Laboratory of Stavros Lomvardas, PhD Zuckerman Mind Brain Behavior Institute | Jerome Greene Science Ctr lomvardaslab.zuckermaninstit…
Columbia University, NYC, NY
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Dogs in labs bring happiness- we just found out that we got partially scooped, yet having Argos here today took the sting away and brought some perspective...
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Spatially resolved epigenomic profiling of single cells in complex tissues cell.com/cell/fulltext/S0092… WOW!!!!!!!
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nature.com/articles/s41586-0… We go as far as our students and postdocs can take us- after Lisa showed on Monday how olfactory neurons activate specific OR repertoires, Ariel shows here why the end up expressing only one of those! Blessed to have them!
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Non-cell autonomous disruption of nuclear architecture as a potential cause of COVID-19 induced anosmia cell.com/cell/fulltext/S0092… Congrats to everyone involved - it really took a village for this one! Marianna Zazhytska, Albana Kodra, Jonathan Overdevest, Ben tenOever et al!
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Stavros Lomvardas Appointed Chair of Biochemistry & Molecular Biophysics cuimc.columbia.edu/news/stav… Deeply grateful to Dean Katrina Armstrong and Dr. Roy Vagelos for the honor of being appointed the P. Roy Vagelos Chair of Biochemistry and Molecular Biophysics!
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Oxytocin receptor is not required for social attachment in prairie voles cell.com/neuron/fulltext/S08… The tragedy of Science-the slaying of a beautiful hypothesis by an ugly fact (Huxley?). Been on the other side and know how much it stinks-but this is why we do science!
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I have committed my scientific career in studying the regulation of these genes; reading this manuscript is extremely fulfilling. I know first hand how hard it is to accomplish what these scientists accomplished. Bravo!nature.com/articles/s41586-0…
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Glorious celebration for Tom Maniatis at the Forum yesterday- before open access and data sharing was even a concept, Maniatis, Fritsch, and Sambrook democratized molecular biology by giving access to cutting edge technologies to everyone in the world! Thank you !
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doi.org/10.7554/eLife.87445 @eLife Olfactory receptor choice is probabilistic but not random. Olfactory neurons select one from a specific OR repertoire, determined by their dorsoventral location. Amazing Lisa Baskhirova figured out how!
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Spatially coordinated heterochromatinization of long synaptic genes in fragile X syndrome: Cell cell.com/cell/fulltext/S0092… Amazing paper showing that CGG repeat expansion causes heterochromatin assembly at FMR1, but also a plethora of other genes in TRANS!
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SATB2 organizes the 3D genome architecture of cognition in cortical ne... sciencedirect.com/science/ar… Another great demonstration of neuron-specific long-range transcriptional hubs. Congrats!
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Direct observation of a condensate effect on super-enhancer controlled gene bursting: Cell cell.com/cell/fulltext/S0092… gorgeous!
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Opposing, spatially-determined epigenetic forces impose restrictions on stochastic olfactory receptor choice biorxiv.org/content/10.1101/… Determined stochasticity or stochastic determinism? Thanks to eLife's new policy our paper on OR expression zones is out and about!
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AddThis | Home authors.elsevier.com/sd/arti… So fortunate to have students like Hani Shayya who can come up with brilliant ideas and have the experimental skills to rigorously test them. So proud of you Hani!
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De novo protein identification in mammalian sperm using in situ cryoelectron tomography and AlphaFold2 docking: Cell cell.com/cell/fulltext/S0092… WOW!
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To the amazing young scientists that received disappointing news :
1. Be proud you made it this far.
2. No selection process is perfect, especially when every candidate is outstanding.
3. There are more chances.
4. Your peers love you and respect you.
5. Prove them wrong.
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I was alway envious of the C.elegans community for their spirit of collaboration and collegiality (at least it seems like this from the outside). After the Keystone meeting in high order genome architecture I felt part of such uplifting and supportive community-thank you all!
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Beautiful gathering with BMB colleagues at the roof of the Zuckerman Institute welcoming our newest colleague, Hashim Al Hashimi- NMR at biochemistry rocks!
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Olfactory receptor choice: a case study for gene regulation in a multi... sciencedirect.com/science/ar… : Lucky to have students that can read, write, and communicate so much better than I could ever dream :)
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events.columbia.edu/go/tom_m… A fantastic scientific symposium in NYC in honor of a fantastic scientist: Please join us in person at the Forum on May 12!
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events.columbia.edu/go/tom_m…
Join us in this journey to the birth of molecular biology through the history of the one and only Tom Maniatis!!!
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You are officially old when your former graduate students present faculty seminars- fantastic, thought-provoking seminar from Josie yesterday at ZI!
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Differential mosquito attraction to humans is associated with skin-derived carboxylic acid levels cell.com/cell/fulltext/S0092… Finally an answer!!!!!
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Some of my very favorite colleagues are in this line up. Please join us this Friday at the most interesting building in Manhattan!
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How about trying to do science in a sustainable way? Week one of our glove recycling efforts. Still working on convincing lab members to recycle tips as we did in U of Crete!
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Supper excited to welcome Dr. Michal Levo at our department. Her elegant and creative approaches in the study of genome architecture and gene transcription will shed new light to the understanding of enhancer-promoter interactions and transcription dynamics in development!
Excited to announce that Dr. Michal Levo @Michal_Levo from Princeton University will be joining the Department of Biochemistry and Molecular Biophysics as an Assistant Professor! Live imaging combined with microC in developing flies- Michal we are so thrilled to have you!
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Join me in November for @KeystoneSymp #eSymposia Higher-Order #Chromatin Architecture in Time and Space, to explore emerging #epigenetic mechanisms, with interactive networking opportunities. keysym.us/VKSChromatin22 #VKSChromatin22
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Wait- what??? RNA-guided transcription factors? Spectacular!!!!
Ever wonder if nature already 'invented' RNA-guided transcription factors like CRISPRi/a? Then look no further... we found many examples of domesticated, nuclease-dead TnpBs that use guide RNAs to repress genes! In bacteria AND phage! A wonderful team effort led by Tanner Wiegand
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WAPL functions as a rheostat of Protocadherin isoform diversity that controls neural wiring | Science science.org/doi/10.1126/scie… Beautiful and important paper from the Canzio lab. Congrats!
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A functional cellular framework for sex and estrous cycle-dependent gene expression and behavior cell.com/cell/fulltext/S0092… WOW!
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Molecular Biology Community Honors Tom Maniatis on 80th Birthday cuimc.columbia.edu/news/mole…
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Scylla and Charibdis at the Maniatis Symposium. Its not the lariat, the enhanceosme, the beta globin cDNA, it is the hundreds of people from all over the world that flew in to celebrate Tom Maniatis!
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Special bonus of having magical Andrew Pruske in the lab is that we had the whole offensive line of Columbia University @GoColumbiaLions visiting us today. Jane and I got a game ball as gift, and an inspiration to work on neurobiology of concussion. Student athletes are amazing!
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#internationalWomensDay gave me a chance to reflect on the amazing, innovative, brilliant and straight up awesome women scientists that made the @Lomvardaslab happen. You all rock!
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Evidence for RNA or protein transport from somatic tissues to the male reproductive tract in mouse doi.org/10.7554/eLife.77733
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genesdev.cshlp.org/cgi/conte… Very intriguing idea that would also explain the specificity by which enhancers activate some promoters but not others during development.
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Time resolution in cryo-EM using a PDMS-based microfluidic chip assemb... sciencedirect.com/science/ar… Amazing paper from the one and only Joachim Franck; when a Nobel Prize does not take away your passion for new breakthroughs!
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Wow- what a great honor! Thank you Qian and all the others that contributed to this spotlight article!
'A noncoding role of coding mRNA in monogenic olfactory receptor choice'
by Yue Hao, Kang-Ying Qian & Qian Li
cell.com/trends/neuroscience…
'Spotlight' commentary on Pourmorady et al., @Nature 2024, @LomvardasLab
nature.com/articles/s41586-0…
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SARS-CoV-2 is associated with changes in brain structure in UK Biobank disq.us/t/45tu2k0 Fantastic (and frightening) new paper describing the effects of Covid in the brain.
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The only thing better than one Maniatis, is two Maniatises- sweet moment from the Maniatis birthday symposium when Silas Maniatis showcased his innovative technologies in spatial genomics!
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Who would not want to start the independent career working with this amazing group of junior faculty? Having peers that get you, share your problems, and can have a drink with you at the end of the week is key for success! BMB is hiring- please apply:apply.interfolio.com/131823
Come join this stellar group of junior faculty! Biochemistry is hiring- if you want to do transformative science and to have fun in the process, apply: apply.interfolio.com/131823
@YaChengLiao1 @shsternberg @LenaSteckelberg @helloanum @FitzpatrickLab @Michal_Levo paved the road!
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nature.com/articles/s41586-0… so cool!
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There are more than one female asian scientists in the world. They are not all the same person-stop confusing them 😡 Equity and inclusion starts with just a little extra effort...
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Mentoring brilliant graduate students and postdocs is such a rewarding endeavor; same day that I was sent this post for professor Clowney's seminar at UCSF, Dr. Eirene Markenscoff-Papadimitriou told me she agreed to join the faculty of Cornell!!!! I am so proud of both you!
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A mouse DRG genetic toolkit reveals morphological and physiological diversity of somatosensory neuron subtypes: Cell cell.com/cell/fulltext/S0092… Congrats Nikhil et al, beautiful study!
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How sexual touch triggers pleasant sensations in mice nature.com/articles/d41586-0… Congrats again to Ish and his team. So satisfying to see all these data transforming into classic papers!
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Dancing with Protein biochem.cuimc.columbia.edu/n… Sometimes I get asked why I took an admin role at the peak of my scientific career. Junior faculty like @helloanum who combine scientific creativity and rigor with kindness and desire to help those in need, is the answer.
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events.columbia.edu/go/tom_m… A day dedicated in the history of molecular biology and genomics that should not be missed. Come learn how everything started, from the first cDNA to Precision Medicine. Celebrating Tom Maniatis!
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Oxytocin receptor is not required for social attachment in prairie voles biorxiv.org/content/10.1101/… This is why genetics are always a good complement to pharmacology....
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Nuclear architecture protein Distal antenna balances genome-binding and phase-separation properties to regulate neuroblast competence biorxiv.org/content/10.1101/… Fantastic new paper from my colleague Minoree Kohwi showing role of nuclear phase separation in development
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A disordered region controls cBAF activity via condensation and partner recruitment: Cell cell.com/cell/fulltext/S0092… This is so elegant!
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Join me in November for @KeystoneSymp #eSymposia Higher-Order #Chromatin Architecture in Time and Space, to explore emerging #epigenetic mechanisms, with interactive networking opportunities. keysym.us/VKSChromatin22 #VKSChromatin22
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Structures of LRP2 reveal a molecular machine for endocytosis cell.com/cell/fulltext/S0092… Wow this paper is the dream of every structural biologist! Amazing work by @ColumbiaBiochem and @ZuckermanBrain colleagues Shapiro and Fitzpatrick and CU nephrologist Jon Barasch
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Just created @ColumbiaBiochem: Please follow the account for exciting news and announcements that will be posted regularly. First week as Vagelos Chair of BMB could not be more exciting.
Welcome to Biochemistry and Molecular Biophysics at the Vagelos College of Physicians and Surgeons at Columbia University. We will be posting news on faculty searches, trainee successes, and great science.
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A transformative gift from two amazing human beings! Efharisto
We are thrilled to announce a $175 million gift from Roy & Diana Vagelos for biomedical research education; the gift will grow the ranks of early career researchers to advance scientific discoveries and improve the lives of patients.
columbiamed.link/3ZmvVNy
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ritaallen.org/stories/announ… I am so proud of my former post-doc Dr. Kevin Monahan for being among the scholars; for those interested in nuclear architecture and neural development, I cannot think of a better mentor!
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For #ECR Abbas Rivzi of @ZuckermanBrain, research is like fly fishing. He approaches both fishing and research with a patience that comes from love of the experience itself—the feeling of flow that both activities provide. 🎣 chanzuckerberg.com/blog/day-…
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cell.com/cell/fulltext/S0092…
This is so cool! Worms and Noelle never stop to amaze!
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This is the first ever example of disease progression via inter-chromosomal interactions. Time to start taking genomic contacts between chromosomes seriously! Congrats Jen and team- I know it was a struggle to convince reviewers that chromosomes interact in a meaningful way!
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Congratulations to our newest faculty member Hashim Al-Hashimi biochem.cuimc.columbia.edu/n…
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Every time you say- how could they give me a shitty score, the preliminary results were a Cell paper, remember: the dude just got the Nobel Prize!!!!!
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To all my Israeli friends and colleagues, our love and thoughts are with you at this difficult day. Be strong.
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We are so lucky to be in a department with such amazing innovators, barrier breakers, and simply badass women!
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Two generations of @ZuckermanBrain leadership welcoming our new president Dr Minouche Shafik ! The future is bright @Columbia @ZuckermanBrain and @ColumbiaPS
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Final chance to register: Nobel laureates, Breakthrough Prize Winners, legends of science and biotechnology are coming together to honor one of the founders of molecular biology and genomics!
events.columbia.edu/go/tom_m…
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We are looking for a research assistant to help a fabulous post-doc at her research project. Great learning experience for anyone with aspirations to apply to graduate or medical school. Information at the following link:opportunities.columbia.edu/c…
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An accomplishment that is possible due to the spectacular students and postdocs that I had the privilege to mentor over the years....
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Hi, don't let anyone tell you that you don't belong because you like to dress differently, or talk differently, or think differently- at some point my hair was not very "academic" and the subject of jokes in the lab. But we all cherished our weirdness-find the place that will
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Olfactory fear conditioning biases olfactory stem cell receptor fate biorxiv.org/content/10.1101/… Continuing upon @tanlongzhi -maybe studying extreme systems reveals new biology widely used but difficult to uncover, like this by @bjmarlin
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SPIDR: a highly multiplexed method for mapping RNA-protein interactions uncovers a potential mechanism for selective translational suppression upon cellular stress biorxiv.org/content/10.1101/… Very exciting!
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Wayne Hendrickson awarded the 13th Ewald Prize for his exceptional contributions to crystallography biochem.cuimc.columbia.edu/n… MAD and SAD methods led to an explosion of structures solved, creating the foundation for today's ability to predict protein structure from sequence.
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Joan Steitz flew to UCSF for the Christine Guthrie Symposium. She described the 1969 CSHL symposium on protein synthesis: 2 women (Guthrie/Steitz) among 300 participants!!! Amazing Pioneers!
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Scientist at Columbia’s Zuckerman Institute Wins Prestigious Brain Prize zuckermaninstitute.columbia.… Awesome, Congrats Larry !
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Having been a finalist 3 times, I can share my thoughts: These judges watch 60 spectacular, highly rehearsed talks describing groundbreaking science, and they have to reject 2/3 or 1/2 of these investigators. I would never want to be in their shoes!
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events.columbia.edu/go/aosbi… For NYC science people that are interested to hear about the past, present, and future of Biochemistry at Columbia, this will be a really fun event!
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A Latent Activated Olfactory Stem Cell State Revealed by Single Cell Transcriptomic and Epigenomic Profiling biorxiv.org/content/10.1101/… Tour de force single cell genomic analysis of the regeneration of the olfactory epithelium!
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So proud of Dr. Marianna Zazhytska for winning the Peter and Patricia Gruber Award for her work on COVID-19 and anosmia. Heroic experiments under very difficult conditions- so well deserved. Hopefully this brings some joy to her family in Ukraine! Congrats to Dr Valero, as well.
The Society for Neuroscience President Gina Turrigiano presents the Peter and Patricia Gruber
International Research Award to Manuel Valero and Marianna Zazhytska. #SfN22 #neuroscience
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Fantastic group of speakers at the 6th Annual Conference on Precision Medicine on April 5th at the Forum
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In addition to the brilliant Ariel Pourmorady, I want to also thank our amazing collaborators @job_dekker and @MarioNicodemi (and their students), and our funders @4DNucleome, @NIDCD, and two special human beings: Roy and Diana Vagelos!
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The developmental basis of fingerprint pattern formation and variation cell.com/cell/fulltext/S0092…
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Afternoon of Science Series: Department of Biochemistry & Molecular Biophysics cuimc.columbia.edu/news/afte…
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Katalin Karikó: The sacrifices and successes of immigrant scientists - Vilcek Foundation vilcek.org/news/katalin-kari…
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Mechanism of target site selection by type V-K CRISPR-associated transposases | Science science.org/doi/full/10.1126… another beautiful study from the Sternberg lab on RNA-guided transposition! Congratulations!!!!!
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Also, the beauty of publishing a paper that does not involve chromatin and epigenetics, is that for once, I am not worried of the criticism from @epigenetichulk 😀
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Lab-Life Balance! | COLUMBIA | Lomvardas Lab lomvardaslab.zuckermaninstit… Who said you cannot do HiC and protect your quarterback at the same time?
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Ligand-induced changes in dynamics mediate long-range allostery in the lac repressor biorxiv.org/content/10.1101/… Fantastic collaborative science from Anum Glasgow @helloanum and her great colleagues just accepted at Nature Communications: Dancing with Protein, indeed.
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The People On This Greek Island Live Over 100 Years | The Art Of Living ... piped.video/GP4ouNyTd0I via @YouTube My home island- or why there are no timers in the Lomvardas lab :)
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Hi Alex, I do not agree that this is sad- it is Claudio's opinion and he has earned right to express it. Although I agree that there is beautiful developmental biology happening right now, some of the issues he raises have merit and they should be discussed.
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"If you clean a vacuum cleaner your are a vacuum cleaner"; quote from my son's 12th grade year book
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For all the structural biologists and CryoEM fanatics, a BNL workshop exploring the idea of combining Soft X-ray Tomography with Cryo-ET: please join us virtually, registration is free.
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Assistant Professor/Associate Professor/Professor (Tenured and Tenure nature.com/naturecareers/job…
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And last but not least, wonder-kid @tanlongzhi and @XieSunney for developing Dip-C- also their preprint on LimCA assets.researchsquare.com/fi… provides further insight to the amazing genomic choreography between chromosomes that gives rise to singularity!
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