Welcome to The Lancet, one of the world’s leading medical journals, published weekly since 1823.

London, New York, Beijing
Many IVF add-on therapies are marketed with the promise of improving treatment success. But what does the evidence show? Find out more in The Lancet Obstetrics, Gynaecology, & Women's Health ⤵️ Paper 1: spkl.io/60177Exux Paper 2: spkl.io/60187ExuI
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NEW—Interim analysis of Russian #COVID19 #vaccine phase 3 trial involving nearly 20,000 participants suggests a two-dose regimen has an efficacy of 91.6% against symptomatic #COVID19. No serious adverse events were deemed to be associated with vaccination. hubs.li/H0FQWFS0
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NEW—UK’s #COVID19 vaccine is safe and induces an immune reaction, according to preliminary results hubs.ly/H0sK2Km0
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On the cover, our Editorial: Why Roe v. Wade must be defended hubs.li/Q01b9FLr0
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Today, three of the authors have retracted "Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis" Read the Retraction notice and statement from The Lancet hubs.ly/H0r7gh50
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NEW Research—No evidence of benefit for #chloroquine and #hydroxychloroquine in #COVID19 patients, urgent randomised trials are needed: finding from a large observational study of nearly 15,000 patients with #COVID19 & 81,000 controls hubs.ly/H0qMlXr0 Thread (1/4)
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Statement from The Lancet in response to President Donald Trump’s May 18 letter to Dr Tedros Adhanom Ghebreyesus, Director-General of the World Health Organization
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NEW—Almost all #COVID19 restrictions are set to end in England on July 19. A group of scientists and health experts outline 5 key concerns and urge delaying complete re-opening until everyone—including the young—is better protected. Read hubs.li/H0RPYj90. @dgurdasani1
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NEW Correspondence—80+ researchers warn that a so-called #herdimmunity approach to managing #COVID19 is “a dangerous fallacy unsupported by the scientific evidence” #WCPH2020 hubs.li/H0xZVrs0
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NEW—Most comprehensive study to date provides evidence on optimal physical distancing, face masks, and eye protection to prevent spread of #COVID19: a systematic review and meta-analysis of 172 observational studies hubs.ly/H0q_BJL0
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NEW Research—First human trial of #COVID19 vaccine finds it is safe and induces rapid immune response: finding from a dose-escalation, single-centre, open-label, non-randomised, phase 1 trial hubs.ly/H0qMrl-0 Thread (1/3)
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NEW—Cervical cancer rates 87% lower in women offered vaccination against human papillomavirus (#HPV) between ages 12-13 than in previous generations, English study confirms. First direct evidence of cervical cancer prevention using bivalent vaccine: hubs.li/H0-BBKj0
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Just published: Two new studies on the novel coronavirus. All Lancet #coronavirus content is fully and freely available at our 2019-nCoV Resource Centre thelancet.com/coronavirus
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NEW—One in three #COVID19 survivors received a neurological or psychiatric diagnosis within six months of infection, an observational study of more than 230,000 patient health records published in @TheLancetPsych estimates. Read hubs.li/H0KD0fx0
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We have published an Expression of Concern on the paper by Mehra et al on hydroxychloroquine and chloroquine published on May 22, 2020 hubs.ly/H0r2vFC0
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Taking a common diabetes medication after testing positive for SARS-CoV-2 reduces risk of developing #longCOVID by 40%, new study in @TheLancetInfDis finds hubs.li/Q01SCsZj0
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The spread of health misinformation and disinformation poses a serious threat to public health. How can we respond to the danger and combat the tide of misinformation and disinformation to protect public health? Find out more in our latest Editorial: hubs.li/Q032YWZ40
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NEW Correspondence "International humanitarian norms are violated in Hong Kong" Personal experience from a medical practitioner providing emergency care to injured protesters engaged in violent confrontation with police at Hong Kong Polytechnic University hubs.ly/H0lXzJm0
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You’re invited to access our most read 2020 content; listen to @richardhorton1 and editors from @TheLancetPH, @TheLancetPsych, @TheLancetInfDis, and @LancetGH in a special #LancetVoice episode reflect on 2020 and look forward to 2021; and, more: hubs.li/H0CNbWY0
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NEW—Even for the #DeltaVariant, vaccine efficacy against severe #COVID19 so high that booster doses for general population are not appropriate at this stage in the pandemic. Expert review of evidence to date by intl. group of scientists: hubs.li/H0X7tVx0 #VaccinEquity
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NEW—An estimated 1.2 million people died in 2019 from antibiotic-resistant bacterial infections, more deaths than HIV/AIDS or malaria. #GRAMPaper reveals the scale of antimicrobial resistance (#AMR), now a leading cause of death worldwide: hubs.li/Q012sG-t0 #AMRSOS
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NEW—More nurses lead to fewer patient deaths and readmissions, shorter hospital stays, and cost-savings for hospitals, suggests study of recent Australian state policy to introduce a minimum ratio of one nurse to four patients for day shifts. Read hubs.li/H0N74zl0.
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NEW—Most people who have had original #COVID19 strain are protected from catching it again for at least 6 months—but those ≥65 years are more prone to reinfection, suggests first large-scale study of its kind. Read hubs.li/H0JsJKg0
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Health and #climatechange: 25 years of inactivity have not been without consequence bit.ly/2h8YChb
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NEW—Preliminary results from Russian trials find that #COVID19 vaccine candidates led to no serious adverse events and elicit antibody response hubs.li/H0vGWRW0 Thread (1/8)
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NEW—First full results from interim analysis confirm that the Oxford #COVID19 vaccine is safe and efficacious against symptomatic COVID-19 disease: hubs.li/H0CcSs60 (1/6)
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Study finds use of chloroquine or #hydroxychloroquine with or without a macrolide is linked to increased rates of mortality and heart arrhythmias among hospital patients with #COVID19 (2/4)
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NEW—Most reliable estimates to date suggest 1 in 8 COVID-19 patients develop #longCOVID symptoms. hubs.li/Q01jjK4x0
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A sub-analysis of 2,000 adults >60 years suggests the Russian #vaccine is similarly effective and well-tolerated in this group. Further research is needed to confirm results in those belonging to unrepresented risk groups and non-white ethnicities.
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NEW Research—First randomised trial of #remdesivir for hospitalised patients who are critically ill with #COVID19 suggests antiviral drug is not associated with significant clinical benefits vs placebo: study of 237 adults from 10 hospitals in Wuhan (1/5) hubs.ly/H0p-BMJ0
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Network meta-analysis of 21 commonly used #antidepressants—all antidepressants are more effective than placebo for short-term treatment of acute #depression in adults hubs.ly/H0b370n0
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Today, we publish the first clinical data from individuals confirmed to be infected with 2019-nCov from Wuhan, China. As for all public health emergencies, we will be making all related #Coronavirus Lancet content fully and freely available thelancet.com/coronavirus
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#LancetWomen: This week, we dedicate an issue to advancing #women in science, medicine, & global health. The collection highlights that #genderequity in science is not only a matter of justice and rights but is crucial to producing the best research hubs.ly/H0gwsRt0
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Countries that reoriente their health systems towards #PrimaryHealthCare are better placed to achieve the #SDGs. Fully embracing the #AlmaAta40 vision of #PHC can deliver substantially greater SDG progress hubs.ly/H0fbFLh0
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Regional causes of death in #Brazil: In 2016, #interpersonalviolence was the top cause of death for males in most states, while for women ischaemic #heartdisease was the leading cause in all states except Roraima #GBDStudy @IHME_UW @minsaude #Abrascão2018 hubs.ly/H0d5Bc10
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Junior doctors working a 34 h shift will make 460% more diagnostic mistakes than when well rested. @sleepdiplomat Matthew Walker asks how can we change the culture of #sleep within medicine? hubs.ly/H0czJzf0
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Current projections estimate 153 million people will be living with dementia by 2050. Nearly half of dementia cases could be prevented or delayed by tackling 14 risk factors starting in childhood, suggests new report from a standing Lancet Commission: buff.ly/46nvoPR
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Preliminary results from a phase 1/2 trial involving 1077 healthy adults found that vaccine induced strong antibody & T cell immune responses up to day 56 of the ongoing trial. These responses may be even greater after a 2nd dose, according to a sub-group study of 10 participants
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Call for papers: Women in science, medicine & global health—planned themed issue coming soon. Submit by March 1, 2018 #LancetWomen hubs.ly/H09v_3m0
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"This evidence should ignite inquiry into the broader health impacts of police violence and advance the challenge to confront racial health inequities as products of racism." Comment by @RheaBoydMD #APHA2018 hubs.ly/H0fvG650
Police killings and their spillover effects on the #mentalhealth of black #Americans: a population-based, quasi-experimental study #APHA2018 hubs.ly/H0fvG1Q0
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Our Editor-in-Chief @richardhorton1 alongside public health academics calls on the UK Government to urgently share scientific evidence used to inform its #COVID19 plans in a letter in @thetimes #COVID19UK
Please read and support our letter in The Times today calling on the UK government to share the evidence, data, and models on which it is basing its policies. Without complete openness the public’s trust will be lost.
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NEW—Chinese phase 2 trial finds #COVID19 vaccine is safe and induces an immune response hubs.ly/H0sK2nR0
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NEW #COVID19 —Experts’ request to the Spanish Government: move Spain towards complete lockdown Correspondence from O Mitjà, À Arenas, X Rodó, A Tobias, J Brew, J M Benlloch on behalf of 62 signatories hubs.ly/H0nWrGG0
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NEW—Paediatricians describe a cluster of 8 children believed to represent a "new phenomenon affecting previously asymptomatic children w/ SARS-CoV-2 infection manifesting as a hyperinflammatory syndrome with multiorgan involvement similar to Kawasaki disease shock syndrome" (1/2)
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Alarmingly, deaths from conflict and terrorism have become one of the fastest growing causes of death globally (increasing by 118% between 2007 and 2017) #GBDStudy hubs.ly/H0fslX50
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Editorial: "PM Narendra Modi vows that his decision to revoke autonomy will bring prosperity to #Kashmir. But first, the people of Kashmir need healing from the deep wounds of this decades-old conflict, not subjugation to further violence & alienation." hubs.ly/H0kj2f80
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NEW Editorial—#COVID19 in Brazil: “So what? calls for leadership at the highest level of government to quickly avert the worst outcome of this pandemic hubs.ly/H0qjgY40 Também disponível em Português hubs.ly/H0qjgY50
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"Ultimately quality & primary care should be indissociable words. Together they may even carry enough weight to start a revolution" For #Astana2018, @LancetGH November is dedicated to #HighQualityHealthSystems & #PrimaryHealthCare incl the @HQSSCommission hubs.ly/H0fgkpj0
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NEW—The ongoing social unrest in Hong Kong may be affecting the mental health of the general adult population—potentially leading to substantial increases in demand for mental and psychosocial support services: finding from a 10-year observational study hubs.ly/H0mwPCv0
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.@LancetCountdown 2017 infographic: increasingly clear #health impacts of #climatechange + benefits from response bit.ly/2zq1lu5
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NEW—First nationwide population-based study presents seroprevalence estimates of antibodies against SARS-CoV-2 at national and regional levels, exploring the landscape of population immunity in Spain (#ENECOVID) @sanidadgob hubs.ly/H0s8-RP0
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NEW: "We are calling upon governments to end the torture of [Julian] #Assange & ensure his access to the best available health care before it is too late" S Frost, L Johnson, J Stein & W Frost @Doctors4Assange on behalf of 117 signatories hubs.ly/H0n2z580
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NEW—UK’s #COVID19 vaccine shows similar safety and immunogenicity results in healthy older adults (aged 56 years & over) to those seen in adults aged 18-55 years: finding from a single-blind, randomised, controlled, phase 2 trial hubs.li/H0B97zg0
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NEW—Correspondence reports initial analysis of neutralising antibody activity against #SARS-CoV-2 variants of concern B.1.617.2 and B.1.351 elicited by partial or full vaccination with #BNT162b2 (#Pfizer-BioNTech). Read hubs.li/H0PzQ7b0. Figure from appendix. @TheCrick
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5 years ago #GH2035 concluded that a grand convergence in health is feasible for all but the poorest countries. For #AlmaAta40, a renewed call for global investment in health recognising efforts to strengthen #PHC hubs.ly/H0fbF090 Next in the #Astana2018 Relay: @GaviSeth
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ICYMI #GBDStudy analysis of #health in #India in 2016 showed vast inequalities between states; with 6 of 10 deaths in 2016 due to non-communicable diseases #NCDs #GBDIndia #StateLevelDiseaseTrends hubs.ly/H0dMKWq0
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GLP-1 receptor agonists, which are effective for weight loss, can cause substantial muscle loss. A Comment in @TheLancetEndo discusses the effects of GLP-1 receptor agonists on skeletal muscle mass: hubs.li/Q02WgC490
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NEW—Privatising NHS services is associated with a decline in the quality of healthcare, increasing deaths from treatable causes, study in @TheLancetPH suggests. hubs.li/Q01fYzGl0
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Global child and adolescent health: a joint call for papers with @LancetChildAdol for a special issue for #IPA2019 @IPA_Congress #childhealth #adolescenthealth hubs.ly/H0d2KZx0
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"A medical catastrophe is unfolding." Written on Christmas Day in #Ethiopia, an appeal to world leaders by A Mark Clarfield, colleagues, & signatories: stand by health workers & patients in #Tigray. hubs.li/Q0126kn70
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#GBDIndia “India needs to invest in suitable surveillance systems to monitor the changing trends in NCDs & injuries, & their related risk factors, across the country.” Balram Bhargava @ICMRDELHI & Vinod K Paul @NITIAayog #StateLevelDiseaseTrends hubs.ly/H0dJ8vX0
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NEW—40% of #dementia cases could be prevented or delayed by targeting 12 risk factors throughout life: finding from 2020 update to @TheLancet Commission on dementia prevention, intervention, and care #AAIC20 hubs.ly/H0s-v8_0
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🗨️ “Vaccines have done more to improve public health than any other medical intervention.” A new Viewpoint focuses on cancer vaccines and the future of immunotherapy—analysing trials, different vaccine approaches, and how the next generation of cancer vaccines can help improve patient outcomes and quality of life. hubs.li/Q03sQVF60
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A year ago, Mahsa Amini died after being arrested and tortured for allegedly breaking Iran’s mandatory hijab law. Mass protests ensued. @richardhorton1 writes about events since, doctors implicated in human rights abuses, and the intersection of health and women’s rights. /2
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Mexico faces ongoing shortages of medicines and drugs. The country's President, López Obrador, has blamed corruption—but analysts say otherwise. David Agren (@el_reportero) reports. hubs.li/H0T0xSN0
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Today #February11 is @WomenScienceDay, read our #LancetWomen issue dedicated to Advancing #WomenInScience, medicine, & global health highlighting that #genderequity in science is not only a matter of justice & rights but crucial to producing best research hubs.ly/H0gxRng0
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"If the social situation and political climate in Hong Kong are left unchanged, the distress of citizens stemming from this social unrest cannot be completely addressed and healing cannot commence." Comment from Xue Yang & Winnie W S Mak @CUHKofficial hubs.ly/H0mxslQ0
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Ultra-processed foods – what’s the impact? In a new Lancet Series, experts warn a global rise in #UPFs presents a growing public health threat. Read the evidence & policy recommendations ⬇️ hubs.li/Q03TLKK30
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NEW—Speed of testing is most critical factor in success of contact tracing strategies to slow #COVID19; a delay of 3 days or more between symptom onset & testing will not reduce onward transmission of virus sufficiently: a modelling study @TheLancetPH hubs.ly/H0sDRtn0
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92% of #pollution-related deaths occur in low- and middle-income countries #pollutioncommission bit.ly/2yB530H
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New #GBDStudy ranks countries by their performance on the health-related #SDG index; global median in 2017 was 59·4 1 Singapore 🇸🇬 2 Norway 🇳🇴 3 Sweden 🇸🇪 4 Israel 🇮🇱 5 UK 🇬🇧 ... ... 194 Somalia 🇸🇴 195 Central African Republic 🇨🇫 hubs.ly/H0ftd_r0
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The US CDC has seen its role minimised & become an ineffective & nominal adviser in the #COVID19 response. NEW Editorial "Reviving the US CDC" looks at how the agency become so ill-prepared to protect the public's health hubs.ly/H0qyWDt0
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#VitaminD supplementation in adults does not prevent fractures, falls or improve bone mineral density—finding from a meta-analysis of 81 randomised controlled trials @TheLancetEndo hubs.ly/H0f0qM_0
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Compared to control group (given a meningitis vaccine), SARS-CoV-2 vaccine caused minor side effects more frequently, but some of these could be reduced by taking paracetamol. There were no serious adverse events from the vaccine
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Human rights violations & abuse persist towards people with #mentalhealth disorders; collective failure to respond to this #globalhealth crisis results in monumental loss of human capabilities and avoidable suffering #LancetGMH #GlobalMHSummit #WMHD18 hubs.ly/H0f4lRJ0
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Women make up 30% of the world’s researchers & 75% of the #globalhealth workforce. But, in all fields, they are disproportionately represented in junior roles and hold a small fraction of leadership positions @TheLancet #LancetWomen @GeordanShannon hubs.ly/H0gwV3T0
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Our new issue is here! On the cover—'Periods on display' and the cultural movement against menstrual shame and #PeriodPoverty. Plus, @WHO air quality guidelines, low #BackPain management, community-acquired bacterial #meningitis, and more. Read: hubs.li/H0Y33_L0
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''We still do not have official guidance from @WHO and the US Centers for Disease Control and Prevention @CDCgov on how to care for surgical patients.'' #LancetEbola Correspondence: Where is the official guidance on #Ebola and #surgery? @globalsurgeon hubs.ly/H0cnRb20
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"It will not be #FreedomDay, it will be a self-inflicted wound..." As cases rise, @richardhorton1 warns against "a plan driven more by libertarian ideology than prudent interpretation of the data" and calls for continued mask-wearing, distancing, and ⬆️ #vaccine coverage.
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NEW—Study confirms first case of #COVID19 reinfection in the USA, indicating exposure to the virus may not translate to total immunity: finding from a case study from the University of Nevada @TheLancetInfDis hubs.li/H0xPxQN0
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A historic opportunity exists to reframe the global #mentalhealth agenda in the context of the broad conceptualisation of mental health and disorder envisioned in the #SDGs #LancetGMH #GlobalMHSummit #WorldMentalHealthDay hubs.ly/H0f46LR0
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NEW #COVID19—First study identifies risk factors associated with death in adults hospitalised with new #coronavirus disease in 2 hospitals in Wuhan, China hubs.ly/H0nsfmD0
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Feeding a population of 10 billion people by 2050 with a healthy & sustainable diet will be impossible without transforming eating habits, improving food production & reducing food waste—new @EATForum@TheLancet Commission #EATLancet #foodcanfixit hubs.ly/H0gcll-0
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In Italy last week, data reported that 20% of health-care workers responding to #COVID19 were infected, and some have died. Editorial outlines the urgent imperative to protect health-care workers hubs.ly/H0nNf-m0
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"The consequences of varying government #COVID19 responses will be long-lasting..." Consistently aiming for elimination over mitigation of #SARS-CoV-2 creates best outcomes for health, the economy, and civil liberties, writes @OliuBarton et al. Read: hubs.ly/H0McpXl0.
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Nearly half of dementia cases could be prevented or delayed by tackling 14 risk factors starting in childhood, including two new risks—high cholesterol and vision loss, suggests new report from the Lancet Commission on dementia. Find out more ➡️ hubs.li/Q02KbpYf0
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NEW—Cases of major depressive disorder and anxiety disorders increased by over a quarter in 2020 due to the #COVID19 pandemic, with women and younger people most affected. First global estimates of the impacts of the pandemic on #MentalHealth: hubs.li/H0Z3-VT0
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Depression—it's one of the leading global public health problems. Although currently available interventions can be effective, limitations exist. A new Review assesses novel and emerging biological treatments for major depressive disorder: hubs.li/Q01w5kxB0
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Today, The Lancet Group announce a new Diversity Pledge expressing our commitment to increasing representation of women and colleagues from low-income and middle-income countries among our editorial advisers, peer reviewers & authors #DiversityandInclusion hubs.ly/H0kb0Yd0
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NEW—A real-time dashboard of clinical trials for #COVID19 "An urgent need exists to track clinical trials, avoid unnecessary duplication of efforts, & understand what trials are being done & where" Correspondence @LancetDigitalH from K Thorlund et al hubs.ly/H0pTtMk0
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NEW—A phase 1/2 clinical trial of #CoronaVac in 550 children and adolescents aged 3-17 years in China suggests two doses of the vaccine are safe and generate a strong antibody response. Read in @TheLancetInfDis: hubs.li/H0R9cT70
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NEW evidence on breakthrough infections indicates people who tested positive for #SARS-CoV-2 after 1 or 2 vaccine doses had significantly lower odds of severe disease, hospitalisation, or #LongCOVID than unvaccinated. hubs.li/H0WrhN70 @TheLancetInfDis
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Alongside this alarming growth in violence, our era is characterised by epidemics such as opioid dependence, #NCDs, depression & dengue fever. Opioid dependence has grown to an unprecedented scale, with 4 million new cases in 2017 #GBDStudy hubs.ly/H0fslYj0
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"Teaching is frequently judged inferior to research by academic leaders." In a new Offline, our Editor-in-Chief challenges this view. Find out more in the latest issue of The Lancet: hubs.li/Q01s5ks90
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NEW Research—New triple antiviral drug therapy of interferon beta-1b, lopinavir-ritonavir, and ribavirin shows early promise for treating #COVID19 in phase 2 randomised trial; but large phase 3 studies in critically ill patients are needed hubs.ly/H0qlcxb0
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Fatigue & headache were the most commonly reported reactions (70% [340/487] of all participants given #COVID19 vaccine only reported fatigue & 68% [331/487] reported headache, vs 48% [227/477] & 41% [195/477], respectively, of participants in control group without paracetamol)
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"vaccination has averted 154 million deaths" On the 50th anniversary of WHO's Expanded Programme on Immunization, Naor Bar-Zeev & colleagues quantify the public health impact of vaccination: hubs.ly/Q02ymFn60
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On #ArmisticeDay100, we remember not only the military feats and sacrifice of soldiers in #WW1, but also the dedicated work of women such as Isabel Emslie Hutton and her female colleagues who provided medical care on front lines across Europe #LancetWomen hubs.ly/H0ftQ_b0
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Time is an under-recognised social determinant of brain health. In The Lancet Healthy Longevity, authors call for temporal justice through research and policies that recognise time as both a resource and a site of inequity in ageing and dementia: hubs.li/Q03R4bCV0
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Authors suggest that these drug regimens should not be used to treat #COVID19 outside of clinical trials and urgent confirmation from randomised clinical trials is needed (3/4)
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