Providing the latest news and research from the TIMI Study Group, an ARO affiliated with Brigham and Women’s Hospital and Harvard Medical School.
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TIMI is proud to celebrate our 40th anniversary! Since 1984, we've been dedicated to advancing the knowledge and care of patients suffering from cardiovascular disease and its risk factors. View the 40th anniversary edition of the TIMI book, now online.
timi.org/40th-anniversary-ti…
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Congratulations to Dr. Michelle O’Donoghue, who has been appointed as the inaugural incumbent of the McGillycuddy-Logue Distinguished Chair in Cardiology at Brigham and Women’s Hospital. @DrM_ODonoghue @BrighamWomens
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Congratulations to TIMI Investigator @BrianBergmark, who has been promoted to Assistant Professor of Medicine at Harvard Medical School!
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Congratulations to James de Lemos, alum of @TIMIStudyGroup and @BrighamFellows, on being named Chief of Cardiology at @UTSWNews. James is a terrific choice to lead UTSW into the future. Looking forward to continued collaborations!
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Our own @BrianBergmark, who was recently promoted to Assistant Professor of Medicine at Harvard Medical School, has just been named as a 2023 winner of @SCAI 's 30 in Their 30s award! Congratulations, Brian!
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In FOURIER, event adjudication followed a rigorous, pre-specified, blinded process by the TIMI CEC using all relevant & available source docs. A recent attempt at reanalysis is fundamentally flawed, using incomplete data to reach incorrect conclusions. Full rebuttal forthcoming!
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Seven years of evolocumab + statin and sustained LDL-C <40 mg/dL caused no adverse effect on cognition. Findings are consistent with 2023 AHA Scientific Statement on LDL-C and the Brain regarding safety of very low LDL-C over the long term @AndreZimerman @rgiugliano #AHA23
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TIMI is very proud to welcome Nicholas Marston and David Berg on as TIMI Investigators. @marstonMD @ddbergMD
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Now in @CircAHA, @PrakritiGaba et al. show lower LDL-C levels, down to <20 mg/dL, are associated with lower risk of adverse cardiovascular outcomes w/o significant safety concerns in #FOURIER-OLE. @DrM_ODonoghue @swiviott @rgiugliano
ahajournals.org/doi/10.1161/…
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AZALEA-TIMI 71 presented by Dr. Christian Ruff as #AHA23 Late Breaking Clinical Trial: The novel FXI inhibitor #abelacimab reduced bleeding by >=2/3 compared with rivaroxaban in AF patients. @rgiugliano @swiviott @sidpatel
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Rigorous #FOURIER event adjudication explained - misguided & uninformed attacks refuted!
timi.org/bmjopenresponse/
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The legendary cardiologist and TIMI Study Group founder, Dr. Eugene Braunwald, joins the #TIMITalks podcast to discuss his career highlights and the formation of TIMI. This not-to-be-missed episode is out now on Apple, Google & Spotify. @marstonMD @ddbergMD
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(1/2) At today's TIMI conference, Dr. Eugene Braunwald recounts the first patient he ever saw with what he and cardiac surgeon Glenn Morrow ultimately realized was dynamic LV outflow tract obstruction and what is now commonly known as hypertrophic cardiomyopathy.
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We're proud to announce that our founder, Dr. Eugene Braunwald, has received the @worldheartfed 's Lifetime Achievement Award world-heart-federation.org/n…
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Dr. Eugene Braunwald’s review on gliflozins in the management of cardiovascular disease out now in @NEJM
nejm.org/doi/full/10.1056/NE…
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Now out in @CircAHA and presented by @RahulAggarwalMD simultaneously at #ESCCongress: The #DOAC Score - a novel bleeding risk score – for patients with atrial fibrillation on DOACs. The DOAC Score can help stratify expected bleeding risk. @rgiugliano
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Dr. Rob Mentz, Chief of Heart Failure Section at Duke University School of Medicine & Editor-in-Chief of the Journal of Cardiac Failure, joins @marstonMD & @ddbergMD to discuss his career & results of the HEART-FID trial on the premiere epi of Season 2 of TIMI Talks! @robmentz
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SGLT2i in Primary Prevention: #Dapagliflozin reduced HHF by 36% and renal outcomes by 49% in patients without preexisting CV disease in DECLARE – TIMI 58. @swiviott @DLBHATTMD care-diabetesjournals-org.ez…
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LDL-C of 70 mg/dL is no longer good enough. Lower is definitely better! Consistent clinical benefit for LDL-C lowering even when starting below 70 mg/dL and getting down to ~20 mg/dL . New article in @JAMACardio ow.ly/rK9a30ldLD2
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Congratulations to TIMI's David Morrow and Elliott Antman, named as two of this year's Boston's Top Doctors in @BostonMagazine @eantman
bostonmagazine.com/find-a-do…
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Congratulations to TIMI's Director of Statistics, Sabina A. Murphy, MPH, who has been named as one of @guide2research's top female scientists of 2022!
research.com/u/sabina-a-murp…
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Topline results from OCEAN(a)-DOSE Extension! Pts on ↑ doses of olpasiran maintained a ~40-50% ↓ in #Lp(a) levels close to 1 year after last dose, & led to a marked ↓ in OxPL-apoB. No new safety concerns identified through to 96 weeks of follow-up. #ESCCongress @DrM_ODonoghue
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Announcing the new TIMI Study Group Podcast, "TIMI Talks"! TIMI Talks will be available on all major podcast distributors and the TIMI website. Stay tuned for Episode 1, an intro to the podcast and an #ACC23 preview, coming soon!
@marstonMD
@ddbergMD
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In #AHA23's Journal Session, @PrakritiGaba highlights the monotonic relationship between lower achieved LDL-C levels, down to <20 mg/dL, and a lower risk of CV events in FOURIER-OLE, with no serious safety concerns over a max of 8.6 yrs. @DrM_ODonoghue @rgiugliano
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In JAMA, Dr. Eugene Braunwald and @AqamarMD ow.ly/Aabj30mwguV discuss the unmet need to address the global burden of hypertension @JAMA_current
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Dr. Eugene Braunwald will give Cardiovascular Grand Rounds on “SGLT2i for Cardio-Renal Failure: 2 Paradigm Shifts”, Thursday, January 9 at 1 pm in the Zinner Breakout Room, Shapiro Building, Brigham and Women’s Hospital. @BrighamWomens
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Special guest Dr. Marc Sabatine discusses the CLEAR Outcomes trial, his dramatic flight to New Orleans, and other #ACC23 highlights with @marstonMD and @ddbergMD in Episode 2 of the TIMI Talks podcast, available now on major podcast platforms and timi.org/the-timi-talks-podc…
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#Olpasiran markedly reduces Lp(a) regardless of baseline concentration. Important implications for phase 3 testing! @DrM_ODonoghue #ACC23
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Olpasiran leads to >95% reduction in Lp(a) at higher doses through RNA interference! Effects were sustained over 3 months. #AHA22 @DrM_ODonoghue
nejm.org/doi/full/10.1056/NE…
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Today at #AHA23, @PrakritiGaba highlights the long-term intraindividual variability in Lp(a) levels among pts with elevated baseline Lp(a) from OCEAN(a)-DOSE. Data suggest that Lp(a) levels may need to be measured >1x in a lifetime! @DrM_ODonoghue
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In DAPA-HF, hsTn identified a strong gradient of risk for HF events & death. CV benefits of #dapagliflozin in HFrEF appear consistent irrespective of baseline hsTn. View the #ESCAbstract on the #ESCCongress Research Gateway cyim.page.link/yQHv via @escardio @ddbergMD
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Dr. David Berg’s paper on a novel risk score for HF & T2DM was featured in the special-themed issue of Circulation: ESC Congress. @CircAHA @ddbergMD @swiviott @BrighamResearch
ahajournals.org/doi/10.1161/…
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On the latest episode of TIMI Talks, @marstonMD and @ddbergMD take a deep dive into ISCHEMIA and ISCHEMIA-EXTEND with renowned clinical trialist (and former @BrighamMedRes resident!) Dr. Judith Hochman. @NYULangone @NYULHCVRC
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Dr. Ben Scirica joins #TIMITalks Episode 5 to discuss cardiometabolic interventions in #diabetes and #obesity and discusses key trials of GLP-1 RAs. Out now on @ApplePodcasts and @spotifypodcasts @marstonMD @ddbergMD
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Notable TIMI Study Group publications in 2019. @swiviott @DrM_ODonoghue @eantman @rgiugliano @BrianBergmark @marstonMD @ddbergMD @BohulaMay @BrighamResearch
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Now online in @JACCJournals: PCSK9 inhibition reduces VTE risk by 31%, associated with degree of Lp(a) lowering, not LDL-C lowering. @marstonMD #ACC20Virtual
onlinejacc.org/content/75/11…
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TIMI Study Group original research publications for 2020:
@BScirica @BohulaMay @rgiugliano @swiviott @DrM_ODonoghue @BrianBergmark @eantman @marstonMD @ddbergMD @fagundes_anton @koyama43878335
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What are the top 10 research lessons learned from TIMI in 2022? Find out at timi.org/top-timi-lessons-of…
@BScirica @EBohula @rgiugliano @swiviott @DrM_ODonoghue @BrianBergmark @ddbergMD @marstonMD @AndreZimerman @FilipeAMoura @PrakritiGaba @SidPatelMD
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Special guest @HeartBobH joins the TIMI Talks podcast to discuss his vast experience in clinical trials and leadership, the use of technology in RCT’s, and Boston sports. Don’t miss this inspiring interview! @marstonMD @ddbergMD
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Data from #COMBINE-AF suggests avoidance of concomitant antiplatelet (APT) Rx in anticoagulated patients with AF when possible. NOAC vs. warfarin reduced ICH in those on APT, but with higher GI bleeding @SidPatelMD @rgiugliano #ESCCongress
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1/2: In a meta-regression of over 300,000 patients with >40,000 major vascular events from >40 clinical trials, triglyceride lowering was associated with a lower risk of CV events, but to a lesser extent than LDL-C lowering.
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Largest analysis across spectrum of renal function with #DOACs vs VKA in #AF shows better efficacy/safety of DOACs consistent, except in pts with highest CrCl. @rgiugliano
ahajournals.org/doi/abs/10.1…
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New @JAMACardio pub from @MarstonMD, @jpirruccello, @giorgio_melloni, et al
1) CAD PRS has greatest predictive power in younger adults
2) Up to 30% of early MI can be attributed to polygenic risk
3) CAD PRS can help guide statin initiation in 1* prev
jamanetwork.com/journals/jam…
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OCT impacts real-time operator decision-making in 86% of PCI's. #imagefirst @circintv @brianbergmark @kevinjamescroce @jason_wollmuth @jjlop131 ahajournals.org/doi/10.1161/…
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No association of #ezetimibe with new onset diabetes. New analysis from IMPROVE-IT further supports addition of ezetimibe to statin to safely achieve even lower LDL-C values. @rgiugliano
ahajournals.org/doi/full/10.…
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In @JACCJournals this week, check out the TIMI Risk Score for Atherothrombosis in Diabetes, a new diabetes-specific risk model developed by @ddbergMD & colleagues, that outperforms traditional risk prediction tools and can inform clinical decision-making. jacc.org/doi/10.1016/j.jacc.…
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In a post-hoc analysis from DECLARE-TIMI 58, dapagliflozin reduced the first, as well as the total number, of AF/AFL events. @ZelnikerThomas @swiviott
ahajournals.org/doi/abs/10.1…
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Our own @DrM_ODonoghue is profiled in Brigham Clinical and Research News!
bwhclinicalandresearchnews.o…
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In a secondary analysis of TRANSLATE-TIMI 70, @AndreZimerman showed that ANGPTL3 inhibitor #vupanorsen caused increases in hepatic fat that were associated with dose of drug and increased liver function tests.#ACC23 @BrianBergmark @marstonMD
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TIMI fellow @AndreZimerman's work on Long-Term Neurocognitive Safety of LDL-C Lowering With Evolocumab: Open-Label Extension Data From FOURIER will be presented tomorrow at 10:30 AM in 204C @rgiugliano #AHA23
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Genetic risk refined prediction of coronary events across the spectrum of ASCVD, & the risk gradient was strongest in pts *without* established ASCVD. Application of CAD PRS may be most useful in pts w/o ASCVD to help focus preventive measures. @AndreZimerman @MarstonMD #AHA23
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Patients in the top 20% of genetic risk derive the greatest relative and absolute benefit from evolocumab, completely mitigating their increased risk. See the talk Sunday 9:15am, Room 112AB. #AHA19 @marstonMD @CircAHA ahajournals.org/doi/10.1161/…"
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Congratulations to TIMI biostatistician Michael Palazzolo, who will receive the John J. Bartko Scholarship Award at the Conference on Statistical Practice in San Francisco this weekend! @AmstatNews
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Dr. Eugene Braunwald will be participating in the EHJ Dialogue on Thursday, 24 September 2020 5pm CEST/4pm BST/11am EDT, discussing his recent ESC lecture on the 400th anniversary of the birth of cardiology. Live-stream on YouTube at piped.video/znHJGotC0e4
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Just in time to listen as you travel to New Orleans, the premiere episode of the TIMI Talks podcast has just dropped! @marstonMD and @ddbergMD introduce the podcast and highlight some exciting presentations at #ACC23 to look forward to.
timi.org/the-timi-talks-podc…
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Dr. Sachit Singal presents his work on Modes of In-Hospital Death in Patients With Cardiogenic Shock (CS): An Analysis From the Critical Care Cardiology Trials Network (CCCTN), in 24 hrs in 103C @CCCTNetwork @BrighamMedRes @SachitSingalMD #AHA23
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In a pooled analysis of four multicenter left main clinical trials, @PrakritiGaba and @BrianBergmark show favorable cardiovascular outcomes with PCI compared to CABG in patients with left main disease and acute coronary syndrome. @TCTConference
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Lowering LDL-C is as effective in reducing risk of CV events in the elderly as in the non-elderly in our new meta-analysis involving 21,492 elderly patients @TheLancet @rgiugliano
thelancet.com/journals/lance…
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Role for PCSK9i in aortic stenosis? Now out in @JAMACardio. @brianbergmark @DrM_ODonoghue @rgiugliano jamanetwork.com/journals/jam…
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In a contemporary #CardiogenicShock population from #CCCTN, presenting HD parameters reflecting ↓ systemic arterial tone and RV dysfunction a/w mortality (but CI & CPO not) @ddbergMD @EBohula @JasonKatzMD @seanvandiepen #ACCCriticalCare #ACC23
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In an #ENGAGE AF-TIMI 58 analysis of pts ≥80 years with AFib, @AndreZimerman showed that pts randomized to #edoxaban 30mg experienced similar rates of SSE but less bleeding, net outcomes, & all-cause death vs. warfarin, regardless of dose-reduction criteria.@rgiugliano #ACC23
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Episode 3 of TIMI Talks is now out! @EBohula joins the podcast to discuss FREEDOM #COVID trial, and @marstonMD and @ddbergMD give an overview of the #PCSK9i broad patent claim before the #SCOTUS. Available on all major podcast platforms and our website. timi.org/the-timi-talks-podc…
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In pts w/T2D from 4 TIMI clinical trials, @FilipeAMoura et al developed and validated the TIMI Risk Score for Kidney Disease Progression in Type 2 Diabetes, which helped identify pts at higher risk and who derive greater benefit from SGLT2 inhibition.@swiviott @rgiugliano #ACC23
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Wealth of new data for PCSK9i over past 18 months: Safety/efficacy in high risk subgroups, plaque imaging in AMI, ongoing large trials, and future Rx to inhibit PCSK9 summarized in 1 comprehensive paper @DanMcClintick @rgiugliano journals.lww.com/co-lipidolo…
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Among patients with established ASCVD, a CAD polygenic risk score was associated with incident complex coronary revascularization procedures. @SachitSingalMD @BrianBergmark @marstonMD #AHA23
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Congratulations to Drs. Sabatine, Braunwald, Antman, Giugliano, Wiviott and Sabina Murphy for being recognized on the Web of Science List of 2019 Highly Cited Researchers. @eantman @rgiugliano @swiviott clarivate.com/webofsciencegr…
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Bempedoic acid & beyond – the potential benefits of inhibiting adenosine triphosphate citrate lyase and fatty acid synthesis @rgiugliano
jamanetwork.com/journals/jam…
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New episode of TIMI Talks is out now! Dr. Christian Ruff joins @marstonMD and @ddbergMD to dive into the results of the #AZALEA-TIMI 71 trial, Factor XI inhibition, and his recent #AHA23 LBCT presentation. Listen now on all major podcast platforms!
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Announcing our new redesigned online platform for TIMI calculators! This interactive tool has several flexible functionalities, detailed descriptions, and allows users to upload data and calculate TIMI risk scores for several individuals.
timi.org/timi-calculators/
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LILAC-TIMI 76 Trial–Can the factor XI inhibitor #abelacimab be the answer to prevent strokes in AF patients deemed to be too high risk for a blood thinner? We plan to find out in a randomized, placebo-controlled trial in ~1,900 patients in 18 countries.
globenewswire.com/news-relea…
ALT Christian Ruff, MD, Principal Investigator of the LILAC-TIMI 76 Trial
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See @TCTMD's coverage of @PrakritiGaba's paper in @JAMACardio on ACS patients with left main CAD. @BrianBergmark
tctmd.com/news/cabg-and-pci-…
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Why were LDL targets lowered over time? @PNPatelMD and @rgiugliano review evidence behind the "lowest is best” hypothesis and options to get patients to goal. globalcardiologyscienceandpr…
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Congratulations to TIMI faculty members Drs Eugene Braunwald, Elliott Antman, Robert Giugliano, Marc Sabatine and Stephen Wiviott, who have been named in the top 1% of most highly cited researchers in the world by @clarivate @eantman @rgiugliano @swiviott
recognition.webofscience.com…
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See all the @TIMIStudyGroup #ACC23 presentations and posters online now at timi.org/american-college-of…
@EBohula @rgiugliano @swiviott @DrM_ODonoghue @BrianBergmark @marstonMD @ddbergMD @SidPatelMD @FilipeAMoura @AndreZimerman @PrakritiGaba @andmsmall
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For any range of 🧪 NT-proBNP, there is ⬆️ absolute & relative risk of HF across BMI, w/most clinically meaningful risk diff in those with low-level NT-proBNP elevation (125-<450). In this group, pattern of ⬆️ ARR w/ 💊 #dapagliflozin for obese high risk pts. @SidPatelMD #ACC23
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TIMI Fellow @PrakritiGaba presents her poster on Intraindividual Variability in Serial Lipoprotein(a) Concentration Among Placebo-Treated Patients in the OCEAN(a)-DOSE Trial, in 24 hrs in the Sci & Tech Hall, Board 1005 @DrM_ODonoghue #AHA23
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Congratulations to TIMI alumnus @ZelnikerThomas for receiving the Paul Dudley White award at #AHA20 for the best submitted abstract from Austria, on biomarkers and MACE in DECLARE-TIMI 58!
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TIMI is proud to note that Dr. Marc Sabatine has been named a Highly Cited Researcher for 2019 by Clarivate.
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Excited to announce TRANSLATE-TIMI 70, a Ph2b lipid-lowering trial of the ANGPTL3 ASO vupanorsen. @swiviott @brianbergmark @marstonMD
timi.org/translate-timi-70
clinicaltrials.gov/ct2/show/…
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Dapagliflozin reduces hospitalization for HF in patients with a broad range of LVEF including HFpEF, and may provide an even greater benefit in HFrEF patients with a lower CV death and mortality. Slides available now on our website: ow.ly/btKa30o5vMO #ACC19
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Findings from #CCCTN Registry support use of hypoperfusion alone as the critical discriminator between pre-shock and cardiogenic shock in absence of hypotension @SidPatelMD @ddbergMD @EBohula #ESCCongress
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Genetically-mediated endothelial cell dysfunction is a strong, independent risk factor for the development of CAD. However, very low levels of serum cholesterol, achieved either naturally or pharmacologically, appear to offset this risk @marstonMD @rajatgupta0009 #ACC23
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Featured in #EHJ's top 10 dyslipidemia papers of '22, FOURIER-OLE highlighted the importance of early and sustained ↓ in LDL-C with PCSK9i. CV mortality ↓ w/evolocumab appears→3 yrs & may grow over time. Long-term Rx ↑ 8y appears safe. @DrM_ODonoghue
ahajournals.org/doi/10.1161/…
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Should ASA be routinely discontinued post PCI? Now in press at @CircAHA @DrM_ODonoghue
ahajournals.org/doi/10.1161/…
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Dr. O’Donoghue discusses gender inequities that still persist in medicine. @DrM_ODonoghue @_triciaward @BrighamConnors medscape.com/viewarticle/939…
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Dr. Filipe Moura presents 'T2DM Polygenic Score Predicts New Onset Diabetes in Patients w/Established Atherosclerotic Cardiovascular Disease: A FOURIER Sub-Study', tomorrow @12:40pm CT, Moderated Posters 5, Science & Tech Hall, Level 3. #AHA22 @FilipeAMoura @rgiugliano
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Dr. Braunwald is not affiliated or associated w/ @BraunwaldHealth & doesn't condone the use of his name in this intentionally misleading way
@BraunwaldHealth Please take @CMichaelGibson 's warning seriously. Dr. Braunwald is a much loved brand and a legend. @TIMIStudyGroup
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First-of-its-kind Critical Care Cardiology Trials Network (CCCTN) Registry focused on #CritCareCardiol finds opportunities for improved quality in #CICU care and foundation for future trials #AHA18
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Dr. Nick Marston's paper on the use of high-sensitivity troponin testing to improve ASCVD risk classification has been covered as the lead story in @medpagetoday @marstonMD
medpagetoday.com/cardiology/…
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We're proud to announce The Massachusetts Consortium on Pathogen Readiness has awarded Dr. David Morrow and the Critical Care Cardiology Trials Network a grant to study the cardiovascular complications of #COVID19
masscpr.hms.harvard.edu/proj…
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While #TIMITalks is on summer hiatus, catch up on Season 1 episodes episodes with Eugene Braunwald, Judith Hochman, Bob Harrington, and more. Season 2 premieres with an #ESCCongress Recap - stay tuned! @ddbergMD @marstonMD
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Dr. David Berg will give Welch Grand Rounds @HopkinsMedicine @JohnsHopkinsSPH on “Personalizing Cardiovascular Prevention in Type 2 Diabetes” today at noon! @ddbergMD
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Be sure to see Dr. Emily Lau's poster on sex and drug discontinuation across TIMI trials @DrM_ODonoghue @emilyswlau #ACC20
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Phase 2 data from the APOC3 inhibitor Olezarsen makes #EHJ’s top 10 '22 papers in dyslipidemia. TIMI & @IonisPharmaceuticals are now enrolling in 4 new Olezarsen trials, incl. the pivotal ph3 CORE and CORE2 trials for pts w/ severe hypertriglyceridemia. @marstonMD @BrianBergmark
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Dr. Sabatine and co-authors detail a thought-provoking Clinical Problem-Solving case from the @BrighamWomens CICU in the latest issue of @NEJM.
nejm.org/doi/10.1056/NEJMcps…
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Expert panel concludes aggressive lipid Rx and low achieved LDL-C are NOT associated with impaired cognition, dementia, or hemorrhagic stroke @rgiugliano
ahajournals.org/doi/10.1161/…
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Individual patient data meta-analysis by TIMI helps define tradeoffs between #PCI and #CABG for patients with left main #CAD #AHA21 @TheLancet
thelancet.com/journals/lance…
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Dr. Erin Bohula will present the CAMELLIA-TIMI 61 trial at Cardiovascular Grand Rounds today -- 1pm in Zinner Breakout Room @EBohula @swiviott @BrighamResearch
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New TIMI Risk Score Provides Individualized CV Risk Profile for Patients With Type 2 Diabetes @ddberg brighamhealthonamission.org/…
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Primary results of the AZALEA-TIMI 71 Randomized Clinical Trial will be presented tomorrow by Dr. Christian Ruff in the Late-Breaking Science session at 8:15 AM in Main Event I @rgiugliano @swiviott @sidpatel #AHA23
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