Cancer Evolution and Genome Instability, Lung Oncologist Air Pollution and Drug Resistance Fair Weather š“
London
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Today our important study on air pollutants in the promotion of lung cancer has been published in @Nature led by @WillHilliam @LimEmilia @DrClareWeeden @SwantonLab ...Thread belowš§µnature.com/articles/s41586-0ā¦
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This is absolutely wild - nature (as in mother) never ceases to amaze nature.com/articles/s41556-0ā¦
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ecDNA are rogue genetic material that amplify genes, contribute to treatment resistance and drive genomic heterogeneity. We report on the Origins and impact of extrachromosomal DNA today in @Nature nature.com/articles/s41586-0ā¦
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3rd day of COVID19 testing #crick fantastic team of scientists clinical virologists and clinician scientists in a London collaboration @uclh @CRUKresearch @hsl @uclcancer @TheCrick @ICR_London to serve clinical staff, the homeless and patients
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1/24 - Can we decipher order from cancer genomes? Our new paper āPervasive chromosomal instability and karyotype order in tumour evolutionā comes out in Nature today: nature.com/articles/s41586-0ā¦ @BCRFcure @TheCrick @CRUKresearch @RosetreesT @uclcancer @SwantonLab @royalsociety
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What is the role of the TME in lung cancer evolution? We are excited to share our new TRACERx paper āSpatial Architecture of Myeloid and T Cells Orchestrates Immune Evasion and Clinical Outcome in Lung Cancerā at #AACR24, out in @CD_AACR today rb.gy/q484j9 Tweetorialš
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Why do some patients benefit less than others from precision cancer medicine? We are excited to share our paper "Mixed responses to targeted therapy driven by chromosomal instability through p53 dysfunction and genome doublingā out in @NatureComms. nature.com/articles/s41467-0ā¦ š§µ
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Excited to share our recent @SwantonLab @NickyMcGranahan & @MariamJHanjani lab work on the genomic evolution of non-small cell lung cancer metastases in #TRACERx, out @Nature
nature.com/articles/s41586-0ā¦
A quick thread [1/13]
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Amazing! cervical cancer in women offered the vaccine between the ages of 12 and 13 (now in 20s) 87% lower than in an unvaccinated population: importance of Prevention and Vaccines - ā¦@CRUKresearchā© congratsšš¾ ā¦@petersasieniā© theguardian.com/society/2021ā¦
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Excited to share our TRACERx nature publication on circulating tumor DNA (#ctDNA, #MRD) detection in resectable lung cancer led by @AbboshChris, @Afrankell, @juditkisistok, Thomas Harrison, Aaron Garnett, @nbirkbak and @NickyMcGranahan ššš Tweetorialš§µ
nature.com/articles/s41586-0ā¦
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gd T cells in cancer: at the front lines. New from @SwantonLab and @HaydayLab out in @NatureCancer today: āA local human Vd1 T-cell population is associated with survival in nonsmall-cell lung cancerā led by @dr_yinwu, @CharlesSwanton & @HaydayLab: nature.com/articles/s43018-0ā¦ 1/12
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1/11 Our study on subclonal immune evasion in non-small cell lung cancer has just been published in @Cancer_Cell
cell.com/cancer-cell/fulltexā¦
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Our paper describing the use of an ultrasensitive circulating tumour DNA detection assay to stratify #TRACERx patients with early-stage non-small cell lung cancer pre-operatively for clinical outcome is out today @NatureMedicine. Thread below š
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We're thrilled to share work on tumour evolution in 421 TRACERx lung cancer patients by @AFrankell @Michi_Dii @drmaiseb @LimEmilia @TakKarasaki @Ward__Sophie RajuVeeriah @ColliverEmma @AMIHuebner @abi_bunkum @ZaccaSimo @MariamJHanjani @NickyMcGranahanš§µā¬ļø
nature.com/articles/s41586-0ā¦
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Amazing to see ā¦@NickyMcGranahanā© and his work inferring T cell infiltrate in tumours from NGS data - started in my lab 2013 as PhD student then independent PI 2018 ā¦@uclcancerā© ā¦ā¦@CRUKLungCentreā© a talented scientist I now learn from! nature.com/articles/s41586-0ā¦
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Delighted to present our paper on the evolutionary characterisation of lung adenocarcinoma (LUAD) morphology in the TRACERx cohort, published @NatureMedicine led by @TakKarasaki @davidallanmoore @NickyMcGranahan @MariamJHanjani @SwantonLab
nature.com/articles/s41591-0ā¦
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LBA1 #esmo22 today I will be discussing three lines of evidence supporting causative link between air pollution and lung cancer in the context of a Tumour promoting role independent of DNA mutagenesis pioneered by Allan Balmain @UCSF and Isaac Berenblum @CRUKresearch
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Amazing- human pancreas 80cm3ā¦. Thatās a lot of kras mutations - yet lifetime risk of pancreas cancer is 1:60 - cancer is very rare at the cellular level
āmean burden of 13 PanINs per cm3; normal.. adult panc has 100s of PanINs, w oncogenic KRASm.ā
nature.com/articles/s41586-0ā¦
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Covid19 Consortium | Crick weblink live with SOPs ready to download please retweet and forward to anyone who would find these SOPs useful ā¦@TheCrickā© ā¦@uclhā© ā¦@CRUKresearchā© crick.ac.uk/research/covid-1ā¦
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Patient-derived xenograft (PDX) models allow cancer researchers to study tumour tissue from patients in mice.
Our @CRUKLungCentre paper @NatureComms describes 48 new PDX models and highlights the importance of intratumor heterogeneity in the development of cancer models (1/9)
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Today our study of the association between replication timing alterations and mutation acquisition during cancer evolution has been published in @NatureComms
nature.com/articles/s41467-0ā¦
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Cachexia is a devastating condition in patients with cancer. Our study on cancer cachexia in #TRACERx is out today in @NatureMedicine led by @Othman_Al_Sawaf, @MariamJHanjani, @SwantonLab:
nature.com/articles/s41591-0ā¦
Key results in a brief š§µ
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We managed to get one last paper rdcu.be/d5gAe over the line before the new yearš„! We are pleased to share the first Nature Cell Biology paper from our lab functionally validating the role of a frequently occurring lung cancer driver, FAT1 in cancer evolution. š§µ1/13
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Light streaming into the Crick an early celebration of the opening of the Outwitting Cancer Exhibition ā¦@TheCrickā© ā¦@CRUKresearchā©
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ā¦@TheCrickā© ā¦@uclhā© ā¦ā¦ā© Covid19 Consortium RTPCR NBT paper: wouldnāt be possible without >150 fantastic scientists, clinician scientists and staff working for 3 months 7d/wk >30,000 tests to keep patients and hcws safe- thank you all nature.com/articles/s41587-0ā¦
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Years of work on genome doubling (WGD) in cancer TRACERx ā¦@NickyMcGranahanā© and ā¦@uclcancerā© ā¦@TheCrick : ā© how WGD mitigates chromosomal instability driven loss of lung cancer essential genes - and overcomes āmutational meltdownā nature.com/articles/s41588-0ā¦
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As if nature couldnāt get even more remarkable - cancer cells shield themselves from the immune system by hiding within other cells elifesciences.org/digests/80ā¦
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The ability to detect adenomas through ctdna is mind boggling and opens up the early diagnosis field for interception see figure 4 congratulations @landau_lab biorxiv.org/content/10.1101/ā¦
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When Salk was asked who owned the patent to his polio vaccine "Well, the people I would say. There is no patent. Could you patent the sun?ā
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We are studying air pollution and cancer risk - just been given this extraordinarily high resolution data by @LimEmilia for NO2 levels across Greater London - yellow high blue low- central London north circular m25 and Heathrow all clearly visible
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How amazing - look at this š@MariamJHanjani recognised @NatureMedicine for her incredible leadership of the @CRUKCOLcentre @CRUKresearch PEACE rapid autopsy program to understand cancer metastases, immune evasion and Cachexia and key player on @CancerGrand
11 trailblazing early-career researchers, shaping the future of #medicine, share what they are most excited about right now and where their research is going in the next 5 years - read now: go.nature.com/3C8xLYS
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It was a wonderful opportunity to speak about air pollution and lung cancer at the @CR_UK @ScottishPower event in Glasgow. Thanks to @LimEmilia and @WillHilliam for their work on this. #COP26
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ā¦@VCCCAlliance ā¦@PeterMacCCā© cancer meeting - thank you for opportunity to speak and making incredible ā¦@JessamyG_drawsā© cartoon of 60 slide talk blended into 1 summary slide much better than I could have done!
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Congratulations ā¦@sarah_blagdenā© ā¦@MariamJHanjaniā© and thanks to our funders ā¦@Michelle_CRUKā© ā¦@CRUKresearchā© - I hope this will be the future of lung cancer prevention news.sky.com/story/groundbreā¦
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COVID19 diagnostic challenges that would speed up testing and get us to 100k tests per day please retweet and/or tackle these key questions ā¦@CRUKresearchā© ā¦@TheCrickā© ā¦@uclhā©
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1/11 Latest from the @SwantonLab @Bartek_Lab @Samuel_Bakhoum @NnennayaKanu @MD_Venkatesan in Cancer Discovery: cancerdiscovery.aacrjournalsā¦ . A special thanks to all involved (including @HarrisLabUMN @lungsforliving @BCRFcure @CRUKresearch @TheCrick). A tweetorial on the main findings
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20 years of discoveries celebrated today ā¦ā©since CRUK was founded @CRUKresearchā© ā¦@Michelle_CRUKā© ā¦@LabVousdenā© ā¦@CRUK_Policyā© - thanks to all our fundraisers shops and staff for bringing cancer discoveries to patients - huge optimism for next 20 yrs!
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So wonderful that ctDNA+ MRD phylogenetic biomarker developed from ā¦@CRUKresearchā© ā¦@uclcancerā© @UCLHresearchā© @TheCrickā© TRACERx consortium defines Atezo survival benefit š ā¦@AbboshChris ā¦@nbirkbakā© ā¦@tompowles1ā© nature.com/articles/s41586-0ā¦
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Now the incredible Mariam Jamal-Hanjani presenting data from the TRACERx Peace cohorts defining the metastatic cascade in Nsclc ā¦@CRUKresearchā© ā¦@uclcancerā© ā¦@TheCrickā©
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Fascinating paper from ā¦@gaddygā© lab >6000 normal tissues profiled w RNAseq - Clonal expansions and driver mutations in normal tissue same drivers found in cancer and mutation burden increasing w age biorxiv.org/content/early/20ā¦
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Fantastic to discuss science with ā¦@ElizSMcKennaā© ā¦@CD_AACRā© ā¦@AACRā© and show Elizabeth round the incredible Crick institute ā¦@TheCrickā© ā¦@CRUKresearchā©
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Applications open for a PhD in ā¦@SwantonLabā© ā¦@TheCrickā© to study the impact of environmental pollution on lung cancer initiation/promotion- join an incredible team+ institute - please apply or retweet ā¦@CRUKresearchā© ā¦@uclcancerā© crick.ac.uk/careers-study/vaā¦
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Fascinating paper on clone size and immune rejection - could this explain why normal cells with coding mutations do not result in a brisk immune reaction? Clone size too limited ā¦@rongejmanā© ? elifesciences.org/articles/4ā¦
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Scalable and Resilient SARS-CoV2 testing in an Academic Centre | medRxiv thanks to @uclh @TheCrick , HSL and ā¦@CRUKresearchā© and the UCLH Crick Covid Consortium for all their hard work driving healthcare worker testing in the NHS medrxiv.org/content/10.1101/ā¦
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Air pollution is linked with 7 million premature deaths annually and is associated with heart disease, cancer and dementia. The vast majority of people live in places where air pollution levels exceed @WHO guidelines
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Why some cancers are 'born to be bad' - BBC : congratulations Samra and TRACERx team and thank you @CRUKresearch bbc.co.uk/news/health-437283ā¦
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Big thank you to ā¦ā¦@scientistatlrgeā© ā¦@FoxChaseCancerā© ā¦@WhetstineLabā© for a fabulous visit in June and this wonderful plaque hand made by ā¦@scientistatlrgeā©!
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Currently uploading 36,000 fastq files for TRACERx cancer evolution data to EGA - watch this space - it is taking rather longer than we planned as files are so huge ā¦.TRACERx data all made possible thanks to @CRUKresearch @uclcancer @TheCrick @UCLHresearch @CRUK_MI
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Read this fascinating review on the role of genome doubling in health and cancer from ā¦@GanemLabā© cell.com/trends/genetics/fulā¦
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ā¦@TheCrickā© ā¦@standardnewsā© I donāt remember discussing this experiment in the lab meeting
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Today we thank our TRACERx patients for generously participating as we consent our 1000th patient. @CRUKLungCentre @CRUKresearch @uclcancer
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The loss of Martin is hard to fathom. He was a great mentor to so many, a shining example of how to lead and practice medicine with humility and perfection, encouraging, irreverent, supportive and hilarious - often all at once. A superstar of Oncology who will be greatly missed.
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Extraordinary study : Association between particulate matter (PM)2Ā·5 air pollution& antibiotic resistance: 500,000 premature deaths in 2018- PM2.5 likely carry abx resistant bacteria and genes : Pm2.5/AMR association >> than prior antibiotic use eur03.safelinks.protection.oā¦
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ADAURA trial of adjuvant osimertinib in egfrm early stage NSCLC shows 12% overall survival benefit consistent across all subgroups and independent of prior adjuvant chemotherapy use - fabulous news for patients with egfrm early stage lung cancer š Roy Herbst and colleagues
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EMBO welcomes thirty Young Investigators - many congratulations ā¦@NickyMcGranahanā© what an incredible achievement for an amazing scientist thankyou ā¦@wellcometrustā© @CRUKresearchā© ā¦@CRUKLungCentreā© ā¦@uclcancerā© ā¦@TheCrickā© embo.org/news/press-releasesā¦
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Not enough attention has been paid to chronic fatigue and out of hours working amongst health professionals and its impact on their safety and of others- these data do not surprise me - I have heard many stories over 25yrs of fatal accidents likely resulting from night work
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When iPhone autocorrect corrects BUT to UTR you know you have been in this field too long
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a blog on our recent TRACERx paper on tumour evolution and immune evasion with ā¦@NickyMcGranahanā© ā¦@TheCrickā© @uclcancerā© and photo of the labs outside Darwinās Home in Downe Village natureecoevocommunity.natureā¦
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Fascinating poster ā¦@ASCOā© role of ultra fine particle pollution around airports and squamous cell lung cancer risk ā¦ more evidence emerging of important role of pollution on lung health
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ā¦@crispinhileyā© presenting results from Darwin2 TRACERx prospective trial Clonal TMB associated with durable clinical benefit and transcriptomic intratumour heterogeneity with worse outcome ā¦@CRUKresearchā© ā¦@uclcancerā© ā¦@TheCrickā© ā¦@CRUKLungCentreā©
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Altogether, this suggests a mechanistic and causative link between air pollutants triggering expansion of pre-existing mutant cells in normal tissues via a clinically actionable inflammatory axis. (Thanks @Biorender)
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Extraordinary finding from the Global Burden of Disease Study 2021 - The Lancet āAmong the specific risk factors analysed for this study, particulate matter air pollution was the leading contributor to the global disease burden in 2021ā thelancet.com/journals/lanceā¦
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We urgently need to understand if other non-mutagenic carcinogens act via a parallel, promotion mechanism but this reveals an exciting potential for molecular cancer prevention! crick.ac.uk/news/2022-09-10_ā¦
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A must read ā¦@NickyMcGranahanā© ā¦@CRUKLungCentreā© @CRUKCOLcentreā© A primer on cancer evolution- many congratulations nature.com/articles/s41568-0ā¦
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Day 1 of cancer grand challenge presentations ā¦@CRUKresearchā© ā¦@theNCIā© ā¦@CancerGrandā© full day of exciting presentations and announcements ahead
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Amazing talk bringing cancer cachexia to the fore by ā¦@TeresaZimmersā© a complex multifaceted syndrome determining cancer outcome thanks for giving TRACERx cachexia @mariamjhanjani ā¦@NatureMedicineā© work a shout out
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Jaw dropping behind the scenes tour ā¦@TheCrickā© - the scale of the architecture and space is mesmerising
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Great to see ā¦@PrzeAskaā© PhD thesis on my shelf - many congratulations-thank you - but whatās with the āunprecedentedā yellow?
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We found that exposure to air pollutants leads to macrophage mediated inflammation. This can directly reprogram lung alveolar type II cells to more a progenitor like state (Still stunned by experiment in 3E!)
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We focused on a growing public health concern: lung cancer in people who never smoke, because 85% of people in the UK do not smoke. If considered as a separate entity, lung cancer in non-smokers is the 8th most prevalent cause of cancer death in the UK.
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ā¦@HaanenJohnā© demonstrates Claudin 6 an emerging anti solid tumour target for CART therapy ā¦
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Great discussion about early onset cancers with @KimmieNgMD and @CRUKresearch @CancerGrand @theNCI funded research: what is the underlying cause ? Obesity, western diet, microbiome, antibiotic use ?
NEW PODCAST: An uptick in cancer rates among younger adults is concerning scientists. Do we know whatās behind it?
Our Chief Executive @JenniferTHF discusses with @KimmieNgMD and @CharlesSwanton.
Listen now š§ health.org.uk/news-and-commeā¦
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Tumour promotion was first proposed by Berenblum & Shubik and developed by Allan Balmain and others. Thank you to Prof Balmain for this excellent N&V nature.com/articles/d41586-0ā¦
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TRACERx study: A great opportunity for a talented Principal or Senior Research Fellow/Software Developer/Senior Bioinformatician to join the TRACERx team @thecrick @uclcancer @crukresearch @SwantonLab Please retweet or apply
nature.com/naturecareers/jobā¦
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Huge congratulations to my outstanding @CRUKLungCentre colleague #CarolineDive recipient of the 2019 Heine H. Hansen Lectureship Award for Small Cell Lung Cancer in recognition for her long-standing work in field of basic sciences. Very well deserved.
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Extraordinary to be ā¦@FoxChaseCancerā© where the Philadelphia chromosome was discovered by Hungerford and Nowell staring at the microscope in aweā¦ and Alfred Knudson who inspired my interest in tumour suppression in the 90s - thx to ā¦ā¦@WhetstineLabā© ā¦ā¦
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Real fear now is that without #PeoplesVote and reversal of this madness we will default to #HardBrexit - Dublin is thriving on staff and industry moving from U.K. in anticipation of this disaster - UK is already poorer- bad for NHS bad for science bad for welfare bad for jobs.
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Beautiful imaging mass cytometry study of Kras mutant lung cancer before and after G12C inhibition from ā¦@JulianDownwardā© lab showing extensive TME remodelling, vimentin up regulation and increase T cell Mo and DC infiltration biorxiv.org/content/10.1101/ā¦
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Wonderful summary of TRACERx latest data by Prof Mitsudomi reviewing ā¦@crispinhileyā© ā¦@SonyaHesseyā© and Wing Liu work - Clonal TMB , metastasis growth rates and Immune evasion mechanisms - thanks ā¦@TheCrickā© ā¦@uclcancerā© ā¦@CRUK_MIā© @CRUKresearchā©
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TRACERx opportunity for bioinformaticians passionate about cancer evolution and tumour immunology- please apply or retweet ā¦@TheCrickā© ā¦@uclcancerā© Senior Research Fellow in Bioinformatics (TRACERx study), - Ref:1869199 atsv7.wcn.co.uk/search_enginā¦
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The introduction of targeted lung cancer screening across the 4 nations really is a tremendous step forward - reasons to be optimistic and celebrate - this will save thousands of lives each year nationalscreening.blog.gov.uā¦
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We revisited a 76 year old (!) theory of cancer promotion ā that cancer starts in two steps: the acquisition of a driver gene (initiation) and then a second step whereby a cancer risk factor acts on these latent cells to trigger disease (promotion).
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Asked directions to the Paris Immune Oncology conference this am āfirst left, first right and itās the castle straight in front of youā what a venue - only in France
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Super excited about this @CancerGrand challenge on ageing of normal tissues and cancer risk and itās potential impact vimeo.com/819439732
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Calling all cancer evolutionary biologists, statisticians and informaticians-Come to the UK and study cancer evolution ā¦@CRUKresearchā© ā¦@ICR_Londonā© ā¦@royalmarsdenā© @AndreaSottorivaā© in a great institution with world leaders. icr.tal.net/vx/mobile-0/appcā¦
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Fascinating study - always wondered why unrelated people who look similar also have similar behavioural traits - I wonder if this begins to shed light on the conundrum cell.com/cell-reports/fullteā¦
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The riddle of cachexia ā scientists move one step closer towards understanding the devastating loss of fat and muscle during cancer - ecancer ecancer.org/en/news/22946-thā¦
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Last footy training session for ā¦@FAndreMDā© before the big day Swanton will teach him all the dirty football tricks he knows - pauseā¦listen to the sound of ā¦@DrChoueiriā© trembling
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Congratulations ā¦@cbailey_58ā© on a phenomenal PhD studying ecdna ā¦@TheCrickā© ā¦@CRUKresearchā© and thank you for all your help during the pandemic - a real star, team player and fantastic clinician scientist - we will all miss you ! (Until you come back in 2024!)
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Finally, we found in pre-clinical models that air pollutants induce IL-1B and blocking this reduced lung cancer promotion by air pollutants. This complements findings from the CANTOS trial which showed that an anti-IL-1B antibody reduced lung cancer incidence.(Ridker 2017 Lancet)
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I donāt think it compromises safety taking photos out of the cockpit window or of the cockpit - pilots have to eat and drink after all- why canāt they take a photo of our wonderful planet for us all to admire if autopilot on or other pilot flying @British_Airways
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The impact of Covid-19 on charity-funded research could be catastrophic for patients & researchers.
Today, joined 60 of the UK's leading scientists to call for a partnership with Government to protect life-saving research: cancerresearchuk.org/sites/dā¦
#ResearchAtRisk
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