We are excited to announce a new computational tool, drug2cell, published in @nature. This tool can provide insights into the precise cellular targets of drugs. Want to know all about it? Keep reading! #genomictool #sangerinnovation
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Welcome on board to the journey through spacetime. In our latest @Nature paper we explore the cellular landscape of the gut - one of the most complex organs in the human body with its own immune and nervous systems nature.com/articles/s41586-0…
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We are pleased to announce Sarah Teichmann has been elected Professor in Stem Cell Medicine at the Cambridge Stem Cell Institute @SCICambridge. We will be moving our group to the Biomedical Campus and look forward to working together. See: stemcells.cam.ac.uk/news/sar…
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You can now check our COVID-19 Cell Atlas online! covid19cellatlas.org Great team effort to unravel the cell-specific expression of ACE2 and TMPRSS2 across human tissues @sangerinstitute @humancellatlas
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🎉Our Human Developing Limb Cell Atlas is now published in Nature! ✨ nature.com/articles/s41586-0… We've delved into the intricate world of limb cell states and architecture, uncovering new spatial patterns and regulatory codes. Here's a thread to share the journey! 👇
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Happy to share our work, a comprehensive single cell & spatial atlas of the human thymus, which uses our newly established common coordinate framework for the thymus, the Cortico-Medullary Axis (CMA), to spatially explore thymic development.#ThymusCCF tiny.cc/p7udvz
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Please check our CellTypist 2.0! celltypist.org It incorporates single-cell data harmonisation & integration, aiming to assemble existing annotated single-cell datasets across the community into a uniformly annotated dataset. doi.org/10.1101/2023.05.01.5… #singlecell
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We are delighted to announce our spatial cell atlas of the human heart is now on bioRxiv 🫀: biorxiv.org/content/10.1101/… This work adds new regions, modalities (spRNAseq, snATACseq) and cell types to the heart cell atlas, including the cells of the cardiac conduction system ⚡️
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We are excited to announce our preprint on the spatial cell atlas of the entire human embryonic limb💪🦵biorxiv.org/content/10.1101/… We reveal the orchestral of genes during limb development in space and time, which also yields disease implication and mouse-human evolutionary insight
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Our latest research on genetic variants and immune response has been published in @NatureGenet and featured on the cover. Explore the comprehensive insights into genetic variants on disease susceptibility at nature.com/articles/s41588-0… @natsuhiku
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Our single-cell integration study maps the entire GI tract, revealing how epithelial cell metaplasia contributes to inflammation in IBD and colorectal cancer. 🧬🦠 Explore the #GutCellAtlas at 🌐 gutcellatlas.org! congrats to @AmandaOPhD and team! @sangerinstitute
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Our #LungImmuneAtlas is online in @SciImmunology ! We've sky-dived🪂 into the immune land🗺️ of the developing human lung, collaborating with @drmarkonikolic's fantastic team at UCL (@DrJoBarnes, @masahiroy15 et al.). Check out the work here science.org/doi/full/10.1126…
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Teichmann alumni get-together at the hca general meeting in Milan! #HCA2024GM @humancellatlas @CDominguezConde from @humantechnopole and jong-eun park from KAIST
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Congratulations to the one and only Chenqu Suo on successfully defending her PhD thesis! 🎉🎓 We are honoured to have you as an incredible member of the lab. Wishing you continued success in your clinical & academic journey, looking forward to collaborating with you again soon!
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Please have a look at our g2g framework on aligning cell trajectories developed by Dinithi Sumanaweera, Chenqu Suo @ana_cujba and others in the team! Congrats! @sangerinstitute @SCICambridge @Cambridge_Uni
Genes2Genes is a Bayesian framework developed by @Teichlab for aligning single cell pseudotime trajectories at the per gene level. nature.com/articles/s41592-0…
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🚨 New publication alert! 🚨 As part of the exciting #HCA publication bundle in @Nature, we reveal metaplasia’s role in inflammation in gut diseases, powered by a single-cell atlas of the entire human gastrointestinal tract. 🌟 nature.com/articles/s41586-0…
Our single-cell integration study maps the entire GI tract, revealing how epithelial cell metaplasia contributes to inflammation in IBD and colorectal cancer. 🧬🦠 Explore the #GutCellAtlas at 🌐 gutcellatlas.org! congrats to @AmandaOPhD and team! @sangerinstitute
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Happy to share our single-cell map of the developing human intestine and connections to Crohn’s disease led by the rising star @elmentaite in collaboration with Alexander Ross, Matt Zilbauer and @VallierLab sciencedirect.com/science/ar…
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A toast from TeichGirls to celebrate the International Day of Women and Girls in Science! @CDominguezConde @RBartolom @emmamarydann @EMadissoon @elmentaite @edenling3 @kedlian @ana_cujba @AmandaOPhD @JulianeWeller & Dinithi, Chenqu #IDWGS2022 #womeninscience #WellcomeGenomeWomen
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#MerryChristmas with lots of love from the lab of Santas 🎅🎄🤶🔔🦌 Wish everyone a prosperous new year! 💪🎆🎓
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Here we are at the TeichLab retreat! It’s great to get together and chat with each other in this beautiful summer day. 🧑‍🔬👩‍💻🌳☕️ Sarah and Kerstin emphasised the importance of team work to achieve excellence and go far in science 💞
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Summer lab retreat was a blast! 🎉 Engaging talks, fun self-introductions into personal passions, inspiring breakout discussions, and a fantastic BBQ to wrap it up. Please check out our new blog post for more details teichlab.org/blog/2023/6/19/… #ResearchCommunity #singlecell #labfun
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Our new method for automated detection of putative cell types, Single-Cell Clustering Assessment Framework (SCAAF), is out! Congratulations to @chichaumiau for spearheading this great Sanger-EBI collaboration!
🔎Identifying cell types from single-cell #RNAsequencing data is now more efficient than ever, thanks to this new method from @emblebi and @sangerinstitute researchers sanger.ac.uk/news/view/autom…
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Many thanks to Dr Kerstin Meyer for the wonderful years of fantastic science & collaborations! Also a picture of the #NextGen of @teichlab members @roserventotormo @JamesCranley @AmandaOPhD
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🎉 Thrilled to share our human embryonic skeletal atlas in @Nature! 🔬 We profiled ~336,000 nucleus droplets & employed spatial transcriptomics to map osteoprogenitor trajectories and regulatory networks for bone and joint formation. 🛠️ Also introducing ISS-Patcher & SNP2Cell
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The lab was celebrating lots of successes together on a sunny afternoon, including - supportive reviewers’ comments🙌 - job offers🎆 - grants awarded🎉 Thanks to @emmamarydann for the delicious Italian tiramisu and Chenqu for the bubbly 🥂🍰
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Really honoured by election to the RS that recognises the great teamwork from past & present TeichLab members & collaborators!
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We are expanding our HCA team with several positions open at the moment! Please, RT! jobs.sanger.ac.uk/vacancy/po… jobs.sanger.ac.uk/vacancy/la… jobs.sanger.ac.uk/vacancy/se…
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Two positions for Bioinformatician & (Junior) Computational Biologist are now open to anyone with motivation and skill to translate single-cell multiomics data to next-generation therapies! 🥊 Find out more & apply by 26 Sep🗓️ jobs.sanger.ac.uk/vacancy/ju… jobs.sanger.ac.uk/vacancy/bi…
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And also our paper, out in @nature: nature.com/articles/s41586-0… A big thanks to everyone who made it possible! @sangerinstitute @imperial @thebhf @dzhk_germany @humancellatlas @teichlab @NosedaLab @kazukane @JamesCranley Krzysztof Polański
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TeichLab old & new heart team reunion
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Pleased to present the preprint of our collaboration w/ the kimber lab which aims to address a vital question in musculoskeletal biology: how faithfully does the development of in vitro chondrocytes recapitulate that of their in vivo counterparts?biorxiv.org/content/10.1101/…
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We are pleased to see this go online @biorxivpreprint! This is a huge international collaboration exploring the cells in the adult human heart @sangerinstitute @MDC_Berlin @imperialcollege @harvardmed @cziscience @TheBHF @humancellatlas @wellcometrust biorxiv.org/content/10.1101/…
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Congrats Krzysztof Polanski @YayonNadav @RBartolom @ioansarr Chuan Xu, Nick England @frode_jahnsen for developping #Bin2Cell!!! We hope that this will be useful for the #SpatialTranscriptomics community to analyse #visiumHD data @10xGenomics @sangerinstitute @czi @SCICambridge
1/5 Looking to analyse @10xGenomics Visium HD datasets in Python? Check out Bin2Cell @teichlab! It joins 2μm spots into cells based on morphology images via nuclear segmentation and smart expansion. GitHub and Preprint: github.com/Teichlab/bin2cell biorxiv.org/content/10.1101/…
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Sarah Teichmann and Aviv Regev gave an opening talk yesterday at #HCA2022GM with an overview of incredible achievements accomplished by the amazing @humancellatlas community and looking into challenges and future opportunities.
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Congratulations to @JamesCranley for passing his viva at @SCICambridge @Cambridge_Uni ! We are incredibly proud of your achievements and excited for your future in science. Well done! Thanks to the incredible examiners Prof Ziad Mallat & Prof Nicoletta Bobola! @sangerinstitute
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Hello, World!
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The Cambridge-Tokyo cardiac collaboration dream team! Facilitated by Takahiro & Kazumasa, with Drs Nomura and Komuro @humancellatlas @SCICambridge @Cambridge_Uni
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#throwback from last Friday's lab retreat. Punting on a beautiful summer day is the best. #Cambridge
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Excited about the spatial transcriptomics session at the UK Conference of Bioinformatics and Computational Biology on 29 Sep. Sarah will chair the session and @CataVallejosM @Mohlotf @emmamarydann will present their recent awesome work on new methods for biological data analysis.
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🎄✨A glimpse into our festive Christmas lunch 🍽️ - a time for great food, laughter, and shared moments. 🎅 Wishing everyone a rejuvenating break this holiday season. Remember to take proper time off, relax, and soak in the joy of the festivities! 🌟 🎁🥳
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Congrats to Dr Sid Lawrence for completing his PhD viva ⭐️! Well done!!! Thanks to the amazing examiners Professor Sarah Snelling @Sarah_JB_S @ndorms and Professor Stephen McDonnell @steveskneesCAM @eoeortho @CambridgeOrtho1 @sangerinstitute @SCICambridge
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Excited to have contributed to this impressive integrated human lung cell atlas, such a great resource for the community! Together with our multi-omic spatial atlas biorxiv.org/content/10.1101/…, we are really heading towards a comprehensive map of the human lungs 🫁🗺️
Excited to share our integrated Human Lung Cell Atlas - combining 46 datasets of the human respiratory system, we map >2.2m cells from 444 individuals across health&disease. Led by @SikkemaLisa, with @MC_Nawijn @Misharin_lab @MDLuecken & many others, thx! biorxiv.org/content/10.1101/…
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Fantastic experience & amazing illustration!
Wonderful keynote from Sarah Teichman (@teichlab) on characterizing spatial and cellular heterogeneity in the human gut, heart, and developing limb. Shows how to jointly leverage insights from scRNA-seq, spatial transcriptomics, and histology. Thanks @ATJCagan for illustrating!
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More open positions @teichlab ! Join us as a Senior/Principal Bioinformatician to work on method development and analysis of large scale multi-modal single cell and spatial data 🧬 Share & apply by Sep 14🗓 jobs.sanger.ac.uk/vacancy/pr…
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An invitation from @Muzz_Haniffa to the whole audience to participate in the annotation of the skin fibroblast atlas @humancellatlas @SCICambridge @sangerinstitute
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Big congrats to Menna @ClatworthyLab 🎉🎉🎉
Delighted to announce the appointment of Menna Clatworthy as Director of #CITIID Menna is Professor of Translational Immunology based at @MRC_LMB. She is also Fellow & Director of Clinical Studies @pembroke1347 and Faculty Associate @sangerinstitute @Cambridge_Uni | @MedCambridge
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Thrilled to be funded and be part of this cohort!
We’re excited to announce 20 new Data Insights grantees addressing challenges in #SingleCell biology by: 🔹Integrating data sets to understand cell functions that regulate health + disease 🔹Applying #ML methods to the analysis of complex data sets czi.co/3K1mtJ4
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Shout out to Luz @LuzGarAl and Roser's group @roserventotormo for the amazing single-cell and spatial analysis of the human endometrium, which cycles as life blooms through the seasons🌺 Cell types enriched in endometrial cancers and endometriosis also shed light for treatments.
Read our December issue! Single-cell analysis of the endometrium, plasma proteome genetics, rare ALS variants and more! go.nature.com/3EvqMsd
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Our recent work with @kevinmbyrd and @blakewarner0 shows that salivary gland cells can be infected with SARS-CoV-2. Fantastic kick-start of the Oral & Craniofacial Biological Network from the @humancellatlas
Researchers have shown that salivary gland cells in the mouth can be infected with #SARSCoV2 😷 #COVID19 bit.ly/39erHPU
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We are looking for an enthusiastic and skilled bioinformatician to contribute to cell atlasing research in the lab. Please apply by 16 Jan 🧑‍💻⏰ Thanks for retweeting! jobs.sanger.ac.uk/vacancy/se…
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We are excited to announce an opportunity for a Research Assistant position in our group @SCICambridge @Cambridge_Uni to help with our work on the @humancellatlas using #organoids jobs.cam.ac.uk/job/48837/
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Teichmann Lab members will run in Cambridge’s Chariots of Fire charity race next Sunday on 18th September! Our runners for this year are Sarah 🏃‍♀️ James @JamesCranley 🏃 Kazumasa @Kazukane 🏃 Veronika @kedlian 🏃‍♀️ Bidossessi @BidossessiH 🏃 (photo from last year's marathon)
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First seminar hosted by teichlab @SCICambridge @Cambridge_Uni by Prof Jasmin Fisher @ucl on #DigitalTwins for #cancerresearch
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Reunion of Japanese TeichLab alumni Natsuhiko, Genta with Sarah, Takahiro and Kazumasa in Shimbashi/Tokyo!
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It was a pleasure to host Prof Mark Davis from @StanfordMed for a lecture @Cambridge_Uni @SCICambridge!
Standing room only this morning to hear Professor Mark Davis' (@StanfordMed) talk for the Cambridge Immunology and Medicine Seminar Series in collaboration with Cambridge Stem Cell Institute. Huge thanks to @teichlab for hosting! @Cambridgeimmuno | @SCICambridge | @Cambridge_Uni
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I pledge to oppose racism and hate through active allyship, continuous unlearning, learning, and listening. Join me by nominating 5 others to do the same. #BlackLivesMatter 👊🏿👊🏽👊🏻and I nominate @Muzz_Haniffa @bayraktar_lab @wikiselev @MarioniLab @fabian_theis
I pledge to oppose racism and hate through active allyship, continuous unlearning, learning, and listening. Join me by nominating 5 others to do the same. #BlackLivesMatter 👊🏿👊🏽👊🏻and I nominate @marakat @GosiaTrynka @teichlab @roserventotormo @minouye271
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Great teamwork from Raghd, @danieljkunz and Tzachi in our lab in collaboration with @davisjmcc, @YuanhuaHuang, @OliverStegle
From @davisjmcc, @YuanhuaHuang, @OliverStegle and Teichmann lab: Cardelino leverages variant information from single-cell RNA-seq data for inferring clonal tree configuration and mapping cells to their clone of origin. nature.com/articles/s41592-0…
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The HCA white paper v1.0 was first published in 2017 humancellatlas.org/wp-conten… The exciting v2.0 will come out later this year! Stay tuned 📢
Sarah Teichmann and Aviv Regev gave an opening talk yesterday at #HCA2022GM with an overview of incredible achievements accomplished by the amazing @humancellatlas community and looking into challenges and future opportunities.
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Great turnout at the Hinxton Immunogenomics Day, organised by Wanseon Lee @WanseonL , @AniaLorenc and our own Lisa Dratva, around all things #TCR #MHC! @sangerinstitute @LoKretschmer @ioansarr @SCICambridge sites.google.com/view/hinxto…
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Delighted about the newest contribution to the Human Cell Atlas of the esophagus, which reveals the origin and developmental pathway of esophageal adenocarcinoma. Great collaboration with @RFitzgerald_lab @MarioniLab
We are very excited to share our new paper published in Science today about the origin of pre-cancerous Barrett's esophagus (BE). Here is a story of how we found out that stomach cells can lead to cancer in the esophagus (1/9) @doctor_kno @johnlzhuang science.sciencemag.org/conte…
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Celcomen: our new tool for spatial causal disentanglement and identifiability in spatial transcriptomics to perform spatial counterfactuals such as localised gene knoc-outs! by @St_Megas and team @sangerinstitute @SCICambridge
Our new work is out! With Celcomen, we introduce spatial causal disentanglement and identifiability in spatial transcriptomics to perform spatial counterfactuals 📖 🔬 Check it out here: lnkd.in/dFutWauH.
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Reunion of recent group leaders from TeichLab @jp24_kaist
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Delighted to share our latest preprint in which we temporally resolve the immune response to COVID-19 using a unique human challenge model.
Preprint alert! Excited and proud to share our work in which we applied single cell multi-omics on a unique-in-the-world SARS-CoV-2 challenge model to resolve the local and systemic immune response to an exact dose of virions in humans over time. (1/6) medrxiv.org/content/10.1101/…
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📢📢 Job alert! Cellular Genetics Informatics Team Leader - call open until September 12th jobs.sanger.ac.uk/vacancy/ce…
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Our tool takes pairs of drugs and their target molecules from drug databases such as @EMBL-EBI’s ChEMBL database. It leverages single-cell profiles and the database’s 19 M drug-target interactions. ebi.ac.uk/chembl/
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Congratulations to Cecilia on her PI position at the Human Technopole! The whole TeichLab is delighted and incredibly proud, and wishes her all the best for the next chapter of her scientific adventure! 🌟
📢 📢 It's a great pleasure to announce that I will be opening my lab in June 2022 @HumanTechnopole
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The Teichmann Lab is looking for an enthusiastic (senior) staff scientist who is experienced in NGS experiments. Apply by 10 Jan, 2022 at jobs.sanger.ac.uk/vacancy/st… Please retweet💪
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Join us at the beautiful Wellcome Genome Campus this summer to meet other single-cell folks, to learn about the incredible advances in the field, and share your science with the community!
📢 Registration open for Single Cell Biology 2022!  #SCB22 Join international #biologists to explore the impact of the technological revolution on our understanding of biology at #SingleCell resolution. 📩Abstracts due 5 April 🌐 bit.ly/3pMrDPN 🌍Hinxton or Virtual
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If you want to get to know more about the personal and professional life of our very own Sarah Teichmann, check out this great interview by the Sanger Comms Team #WomenInSTEM #HumanCellAtlas
From a teenage author 📙 to aiming to map every cell in the human body🧍Sarah Teichmann has had an inspirational career so far. Read about our Head of Cellular Genetics on our blog ⬇️ #WomenInSTEM #HumanCellAtlas @teichlab bit.ly/3dXI5Ut
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The 25th Human Genome Meeting will take place in Tel Aviv on the May 23-25, 2022 - Save the date! hugo-hgm2022.org/
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By inducing antiviral responses in human fibroblasts, we obtained genetic variations at single-cell resolution and identified 1275 eQTLs, many colocalizing with susceptibility GWAS loci of infectious and autoimmune diseases, e.g. COVID-19 at OAS1. nature.com/articles/s41588-0…
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Great collaboration! @Shields_Lab @mirjana_e @Muzz_Haniffa
An awesome collaboration with @teichlab @mirjana_e @Muzz_Haniffa! Single-Cell RNA Sequencing Reveals a Dynamic Stromal Niche That Supports Tumor Growth cell.com/cell-reports/fullte…
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Job Alert! Call for Principal Bioinformatician - application open until the 18th of May jobs.sanger.ac.uk/vacancy/pr…
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A huge shoutout to our collaborator labs for their invaluable contributions! 🙌 Special thanks to Barbara Wold's lab, @bayraktar_lab, @AlainChedotal's lab, @MarioniLab, @MekaylaStorer, and countless others who played a crucial role in this groundbreaking work.
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The deadline is next week. We are looking forward to meeting you and creating a fruitful 2022 together! Please help spread the news! 🎉
The Teichmann Lab is looking for an enthusiastic (senior) staff scientist who is experienced in NGS experiments. Apply by 10 Jan, 2022 at jobs.sanger.ac.uk/vacancy/st… Please retweet💪
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Join me in Milan on 29-30 September for the 2024 Human Cell Atlas General Meeting! Hear about our scientific progress and help plan future annotation, querying, and spatial omics activities. Early bird registration<humancellatlas-dot-yamm-trac…> rate runs until the end of June.
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@Mona_Litvinuk and @cartalop from the lab have led this fantastic effort to fine map 500k cells across heart regions. You can explore the dataset at heartcellatlas.org Great team! @MDC_Berlin @Imperial @harvardmed @sangerinstitute @humancellatlas biorxiv.org/content/10.1101/…
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Thanks to the @CZI, @wellcometrust @humancellatlas, @BHF we have mapped half a million cardiac cells from six regions and 14 donors, and our study provides better understanding of cardiac function at the single cell level.
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Drug2cell allows us to make mechanistic inferences, including drugs’ side effects such as those impacting  heart rate ❤️. It stems from a collaboration from @Sangerinstitute @imperialcollege and others.
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Please have a look at our perspective article on Molecular Connectomics! By @St_Megas @YayonNadav Kerstin Meyer now available @PLOSBiology
🌟 I am thrilled to share that our perspective article on Molecular Connectomics, co-authored with @YayonNadav, Kerstin Meyer, and Sarah Teichmann @teichlab FMedSci FRS, has been accepted for publication in @PLOSBiology. 1/n
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Thanks @ListerInstitute for sharing our work! It was a great collaboration with @Muzz_Haniffa @sangerinstitute @SCICambridge @humancellatlas
Congrats to @teichlab and former Lister Fellow Dr Sarah Teichmann for contributing to this incredible 'multi-omics' research. It adds to the Human Cell Atlas and provides 'recipes' that may help grow hair follicles or skin grafts. doi.org/10.1038/s41586-024-0…
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