Long COVID Status Update 2025 Dec 22 Symptoms Summary * Severe since 2022: Brain fog, PEM, PENE. During 2022 I was bedridden for 6 months. I could barely walk down a flight of stairs, felt unsteady and unbalanced. Could not read or copy a 7 digit phone number. Brain was severely malfunctioning to the point where I struggled to form sentences. Driving was dangerous. * Some improvement 2024: Feel chronically ill. Thinking is difficult. Brain fog in and out. Physical exertion is punished. For example assembling this IKEA furniture took me ~2 days of effort followed by 3 days of PEM crash. * POTS: Maybe moderate? I am not terrible most of the time but briefly exerting at odd angles like to pick up kids makes me dizzy. Full on tilt table test makes me feel VERY BAD for 2-3 days. * MCAS? Not sure. Many of my symptoms get worse if I stop my antihistamine medications. Hydroxyzine seemed to be the most effective but I had to stop it recently due to drug interactions. Currently on the much weaker loratadine. * Chronic prostatitis. Started at the same time as LC back in 2022. Crippling pain. Inflammatory something caused tissue to obstruct leading to BPH. * Complex autoimmune changes 2022-2023: CCP IgG positive suggests RA. I received some symptom mitigation from hydroxychloroquine. By 2025 CCP IgG disappeared but I became ANA positive instead. Treatments that didn't work - LDN, long duration Paxlovid, Adderall, Metformin (drug interaction) - rapamycin - sort of works but causes problems over time. This again feels like a clue mitigating downstream problems not the upstream cause. - splenic nerve stimulation - This was an interesting failure! It caused a WONDERFUL FEELING OF TOTAL RELAXATION as the brain-on-fire went away entirely. For 18 hours I felt great. That was followed by symptoms coming back ... then slowly I felt sicker and sicker. It is known to reduce cytokines. I think it causes temporary immune compromise allowing for viral activation. Two weeks later I was symptomatic and tested positive for COVID on a home antigen test. That was an interesting and spectacular failure. I intend to try it again in combination with the combination treatments described below. Treatments - November 2023: hydrogen inhalation mitigates my brain-on-fire symptoms every time. Hypothesis: cancels out reactive oxygen in all cells in your body, temporarily mitigates problems with damaged mitochondria. This is definitely a downstream mitigation but not addressing the upstream cause. Unfortunately the effects wear off after only a few minutes. It isn't a solution, more of a clue, but it is at least something I can use to cope during a heavy PEM crash. I should write a thread exclusively on the topic of hydrogen inhalation for LC/ME. - December 2024 azithromycin caused significant symptom improvement for 1 month. Temporary improvement to brain fog and PEM, and temporary near remission of prostate pain. The effect stopped working so I discontinued. I have to wonder if long-term antibiotics might have been the cause of autoimmune biomarkers changing over time. - July 17th 2025: 1st Pemgarda. See my other thread. nitter.app/wtogami/status/1946097… - October 3rd: brain fog was very bad. Two days after Novavax brain fog improved a lot and stayed that way for two weeks. Unfortunately it feels like brain fog might be a separate thing from cognitive dysfunction. Exertion still caused neuro crash and inability to think. - October 22nd: Started val/cel combo. Val alone seemed to improve my PEM baseline 30%. Cel seems to be reducing inflammation a minor amount. Honestly not sure what cel is doing but sticking to it because of the Pridgen Protocol. GP is concerned about the long-term GI risks of that high cel dose. I didn't randomly decide to try val/cel. My labs this year on multiple occasions have read high EBV IgM which suggests dormant viral reactivation. Valacyclovir is not targeted at EBV. My guess is multiple other dormant Herpes-family viruses are reactivated at the same time. ID doctor wanted me initially to try valganciclovir which is targeted against CMV. I decided to try valacyclovir first because of excellent safety profile (no black box warning). Whatever val is doing seems to be suppressing a major portion of a persistent infection. I still feel constantly ill. Ability to think has improved by 30% on a sustained basis which is a lot better than past years. That might be due an improved my PEM baseline. I'm not sure. I tried to play catch up with years of defferred maintenance, overdid it and caused a neuro crash for a few days. December 4th: azithromycin again mitigated both neuro and prostate symptoms. - Very Soon: 2nd Pemgarda The Pridgen Protocol trial suggested better results for those who took combination Paxlovid during a portion of the long duration val/cel. In my case I'm combining long duration val/cel with Pemgarda and Paxlovid. nitter.app/wtogami/status/1946097… My previous Pemgarda didn't yield lasting improvement. I had some serious problems like heavy drug interactions with the combination antiviral. This time I eliminated all meds that conflict with Paxlovid. I'm refusing the pre-medications that interfere with my ability to feel what effect if any Pemgarda is doing to me. - Biomarker Monitoring I'm periodically getting freezing blood/serum/plasma vials before each big treatment. If a big change happens after a treatment then analyzing before and after vials may help to figure out what changed. Future Stuff I want to try 1) Microdosing GLP-1. No reason not to try this. I previously could not try because it had a dangerous interaction with those same meds that I can't take with Paxlovid. But after elimination I can try both this or the milder Metformin again. 2) I'm interested in antiretrovirals where some people had success like with Maraviroc. 3) I am intrigued by the anecdotes coming from the Anktiva LC trial. I have now begun monitoring biomarkers to help determine if I am a good candidate for these immune modulating treatments.

The Alaskan separatist movement is entirely organic. The green men are clearly Alaskans trying to defend themselves from the regime. Why is Washington bombing Alaskan civilians?

I'm not aligned with the truckers but shutting down bank accounts of protestors strikes me as too much like the shit the CCP does to cripple critics in Hong Kong. You lost the plot if you call yourself a liberal democracy while calling people you disagree with "terrorists".

My previous plan to buy a Tesla car and solar roof is conflicting with my disgust with unethical market manipulation and shitcoin promotion.

Recently one of my oldest and dearest friends in tech blamed Bitcoin for the GPU shortage. Bitcoin mining has not used GPU's since ~2013.

Operation Chokepoint 2.0: Today I heard this from the management of a small US bank.

There is no such thing as crypto "diversification" to reduce risk.

June 2019 I met my favorite Satoshi.

Reminder - Nobody has the right to speak for Bitcoin. Bitcoin has no official website.

Dear @nayibbukele, Please be careful. 1) Nobody has the right to speak for Bitcoin "officially". 2) History should raise severe caution flags: * Brock raised billions for EOS ICO, later sued for fraud and SEC violations. * also see: Chinese prison labor coindesk.com/brock-pierce-bl…

Remember when the government sued to stop a beef farm from testing to reassure their customers? It's cheaper to ignore the problem and continue feeding animals parts to animals.

I was among the first who supported you when it was about raising awareness. You've done some heroic things but you've lost control of yourself. This is about the country, not you. Please focus on yourself in quiet reflection. That is the most respectful thing you could do now.

Greta is not relevant to this conflict. You can see the awkwardness in Zelenskyy's face. He took the meeting because he can't afford to alienate any possible foreign supporters no matter how irrelevant or self-promoting their visit is.

Greenpeace was directly harmful to their own climate goals for decades in their campaign against nuclear power.

Did they shoot down one of these before escaping?

1 BTC = 0.995 BTC ETF's will enable innovation of this type.

I witnessed my dear friends haunted by these fraudulent lawsuits for years. It caused stress and health problems. Craig is an evil man that deserves punishment.

Which is the real water that should be fed to babies?

I hadn't heard of this guy since Breaking Bitcoin 2019. At a group dinner he introduced himself as a BCH-only VC and wanted to debate. I responded, "It doesn't matter what you or I think. The market had decided a long time ago." He stormed out. Now he's backing another winner.

Bitcoin is distinct from all the centrally controlled securities (ETH, ICO's and many other alts). Satoshi's wisdom was not only in its creation but also in stepping back. Lack of central authority is why Bitcoin endures. Nobody to pay for marketing campaigns is a feature.

I have been substantially disabled by Long COVID since 2022. Received Pemgarda infusion July 17th, 2025 after reading a few anecdotes of it helping other patients. Also read it did nothing for others. I will be posting my daily progress and answering questions in 🧵 below./1

This past week I asked a few nurses. All of them would get the current recommended childhood vaccines for their kids in another country if it became unavailable here.

Pleasantly surprised my Austin chiropractor now accepts Bitcoin Lightning payments to his non-custodial wallet. He's a damned good chiropractor too. Highly recommended! adjustmefirst.com

Bitcoin Lightning Network payment experience was excellent at McDonald's El Salvador. Same touchscreen self ordering machines as in the States. No different from credit card checkout. @OpenNodeCo processing integrated into a smooth experience. (Thread 0/4) 👇

Shitcoin companies are laying off staff during "Crypto winter". Bitcoin Only companies are hiring and struggling to find enough talent.

Only the morally corrupt would write or believe this statement.

That doesn't look consensusal.

We're instead witnessing selective breeding for humans to achieve dog-level IQ by 2050.

Good to see the market has grown to be immune to China. Countries that respect freedom and property rights will prosper.

It is surprising to me Russia somehow has true believers willing to take out their opponent with a suicide grenade rather than be taken prisoner. They surely can't believe they would be mistreated as a POW?

Modern medicine isn't allowing Darwin to do his job.

Supposedly BCH is +32% today while BTC is +7% but when you look at the relative Buy Support on coinmarketbook.cc you need to scroll past the first page to even find BCH. By this metric the market for BCH is dangerously false. Don't be another victim of false Bitcoin fraud.

I'd feel more comfortable about @Bitcoin if it tweeted something like: "This account expresses opinions of a fan. Nobody has the right to speak for Bitcoin, including this account." This message pinned for a while would be fantastic.

Update: BCH now below 8% hashrate relative to BTC. fork.lol/pow/hashrate Real risk of double-spend causing exchange insolvency. * 6 hours and 20 confs wasn't enough to protect against the BTG exchange theft. * Vulnerable to single persons, intentionally or via hacked pool.

Until the big blockers lost the war in 2017, Coinbase literally tried to seize control of "Bitcoin" and force it into the fake "decentralized" dystopia we now are witnessing at ETH.

I have no idea who this Cuban guy is but yeesh this is cringe.

This is the most popular Russian flag.

I'm no expert trader but I consider gaining Fidelity but losing Binance to be a net win.

Past week I met a few big companies in Korea ... * Did not know about Lightning or layer 2. * Did not know anything about ETH's massive failures, e.g. Parity multisig. The upcoming community translation project will educate many over time. Quality information speaks for itself.

Money needs to be boring. Security and reliability allows people to focus on their own business instead of "exciting" emergency updates.

BTC vs ETH

Why is the lady in a Mario warp pipe?

Not true. They are quite skilled at sending cruise missiles at civilian apartment buildings.

Here's one chart describing why "BTC dominance" is a completely worthless metric. Included data is from: * BTC "market cap" * all gold ever mined * "broad" fiat money supply Let's focus on the real opponent please? The alts are ephemeral distractions.

Local Wendy's. Dining room is closed. Manager at drive-thru says, "I have no employees. Can sell you only nuggets and fries. Cash only because my credit card machine is broken."

My prediction: The Merge will eventually happen then things won't miraculously improve. PoS was never a "scaling" solution. They hit fundamental limits a long time ago. Blockchains do not scale. They already had many disasters but then sharding will increase dapp complexity. 🍿🍿

The $$ gets the headline but what she says about how mining can lead to more renewable power generation investment is important. Intermittent power sources are more profitable if there is a sink to buy up all that excess energy. Tesla et al should be focusing on this potential.

The first step of being a validator is to validate. This influencer is quite dishonest as he knows full well very few people validate with their own ETH full node. They instead trust a small number of centralized providers and pools. This is already bad and will only grow worse.

BCH's absurd little civil war has an unexpected benefit. Any hashrate they deploy to fight their fellow morons effectively hands free money to the BTC miners.

Bullshit.

Bitcoin is boring and conservative. I hope it stays that way.

Seems far more likely other Russians are behind the attack?

There is a non-zero chance of a ETF custodian making a mistake.

Sounds like the FBI had the easiest recovery op because the "hackers" were grossly incompetent. Bitcoin is working as intended.

Is nobody there discussing H5N1?

My roof is ~14 years old and needs to be replaced anyway. Their solar tiles in particular seemed like a good idea for longevity, durability against Texas hail, and clean rainwater collection. But I really can't reward undisciplined, unethical behavior by giving him money.

Claro is a national mobile network provider in El Salvador. Their Bitcoin Lightning Network top up experience is so fast that the activation SMS upstaged this photo attempt of the successful LN payment. Excellent LN experience powered by the Open Source @BtcpayServer. (Thread) 👇

Update: BCH 30-day avg falls to 7% hashrate. fork.lol Matters bc of the risk of exchange insolvency from double-spend theft. ~85 BCH confirmations roughly equiv in cost to security of 6 BTC blocks. NOT HYPOTHETICAL. Reorg theft happened multiple times this year.

USD sinks to all time low.

Today I am thankful that these morons sequestered themselves into their own pocket universe where they can safely demonstrate the unsustainability of externalizing costs to other people.

BTC fees earning miners far more than the BCH block subsidy. Further nobody is using BCH.

The greatest evidence against the possibility of time travel or FTL is Bitcoin's PoW continuing to work as expected.

According to Google Project Zero they discovered 0-day "Internet-to-baseband remote code execution" affecting many millions of Samsung and Pixel 6+ modems. Read it for yourself. It sounds very bad. If you have an affected phone you may want to turn off your SIM card until your vendor patches this. The writer claims it's already patched by Google in the March 2023 patch level. Unfortunately that patch had been withheld from Pixel 6* due to bugs so the blog is incorrect about this already being fixed for Pixel owners. It sounds like Samsung has a much bigger mess due to the wider variety of phones, firmwares, and providers for which they must now rush an update without breaking it. Not an easy task but they must do it. Don't blame Google for releasing this advisory. Samsung had months to respond in a timely manner. Do blame Google for failing to protect their own customers prior to their own advisory. I like Pixel and I want them to do better. googleprojectzero.blogspot.c…

I visited Japan for a total of 9 months during the past 2.5 years of the pandemic. Gov lacked ability to shut anything down except borders. Despite the lack of mandates people wear masks near 100% indoors/trains, and after Omicron most of the time outdoors. That seems to matter.

I'm beginning to suspect the administration may have some untoward relationship with Russia. 🤔

It's only realistic for him to concede 20% of the company for the attacks to stop.

This fellow @DrRoyMurphy is exhibiting the laziest attempt of BCH marketing fraud. Without proof claimed to be of earliest Bitcoin devs. Curiously got lots of historical and technical details wrong. Next time do some basic research before you commit fraud? CSW was better.

Gold is useful to industry due to its non-corrosive property but it isn't usable while its price is high. Bitcoin unlocks the true potential of gold to benefit society.

It can be simultaneously true that Roger Ver does not deserve jail time for tax evasion while he does deserve condemnation for his deceptive and fraudulent conduct.

You said fictional?

ETH had a third emergency update in a month yet price unaffected. Why? Almost zero people use it for anything outside of speculation. Further, traders don't run nodes. They instead rely upon centralized providers.

Russians have been messing with Americans in America for years and we did nothing about it.

Russian losses are identically shocking but Russians don't care.

It cannot be overstated how important it was that Bitcoin demonstrated in 2017 that nobody has the right to force changes without agreement of everyone. This is a key way in which Bitcoin differs from the centralized securities, and why BTC will endure for 100+ years. nitter.app/urbanarson/status/9871…

BAB abandoned their "0-conf is safe narrative" in favor of ~110 minutes plus moral hazard for finality. Sooooo much better than ultra-efficient, trustless LN channels.

Please be careful about ".btc". Stacks seem like polite builders but in reality they commit affinity fraud. Basically they misleadingly claim to be "on" or about Bitcoin while it is really about their own token. Bitcoiners will look upon .btc tagged people with suspicion.

Bitmain created this coin, maintains most of the mining, and now proudly announces their ability to adjust the inflation rate as if they are a central banker. I'd like to help them with "Database", the latest FOMO tech that will revolutionize scaling for their centralized ledger.

I liked the old Nic. His heart was in the right place.

10/ The only way Bitcoin will survive 100+ years is if nobody has coercive power to force changes upon other people. #UASF #WeAreTheBadger

How the f- is this a SEC approved ETF?

I speak as one of many in the Bitcoin community in expressing outrage. The leaderless Bitcoin movement is better off without dangerous self-aggrandizing affinity scammers, and had grown stronger from the failure of the Bitcoin Foundation who had several such people at the helm.

Hearing from locals and fellow travelers: * Chivo needs to make LN receiving default. Onchain is a bad idea for small amounts. UX confusion, can't find LN option. * Some reports of Chivo LN being not reliable? * McDonald's LN payment is very reliable because they use @OpenNodeCo

Seriously. You expected better?

Charged my credit card. 1 hour later refunded my credit card. JPY is dropping that fast.

Dammed if you do. Dammed if you don't.

I was there tonight. I had hoped to meet you in person. I will visit the museum sometime.

Props to @CaitlinLong_ for warning about paper Bitcoin for years!

Emergency. Convincing high pressure phone call tricked me into enabling somebody to hijack my GMail account. I should have known better. Anyone have a contact at Google to help me recover my account?

This seems definitive. He wanted to help and he did by helping to raise awareness among the Western public. It's better that he's not there anymore. I wish him luck. mobile.twitter.com/MalcolmNa…

If you want to maintain a grip on power you need to install loyalists in every leading role.

For the sake of your people please be careful. One will use your country to promote itself and governments including you are able to influence. The other exists because the people demand a fixed set of rules that no government can corrupt. The moral authority is not equivalent.

Scaling on-chain simply does not work. Be careful about unrealistic promises and those who make them.

7zip had a recent arbitrary code execution exploit. Would be funny as heck.

Please see this summary of why the vast majority of the Bitcoin ecosystem considers Brock Pierce to be a fraud. Nobody has the right to speak for Bitcoin. Especially not guys like this that so shamelessly lie for the purpose of self promotion.

There is something far scarier than buying Bitcoin. Selling Bitcoin.

ETH network is yet again crippled by technical malfunction. Price responds by going up. Perhaps ETH would be better off dropping the decentralization theater. "Database" technology would bring untold levels of reliability. Your traders won't notice any difference.

Nuclear. For decades. They contributed to the anti-nuclear sentiment that caused significantly more carbon intensive fuel imports and recently screwed over the economy and national security of Germany and Japan. Greenpeace and Green parties must be punished for these mistakes.

All of the developers that I know across many countries have sold 100% of easily split-able BCH. This may be of concern to those who know the role of developers in defending the security and reliability of a network.

Translation: "I am displeased with how I have been unable to externalize the costs of my inefficient layer 1 parasitic protocol. I never even had the chance to be priced out. I blame the BTC devs for my unscalable ideas needing to be demonstrated as infeasible on other networks."