⭐️The UK DRI exists to transform the lives of people affected by or at risk of neurodegenerative conditions.⭐️
Our vision is ‘healthy brain🧠ageing for all’.
Our research will transform lives.
We are the UK DRI.
@The_MRC@alzheimerssoc@AlzResearchUK@lifearc1@TheBHF@NIHRresearch
This week we welcomed the legendary Rory Cellan-Jones (@ruskin147), to the living lab at our UK DRI Care Research & Technology Centre🙌
Rory wrote about his experience in a brilliant blog post, which you can read here👉buff.ly/3FMDXro
It is our pleasure to announce that Prof Siddharthan Chandran has been selected as the new Director of the UK DRI 👏🎉 🧠 👏 🎉 🧠
Prof Chandran is a world-leading clinician-scientist, renowned for his pioneering work in MND & neurodegeneration research👉buff.ly/3NaJavM
Image 2 of 4: Eruption of Etna's Embers
Human neurons grow in a device (bottom), and the 'wires', which carry the electrical impulses, travel through tiny grooves to get to the other side (top). This chaotic network of the wires gives the effect of a volcanic eruption.
4/6
We are delighted to announce that Prof Mina Ryten has been appointed as the new Director of the UK DRI Centre at Cambridge University, and Van Geest Professor! 🎉👏🧠🧬🎉👏🧠🧬
Read more👉bit.ly/3VVnurK
CONGRATULATIONS to geneticist Prof John Hardy (UK DRI at UCL) on the announcement of his knighthood in the New Year honours! 🎉🥳
Read more 👉bit.ly/3FOOtMS
HUGE congratulations to @TSpiresJones (Group Leader, UK DRI at Edinburgh) who will become the next President-Elect for @BritishNeuro!
👏🥳👏🎉👏🧠
Read more about the announcement & Tara's manifesto 👉 bit.ly/3e1IKqk
It is a pleasure to announce that our new Centre Director for UK DRI at King’s is Prof Jernej Ule (@ule_lab), an expert in RNA biology and its role in neurodegenerative diseases such as ALS/FTD 🥳🎉🧠
Read more 👉 bit.ly/3Ls1vCa (1/4)
Exciting news today as new drug lecanemab is reported to have slowed cognitive decline by 27% in people with early-stage Alzheimer's disease, in a large, phase 3 clinical trial.
Read more in our latest news story👉buff.ly/3CgAy2u
Delighted to announce Prof David Attwell (@ucl) as Centre Director of our groundbreaking new Centre for Vascular Dementia Research, a partnership with @TheBHF!🎉👏
Prof Attwell's extensive experience brings a wealth of leadership & vision to the role👉buff.ly/3PQbDJL
New year, new labs! So exciting to move into our shiny, newly-refurbished space @UCL Cruciform building! Within these walls we will help #conquerdementia
Terrific news today as results from phase 3 trial of #Alzheimers drug donanemab presented at #AAIC23 confirm the drug significantly reduced amyloid in the brain & slowed disease progression👏 🧠
UK DRI researchers comment on the encouraging results🙌 👉buff.ly/3K0pr1c
We're thrilled to announce 4 new UK DRI Emerging Leaders: @SophieMorse20, @jojacksonhere, Dr Emma Clayton & Dr Philip Weston👏 🎉 🥳
The initiative supports exceptional ECRs on their journey to independence. Find out more about our new Emerging Leaders👉buff.ly/3FOgKV9
Huge congrats to @TSpiresJones (UK DRI at Edinburgh) who has been elected as a Fellow of the @acmedsci today!👏
Prof Spires-Jones is one of 58 exceptional scientists recognised for their remarkable contributions to advancing biomedical & health sciences👉buff.ly/3QQjTd6
"I am truly excited to lead our brilliant team of researchers and collaborators in pushing the boundaries of science and unlocking vital understanding."
New UK DRI at Cambridge Director Prof Mina Ryten in @CambridgeIndy ⬇️
buff.ly/3HQJ9ei
Image 2 of 5: Brain defenders
A mouse brain magnified 100x to show individual cells. The red and green colours highlight immune cells of the brain gathering around amyloid plaques - the protein deposits found in Alzheimer's.
4/7
We urgently need to accelerate progress in dementia research and develop new treatments.
We've joined other leaders in the field to call on the government to take action now 👇
Absolutely delighted for Prof Giovanna Mallucci (Centre Director, UK DRI at Cambridge) who has been awarded the prestigious 2021 Potamkin Prize for Research in Pick's, Alzheimer's and Related Diseases 🎉👏🧠🥳
Read more about the announcement👉 bit.ly/2Q8BuRp
We are delighted to announce a new partnership with @TheBHF to establish the UK’s first research centre dedicated to vascular dementia!👏 🎉 🙌
With our combined expertise, we will transform the research landscape for this devastating condition🤝👉buff.ly/47EsPbH
🚨Breaking 🚨FDA approves Aduhelm (aducanumab) for the treatment of Alzheimer's disease
Significant milestone as the first disease-modifying drug for the condition
fda.gov/drugs/news-events-hu…
Image 5 of 5: Lava lamps
TAF15 (pictured in red) is a mutant protein involved in neurodegenerative disease. Here the TAF15 protein forms bubbles (green) filled with RNA, that assemble around the cell nucleus (blue).
7/7
We're delighted to announce 3 new UK DRI Emerging Leaders: @M_Malpetti, @AnnaMallach, & @val_jaramillo! 🎉 🙌 👏
The initiative supports exceptional ECRs on their journey to setting up an independent lab. Find out more about our new Emerging Leaders👉buff.ly/47lcA4a
Congratulations to the UK DRI's @TSpiresJones for receiving the Inge Grundke-Iqbal Award from @alzassociation at #AAIC24! 👏
This award is presented to the senior author of the most impactful study published in Alzheimer’s research in the past 2 years👉buff.ly/3WK21Uz
Congratulations to UK DRI researchers Prof Karen Duff and Prof Siddharthan Chandran, who have who have been elected as Fellows of the @acmedsci for their outstanding research into neurodegenerative diseases! 🎉
Read more 👉 bit.ly/3N4DwtF#AMSFellows2022
Delighted to welcome HRH Princess Royal to the @UKDRI@UCL labs. Our scientists demonstrated their research and recent recruits discussed the importance of a free flowing international community of researchers—all essential ingredients to conquer dementia. ukdri.ac.uk/news-and-events/…
Lab-grown brain organoids hint at potential treatment options for motor neurone disease and frontotemporal dementia 🧠
📰 New @NatureNeuro article out today from Cambridge researchers including UK DRI Group Leader Dr Gabriel Balmus👉bit.ly/3ptcofg
We’re over the moon that the @Brain_Prize has been awarded to our Director Bart De Strooper and our Professor John Hardy @UCLBrainScience – congratulations to all four winners on this outstanding recognition! ukdri.ac.uk/news-and-events/…#brainprize
Exciting research by Prof Bart De Strooper has discovered how neurons die in #Alzheimers🧠
The study reveals new insight into the mechanism by which neurons initiate a form of cell death known as necroptosis, when exposed to amyloid plaques & tau tangles👉buff.ly/3ZhCi5s
Huge congrats to @DrPujaM, the winner of our Science Imaging Competition 2023, for her amazing image 'Eruption of Etna's Embers' 🥳🎉👏
Neurons grow in a device (bottom), & 'wires' carrying the electrical impulses travel through tiny grooves to get to the other side (top)
🧵1/6
We're delighted to welcome a new Group Leader to the UK DRI at King's!🎉👏🥳
Dr Andrea Serio (@The_SERIOus_Dr) aims to tackle motor neuron disease (MND) from a unique angle, applying principals from his background in bioengineering👉buff.ly/3Or9tjr@KingsIoPPN
THRILLED to announce a major cell model initiative for Alzheimer’s 🧠
Led by Prof Julie Williams & UK DRI at Cardiff 🏴 - iPSC Platform to Model Alzheimer’s Disease Risk (IPMAR) - aims to become one of the largest cellular model resources available 🔬
👉 bit.ly/3u6N6TU
🗣️Announcing our new £2M initiative - Multi-‘omics Atlas Project (MAP)🧠- led by UK DRI at Imperial
This human brain atlas will use an unprecedented range of techniques to examine tissue from across the course of Alzheimer's disease
📰Read more➡️bit.ly/38m38gO
Huge congratulations to the brilliant Dr Soyon Hong (@soyonhonglab, UK DRI at UCL) - awarded this year's 'David Hague Early Career Investigator of the Year' at #ARUK2023 by Caroline van den Brul MBE👏🧠🎉🏆
Read more & watch our new film with Dr Hong👉buff.ly/3FrKYxx
Brilliant podcast with @axl_montagne (UK DRI at Edinburgh), discussing his research into the role of blood brain barrier dysfunction in the diseases that cause dementia.
Check it out ⬇️
@foundmyfitnessbuff.ly/3ZCfKvK
We have a new Research Fellow position open in the lab of Prof Karen Duff (Centre Director, UK DRI at UCL)
Ideally suited for a newly qualified postdoc interested in understanding the role of abnormal tau protein in neurodegenerative disease
🗓️ 5 Feb 👉 bit.ly/3oj64D4
We're delighted today to announce our new 'Emerging Leaders' programme - an initiative to support research fellows on their journey to independence! 🎉🧠
Find out more about programme & first UK DRI Emerging Leaders👉 bit.ly/2Qdq8eS (1/4)
Exciting news today as results from phase 3 trial of #Alzheimers drug lecanemab presented at #CTAD22 confirm the drug reduced amyloid in the brain & slowed cognitive decline👏
UK DRI researchers comment on the news, hailed as 'the beginning of the end'🙌👉buff.ly/3FbOnB0
Important new research led by Prof Siddharthan Chandran & Prof Josef Priller (UK DRI at Edinburgh) reveals insight into why motor neurons degenerate in MND🧠
Microglia, the brain's immune cells, show impaired waste clearance & build up of toxic proteins👉buff.ly/3NaGhNu
We're in Brighton for the next few days for our annual conference, Connectome 🥳 🧠 🙌
Researchers from across all UK DRI centres are coming together for a packed programme of exciting science! Stay tuned for updates.
#Connectome2023
And that's a wrap! Thank you to everyone who joined us for #Connectome2022 over the last few days👏
It was brilliant to catch up with you all on our 5th anniversary - here's to the next five!
Full vid👉piped.video/dCciX8Y-BWI
Image 3 of 4: Pirates of the Caribbrain: The Curse of the Plaque Pearl
A protein called complement receptor 1 (CR1) is found on microglia and astrocytes (red) and amyloid-beta plaques (green/yellow) in the Alzheimer's disease brain.
5/6
Encouraging news today as a second Alzheimer's drug, donanemab, has been shown to slow cognitive decline in a phase 3 trial👏
More in the @Independent👉buff.ly/3LsJl50
This month we're celebrating a significant 5-year anniversary for the UK DRI 🎉, when in 2016 we selected @UCL as the Institute’s hub & Prof Bart De Strooper to lead as National Director 🎊 (1/6)
Huge congrats to Dr Sarah Marzi (@sj_marzi) who will be joining the UK DRI at King's as a new Group Leader this September!🥳🎉👏
Dr Marzi will apply her background in epigenetics to tackle amyotrophic lateral sclerosis (ALS)👉buff.ly/3Yip0p6@KingsIoPPN
🎉 Big congratulations to Dr Soyon Hong, Dr Tim Bartels & Prof Adrian Isaacs (UK DRI at UCL), who have each been awarded a Collaborative Pairs Pilot Projects award by @ChanZuckerberg, as part of a world-wide call 🌍
Read more about the projects ➡️ bit.ly/2YcH4CX
VERY excited to be hosting our first research & careers mini-conference for secondary school students! 🎉🥳
Brilliant chance to go behind the scenes & hear from academics/clinicians about their work on the brain 🧠
🗓️ 15-16 Sept 👉 ukdri.ac.uk/events/making-it…
🎉We are delighted to be hosting a special interest event at #FENS2020 🎉
Come join...
✅ Bart De Strooper
✅ Karen Duff
✅ John Hardy
✅ Giovanna Mallucci
... for a discussion on key outstanding questions in dementia research 🧠
⏰9:30 🗓️15 July ➡️ bit.ly/2V8BS1v
It's #InternationalDayOfWomenAndGirlsInScience! #IDWGS2021 🎉
A special thanks to everyone taking on the challenge of #dementia in labs, offices, clinics... around the world! 🙌
To celebrate, we'll be sharing some highlights from the last year ⬇️
Huge congratulations to Prof Sarah Tabrizi (UK DRI at UCL) who has received the 2022 Osler Medal and the Huntington’s Disease Society of America (HDSA) 2022 Outstanding Research in Huntington’s Disease Award 🎉👏👉buff.ly/3OtkJJr
Today marks the start of World Alzheimer’s Month!🧠
Throughout Sept, we’ll be shining a spotlight on our dementia researchers and initiatives across the Institute
Stay up to date via our blog👉 bit.ly/2WOoe7I
& subscribe to our new e-newsletter👉 bit.ly/3t3riZz
Congratulations to Prof Paul Matthews (Centre Director, UK DRI at Imperial) who has been appointed the new Director of @RosFrankInst!
Huge thanks to Prof Matthews for his hard work & commitment to UK DRI, & we look forward to continuing to work together👉buff.ly/3RguQFk
After 6 years as UK DRI Director, Prof Bart De Strooper is stepping down to focus full-time on his research.
His lab will remain within the UK DRI, where he will continue his world-leading work on understanding the fundamental mechanisms of Alzheimer’s👉buff.ly/3EchbaH
Congratulations to Prof Joanna Wardlaw CBE (Group Leader, UK DRI at Edinburgh) who has been awarded this year's @BritishNeuro 'Outstanding Contribution to Neuroscience Award'! 🧠 🎉👏
More about Prof Wardlaw's research👉ukdri.ac.uk/team/joanna-ward…
Huge CONGRATULATIONS to this year's #BNAPrizes winners👏✨🥳
Outstanding Contribution to Neuroscience 2021: Professor Joanna Wardlaw
Public Engagement of Neuroscience 2021: The BrainBus team
Awarded live at the #BNAFestiveSymposium!
Full info here: buff.ly/3INlxGX
Positive peer pressure: new @CellReports study reveals how neurons & astrocytes cooperate to maintain a healthy homeostatic state in microglia
From the team at UK DRI at Edinburgh, led by Dr Jing Qiu & Prof Giles Hardingham
Read the full story👉 bit.ly/3cdVHxt
Today, on #WorldAlzheimersDay, UK DRI acknowledges all those impacted by the disease & other causes of dementia
Our 600+ researchers are working hard to uncover the causes of #dementia and identify promising treatments
Prof Bart De Strooper reflects 👉 bit.ly/3iNRamk
Super interesting study, led by @w_mcewan (UK DRI at Cambridge) reveals new insight into the mechanisms underlying an experimental antibody therapy for Alzheimer's🧠
The findings could pave the way for safer and more effective immunotherapy drugs👏👉buff.ly/3G7jhua
🎉We are thrilled that planning approval has been given for a new world-leading research centre for #dementia & neurological disease research 🧠
The site will house >500 researchers from @UKDRI & @UCLIoN 🥼🔬
Read more about the new centre here ➡️ bit.ly/2kqLPZ1
We’re excited to announce our first Grand Challenge to improve early diagnosis of #Alzheimers
Led by @marcaurelbusche (UK DRI at UCL), the highly collaborative project will develop a biomarker that accurately detects the earliest signs of disease👉buff.ly/3kdW4yS
1/4🧵
A new study by @w_mcewan & @_sophiesanford reveals that type-I interferons, a part of the innate immune response, may increase the build up of misfolded toxic tau protein in Alzheimer’s🧠
The research could provide a new avenue for disease therapeutics👉 buff.ly/3ShIjxI
We're excited to welcome a new Group Leader to the UK DRI at Edinburgh!🎉👏
Dr Philip Hasel (@HaselPhilip) is researching the function of a specific type of astrocyte only found at the brain border, in health and disease.
Find out more about his work👉buff.ly/3Jm7lWC
Image 1 of 4: Axon Hurricane
Long projections known as axons extend away from the cell bodies of neurons that are derived from stem cells. The axons naturally form a right-turning hurricane-like shape.
3/6
Fantastic talk from Prof Bart De Strooper (UK DRI at UCL), kicking off the ‘Neuroimmune function in neurodegenerative disease’ session at #AAIC2023 this morning! 👏
Team led by Prof Bart De Strooper (UK DRI Director) & Dr Mark Fiers @CBD_VIB, have used pioneering spatial transcriptomics to probe brain cells in the direct vicinity of amyloid plaques in Alzheimer’s
📰New @CellCellPress publication out today
➡️ bit.ly/2WIZiv6
Today in The @Guardian our Director urges @Pfizer to reconsider ending their efforts in dementia drug discovery - "We need to know that like us, you’re in this for the long run and won’t quit until the job is done. Are you with us?" theguardian.com/commentisfre…@UCLIoN
The UK DRI Biomarker Factory, led by Prof Henrik Zetterberg and Dr Amanda Heslegrave (@ajh1269) supports the development of new fluid biomarker tests, leading the way for simple blood tests for neurodegenerative conditions.
Take a tour of the factory👉buff.ly/4bD7cKB
🔔 Our Director, Prof Siddharthan Chandran, was invited to discuss our work in dementia and neurodegenerative conditions this week with the House of Commons Science, Innovation and Technology Committee.
The Select Committee was investigating how UK science and research is contributing to the eradication of diseases.
🎯 Listen to Siddharthan comment on what the future of dementia and neurodegeneration research and detection looks like and why the work of the UK DRI is so important.
📺 You can watch the full recording on Parliamentary TV (10:18 to 10:59) buff.ly/3BOxwFj
“This is an enormous clue to what’s going wrong,” - Prof Julie Williams (UK DRI at Cardiff).
New research has uncovered 42 new genes associated with increased risk of Alzheimer's 🧠
Read more in the @guardian ⬇️theguardian.com/society/2022…
Huge congratulations to @_sophiesanford, who has today been awarded the @BritishNeuro Award for Public Engagement of Neuroscience, for her work pioneering Making it Brain - a free, online careers event for students👏🎉
Read more👉buff.ly/3VRYpNB
Huge congratulations to Prof Sarah Tabrizi (UK DRI at UCL), Prof Bill Wisden & Prof Paul Elliott (both UK DRI at Imperial), who have been elected as Fellows of the @royalsociety today in recognition of their invaluable contributions to science!👏🥳👉buff.ly/44IjzTy
Interesting new research led by @TSpiresJones (UK DRI at Edinburgh) has revealed fresh insight into how misfolded tau spreads through the #Alzheimers brain, via synapses🧠
Scientists say the study could hold the key to stopping the disease progressing👉buff.ly/3Ie0Zsd
“This is the beginning of the end for dementia,” said Prof Nick Fox, as we officially opened our hub at UCL.
Thanks to our funders @The_MRC@alzheimerssoc@ARUKnews and everyone who has helped bring promise to the millions of people affected by dementia.
ukdri.ac.uk/news-and-events/…
🎉👏 Congratulations to Professor Karen Duff (Centre Director, UK DRI at UCL) on picking up the 2020 'Outstanding Contribution to Neuroscience' award from @BritishNeuro! 👏🎉
Fantastic to hear from our first keynote speaker @wysscoray (@Stanford) at #Connectome2023 today!
A fascinating talk on his incredible work looking at how circulatory blood factors modulate brain structure & function, & factors from young organisms can rejuvenate old brains🧠
HUGE congratulations to Dr Wioleta Zelek (UK DRI at Cardiff) & Dr Aitana Sogorb-Esteve (UK DRI at UCL) recipients of prestigious Race Against Dementia fellowships & our latest UK DRI Emerging Leaders🎉
#WorldAlzheimersDay2021
Learn about their projects👉bit.ly/2XBxaO5
We're thrilled that the Scottish Government are investing £400,000 over the next three years in our @EdinburghUni centre to develop new treatments for Motor Neurone Disease (MND).
ukdri.ac.uk/news-and-events/…#scotland#mnd
SO EXCITED to be in sunny Brighton today at the #BYOB2023 Brain Science Fair teaching families about neuroscience! 🧑🔬
We've got jelly brain dissection & toxic protein Tetris from the team at UK DRI at Cambridge 🧠
Last entry to the Brighthelm Centre 2pm!
Image 5 of 5: AstrocytER
The endoplasmic reticulum (ER), a network of membranes through which proteins and other molecules move, is stained within astrocytes, the star shaped supporting brain cells.
7/7
"We’re at the end of the beginning of our misunderstanding of the disease, & we’re at the beginning of being able to end it."
🗣️Interview out today with Centre Dir. at UK DRI at UCL, Prof Karen Duff, discussing tau, selective vulnerability & trials
👉 bit.ly/2JxOmg8
Congratulations to Prof Sir John Hardy (UK DRI at UCL) who has been elected a Foreign Member of the Chinese Academy of Sciences (CAS)!👏 🎉
Read the full story⬇️
@UCLIoNbuff.ly/3SOIPnf
Congratulations to Dr Sam Barnes & Dr Soyon Hong (@soyonhonglab), who were awarded funding in the 4th round of our Cross-Centre Postdoctoral Awards!👏🎉
Their project will investigate the role of microglia in #Alzheimers👉buff.ly/3CBYm0D
The UK Dementia Research Institute (UK DRI): Five years of innovation in discovery science🧠🧪🔬
📽️ Who we are👉buff.ly/3UVRiDa
📖 What we do & how we do it👉 buff.ly/3GwWmts
📩 Sign up for our monthly newsletter👉 buff.ly/3QdFXN4
"I hope my work helps us to start unravelling some of the mechanisms that lead to Alzheimer's disease"
@nlconnor_robson is an @AlzResearchUK fellow & Emerging Leader at the UK DRI at Cardiff, where she is researching the genetics of late-onset #Alzheimers🧠⬇️
#WorldBrainDay
New Alzheimer's drug donanemab has hit headlines today as it was reported to slow cognitive decline by 35% in a phase 3 trial🧠🙌
UK DRI researchers comment on the momentous news👉buff.ly/44qPAid
ALT A photo of Prof Bart De Strooper next to a quote that reads: “We will need to wait for the full results to be presented in the summer to assess the data in more detail, but the effects are convincing and these initial results confirm that amyloid beta is a good target, and that treating people earlier is going to give better results.
This reinforces the need for effective diagnostics alongside these
emerging treatments.”
Head injuries may worsen cognitive decline decades later
People who experienced head injuries in their 50s or earlier score lower than expected on cognitive tests at age 70, according to a new study co-led by Prof Nick Fox (Group Leader, UK DRI at UCL)
👉bit.ly/38wWNlQ
Brilliant presentation from @DrArpan100 at #BNA2023 on the innovative @mndsmart and ongoing exciting developments taking place
An ambitious initiative with huge potential to change lives!
🖥️Fantastic opportunity to catch Prof Sir David Klenerman (UK DRI at Cambridge) - all welcome! 🙌
"Detecting and Characterising the Protein Aggregates Formed in Neurodegenerative Diseases"
Webinar hosted by @KingsIoPPN
🗓️28 April ⏰12pm BST➡️bit.ly/2VRegxV
A team led by @nir_grossman (UK DRI at Imperial) have developed a new technology that, for the first time, allows structures deep inside the brain to be electrically stimulated without surgery.
It's now being trialled as a treatment for Alzheimer's👉 buff.ly/45EQzej
Congratulations to Dr Kat Bowles 👏(@bowles_lab, UK DRI at Edinburgh) who has been awarded a Tauopathy Challenge Workshop Prize from @RCFNeuro, in partnership with @CurePSP & the Aging Mind Foundation 🧠
👉shorturl.at/IPzBq
Excellent workshop led by @e_a_english from @WomeninNeuroUK at #ARUKConf24!
Important discussion about the leaky pipeline in dementia research, and an open and honest panel discussion and Q&A👏👏
#WiNUKxARUK
Since its launch in 2017, the UK DRI has made important progress in overcoming dementia.
Now, we are thrilled to announce major funding that will set us on track for success in our next phase👉buff.ly/3I6pjge
1/2
ALT Headshot image of Prof Bart De Strooper, Director of the UK DRI, next to a quote that reads 'I am immensely proud of everything we have achieved at the UK DRI over the past five years. We are delighted that this has been recognised in our recent institute-wide review and that we have been awarded five more years of funding, so we can continue to push on with our ambitious programme of research.'
Great talk from Prof Bart de Strooper at 'Unravelling Dementia Together' at the British Embassy in Brussels today👏
Basic research is crucial to cure dementia, & international collaboration is pivotal to solve this global issue🤝
Congratulations to Dr Soyon Hong (@soyonhonglab), Dr Tim Bartels & Prof Adrian Isaacs (@isaacs_adrian) who have each been awarded major funding from @cziscience's Collaborative Pairs Programme! 🥳👏
Find out more about the scheme & their projects👉buff.ly/3fUDl9t