm excited to share that I was named a Zenith Fellow by the Alzheimer's Association this year.
Very grateful for the longstanding support my trainees and I have received from the @alzassociation to do high-risk, high-reward research.
#endalz
alz.org/zenith_society/fello…
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Which neurons are selectively vulnerable to #Alzheimers disease?
Our snRNA-Seq study is out today in @NatureNeuro!
Wonderful collaboration with @grinberg_t lab, @UCSFmac, @czbiohub, U São Paulo, led by @KunLeng2 & @EmmyLiTweets in the @KampmannLab.
tinyurl.com/y4nkzyv3
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Of mice and men... Microglia from human Alzheimer's patients do NOT show the "disease-associated microglia" signature described in Alzheimer's mouse models biorxiv.org/content/10.1101/…
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Celebrating the happy news of my promotion to @UCSF Associate Professor with my wonderful lab. Thank you all for your incredible enthusiasm, smart ideas, and perseverance ❤️❤️❤️ #kampmannlabproud
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Our CRISPRi screening platform for iPSC-derived neurons came out in @NeuroCellPress today and the beautiful artwork by Connor Ludwig was chosen for the cover: Neurons forming a volcano plot (the graph we use to show the results from a genome-wide screen) cell.com/neuron/fulltext/S08…
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My lab threw me a surprise birthday party! 🥳 - I really have the best lab ♥️♥️♥️. Thank you @KampmannLab!
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Excited to share our preprint “CRISPRi screens in human astrocytes elucidate regulators of distinct inflammatory reactive states”
Led by @KampmannLab @KunLeng2, great collaboration with @LippmannLabVU @schrag_matthew Steve Fancy @UllianErik @yezhangyezhang
biorxiv.org/content/10.1101/…
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Thrilled to share our preprint "A CRISPRi/a platform in iPSC-derived #microglia uncovers regulators of disease states"!Collaboration with @LiGanLab, led by @KampmannLab @DraegerNina & @sydsat and @LiGanLab Cindy Huang
1/3 biorxiv.org/content/10.1101/…
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Interested in CRISPRi in iPSCs and derived cell types? Together with @AllenInstitute & @WardLab_NIH, we generated a highly characterized, publicly available line. Big thanks to @KunLeng2, @DraegerNina, Olivia Teter, @sydsat & others in the @kampmannlab!
tinyurl.com/y6fgqvnj
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Tenure-track faculty search of the @Ucsf_Biochem Department is open for applications!
We are looking for creative, innovative scientists asking fundamental questions in any area of biology.
Join our vibrant, collaborative, and supportive community!
aprecruit.ucsf.edu/JPF04089
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CRISPR-based functional genomics for neurological disease - out today in @NatRevNeurol. A summary of the state of the field, and very much also a white paper for future directions! Looking forward to your feedback! nature.com/articles/s41582-0…
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Tenure-track faculty search of the @Ucsf_Biochem
Department is open for applications!
We are looking for creative, innovative scientists asking fundamental questions in any area of biology.
Join our vibrant, collaborative, and supportive community!
aprecruit.ucsf.edu/JPF04637
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Watch tau fibrils (red) enter cells and trigger aggregation of previously soluble tau there (green) - from our new paper in @jbiolchem jbc.org/content/early/2019/1…
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Excited to share our new preprint!
In research led by @Brendan__Rooney & @KunLeng2 in the @KampmannLab, we found that in inflammatory astrocytes, mTOR signaling causes lysosomes to be remodeled, deacidified and exocytosed, causing neurotoxicity.
(1/2)
biorxiv.org/content/10.1101/…
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I feel so lucky to have such an awesome lab!
Thank you for the birthday surprise, @KampmannLab! 🎂🥰
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I'm thrilled to be a scientific co-founder of Montara (montaratx.com) - to develop better therapies for neurological diseases.
Building on tech from @kevansf @UCSF, our BrainOnly platform can drug targets in the brain while blocking side effects elsewhere.
(1/3)
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Passionate about both research and #DEI?
Applications just opened for this tenure track faculty search across @UCSF basic science departments, in all areas of fundamental biomedical research.
Join our vibrant, collaborative, supportive community!
aprecruit.ucsf.edu/JPF04050
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The @kampmannlab statement of our Mission and Values is now online. We developed it as a lab, and it is a living document. We will discuss every year at our lab retreat specific ways in which we can meet our goals & live up to our values. #kampmannlabproud
kampmannlab.ucsf.edu/mission…
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Excited to share our new paper:
mTOR activation induces endolysosomal remodeling and nonclassical secretion of IL-32 via exosomes in inflammatory reactive astrocytes
Project led by @KunLeng2 & @Brendan__Rooney. jneuroinflammation.biomedcen…
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Excited about this collaboration with @GeschwindLab (Yoni Cooper):
Pioneering use of CRISPRi in neurons/glia to pinpoint cell type-specific targets of neurodegeneration-associated variants!
@KampmannLab contributors: @noamteyssier @DraegerNina @sydsat
science.org/doi/10.1126/scie…
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Excited to share our new preprint describing a highly scalable #CRISPR screening platform based on neuronal activity.
biorxiv.org/content/10.1101/…
Read more below from @scboggess04, who led this project:
Have you ever wanted to profile how a molecular pathway affects neuronal activity, but didn't know where to start?
I'm excited to share "A Massively Parallel CRISPR-Based Screening Platform for Modifiers of Neuronal Activity" 1/ biorxiv.org/content/10.1101/…
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Tenure-track faculty search of the
@Ucsf_Biochem Department is open for applications!
We are looking for creative, innovative scientists asking fundamental questions in any area of biology.
Join our vibrant, collaborative, and supportive community!
aprecruit.ucsf.edu/JPF05209
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Are you a senior graduate student who is ready to launch their own lab in a supportive, collaborative environment?
Check out the @UCSF Sandler Fellows Program.
Nomination deadline: January 13, 2023
fellows.ucsf.edu/
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New @AllenInstitute Cell Science Junior Fellows Program launches today. Honored and excited to be an inaugural fellow together with @davidvanvalen and @JohSchoeneberg! alleninstitute.org/what-we-d…
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Which neurons are most vulnerable to
#Alzheimers disease? Check out our snRNA-Seq
study, led by @KunLeng2 & @EmmyLiTweets in
the @KampmannLab in collaboration with
@grinberg_t, @UCSFmac, @czbiohub &
University of São Paulo 1/3 biorxiv.org/content/10.1101/…
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Very moved to receive an "Excellence in Graduate Student Mentoring Award" from the @UCSF Biomedical Sciences Graduate program, along with Anita Sil, Eric Huang and Matt Spitzer. Based on the nomination from students and postdocs - thank you @KampmannLab ❤️
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Excited to share our new preprint:
CRISPRi-based screens in iAssembloids to elucidate neuron-glia interactions
biorxiv.org/content/10.1101/…
Project led by @KampmannLab student @EmmyLiTweets, check out her tweetorial here:
It’s alive on BioRxiv! Super excited to present our paper on CRISPRi-based screens in 3D neuron-astrocyte-microglia co-culture (iAssembloids) to examine neuron-glia interactions.
Description of this work in the thread below! Too many words! (1/8)
biorxiv.org/content/10.1101/…
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CRISPRoff epigenome editing - exciting work led by
@jamesknunez in the @JswLab & @LukeGilbertSF labs. Happy that we could contribute to establishing CRISPRoff in human iPSC-derived neurons.
cell.com/cell/fulltext/S0092…
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Congratulations again @DJuliusSF!!! Thank you for an inspiring speech about basic research in academia, and a celebration with - of course - lots of hot peppers!!! 🌶️🌶️🌶️🍾
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Honored to receive the @arcinstitute Ignite Award.
Congratulations to all awardees! 🎉🎉🎉
Looking forward to interactions with the innovative @arcinstitute community.
🧠At Arc, we believe great science happens when creative minds can pursue their boldest ideas.
Today, we welcome new researchers to the Arc community to conduct curiosity-driven, collaborative research into complex diseases—from cancer to conditions like autoimmune dysfunction.
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Deep mutational scanning of alpha-synuclein under different stress conditions - excited to share the preprint resulting from our project-based class for first-year @ucsf @ucsfipqb Biophysics & Bioinformatics PhD students: biorxiv.org/content/10.1101/…
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Deep mutational scanning of alpha-synuclein under different stresses - results from our project-based class for first-year @ucsf @ucsfipqb Biophysics & Bioinformatics PhD students, with key leadership from @rnewberry17: now accepted at @ChemicalBiology! pubs.acs.org/doi/full/10.102…
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Scientists ID Brain Cells Most Vulnerable to Alzheimer’s Disease.
Great news feature by @ucsf @lore_nick about our paper that came out today in @NatureNeuro.
ucsf.edu/news/2021/01/419501…
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Congratulations to @kampmannlab postdoc Avi Samelson @asamelson1 for receiving an @NIH @NIHAging K99/R00 Award for his research on mechanisms driving disease states of #tau in neurodegeneration.
Very excited for the research of the future Samelson Lab!
🎉🎉🎉
#kampmannlabproud
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Interested in joining the @KampmannLab @UCSF as a research associate? Great opportunity to gain research experience before applying to grad school in a fun, diverse, supportive environment. please RT - thanks! sjobs.brassring.com/tgwebhos…
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Excited to co-direct the Tau Center Without Walls @tauCWOW with Alison Goate @SinaiBrain and @GeschwindLab, working with awesome colleagues @dlswaney @grinberg_t @timschang @TheBiocheminist and wonderful trainees!
Projects led by our PIs will use multiomics & functional genomics #CRISPR screens to understand molecular & cellular differences in gene expression & cell function due to H1/H2 haplotype inversion leading to new therapeutic targets for treating tauopathies geschwindlab.org/cwow/
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Congratulations Dr. Stephanie See! So proud of my first graduate student @stephanieksee. Excited for her next adventures in science. Thank you for your contributions to the @KampmannLab!
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Thrilled to present our preprint “Genome-wide CRISPRi/a screens in human neurons link lysosomal failure to ferroptosis”, work led by @blueboytrl in the @kampmannlab @ucsf in collaboration with the Xu lab @UCBerkeley and @DataTecnica. 1/n
biorxiv.org/content/10.1101/…
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Wow, my conference talk was turned into an artist's illustration. Having a great time at the @CEGS_CMAP Mutational Scanning Symposium #varianteffect21
Martin Kampmann on deep mutational scanning to capture disease-relevant protein conformations in neurodegenerative diseases #varianteffect21 @MartinUCSF
ALT Artist Alex Cagan's sketch of Martin Kampmann's talk at the Mutational Scanning Symposium. Dr. Kampmann appears at center in a checkered shirt, surrounded by text highlights of his talk.
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Excited to share our preprint:
#CRISPR i-based screen of #Autism Spectrum Disorder risk genes in #microglia uncovers roles of ADNP in microglia endocytosis and uptake of synaptic material
biorxiv.org/content/10.1101/…
Read more from first author @OMTeter below:
I am excited to share our work in which we conducted a CRISPRi-based screen to assess 102 Autism Spectrum Disorder (ASD) risk genes in microglial uptake of synaptic material! (1/7)
biorxiv.org/content/10.1101/…
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Excited to share our preprint:
Scalable, cell type-selective in vivo AAV-based #CRISPR screens in mice
biorxiv.org/content/10.1101/…
Project led by @biswaramani, @IVLRose, @its_a_pandemic in the @KampmannLab.
Read Indigo’s tweeprint here:
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The potential of #CRISPR - based functional genomics to discover mechanisms and therapeutic targets in neurodegenerative diseases:
A personal perspective from @AdrianoAguzzi and myself now out in @ScienceMagazine
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Reprogramming the Brain’s Cleaning Crew to Mop Up Alzheimer’s Disease:
New CRISPR Technology Puts Diseased Microglia Back on Track
🧠🧬🧹
News story from @ucsf about our new paper, written for a general audience:
ucsf.edu/news/2022/08/423446…
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Passionate about both research and #DEI?
Applications just opened for this tenure track faculty search across @UCSF basic science departments, in all areas of fundamental biomedical research. Join our vibrant, collaborative, supportive community!
aprecruit.ucsf.edu/JPF04665
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Excited to present our platform for CRISPR-based genetic screens in iPSC-derived neurons. Led by Ruilin Tian (@blueboytrl) and Connor Ludwig in the lab @UCSF and @czbiohub, and a wonderful collaboration with @wardm50 and his team @NIH.
Obtaining human brain tissue is a challenge that has long slowed efforts to research diseases like Alzheimer's. A new study shows how researchers in the lab of @MartinUCSF used a form of CRISPR invented at UCSF to modify human neurons grown in the lab. ucsf.edu/news/2019/08/415166…
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Honored to be part of the first cohort of investigators funded by the Kissick Family Foundation & @MilkenInstitute Frontotemporal Dementia research program.
#endFTD milkeninstitute.org/content-…
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Excited to share our preprint!
#CRISPR screens in iPSC-derived neurons reveal principles of #tau proteostasis
biorxiv.org/content/10.1101/…
Work led by @asamelson1 in the @KampmannLab - read his tweetorial here!
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Image-based pooled whole-genome CRISPRi screening for subcellular phenotypes - Excited to have contributed to this work led by @gil_kanfer in the @LabYoule! rupress.org/jcb/article/220/…
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Physically distanced @KampmannLab celebration for @blueboytrl 's graduation. So nice to see everybody. Congratulations and 恭喜, Dr. Tian! 🍰🍾🎉
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Interested in applying proteomics and functional genomics to uncover molecular mechanisms of brain disease? Two postdoc opportunities in the @KroganLab @UCSF for a collaborative project with the @KampmannLab! Please RT. opportunities.ucsf.edu/conte…
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100% agree with this thread. I think the key to happiness is to not compare yourself to others. But to try to be the best version of yourself - based on your own values, not those of others. And often in ways that may not be publicly visible.
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Titrating gene expression using libraries of systematically attenuated CRISPR guide RNAs nature.com/articles/s41587-0…
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The LRP1 receptor is required for tau spreading in the brain - excited to contribute to this exciting work led by Jenny Rauch in the @KosikLab! nature.com/articles/s41586-0…
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Thank you @alzforum for featuring our preprint, led by @RuilinSUSTech: First genome-wide screens in human neurons, uncovering how dysfunctional lysosomes cause lipofuscin and ferroptosis in neurons. And introducing @CRISPRbrain! alzforum.org/news/research-n…
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#Tau fibrils induce nanoscale membrane damage and nucleate cytosolic tau at lysosomes
Exciting new results from @TheHurleyLab - happy that we could contribute.
biorxiv.org/content/10.1101/…
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Thrilled to share our preprint: In work led by postdoc Xiaoyan Guo @XiaoyanGuo99 in the lab, we discovered how mitochondrial dysfunction is signaled to the integrated stress response in human cells.
biorxiv.org/content/10.1101/…
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.@KampmannLab lunch to celebrate that we managed to do our annual spring cleaning today (only ~6 months late) - yay! #itsapandemic
✨🧽🧼🧹✨🎉😅
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Happy #InternationalDayOfWomenAndGirlsInScience Day!
Shoutout to the fantastic #WomenInScience in the @KampmannLab and everywhere!
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We stayed local for the @KampmannLab retreat this year - had 3 awesome days with potluck, scavenger hunt, games, team building, Angel Island hike, workshopping lab culture and mission, and … tie-dye lab T-shirts! Thanks everyone for your great ideas and contributions. ♥️
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The @KampmannLab is looking for a new Staff Research Associate - great opportunity to gain research experience before applying to graduate school.
Molecular & cellular mechanisms of neurodegeneration.
Please share 🙏😊
Apply here: sjobs.brassring.com/tgwebhos…
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Learning to control microglia using CRISPR
Thank you @NIH for supporting our work
(first author @DraegerNina, collaboration with @LiGanLab)
and for this write-up!
nih.gov/news-events/nih-rese…
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Excited to share our preprint: PIKfyve inhibition blocks endolysosomal escape of α-synuclein fibrils and spread of α-synuclein aggregation.
Common theme for #neurodegeneration and #COVID19!
Project led by the intrepid @stephanieksee (1/2)
biorxiv.org/content/10.1101/…
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Congratulations on your fantastic thesis talk and research, Dr. @KunLeng2! 🍾🍰🎓
Thank you for your many contributions to the @KampmannLab: scientific and social, shaping our stimulating and supportive lab culture!
We will miss you lots. All the best for your next adventures!
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Shoutout to all of our trans and non-binary siblings on today's #TransDayOfVisibility ! #TransRightsAreHumanRights
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Excited that we (@kampmannlab @asamelson1) could contribute to this work by @LiGanLab
(and collaborate with our former summer student @CelesteParraB):
Human iPSC 4R tauopathy model uncovers modifiers of tau propagation
cell.com/cell/fulltext/S0092…
Thrilled to announce our latest work in @CellCellPress! We've developed a new human neuron model that effectively mimics tau aggregate spread in tauopathy. Details here: cell.com/cell/fulltext/S0092… (1/5)
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CRISPR–Cas9 screens reveal regulators of ageing in neural stem cells - exciting work from @BrunetLab nature.com/articles/s41586-0…
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What is the toxic conformation of alpha-synuclein? Our DMS results reveal a long amphipathic helix as the toxic species in yeast. Collaboration with Bill Degrado, led by postdoc Robert Newberry, with contributions from Eric Chow & Jaime Leong. nature.com/articles/s41589-0…
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A long overdue celebration of several @KampmannLab member achievements - now that everyone is back from summer travel!
Details in the next posts.
Congratulations @Synaptikshroff, @biswaramani, Sarah (SK) Kaufman, @MorAlkaslasi, @KunLeng2!
🥂🎉😁
#kampmannlabproud
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Congratulations to the 3 @KampmannLab PhD students who all passed their quals with flying colors this summer:
@parkergrosjean 🎉
@noamteyssier 🎉
@IVLRose 🎉
#kampmannlabproud
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It’s spreading.... Our movie of templated tau aggregation was featured as the Image of the Day in The Scientist Magazine @KampmannLab the-scientist.com/image-of-t…
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Congratulations Sarah Kaufman (joint @KampmannLab & Seeley lab) on transitioning to @USCSF Neurology Assistant Professor, and receiving @_BrightFocus and @alzassociation fellowships for your research on #tau strains and selective vulnerability.
🎉🎉🎉
#kampmannlabproud
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Excited to be part of the new Weill Institute for Neurosciences (WIN!)
Grand opening! The UCSF Joan and Sanford I. Weill Neurosciences Building, made possible by a $185M gift, brings together our world-renowned research and patient care in neurology, neurosurgery, and psychiatry.
ucsf.edu/news/2021/10/421691…
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Haha I love it when I see the latest results from the lab via Twitter in real time. Way to go @Brendan__Rooney!
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Very proud of my lab members who decided at the onset of the pandemic to leverage our tools for COVID research.
Led by @KampmannLab @RuilinSUSTech & @asamelson1, and amazing collaboration with other labs @UCSF and around the world!
Read Tweetorial by @asamelson1 to learn more:
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So proud of my lab. ❤️ We started implementing our action plan for lab shutdown, doing science remotely, and volunteering to provide more #COVID19 tests to the community - and supporting each other during these difficult times! #KampmannLabStrong
Things are bad, but at least we can bring our best friends to our Zoom meetings #COVID19 #staycalm #KampmannLabStrong
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Looking forward to giving a @ScienceMagazine webinar this Wednesday. Hope to see you there!
Join #ScienceWebinars for our next free, educational broadcast
Mining the Mind: CRISPR-based genome-wide screens in iPSC-derived brain-disease models
Live on 3/10 at 12p ET
Register today and submit your questions for our speaker!
fcld.ly/6qo04ns
#webinar #genome #CRISPR
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A proximity-dependent biotinylation map of a human cell: an interactive web resource @gingraslab1 biorxiv.org/content/10.1101/…
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Confronting false discoveries in single-cell differential expression nature.com/articles/s41467-0…
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Endogenous tagging + 3D live-cell imaging + mass-spec interactome = opencell.czbiohub.org, an open-source map of the human proteome. So excited for our first release, wonderful collaboration with @labs_mann @loicaroyer & many other colleagues. @OpenCellCZB
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