Man of Science 🧬 AI & Gerophysics to understand Aging. 🇸🇬 Rethinking the Fundamentals of Aging & Rejuvenation Biology @TTIScience 🇺🇸
Singapore & Europe
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Academia has institutionalized infantilization.
PhD students in their mid 20s are treated as kids.
Researchers in their mid 30s are junior and need approval from seniors.
It’s keeping adults in intellectual adolescence, and independence is delayed until they are obedient.
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There are only 23 organisms with a maximum lifespan larger than humans:
Hexactinellid sponge: ~15000y
Great Basin bristlecone pine: ~5062y
African baobab: ~2500y
Epibenthic sponge: ~1550y
Common ginkgo: ~1000y
Umbrella thorn: ~650y
Ocean quahog clam: ~507y
Greenland shark: ~392y
Escarpia laminata: ~300y
Seepiophila jonesi: ~300y
Lamellibrachia luymesi: ~250y
Bowhead whale: ~211y
Rougheye rockfish: ~205y
Red sea urchin: ~200y
Galapagos tortoise: ~177y
Pacific geoduck: ~168y
Shortraker rockfish: ~157y
Aldabra tortoise: ~152y
Lake sturgeon: ~152y
Orange roughy: ~149y
Warty oreo: ~140y
Eastern box turtle: ~138y
Mediterranean spur-thighed tortoise: 127y
Data from AnAge create by @jpsenescence
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Longevity hack for men:
Date and marry a women that’s 5-10 years younger than yourself.
It’s associated with a 11% reduction in mortality risk, compared to men who are married to women of the same age or older.
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There are ~640 000 hours in the average life. Time⌛️
There are many dollar millionaires, but there almost no hour millionaires - which would mean living to 114 years.
Let’s change that. ⏳
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If you were 100 in 1850 you would most likely die within ~2 years.
If you turn 100 in 2025 you would most likely die within ~2 years.
We really haven’t made progress in the last 175 years when it comes to pushing the boundaries of life extension, especially as old age.
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Many #Longevity Researchers seem still unaware of the amount of #crypto wealth has flown into the #aging ecosystem in 2021/22.
So here’s a list of the projects that would not exist without donations made by generous crypto-philanthropists. 1/12
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China being optimistic about Longevity and extending lifespan is a fantastic thing.
Would be great to see more scientists in the west talk about the real possibility of 120-150 years lifespans.
It’s where current Gerophysics models converge to.
Delusional thinking about healthspan and longevity, now from China
"In 5 to 10 years nobody will get cancer."
"Living to 150 is definitely realistic. In a few years this will be the reality."
@ATHigginsNYT w/ @prof_horvath @gladyshev_lab
nytimes.com/2025/11/08/world…
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Biotech is accelerating
A 60-year-old man in Germany has become at least the seventh person with HIV to be announced free of the virus after receiving a stem-cell transplant go.nature.com/3yf3fOg
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He’s probably right. But the timeframe for this is 20-50 years and not 5-10 years.
Dario Amodei from Anthropic believes AI can cure most forms of cancer, prevent Alzheimer’s, and double the human lifespan @60Minutes
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A friend remarked:
If Longevity Escape Velocity works out in the next decade it would be the most Boomer flex ever.
They rode the waves of prosperity:
Affordable Homeownership🏠
Low Education Costs👨🎓
Job Stability
Economic Growth 📈
And soon eternal life.
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May you live to a healthy 150 years old due to scientists that research aging and rejuvenation.
“There is a decent chance in the next 3 years we figure out how to reverse aging and nobody dies anymore”.
Human megalomania on full display. Playing God never works, never will work and I fundamentally believe it will always end badly. Sooner or later.
Memento mori.
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Longevity Clinics in a nutshell:
1.) Do a bunch of non-standardize tests that mostly measure things that we have no idea if they are relevant to Longevity and aging.
2.) Peddle supplements/drugs without human data that proves usefulness to extend longevity.
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A civilization where everyone gets to live healthily to ~200 years instead of only ~80 years would be a much better society in all aspects.
Culturally. Technologically. Spiritually. Scientifically.
Anyone has reasoning why this would not be true?
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Turns out that people from outside the aging biology field think that aging biology research must be very well funded due to all the billionaires wanting to live forever.
Reality is far from that.
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Think about Altman whatever you want. But he’s putting his money into all pillars of the future: AI, Energy, and Biotech.
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120 years is realistic as humans lived that long.
150 is in the realm of possibility as various Gerophysics models from different groups arrive at the same conclusion.
However, most of the current biology in aging research is probably not relevant to get there.
We need to expand and look beyond the current trendy biology of hallmarks.
Popular Mechanics has published a second article on Gero’s discovery: why the natural human lifespan is capped at about 120–150 years.
This is not just a scientific curiosity. It’s a major step forward in understanding aging—and in charting the path to overcome these limits. We believe this breakthrough will one day be written into biology textbooks.
Think of it like finally having the correct diagnosis for a patient: for the first time in human history, we understand exactly why our lifespan is limited. Building on this, our next findings suggest promising ways forward.
We have identified mechanisms that may allow people to reach 120–150 years free of disease (see the “effective temperature” paper in the comment) and outlined hypotheses on how this natural limit could be surpassed (last link below).
Links to the related papers are in the comment.
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The path to curing all diseases and extending healthy lifespan to 120 years for all goes through understanding the biology of aging.
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Whoever develops the first medicines that show real rejuvenation in humans will go down in history.
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You can now use $VITA and other cryptocurrencies to buy a GlycanAge test, and get insights into your glycome and biological #age.
@vitadao @glycanage #Longevity #Crypto
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Life extension to 120 years for everyone is a realistic possibility.
Beyond that we do not know.
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If we gain full control of biology and are able to fully rejuvenate and reverse aging, 90 year olds would be fit to fight on the frontline again.
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Let me summarize the book for you:
There’s currently not much we can do for longevity apart of what doctors have preaching for 50 years:
Eat healthy, exercise and sleep well.
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The longevity protocol won't make live you forever.
That being said Bryan is doing more for Longevity Medicine for the masses than Longevity Physicians and Longevity Clinics without charging $25K a year.
We just raised $60 million for Blueprint.
To bring my longevity protocol to you.
Our society has made us unwell…metabolically, mentally, spiritually. We’re addicted. Social media, porn, nicotine, junk food, fast food, smartphones, streaming, energy drinks, and gambling. Each perfectly engineered to keep us in their grip.
Years ago, I was owned by these systems. They wrecked me, and my health. I wish there had been someone in my life helping me break free. Blueprint will be that system. Collectively, we will claw our power back. Blueprint will take better care of people than they can themselves. Better than the healthcare system does. Better than our societal norms allow.
We will be your home for health.
Blueprint will help you feel clear-headed and vibrant. You will become more jacked and beautiful with our presence in your life. There’s nothing better than feeling your best.
Some of the world’s most powerful people are backing Blueprint.
Talent are pivoting their careers to join our team. They rightly see that Blueprint is in the right place, at the right time, for the global emergence of the new macro trend of health, anti-aging and Don’t Die.
In this post I’ll cover:
+ Who’s investing
+ What Blueprint will be
+ Who’s joining
+ Open positions
+ How to get early access
The next era of human is here.
[WHO’S INVESTING]
This remarkable group of people are Blueprint investors. They are backing the next great frontier: human longevity.
+ Akshay Bd
+ Alex Hormozi
+ Amanda Cassatt
+ Andrej Karpathy
+ Ari Emanuel
+ Balaji Srinivasan
+ Bill Lee
+ Brad Keywell
+ Brian & Veronica Grazer
+ Bryan Meehan
+ Cameron Winklevoss
+ Carter Reum
+ Chris Hollod
+ Dan Manges
+ Dave Morin
+ Don Wilson
+ Drew Houston
+ Emmett Shear
+ Eric Demuth
+ Fareed Adib
+ Generational Family Office
+ Jason Fried
+ Jay Shetty
+ Joe Gebbia
+ Joe Lonsdale
+ John Carmack
+ Joshua Kushner
+ Kamal Ravikant
+ Karim Beguir
+ Kevin Hartz
+ Kim Kardashian
+ Kyle Widrick
+ Logan Paul
+ Michael Cao
+ Michael Kives
+ Naval Ravikant
+ NIV
+ Olaf Carlson-Wee
+ Paris Hilton
+ Pippa Lamb
+ Saquon Barkley
+ Ken Katz
+ Seth Bannon
+ Shayne Coplan
+ Steve Aoki
+ Steven Bartlett
+ Suna Said
+ Tyler Winklevoss
+ Winnie Liu
+ Wojciech Zaremba
[TEAM]
Defeating death would be humanity’s greatest accomplishment. Big things are happening right now in our small corner of the galaxy. We see the consequence of this moment and are working to positively influence the future of intelligent existence. We believe that product is philosophy and companies can influence the world.
Join if you love to work insanely hard and also get eight hours of sleep.
Joining our team as CEO is Gyre Renwick. He was previously President of Modern Health and before that an executive at Google Health and Lyft Healthcare. Gyre builds complex health systems into growth engines.
In this next chapter, I am doubling down on Blueprint and Don’t Die. I’m all in. Gyre will run the business and I will focus on vision, strategy, and birthing Don’t Die into the world.
Blueprint is the practical manifestation of Don’t Die. They are the same thing. I will continue to juggle many full-time jobs: rejuvenation athlete, Blueprint vision, leading the Don’t Die moral philosophy and ideology, building a global community, and content creation. Ultimately, both Blueprint & Don’t Die ladder up to the same thing, answering the question: ‘what does humanity do as we give birth to super intelligence?’.
Kate Tolo (co-founder), Gyre, and I will be in lockstep building this mission together.
Roles we are filling now:
+ Chief Technology Officer
+ Chief Product Officer
+ Chief Medical Officer
+ Chief Marketing Officer
+ Engineers of all types
+ See all open roles
Refer your most talented friends. If you don’t see a job fit, still email us.
[BLUEPRINT VISION]
We’re making my protocol accessible to everyone. To replicate everything including the measurements, protocols, therapies - and make it easy and accessible for others to do in a community. For your family and friends to do this too.
Many think that the world’s most powerful people have their health figured out. The truth is, most everyone is floundering. Luxury concierge services often do little for wealthy people as the biggest gains are not in expensive therapies but daily habits. We will help you build life foundations, starting with the basics and graduating to advanced therapies.
Our goal is to be more effective in helping you achieve your health goals than any health system or concierge in the world.
Blueprint will build around:
+ your preferences
+ your budget
+ your preexisting conditions
+ your prior results
+ your prescriptions
+ your level of effort
It’s health within context.
I built Blueprint to solve my own problem. My body and mind were broken, and I didn’t know who to trust to help me fix it. Everyone disagreed with everyone else. I found sanity in gathering a team of doctors and building a protocol based upon robust measurement and scientific evidence. It’s a methodical process that produces better outcomes and results in fewer mistakes and wasted time.
After my team and I built a protocol for me, my friends and family asked if they could get access too. Then their friends and family asked and I said yes again. The circle kept on expanding until we stumbled into Blueprint becoming a company.
We will tell you to do less. Most good health can be achieved with very little effort. It’s the systems, infrastructure, knowledge, and piecing through the noise that is hard.
Blueprint is Bryan Johnson’s protocol, for everyone.
What this will practically mean:
+ Blood draws
+ Food delivery
+ GLP-1s
+ Rx prescriptions
+ Free protocols
+ Toxin testing
+ At-home tests
+ Skin care & hair care
+ Nutrition & supplementation
+ Advanced therapies
And your AI health companion will make it simple.
I like to call this my Autonomous Self. In the same way you put in an address and digital navigation tells you the best way to get there, Blueprint is navigation to vibrance. Our goal is to remove the thinking and hassle for you so that you can focus on building durable life habits and achieve the best health of your life.
I love thinking about what the future will say about us. When I think from the perspective of those who exist in the year 2500, I think they’ll observe that the 2020s and 2030s was the time when humans figured out that they were the first generation who wouldn’t die.
Early access below.
What an amazing opportunity. Let’s do this together.
Bryan
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This is the current real #longevity olympics.
10 oldest people alive right now!
Let's see if @bryan_johnson is on that list in the next 65-70 years. Or anyone from the Longevity Community who should have longevity alpha.
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A reason why small molecules that could impact human longevity - such as Metformin and Rapamycin - have not been tested yet in larger clinical trials is that no one seriously made an effort to do so.
The „there is no money“ is just an excuse.
What I mean by that that no person was so obsessed about getting it done that they made it their sole point of focus.
Usually the people who lead these attempts juggled multiple projects and other academic commitments that distracted them from the big thing that would matter - and meanwhile kept them safe and comfortable.
To get these projects of the ground a person is needed that puts everything into it. Let’s try to find this person.
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Prevention of age-related diseases is more impactful than trying to find a cure for age-related diseases.
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If every single #longevity physician on earth was forced to publicly & honestly answer the following 20 questions, longevity medicine as we know it would no longer exist.
1. How do you define "longevity medicine," and what distinguishes it from pseudoscience or wellness trends?
2. What percentage of the interventions you prescribe are supported by robust, randomized, controlled trials?
3. Do you disclose financial conflicts of interest related to specific supplements, treatments, or diagnostics?
4. Can you name a single intervention you recommend that has conclusively shown to extend human lifespan in real-world conditions?
5. What biomarkers do you use to measure aging, and are they validated as causal or merely correlative?
6. How do you differentiate between correlation and causation when evaluating aging biomarkers?
7. Are there reliable surrogate endpoints for aging, and are they used in your practice?
8. How do you account for individual genetic variation in response to longevity treatments?
9. How do you address the translational gap between animal models and human longevity outcomes?
10. Can you demonstrate how your interventions compare to placebo effects in controlled studies?
11. What proportion of your patients experience measurable improvements in aging-related biomarkers?
12. How do you quantify the cost-benefit ratio of your treatments for your patients?
13. How do you measure improvements in healthspan versus lifespan in your patients?
14. What percentage of your interventions require continuous use to maintain their benefits?
15. Are you transparent with patients about the experimental nature of many longevity interventions?
16. Have you ever exaggerated the benefits or downplayed the risks of a longevity intervention to attract clients?
17. How do you handle cases where patients see no improvement despite full compliance with your protocols?
18. How much of what you offer could be achieved with lifestyle changes alone, without costly treatments?
19. What is the average cost of your services annually, and how do you justify that cost to patients?
20. Can you provide data on the long-term outcomes of your patients, such as healthspan improvements or reduced disease incidence?
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Let me know what questions you have for @davidasinclair and @BKennedy_aging!
#AgingResearch #longevity #HealthyLiving #antiaging #rejuvenation #prevention #geroscience #lifespan #biogerontology
Tomorrow @davidasinclair and I will discuss #aging, #genetics, and #reprogramming.
If you have any questions post them below and @MaxUnfried will collect them for the Q&A.
You can still sign up here: bit.ly/3l0B4b1
@NUSMedicine @harvardmed @Tsinghua_Uni
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If exercise and caloric restriction don’t influence biological age, then either the principles of Longevity Medicine are flawed, or DNA methylation clocks may not accurately reflect the aging process.
This sets the stage for an interesting discussion.
Effect of longevity interventions on epigenetic clocks:
Strongest:
1. Arthritis therapy/anti-TNFa
2. Metformin
3. HBOT
4. AC-11
5. Bypass
6. Ketamine
7. Vegan/Mediterranean
No effect:
1. Rapamycin
2. Omegas
3. Exercise
4. Vitamin B
5. CR/IF
6. Ozempic
7. Follistatin
More ⬇️
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Thank you @mkaeberlein for always calling 🐮💩 when it is required.
You earned yourself a meme. 😜
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My expectations is that this first generation of epigenetic reprogramming companies will all fail - and in the near-term not enable rejuvenation or impact aging.
However, I also believe that in 20-30 years generation 3 or 4 will actually be useful medicines.
And that’s okay.
Many drugs and therapeutic classes have histories of initial failures, abandonments, or iterative generations before success, often due to toxicity, efficacy issues, or delivery problems.
Statins, monoclonal antibodies, PD-L1 Inhibitors, GLP-1 agonists all went through these cycles over a few decades.
And I don’t think reprogramming will be much different here.
But still a lot of respect for the current companies giving their best on the frontier of reprogramming such as Altos Labs, @RetroBio_ , YouthBio, @newlimit, @ShiftBioscience, etc.
They are the stepping stone to the future of medicine.
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We can add 20 years of healthy lifespan over the next 3 decades if we focus on understanding the fundamental biology of aging. That’s my conviction.
However, let’s face it currently research on aging biology is a luxury only stable and rich economies can afford.
Stable geopolitical structures and peace are imperative for longevity science to be funded, as is economic growth. Ä
The biggest slow down for the development of healthy life extension medicines would come from 1.) a longer economic downturn, and b.) larger military conflicts.
1.) would just reduce resources for science in general, and 2.) would move priorities to manufacturing a war machinery with little importance for longevity.
Any of these could delay progress in aging biology by decades.
Bottom line is, that lobbying for peace, geopolitical stability, and economic growth might be more important than lobbying for funding Longevity science itself.
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The folks who are working in the field of longevity will be the first to know and the first to have access to medicines to extend healthy lifespan.
It’s an advantage especially late in life.
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The big question is : What is the science that is supposed to get there?
Unfortunately, no-one in the aging science community has currently a clue what therapies could get us to 160.
There’s lots of hopeful speculations, but no data to point to, nor a consistent model.
So in five years, people live up to 160 years on average.
1) What has Dario seen that leads him to conclude this?
2) what does it mean for our welfare state? Pensions?
3) will Anthropic help with this, are they researching it?
Fundamental questions that need to be answered now.
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I’d argue that the most influential person in longevity is Xi Jinping.
If the Chinese Academy of Sciences has the highest research output on the Nature index, the countries leadership has the most influence on the scientific agenda, and hence can massively influence longevity science.
Top 10 Most Influential People in Longevity
1. Bryan Johnson
2. David Sinclair
3. Peter Attia
4. Sam Altman
5. George Church
6. Matt Kaeberlein
7. Aubrey de Grey
8. Brian Kennedy
9. Ray Kurzweil
10. Peter Diamandis
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A pro-longevity Senator. We need more of them.
As a country, we must reform our broken “sick-care system.” We need to turn our focus to preventing chronic age-related diseases before they manifest, rather than reacting to them once they do. People are living longer now, but getting sick at relatively the same time as they were decades ago. People now spend a larger percentage of their lives in sickness. This puts tremendous stress on individuals and society’s wallet and psyche. We must focus on increasing healthspan (healthy lifespan) in our country — it’s important for the future of America.
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Aging biology is about preventing aging.
Not just about preventing age-related diseases.
It’s about being youthful younger, not just free of disease.
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In 2019 when you end to an aging conference 95% of companies were doing hard biotech.
Now it feels more like only 50%.
Wellness apps, snake oil supplements, and longevity clinics have inflated the field.
None of these have any reliable data that the extend lifespan though.
To be honest, I don’t think the longevity field has truly grown in recent years—it’s more of an illusion. What’s actually happening is that more people who previously identified with wellness or biotech have rebranded themselves using trendy longevity buzzwords. However, the number of organizations and individuals genuinely driving progress in longevity has remained almost unchanged.
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A lot of money is flowing into age-related diseases, and a lot of people are thinking about curing them.
Not much money is going towards extending maximum lifespan, and not much tought is spend on it.
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What if there is actually no Longevity Escape Velocity, but instead a Longevity Barrier or a Gerontological asymptote?
@aubreydegrey coined Longevity Escape Velocity (LEV) as the rate of medical progress required to extend human life faster than aging progresses, and it’s inspired by the the physics concept of gravitational escape velocity. @LongevityEVF is exploring combination therapies for robust lifespan extension.
In physics the barrier that prevents anything from exceeding the speed of light is typically referred to as the light-speed barrier as this speed acts as an asymptotic boundary.
Similarly, a Longevity Barrier would be an asymptote beyond which no further meaningful extension of human lifespan is possible, regardless of medical or technological intervention—a fundamental biological limit akin to the speed of light in physics.
Some scientists like @fedichev propose with quantitative models that there might be indeed such a limit to lifespan, and @jangruber467 and @UriAlonWeizmann have similar models.
Aubrey and Peter both discussed that previously, and it’s certainly important that more people discuss this as only one of the concepts - Longevity Escape Velocity or a Longevity Barrier can be true.
The Longevity Barrier may be set by fundamental constraints such as irreversible entropy, genomic instability, energy limitations, loss of biological information, or evolutionary design limits. Together, these forces could create an insurmountable threshold beyond which further lifespan extension becomes biologically impossible. But we just don’t know.
To answer these questions more basic researcher is needed, and in a world where everyone rushes to translation without deeper biological understanding, resulting in many failed clinical trials, we are taking 2 steps back with the @TTIScience to find answers to fundamental questions in aging biology, and building a strong foundation that allows for predictive biology.
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Very disappointing that the Academy for Health & Lifespan Research doesn’t explicitly mention “extending lifespan” in their joint statement - especially given their name. Instead, the focus is solely on “healthspan” as the scientific imperative. This framing does not reflect the full scope of the field and narrows the conversation in a way that may limit progress.
I think that one reason for this might be that the organization is, at its core, is shaped by a gerontocratic structure, with most affiliated scientists in their mid-50s to 70s. Many within this age group may doubt that significant lifespan extension can be achieved within their own lifetimes. In contrast, there seems to be broader confidence among them that a geroprotector offering 2–3 years of additional healthspan might be developed in the short term, and understandably, this becomes the focus, as it would directly impact their personal health.
But this position risks being overly self-referential. It may reflect what is achievable within a specific career horizon, rather than what is possible for the field or for future generations. As such, the statement favours near-term outcomes at the expense of long-term breakthroughs in life extension.
In contrast, many younger scientists in the field are far more willing to engage with the scientific and technological challenges of extending human lifespan to 120 and beyond. With a 50-60 year time horizon ahead of them, they bring not only optimism but also the freedom to question assumptions and explore novel approaches - often in ways that can reshape the entire research agenda. And well, scientists in their 20s and 30s the have the time to see this through and bring it to fruition.
The big issue here is obviously that in the current systems young scientists are not given the resources to try out high-impact lifespan moonshots, and by the time they reach an age where large-scale funding is available to them, many will have shifted their priorities toward incremental healthspan-focused research - mirroring the current status quo.
To be clear: the Academy includes many exceptional scientists who have contributed greatly to geroscience. But I would encourage them to more consciously represent the full spectrum of perspectives across generations - and to ensure that vision for the field is not constrained by the personal timelines of its current leadership.
Aging researchers have just released a joint statement:
"Advancing Geroscience: A Scientific and Economic Imperative."
Like & forward if you support funding for aging research 🧵
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Congrats to the @ResearchHub team.
A sincere project, that cares about scientists in DeSci is rare so great to see them be recognized.
Keep in mind most DeSci projects use science as camouflage to do financial crypto acrobatics - without benefit to science or the “mission”.
Assets added to the roadmap today: ResearchCoin (RSC)
coinbase.com/blog/increasing…
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I do hope that European Universities push back against this.
Erasmus should be from Europeans, for Europeans. 🇪🇺
That being said: we should have a seperate program for the smarter people in North Africa and bring them to Europe and educate them there.
The EU opens the Erasmus Program to North Africa and the Middle East in a "Pact for the Mediterranean" worth 42 billion euros to facilitate visa issuance, particularly for students from Morocco, Tunisia, and Egypt
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All eggs in the reprogramming basket is certainly not the best bet.
Especially since reprogramming has thus far not outperformed Rapamycin or Caloric Restriction in mice.
Obviously, they should be throwing cash at my lab instead… said every scientist ever. But also seriously funding many of the cool avenues for healthy aging we now know about instead of sinking it all on reprogramming would be great.
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Progress in understanding the biology of aging and life extension is a necessity for space exploration.
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We should think about how to spend trillions of dollars on aging biology in a credible way.
Billions won't suffice.
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It’s important for aging and rejuvenation biotech to tell a tale of boldness and inspiration.
The chance to be slightly more healthy doesn’t make the cut.
The objective must be no diseases & no aging.
statnews.com/2025/05/07/trum…
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At @balajis The Network State Conference @NiklasAnzinger quotes @aubreydegrey to make the case for #DeSci and #Longevity Escape Velocity.
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With the right scientific coordination adding 15 years of healthy lifespan for everyone in the next 30 years is absolutely doable.
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I’ll take longevity supplements seriously when they show data from randomized controlled trials with large cohorts.
Until then, I consider them scam until proven differently.
This includes NR, NMN, AKG, Taurine, etc.
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Would love to see a global Longevity agreement coming out of this that states that each nation will spend 1% of their GDP on science and biotech that will get us to 150 years.
Beijing parade produces unexpected aside as Chinese and Russian leaders overheard discussing biotech, organ transplants and extended lifespan.
longevity.technology/news/xi…
#longevity #biotech #geopolitics #immortality #worldleaders
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The recordings of the #Zuzalu #Longevity Biotech Conference are online now - if you couldn't make it in person here's your chance to catch up:
zuzalu.streameth.org/archive
Featuring talks and panels by @ScheibyeKnudsen @sebastian_gero @BenAnderson421 @fedichev @BKennedy_aging @marcpbernegger @AlexandraBause @senstweet @maximon_ag @longevion @emilkendziorra @Replacing_Aging @LauraMinquini @LynaeBrayboy @realNathanCheng @sdainow @LifespanIO @vitadao and many more.
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When will we see the first sport events to raise funding for aging biology?
There’s swimming and running events to fight cancer or dementia - aging research should use the same mechanism to raise awareness.
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What’s keeping us from testing pharmacological longevity interventions in people 80 years and older?
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The financial market crashing sucks.
But you know what sucks even more.
That your body is aging.
Market crash’s might wipe out your portfolio.
Aging wipes out your life.
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This years @ARDD_Meeting is fantastic.
A ton of excitement by the #longevity research community about what we are doing with @vitadao!
📅 Day 3 of ARDD! Haven't met the VitaDAO team yet? 🤝 What are you waiting for?
Come say hello and learn more about funding longevity research & DeSci! 🧬🔬
Livestream: video.ku.dk/live/88008998/b5…
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Flatten this curve.
Biomedical researchers need to be better at math
Gompertz law of mortality is an exponential
This means factors compound to kill us
your single target even if it is acting on an entire cell population won’t work for most diseases people care about. The effects don’t register on an exponential scale
Below is gompertz equation
Gompertz is base natural log, e =2.7 (like many natural phenomena)
This means the mortality rate increases by a factor of 2.7 every 8 to 10 years of age (b = 8-10 in the US)
This makes sense because the longer aging sets in the harder it is to successfully drug something
Sure, stopping eating using GLP1 works but that’s just caloric restriction. Not a solution for significant lifespan extension
Need to identify therapies that can make the exponent go to 0 such that e^0 = 1
Most therapies have a 5-20% effect, but what we need are 5000-20000% effects
Let’s zoom out and think of the math needed
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A lot of Longevity influencers, if they were alive in the past, would have drank mercury to unlock the secrets to immortality.
But mercury is toxic.
So nowadays they are kind of lucky that most supplements they promote won’t poison you, nor extending your healthy lifespan.
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Studying aging across the tree of evolution and evolution inspired drug discovery is what’s needed.
Model organisms in general mislead on aging and its diseases.
🐭 Could scientists have been getting it wrong all along?
In Ep. 6 of Decoding Longevity, @fedichev (@hacking_aging ) explains why animal models are misleading us—and what to do about it.
Hosted by @rv_sehgal& @MacsueJ
#Longevity #AgingScience #Gero #Gerophysics #DcodLongevity
ALT https://open.spotify.com/episode/5PuTCbkQu3ptSQOXhQeL1P?si=JmG4ByFKQk-YFE7FXFgWaQ
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The Physics of Aging - Gerophysics - is gaining wider interest amongst the aging biology community.
But where should articles on Gerophysics be published?
To solve this @fedichev , @jangruber467, Andrew Rutenberg, @BKennedy_aging and I teamed up with npj Aging on a new Special Collection on Gerophysics.
This collection brings together work at the intersection of physics and aging biology. By applying concepts from statistical mechanics, dynamical systems, and network theory, Gerophysics seeks to build quantitative, predictive models of aging - moving beyond description toward a theoretical framework for longevity and rejuvenation. We welcome contributions that explore aging through the lens of physical principles and systems-level modeling.
Submissions are now open: nature.com/collections/hhdcb…
A big thank you to Sarah Mitchell and Aicha Hanna and the npj Aging Team (@Nature_NPJ) to support this topic!
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If Vogue is now promoting Longevity we might soon reach the peak of this longevity trend cycle.
This hype cycle was mainly about longevity clinics, supplements, and epigenetic reprogramming.
Sadly, still nothing available for the extension of maximum healthy lifespan.
Longevity culture is more alive than ever. Vogue is calling it 2025’s hottest trend. Well, of course! What better way than to live a long, healthy life for many years?
100 will be the new 60s
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Wondering if small molecule research holds the #longevity field back.
They are the lowest hanging fruits to get small effects on health- & lifespan extension.
Experiments are uncomplicated and unsophisticated allowing academics to publish quickly.
Seems to stifle innovation🫤
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I just wanna have a little clone of myself whose organs I can harvest when I need them.
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Simple thesis.
It’s not magic. No spell book needed.
Fundamental research will provide all the answers to defeating aging and rejuvenation.
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Humanity should spend at least an equal amount of money on increasing human biological intelligence as it does on AGI.
One can legitimately have different ideas and frames for how ASI will go down but the notion that birthing a vastly smarter species with near costless and near instantaneous reproduction will automatically turn out well for the biosphere is... unimaginative.
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Kind of insane that most universities don’t have programs on aging biology and medical schools on longevity.
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