Liver biologist, human pluripotent stem cells, cell based therapy believer, opinions are my own.
- Tweets 2,010
- Following 457
- Followers 3,735
- Likes 2,978
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New paper from @VallierLab is online. "Acquisition of epithelial plasticity in human chronic liver diseases". Amazing work from @chrisgrbbn and @VasileiosGalan in collaboration with @imohorianu and Mike Alison. Few key points:
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link.springer.com/article/10…
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Big personal news. After 20 amazing years at @Cambridge_Uni , @VallierLab will be be moving to Berlin joining the @BIHregeneration and @BIH_Innovation. Setting a brand new lab and recruiting postdoc, PhD and RA. More detailed info very soon.
Great news! 🍾In July, Ludovic Vallier @VallierLab from @Cambridge_Uni will start his Einstein Professorship for #stemcells in Regenerative Therapies at @berlinnovation @ChariteBerlin. The goal of his research: to transplant liver #organoids into patients. einsteinfoundation.de/en/med…
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The @VallierLab has decided to use the current time to learn new skills on bioinformatics. For that, @rutetomaz @AnnaOsnato Fatima Lugtu created a website combining useful tutorials and courses. Very nice tools for all. Please retweet and comment.
vallierlab.wixsite.com/pipel…
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1/8 New publication @VallierLab showing that cholangiocytes organoids can repair the human biliary tree independently of their region of origin. Incredible work from F.Sampaziotis and collaborator @KSaebParsy. Funded by @ERC_Research and @NIHRresearch.
science.sciencemag.org/conte…
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1/Publication alert @vallierLab. Our manuscript describing single cell map of human liver development and derivation of hepatoblast organoids is now online in full: nature.com/articles/s41556-0…
Amazing work from B Wesley and A. Ross.
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The new @VallierLab in Berlin is taking shape. Hoods have arrived and cell culture rooms are ready and first post doc has joined the team. Exciting times!
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Honoured to become fellow of the Academy of Medical Sciences. This achievement is shared with past and current members of @VallierLab. Big thank you all!
Congratulations to Professor Ludovic Vallier who has been elected to the fellowship of the Academy of Medical Sciences! Ludovic is Professor of Regenerative Medicine @Cambridge_Uni & his research focuses on mechanisms controlling early cell fate decisions @VallierLab @acmedsci
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Our manuscript showing that genetic background influence capacity of differentiation of "naive" mouse ESCs is now available. Great work from @OrtmannDaniel and Stephanie Brown. Great collaboration with @jacksonlab.
cell.com/cell-stem-cell/full…
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Major milestone for @VallierLab. We have a coffee machine !
This is a major achievement as this was supposed to be impossible. Those who knows the system will understand...
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Super happy and excited for @VallierLab to be selected for the HOPE program. Great collaborative project with @kellystevenslab and @KSaebParsy. Our goal to build a bioartificial liver against liver diseases.
We're pleased to announce the selected performers for our $50M HOPE program.
Learn more: wellcomeleap.org/HOPE
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Very happy to join the Stem Cell Reports editorial team, to help the publication of exiting new science and to support the stem cell field.
Stem Cell Reports would like to welcome its newest Associate Editor Ludovic Vallier, from the Wellcome and MRC Cambridge Stem Cell Institute. He joins an international team of accomplished stem cell scientists and editors bit.ly/2APcabl. @VallierLab @ISSCR @martinperaJAX
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First talk first clash, a tread. This is a good start. Conclusion of the speaker: hIPSCs show a high level a variability to generate specific cell type in vitro and thus they are not pluripotent. I can't believe that we are still having this discussion in 2023. A tread.
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Movie explaining our recent work on cholangiocytes organoids transplantation in human liver.
cam.ac.uk/research/news/lab-…
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Perfect storm for UK science: flat funding for the next few years, wellcome going awol, uncertainty on EU funding, problem of recruitment for post-docs, Top EU PhD students disappearing (i.e uni fees), etc.
bbc.co.uk/news/science-envir…
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Our manuscript looking into variability of endoderm differentiation between hIPSC lines using Single Cell RNASeq is finally published. What an effort from @MariyaChhatriw2 and the team. Definitely not something to do too often...
nature.com/articles/s41467-0…
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My lab @BIHregeneration is recruiting 3 post docs to work on:
1 Liver regeneration during human chronic disease.
2 Genetic screen to uncover new mechanisms controlling lipid metabolism in hepatocytes
3 Create enhanced hepatocytes for cell based therapy
jobs.bihealth.org/PostDoc-fm…
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Finally arrived in Berlin for my first commute (more explanation later). For 9 euros you can travel as much as you want by train everywhere in Germany for a month. This is like a parallel universe...
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Apply now to the Wellcome PhD programme in stem cell biology and Medicine. This is an amazing opportunity to do a PhD on stem cell biology.
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Preprint Alert @VallierLab . Pluripotency factors and epigenetic regulators are cell cycle regulated in hPSCs to allow cell fate decisions. Great work from @AnnaOsnato.
biorxiv.org/content/10.1101/…
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Our manuscript describing variability in "naive" ESCs is now published @CellStemCell:
doi.org/10.1016/j.stem.2020.…
To read with companion manuscript from collaborators @Laura_Reinholdt @stevemunger
DOI:doi.org/10.1016/j.stem.2020.…
Genetic rules differentiation and pluripotency capacity
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Just a reminder that my lab in Berlin is recruiting 3 post doc Fellows. Cool projects, excellent environment and a lot of opportunities for personal development.
My lab @BIHregeneration is recruiting 3 post docs to work on:
1 Liver regeneration during human chronic disease.
2 Genetic screen to uncover new mechanisms controlling lipid metabolism in hepatocytes
3 Create enhanced hepatocytes for cell based therapy
jobs.bihealth.org/PostDoc-fm…
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Consensus review on liver organoids nomenclature. Very useful to agree on nature of these cells so we can compare results/studies. So far adult liver organoids = cholangiocytes. Proliferating hepatocyte organoids can only derived from foetal tissue.
cell.com/cell-stem-cell/full…
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Friday evening humour: I can't wait for all these new in vitro systems to discover that Nodal/Activin signalling is important to maintain pluripotency in late epiblast and to drive endoderm differentiation during gastrulation...
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Looking forward to give my first remote seminar. My talk will focus on human PSCs pluripotency/differentiation and cell cycle. I will try to answer the question: why stem cells differentiate and divide at the same time.
#StemCellsAtLunch is back next Tuesday at 2pm!
Join us for talks from Prof Ludovic Vallier from
@SCICambridge & Dr Jianping Fu from @UMich!
#stemcells
bit.ly/2Mkc265
@VallierLab @umichme @MTewary @lea_rbibo @kingsmedicine
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Preprint Alert @VallierLab. We looked at epigenome /transcriptome during cell cycle progression upon differentiation of hPSCs. Differentiation starts before division and each cell cycle results in a new cell. Cell cycle rules differentiation!
biorxiv.org/content/10.1101/…
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Yesterday Nature meeting on organoids was very interesting. Fantastic science (but can't tweet about it). My main messages to take home were:
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1/ Our new publication describing a method to generate human hepatocytes by forward programing is now fully available. See tread for summary. Amazing work from the team @VallierLab and from lead authors @rutetomaz.
elifesciences.org/articles/7…
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TGFb is necessary for human pluripotent stem cells corresponding to pre-implantation stages suggesting a conserved function for this pathway during progression of development. Great work from @AnnaOsnato, @OrtmannDaniel and collaboration @RuggGunnLab
elifesciences.org/articles/6…
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Great news. The UK will continue to benefit from the EU Horizon and ERC.
nature.com/articles/d41586-0…
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Few days to register to virtual meeting 'From Stem Cells to Human Development" in September organised by development. Great list of speakers and exciting science.
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The @vallierLab is organising a symposium on hPSCs on the 16/04/2024 focusing on disease modeling, cell based therapy, developmental biology and more. Great list of speakers, historic venue, free registration and Berlin in spring. What else?
To register: bihealth.org/en/news/events/…
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Our first attempt to analyse human gut development using single cells. Glad to have initiated this project and to see it published. Congratulations to @elmentaite, Alexander Ross, Matt Zilbauer, and @teichlab
sciencedirect.com/science/ar…
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1/That's it. Our collaborative effort on COVID19 and cholangiocytes is now online. It was initiated @VallierLab at the start of pandemic by @FSampaziotis @BreviniTeresa. We hope this finding result in clinical trials and new treatments.
nature.com/articles/s41586-0…
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The @VallierLab has moved into the JCBC and we are up and running. Cells are growing and we had our first celebration!
Great work from the team which in 2 days has unpacked and reinstalled the lab. Big thank you to the @SCICambridge team for all their help and support.
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This preprint made my day. Very exciting hypothesis from Robin Franklin @SCICambridge. MMR vaccine could protect against Covid19 explaining why kids are protected. Could it be that simple? I want to believe after all this is Easter.
medrxiv.org/content/10.1101/…
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Today, I will give the talk at the Cambridge Stem Cell institute Group Leader seminar.
"Human pluripotency, what did we learn in 20 years?"
Join me from JCBC lecture theatre and on Zoom at 4 pm BST.
us02web.zoom.us/j/8639832135…
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Almost 10 days since @VallierLab has shut down. What did we learnt:
- Remote work with team/lab is a lot of work
- How Zoom works
- To avoid Zoom overdose
- Unimportance of International travels
- Definition of Agoraphobia
- Rice is very difficult to cook...
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Amazing news from Japan. Transplantation of hESCs derived hepatocytes in new born with urea cycle disorder for bridge therapy. That's extremely bold. Hopefully data will be published soon.
ncchd.go.jp/en/news/2020/pr_…
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While I was away our last paper @VallierLab for 2018 was published describing method to cell cycle synchronise human pluripotent stem cells without secondary effect. Next few manuscripts will be based on this approach.
cell.com/stem-cell-reports/f…
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The Cambridge Stem Cell Institute is recruiting new group leaders. Fantastic environment, state of the art facilities, nice colleagues, talented students, etc. Don't hesitate to apply!
We are recruiting new Group Leaders and welcome applications from across all of stem cell biology, including research relevant to:
i. Cardiovascular disease & Epithelial tissues
ii. Computational Biology
iii. Cell and Gene therapy
iv. Ageing
More here: jobs.cam.ac.uk/job/27259/
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New conference on : Organoids Advances and Applications 28-30th of September with co-organisers @Mad_Lancaster, @priscaliberali, @TheSpenceLab and Daniel Stange.
coursesandconferences.wellco…
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Happy holidays from @VallierLab in Cambridge and in Berlin with all the best wishes for the new year.
🎄🎄🎄🎄🎄
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Single cell analysis on gastrulating human embryo. Key knowledge on early development. Exciting work from @Scialdone @LabSrinivas @anto_scial and colleagues nature.com/articles/s41586-0…
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Looking forward to present at the ISSCR Webinar: "Developing Standards for Stem Cell Research". My very ambitious title: "Origin of variability between human pluripotent stem cell lines and solution(s)"
isscr.org/meetings-events/is…
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Another science leader going to industry. Interesting and necessary trend for pharma. The resource invested could make a real difference for the development of new therapies.
endpts.com/doug-melton-to-re…
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Already time for the concluding remarks #organoids21.
1/ Organoid based models are more and more complex with co-culture and bioengineering.
2/ Combination allow to answer new questions such cross talks between immune cells or niche
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Program for 2 interesting Keystone joint meetings: Advances in the Application of Stem Cells and their Role in vivo / Organoids as Models of Development and Disease, and their Impact on Drug Discovery. Registration until 6/12.
keysym.us/KSStemCell23
keysym.us/KSOrganoids23
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Yesterday @VallierLab decided to take own measures against Covid-19. Maybe not necessary but we can't be complacent.
- Professional travels are banned even within the UK.
- Personal travel in "hot" zones (all of Europe and US) are not advised and might require self quarantine
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I am currently dealing for the first time with the necessary visa for EU master student visiting the lab in January. Brexit reality. What a waste.
👩🏼🎓🧑🏼🎓Etudiant(e)s 🇫🇷 au Royaume-Uni 🇬🇧 | #Brexit
Si vous ne résidez pas au 🇬🇧 avant le 31 décembre 2020 vous devrez effectuer une demande de visa étudiant.
Si vous êtes résident avant le 31/12, demandez votre #SettledStatus dès maintenant !
💬Parlez-en entre vous !
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Some positive news of sort, the @VallierLab is back in the lab! with a lot of precautions and physical distancing. Very progressively restarting experiments but definitely excited.
TY @MarionPerrin8 for providing these fashionable masks.
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We are recruiting a post doc to lead our effort on pluripotency. This is a key post with a lot of opportunities and exciting science. Please apply and retweet or contact me for more info.
jobs.cam.ac.uk/job/24972/
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Mouse organogenesis elucidated by spatial and single cell analysis. What a title! Looking forward to use these data to understand liver organogenesis.
nature.com/articles/s41587-0…
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After few hours using Mastodon, I better understand why it is named after a very large and slow animal...Let's hope that Twitter can survive.
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Exciting clinical trial showing that CRISPR/Cas9 can be used for gene therapy against inherited liver diseases.
nejm.org/doi/pdf/10.1056/NEJ…
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A souvenir from the @VallierLab retreat last week in Barcelona. As a PhD student told me once, we might not be doing the best science but we do have the best retreat...
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- Practice social distancing as much as possible
- Work from home as much as possible
- Wash hands as often as possible
- Be prepared for potential shut down
- Most importantly take care of each others!
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Since this platform could soon collapse. @VallierLab has a profile on Mastodon with the same name. Too bad, Twitter has been a major source of info, expression and communication these past few years. At least, we are all learning what not to do as a manager...
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EU student who wants to do an internship in an UK lab (often working for free for 6 months) will have to pay £800 for visa and health care + language test to demonstrate level while EU PhD student will pay oversea uni fees (27K/year).
theguardian.com/politics/202…
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Looking forward to describe how basic research research @VallierLab has resulted in the creation of several biotechs including @DefiniGEN and Aculive Therapeutics (ACLx) from disease models to cell based therapies.
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This is an incredibly bad news. This is such an important funding source for young investigators. I will never have been able to develop my research in the UK without ERC funding.
And here it is -- communication from @ERC_Research to UK-based #ERC starting grant grantees... UK awardees will have two months time to move their grant to the EU proper, otherwise they will lose their STG. Thank you #Brexit #BrexitReality.
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Very happy to be affiliated to the @MPI_MolGen in Berlin. Looking forward to explore new collaborations and to develop an exciting program on liver organogenesis.
if interested to join post doc position available here:
molgen.mpg.de/4547725/job_fu…
🙌 Welcome to the Institute! #StemCell researcher Ludovic @VallierLab joins the @MPI_MolGen as a #MaxPlanckFellow. The @berlinnovation Group Leader has a special interest in the liver and revealed that he “fell in love with the city” – Berlin.
🔗 molgen.mpg.de/4549095/
ALT Portrait photo of Prof. Ludovic Vallier in a suit, in front of a wooden background. Credit: A. Ausserhofer, BIH.
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Super privileged to be included in this group. @MPI_MolGen rocks!
Great to see so many of our scientists included in @TspWissenschaft @Tagesspiegel list of the 100 most important minds in #berlin #science! Congrats to @bulutkarslioglu @_taktas_ @VallierLab and A. Meissner! Btw, all 4 are recruiting PhD students --> molgen.mpg.de/IMPRSPhDprojec…
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That was fun interview. Rare opportunity to discuss about the research @VallierLab and beyond. The podcast should be available sometimes next week.
Next week's guest is Dr. Ludovic Vallier (@VallierLab) from @SCICambridge who studies the endoderm!
Take a read through his recent @CellStemCell paper showing that PSC lines from distinct genetic backgrounds have divergent differentiation capacities. bit.ly/2CpEIJv
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Exciting meeting on cell based therapies using stem cells in LA.
8-10 December 2022.
Deadline early registration 5th of August.
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Very nice to visit the new Abcam building yesterday and first time for me to represent @SCICambridge as deputy director. Great discussions on new technologies and growing need on antibodies (need to validate our ScRNA-Seq data...). Looking forward to future interactions!
The team enjoyed hearing Ludovic @VallierLab talk to them all about @SCICambridge, non-alcoholic fatty liver disease
and 3D cultures - and everything in between! Don't think we've seen so many questions at one of our guest speaker talks.
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All the best wishes for the festive season and for the incoming new year from @VallierLab @BIHregeneration. What a year! Thank you to all of you who helped us to start a new team and built a new lab.
This has been quite an adventure and we are looking to an exciting year 2024
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The AcuLive Therapeutics (ACLx) team celebrating a major milestone. Amazing amount of work generated in few months to develop new therapy against acute liver failure using technology from @VallierLab. A big thank to all @rutetomaz, Silvia B, Fabian B and Marcus Y.
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Today my new ERC consolidator grant New-Chol is starting. Thank you ERC for supporting the @Vallierlab for the next 5 years to work on liver again. Absolutely vital for my group.
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1/ Exciting visit from @BIH_Innovation and @BIHregeneration at Cambridge Uni @VallierLab to share vision and strategy on research translation with C. Baum, G.Duda, T.Rosenmund and T.Gazlig.
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Last Friday. Farewell party for Daniel Ortmann. Sad to see a great scientist and a friend leave @VallierLab. He was always a model and great relay in the team. We will miss him but all the best for the new adventure @bitbioltd.
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This is just reminder that he is not the cause of the problem but the consequence. The future will be challenging.
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First Stem Cells UK meeting on 1st October 2019. One day meeting aims to bring together stem cell researchers from across the UK. Could it be the revival of a UK society for stem cell research?
stemcells.cam.ac.uk/events/s…
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Thrilled to have been awarded a Technologies to Tools grant from the NC3Rs to develop in collaboration with the Medicines Discovery Catapult new methods to phenotype liver diseases models using hPSCs.
nc3rs.org.uk/news/awards-acc…
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Not sure that I should repost this kind of info...Nonetheless, it was fun and interesting to answer these questions.
Ludovic Vallier (@VallierLab) has been an ISSCR member for nearly two decades. Read his Member Spotlight to learn about his lab’s research on liver development and disease, his advice to young scientists, and why he values the ISSCR community 👉 bit.ly/3vfhscC
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New post doc position available @VallierLab part of the CZI liver project (chanzuckerberg.com/science/p…). Great opportunity to combine single cell analyses and functional validations in liver organoids to study liver development. Please retweet or apply.
jobs.cam.ac.uk/job/23541/
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Me trying to explain our program on cell based therapy against liver diseases. Thank you for the @CambridgeBRC and the NIHR to support this research funded by @ERC_Research and previous EU funding (InnovaLiv and TissueGEN).
For #OrganDonation Week we interviewed Prof Vallier, our Transplantation & regenerative medicine theme lead. View this 1-min film piped.video/RR4Mhsj-fXg for how his team's research could potentially help future liver disease patients @VallierLab @CUH_NHS @NIHRCRNEastern #CamBRC
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Starting the round table on organoids with Hans Clevers will be chairing session on disease modelling this pm
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1/ Preprint alert. @VallierLab found that FXR controls the expression of ACE2 on different cell types and that this pathway can be controlled by existing drugs to decrease SARS-Cov2 infection. Amazing work from
@FSampaziotis @BreviniTeresa
biorxiv.org/content/10.1101/…
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On my way to Cambridge with a stop at the Crick to meet with Alma mater Foad Rouhani. Looking forward to meeting old friends and new collaborators.
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The advantage of remote conference #organoids21 is that you can eat Sushi on your desk while listening great talks live with Jarno Drost on pediatric kidney cancer originating from neural crest during development.
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The best Stem Cell symposium of the year please forward the information and register.
Join us to hear talks from speakers working across multiple tissues at different scales from basic to translational research. Full programme details available on our website ➡️bit.ly/2Ssj24t #CamStemCell
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Stem cell reports is looking for early career scientists to join the Early Career Scientist Editorial Board (ECEB). Great experience to learn about editorial job and to work for the best journal in the stem cell field.
Stem Cell Reports is seeking highly motivated and accomplished early career scientists for a potential two-year appointment to join the Early Career Scientist Editorial Board (ECEB). To learn more and apply, bit.ly/3FvM22n. @martinperaJAX @ISSCR
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Latest publication of @VallierLab in collaboration with @t_rayon group and Irina Mohorianu describing culture conditions driving differentiation of surface ectoderm vs Amnion using hPSCs. Amazing work from Shota Nakanoh the main force behind this work.
science.org/doi/10.1126/scia…
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Preprint alert @VallierLab . Protocol to derives neuroepithelial stem cell progenitors from GMP grade hPSCs. Collaboration @The_MRC @UKRMP_PSEC and fantastic work from @LorianaVitillo.
biorxiv.org/content/10.1101/…
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Congratulations to Marta Vila-Gonzalez @VallierLab for her Sir Henry Wellcome Postdoctoral Fellowship. A well deserved success! I look forward to an exciting project on Cystic Fibrosis and Ionocytes.
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looking forward to present my talk at the annual meeting of the FSSCR @FSSCR_officiel.
Title: "In organoids we trust (to model human development)"
Not sure why I chose this title but this looks definitely fun....I definitely need to stop that.
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Our latest publication is online: rdcu.be/H0p3. TGFbeta controls epistranscriptome in hPSCs.
Thank you @berteroale, stephanie, and all the team @VallierLab for their fantastic work!
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1/ Reading this publication, I almost fall of my chair. Good news. Next time that one of my student come to see me and complain about background of differentiation, i can advise to not worry since there are hPSCs founder cells.
sciencedirect.com/science/ar…
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on my way to give evidence to the the royal college of surgeons commission on the future of surgery regarding stem cells and regenerative medicine rcseng.ac.uk/standards-and-r… and yes, i am wearing a tie.
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Recent publi @NatureCellBio show TGFbeta/Activin signalling seems to be essential for all the human pluripotent stem cells derived so far. So do they really represent different pluripotent states or the same state grown in different culture conditions?
nature.com/articles/s41556-0…
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Interview following my talk at the CSCRM. I understand why our kids are endlessly mocking my accent.
"The drive is to generate more #knowlege"
PhD student @AliceVickers5 interviews Prof Ludovic Vallier about his work generating #pancreas, #lung, #gut & #liver cells from #stemcells & his #celltherapy goals
soundcloud.com/user-56381585…
@SCICambridge @VallierLab @CambridgeBRC
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Our group is looking for a lab manager. Most important job in the lab! So please retweet and forward to potential candidates. Profile is very broad but key aspects is teamwork and multi-tasking. Training on hPSCs and organoids included.
jobs.cam.ac.uk/job/31395/
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