Many IVF add-on therapies are marketed with the promise of improving treatment success. But what does the evidence show?
Find out more in The Lancet Obstetrics, Gynaecology, & Women's Health ⤵️
Paper 1: spkl.io/60177Exux
Paper 2: spkl.io/60187ExuI
NEW—Interim analysis of Russian #COVID19#vaccine phase 3 trial involving nearly 20,000 participants suggests a two-dose regimen has an efficacy of 91.6% against symptomatic #COVID19. No serious adverse events were deemed to be associated with vaccination. hubs.li/H0FQWFS0
Today, three of the authors have retracted "Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis" Read the Retraction notice and statement from The Lancet hubs.ly/H0r7gh50
NEW Research—No evidence of benefit for #chloroquine and #hydroxychloroquine in #COVID19 patients, urgent randomised trials are needed: finding from a large observational study of nearly 15,000 patients with #COVID19 & 81,000 controls hubs.ly/H0qMlXr0
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Statement from The Lancet in response to President Donald Trump’s May 18 letter to Dr Tedros Adhanom Ghebreyesus, Director-General of the World Health Organization
NEW—Almost all #COVID19 restrictions are set to end in England on July 19. A group of scientists and health experts outline 5 key concerns and urge delaying complete re-opening until everyone—including the young—is better protected.
Read hubs.li/H0RPYj90. @dgurdasani1
ALT Quote: We believe the government is embarking on a dangerous and unethical experiment, and we call on it to pause plans to abandon mitigations on July 19, 2021.
NEW Correspondence—80+ researchers warn that a so-called #herdimmunity approach to managing #COVID19 is “a dangerous fallacy unsupported by the scientific evidence” #WCPH2020hubs.li/H0xZVrs0
NEW—Most comprehensive study to date provides evidence on optimal physical distancing, face masks, and eye protection to prevent spread of #COVID19: a systematic review and meta-analysis of 172 observational studies hubs.ly/H0q_BJL0
NEW Research—First human trial of #COVID19 vaccine finds it is safe and induces rapid immune response: finding from a dose-escalation, single-centre, open-label, non-randomised, phase 1 trial hubs.ly/H0qMrl-0
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NEW—Cervical cancer rates 87% lower in women offered vaccination against human papillomavirus (#HPV) between ages 12-13 than in previous generations, English study confirms.
First direct evidence of cervical cancer prevention using bivalent vaccine: hubs.li/H0-BBKj0
Just published: Two new studies on the novel coronavirus. All Lancet #coronavirus content is fully and freely available at our 2019-nCoV Resource Centre thelancet.com/coronavirus
NEW—One in three #COVID19 survivors received a neurological or psychiatric diagnosis within six months of infection, an observational study of more than 230,000 patient health records published in @TheLancetPsych estimates. Read hubs.li/H0KD0fx0
We have published an Expression of Concern on the paper by Mehra et al on hydroxychloroquine and chloroquine published on May 22, 2020 hubs.ly/H0r2vFC0
Taking a common diabetes medication after testing positive for SARS-CoV-2 reduces risk of developing #longCOVID by 40%, new study in @TheLancetInfDis finds
hubs.li/Q01SCsZj0
ALT Cumulative incidence of post-COVID-19 condition (long COVID) diagnoses over 10 months after randomisation.
The spread of health misinformation and disinformation poses a serious threat to public health.
How can we respond to the danger and combat the tide of misinformation and disinformation to protect public health?
Find out more in our latest Editorial: hubs.li/Q032YWZ40
ALT Cover of The Lancet's Jan 18th, 2025 issue. Quote reads: "Disinformation has become a deliberate instrument to attack and discredit scientists and health professionals for political gains. The effects are destructive and damaging to public health."
NEW Correspondence "International humanitarian norms are violated in Hong Kong"
Personal experience from a medical practitioner providing emergency care to injured protesters engaged in violent confrontation with police at Hong Kong Polytechnic University hubs.ly/H0lXzJm0
NEW—Even for the #DeltaVariant, vaccine efficacy against severe #COVID19 so high that booster doses for general population are not appropriate at this stage in the pandemic.
Expert review of evidence to date by intl. group of scientists: hubs.li/H0X7tVx0#VaccinEquity
NEW—An estimated 1.2 million people died in 2019 from antibiotic-resistant bacterial infections, more deaths than HIV/AIDS or malaria.
#GRAMPaper reveals the scale of antimicrobial resistance (#AMR), now a leading cause of death worldwide: hubs.li/Q012sG-t0#AMRSOS
NEW—More nurses lead to fewer patient deaths and readmissions, shorter hospital stays, and cost-savings for hospitals, suggests study of recent Australian state policy to introduce a minimum ratio of one nurse to four patients for day shifts. Read hubs.li/H0N74zl0.
NEW—Most people who have had original #COVID19 strain are protected from catching it again for at least 6 months—but those ≥65 years are more prone to reinfection, suggests first large-scale study of its kind. Read hubs.li/H0JsJKg0
NEW—Preliminary results from Russian trials find that #COVID19 vaccine candidates led to no serious adverse events and elicit antibody response hubs.li/H0vGWRW0
Thread (1/8)
NEW—First full results from interim analysis confirm that the Oxford #COVID19 vaccine is safe and efficacious against symptomatic COVID-19 disease: hubs.li/H0CcSs60 (1/6)
Study finds use of chloroquine or #hydroxychloroquine with or without a macrolide is linked to increased rates of mortality and heart arrhythmias among hospital patients with #COVID19 (2/4)
A sub-analysis of 2,000 adults >60 years suggests the Russian #vaccine is similarly effective and well-tolerated in this group. Further research is needed to confirm results in those belonging to unrepresented risk groups and non-white ethnicities.
NEW Research—First randomised trial of #remdesivir for hospitalised patients who are critically ill with #COVID19 suggests antiviral drug is not associated with significant clinical benefits vs placebo: study of 237 adults from 10 hospitals in Wuhan (1/5) hubs.ly/H0p-BMJ0
Network meta-analysis of 21 commonly used #antidepressants—all antidepressants are more effective than placebo for short-term treatment of acute #depression in adults hubs.ly/H0b370n0
Today, we publish the first clinical data from individuals confirmed to be infected with 2019-nCov from Wuhan, China. As for all public health emergencies, we will be making all related #Coronavirus Lancet content fully and freely available thelancet.com/coronavirus
#LancetWomen: This week, we dedicate an issue to advancing #women in science, medicine, & global health. The collection highlights that #genderequity in science is not only a matter of justice and rights but is crucial to producing the best research hubs.ly/H0gwsRt0
Countries that reoriente their health systems towards #PrimaryHealthCare are better placed to achieve the #SDGs. Fully embracing the #AlmaAta40 vision of #PHC can deliver substantially greater SDG progress hubs.ly/H0fbFLh0
Junior doctors working a 34 h shift will make 460% more diagnostic mistakes than when well rested. @sleepdiplomat Matthew Walker asks how can we change the culture of #sleep within medicine? hubs.ly/H0czJzf0
Current projections estimate 153 million people will be living with dementia by 2050.
Nearly half of dementia cases could be prevented or delayed by tackling 14 risk factors starting in childhood, suggests new report from a standing Lancet Commission: buff.ly/46nvoPR
ALT Lancet infographic conceptualising risk factors for dementia.
Preliminary results from a phase 1/2 trial involving 1077 healthy adults found that vaccine induced strong antibody & T cell immune responses up to day 56 of the ongoing trial. These responses may be even greater after a 2nd dose, according to a sub-group study of 10 participants
"This evidence should ignite inquiry into the broader health impacts of police violence and advance the challenge to confront racial health inequities as products of racism."
Comment by @RheaBoydMD#APHA2018hubs.ly/H0fvG650
Our Editor-in-Chief @richardhorton1 alongside public health academics calls on the UK Government to urgently share scientific evidence used to inform its #COVID19 plans in a letter in @thetimes#COVID19UK
Please read and support our letter in The Times today calling on the UK government to share the evidence, data, and models on which it is basing its policies. Without complete openness the public’s trust will be lost.
NEW #COVID19 —Experts’ request to the Spanish Government: move Spain towards complete lockdown
Correspondence from O Mitjà, À Arenas, X Rodó, A Tobias, J Brew, J M Benlloch on behalf of 62 signatories hubs.ly/H0nWrGG0
NEW—Paediatricians describe a cluster of 8 children believed to represent a "new phenomenon affecting previously asymptomatic children w/ SARS-CoV-2 infection manifesting as a hyperinflammatory syndrome with multiorgan involvement similar to Kawasaki disease shock syndrome" (1/2)
Alarmingly, deaths from conflict and terrorism have become one of the fastest growing causes of death globally (increasing by 118% between 2007 and 2017) #GBDStudyhubs.ly/H0fslX50
Editorial: "PM Narendra Modi vows that his decision to revoke autonomy will bring prosperity to #Kashmir. But first, the people of Kashmir need healing from the deep wounds of this decades-old conflict, not subjugation to further violence & alienation." hubs.ly/H0kj2f80
NEW Editorial—#COVID19 in Brazil: “So what? calls for leadership at the highest level of government to quickly avert the worst outcome of this pandemic hubs.ly/H0qjgY40
Também disponível em Português hubs.ly/H0qjgY50
NEW—The ongoing social unrest in Hong Kong may be affecting the mental health of the general adult population—potentially leading to substantial increases in demand for mental and psychosocial support services: finding from a 10-year observational study hubs.ly/H0mwPCv0
NEW—First nationwide population-based study presents seroprevalence estimates of antibodies against SARS-CoV-2 at national and regional levels, exploring the landscape of population immunity in Spain (#ENECOVID) @sanidadgobhubs.ly/H0s8-RP0
NEW: "We are calling upon governments to end the torture of [Julian] #Assange & ensure his access to the best available health care before it is too late"
S Frost, L Johnson, J Stein & W Frost @Doctors4Assange on behalf of 117 signatories hubs.ly/H0n2z580
NEW—UK’s #COVID19 vaccine shows similar safety and immunogenicity results in healthy older adults (aged 56 years & over) to those seen in adults aged 18-55 years: finding from a single-blind, randomised, controlled, phase 2 trial hubs.li/H0B97zg0
NEW—Correspondence reports initial analysis of neutralising antibody activity against #SARS-CoV-2 variants of concern B.1.617.2 and B.1.351 elicited by partial or full vaccination with #BNT162b2 (#Pfizer-BioNTech).
Read hubs.li/H0PzQ7b0. Figure from appendix. @TheCrick
5 years ago #GH2035 concluded that a grand convergence in health is feasible for all but the poorest countries. For #AlmaAta40, a renewed call for global investment in health recognising efforts to strengthen #PHChubs.ly/H0fbF090
Next in the #Astana2018 Relay: @GaviSeth
GLP-1 receptor agonists, which are effective for weight loss, can cause substantial muscle loss.
A Comment in @TheLancetEndo discusses the effects of GLP-1 receptor agonists on skeletal muscle mass: hubs.li/Q02WgC490
ALT Figure showing selected key roles of skeletal muscle as a structural versus metabolic organ. Copyright: Elsevier Ltd. All rights are reserved.
NEW—Privatising NHS services is associated with a decline in the quality of healthcare, increasing deaths from treatable causes, study in @TheLancetPH suggests. hubs.li/Q01fYzGl0
"A medical catastrophe is unfolding."
Written on Christmas Day in #Ethiopia, an appeal to world leaders by A Mark Clarfield, colleagues, & signatories: stand by health workers & patients in #Tigray.
hubs.li/Q0126kn70
ALT We appeal to the world's medical community to demand protection of hospitals such as Ayder from attack, and plead for assistance in ensuring the provision of food, equipment, and medications to care for the civilian population of Tigray.
NEW—40% of #dementia cases could be prevented or delayed by targeting 12 risk factors throughout life: finding from 2020 update to @TheLancet Commission on dementia prevention, intervention, and care #AAIC20hubs.ly/H0s-v8_0
🗨️ “Vaccines have done more to improve public health than any other medical intervention.”
A new Viewpoint focuses on cancer vaccines and the future of immunotherapy—analysing trials, different vaccine approaches, and how the next generation of cancer vaccines can help improve patient outcomes and quality of life. hubs.li/Q03sQVF60
ALT Figure: Types of therapeutic cancer vaccines. APCs=antigen-presenting cells. Full figure description in the paper.
A year ago, Mahsa Amini died after being arrested and tortured for allegedly breaking Iran’s mandatory hijab law. Mass protests ensued.
@richardhorton1 writes about events since, doctors implicated in human rights abuses, and the intersection of health and women’s rights. /2
Mexico faces ongoing shortages of medicines and drugs. The country's President, López Obrador, has blamed corruption—but analysts say otherwise. David Agren (@el_reportero) reports. hubs.li/H0T0xSN0
"If the social situation and political climate in Hong Kong are left unchanged, the distress of citizens stemming from this social unrest cannot be completely addressed and healing cannot commence."
Comment from Xue Yang & Winnie W S Mak @CUHKofficialhubs.ly/H0mxslQ0
Ultra-processed foods – what’s the impact?
In a new Lancet Series, experts warn a global rise in #UPFs presents a growing public health threat.
Read the evidence & policy recommendations ⬇️
hubs.li/Q03TLKK30
ALT Part of a Lancet Infographic summarising the findings from the Lancet Series on Ultra-Processed Foods and Human Health.
ALT Part of a Lancet Infographic summarising the findings from the Lancet Series on Ultra-Processed Foods and Human Health.
ALT Part of a Lancet Infographic summarising the findings from the Lancet Series on Ultra-Processed Foods and Human Health.
NEW—Speed of testing is most critical factor in success of contact tracing strategies to slow #COVID19; a delay of 3 days or more between symptom onset & testing will not reduce onward transmission of virus sufficiently: a modelling study @TheLancetPHhubs.ly/H0sDRtn0
New #GBDStudy ranks countries by their performance on the health-related #SDG index; global median in 2017 was 59·4
1 Singapore 🇸🇬
2 Norway 🇳🇴
3 Sweden 🇸🇪
4 Israel 🇮🇱
5 UK 🇬🇧
...
...
194 Somalia 🇸🇴
195 Central African Republic 🇨🇫
hubs.ly/H0ftd_r0
The US CDC has seen its role minimised & become an ineffective & nominal adviser in the #COVID19 response. NEW Editorial "Reviving the US CDC" looks at how the agency become so ill-prepared to protect the public's health hubs.ly/H0qyWDt0
#VitaminD supplementation in adults does not prevent fractures, falls or improve bone mineral density—finding from a meta-analysis of 81 randomised controlled trials @TheLancetEndohubs.ly/H0f0qM_0
Compared to control group (given a meningitis vaccine), SARS-CoV-2 vaccine caused minor side effects more frequently, but some of these could be reduced by taking paracetamol. There were no serious adverse events from the vaccine
Our new issue is here! On the cover—'Periods on display' and the cultural movement against menstrual shame and #PeriodPoverty.
Plus, @WHO air quality guidelines, low #BackPain management, community-acquired bacterial #meningitis, and more. Read: hubs.li/H0Y33_L0
ALT Historically, the anatomy and physiology of bodies with vaginas have been neglected.
"It will not be #FreedomDay, it will be a self-inflicted wound..."
As cases rise, @richardhorton1 warns against "a plan driven more by libertarian ideology than prudent interpretation of the data" and calls for continued mask-wearing, distancing, and ⬆️ #vaccine coverage.
NEW—Study confirms first case of #COVID19 reinfection in the USA, indicating exposure to the virus may not translate to total immunity: finding from a case study from the University of Nevada @TheLancetInfDishubs.li/H0xPxQN0
NEW #COVID19—First study identifies risk factors associated with death in adults hospitalised with new #coronavirus disease in 2 hospitals in Wuhan, China hubs.ly/H0nsfmD0
Feeding a population of 10 billion people by 2050 with a healthy & sustainable diet will be impossible without transforming eating habits, improving food production & reducing food waste—new @EATForum–@TheLancet Commission #EATLancet#foodcanfixithubs.ly/H0gcll-0
In Italy last week, data reported that 20% of health-care workers responding to #COVID19 were infected, and some have died. Editorial outlines the urgent imperative to protect health-care workers hubs.ly/H0nNf-m0
"The consequences of varying government #COVID19 responses will be long-lasting..."
Consistently aiming for elimination over mitigation of #SARS-CoV-2 creates best outcomes for health, the economy, and civil liberties, writes @OliuBarton et al. Read: hubs.ly/H0McpXl0.
Nearly half of dementia cases could be prevented or delayed by tackling 14 risk factors starting in childhood, including two new risks—high cholesterol and vision loss, suggests new report from the Lancet Commission on dementia.
Find out more ➡️ hubs.li/Q02KbpYf0
ALT Lancet infographic representing the risk factors for dementia.
NEW—Cases of major depressive disorder and anxiety disorders increased by over a quarter in 2020 due to the #COVID19 pandemic, with women and younger people most affected.
First global estimates of the impacts of the pandemic on #MentalHealth: hubs.li/H0Z3-VT0
Depression—it's one of the leading global public health problems.
Although currently available interventions can be effective, limitations exist.
A new Review assesses novel and emerging biological treatments for major depressive disorder: hubs.li/Q01w5kxB0
ALT Figure 2: Reported location of effect of novel and emerging treatments for depression
rTMS=repetitive transcranial magnetic stimulation.
Today, The Lancet Group announce a new Diversity Pledge expressing our commitment to increasing representation of women and colleagues from low-income and middle-income countries among our editorial advisers, peer reviewers & authors #DiversityandInclusionhubs.ly/H0kb0Yd0
NEW—A real-time dashboard of clinical trials for #COVID19
"An urgent need exists to track clinical trials, avoid unnecessary duplication of efforts, & understand what trials are being done & where"
Correspondence @LancetDigitalH from K Thorlund et al hubs.ly/H0pTtMk0
NEW—A phase 1/2 clinical trial of #CoronaVac in 550 children and adolescents aged 3-17 years in China suggests two doses of the vaccine are safe and generate a strong antibody response. Read in @TheLancetInfDis: hubs.li/H0R9cT70
NEW evidence on breakthrough infections indicates people who tested positive for #SARS-CoV-2 after 1 or 2 vaccine doses had significantly lower odds of severe disease, hospitalisation, or #LongCOVID than unvaccinated. hubs.li/H0WrhN70@TheLancetInfDis
Alongside this alarming growth in violence, our era is characterised by epidemics such as opioid dependence, #NCDs, depression & dengue fever. Opioid dependence has grown to an unprecedented scale, with 4 million new cases in 2017 #GBDStudyhubs.ly/H0fslYj0
"Teaching is frequently judged inferior to research by academic leaders." In a new Offline, our Editor-in-Chief challenges this view.
Find out more in the latest issue of The Lancet: hubs.li/Q01s5ks90
ALT Cover of The Lancet, November 11, 2022. Quote: "Science is important. But education is the vector that transmits to every new generation curiosity, passion, and commitment to reimagine the future, extend the limits of human possibility, and achieve a more just social world."
NEW Research—New triple antiviral drug therapy of interferon beta-1b, lopinavir-ritonavir, and ribavirin shows early promise for treating #COVID19 in phase 2 randomised trial; but large phase 3 studies in critically ill patients are needed
hubs.ly/H0qlcxb0
Fatigue & headache were the most commonly reported reactions (70% [340/487] of all participants given #COVID19 vaccine only reported fatigue & 68% [331/487] reported headache, vs 48% [227/477] & 41% [195/477], respectively, of participants in control group without paracetamol)
"vaccination has averted 154 million deaths"
On the 50th anniversary of WHO's Expanded Programme on Immunization, Naor Bar-Zeev & colleagues quantify the public health impact of vaccination: hubs.ly/Q02ymFn60
ALT Figure showing deaths averted, years of life saved, and years of full health gained due to vaccination. Copyright: 2024 World Health Organization; licensee Elsevier Ltd. CC BY 3.0 IGO
On #ArmisticeDay100, we remember not only the military feats and sacrifice of soldiers in #WW1, but also the dedicated work of women such as Isabel Emslie Hutton and her female colleagues who provided medical care on front lines across Europe #LancetWomenhubs.ly/H0ftQ_b0
Time is an under-recognised social determinant of brain health.
In The Lancet Healthy Longevity, authors call for temporal justice through research and policies that recognise time as both a resource and a site of inequity in ageing and dementia: hubs.li/Q03R4bCV0
ALT Figure Integrative illustration of micro (individual)-level, meso (relational and organisational)-level, and macro (systemic)-level factors that shape people’s experience, use, and availability of time relevant to brain health. Copyright: 2025 The Author(s). Published by Elsevier Ltd. CC BY 4.0.
Authors suggest that these drug regimens should not be used to treat #COVID19 outside of clinical trials and urgent confirmation from randomised clinical trials is needed (3/4)