Professor of #bioengineering and Applied Physics @stanford Prolific inventor at the nexus of #biology, #physics, and #tech
- Tweets 448
- Following 322
- Followers 5,480
- Likes 456
While on a lecture tour in Japan, I was able to divert to Hokkaido for a few days to ski their world-class powder snow. I've been skiing since I was six years old, and Niseko and Kiroro did not disappoint!
15
22
584
131,875
In @CellCellPress, I share a major conceptual challenge for biology in the next decade, inspired by Crick’s Central Dogma: understanding information flow in the cell, the smallest indivisible unit of life bit.ly/4hQMmva
15
110
526
73,810
In our study, we describe Smart-seq-total, an RNA-sequencing method that delivers a broad picture of the total cellular RNA content.
Click here to learn more: bit.ly/3pVQ10I
@alinaisakovaSci @PNASNews
4
66
282
Excited to share a new study in @nature led by @Wenfei_Sun and in collaboration with Thomas Sudhof’s lab that maps a memory engram. It shows the interplay of neurons and astrocytes in long-term memory formation. Congrats to the team for this work. bit.ly/3SyEUt3
4
41
210
31,562
Virtual cell models have the potential to transform biological research. Today @ChanZuckerberg released an initial set of models, including scGenePT and SubCell, designed to be easy to run and build upon. This is a really exciting time in biology. czi.co/4g1jTSa
56
210
13,234
Using #singlecell #transcriptomics, we created a molecularly defined phenotypic reference of human cell types spanning 24 human tissues and organs.
bit.ly/3DlKg10 @biorxiv @czbiohub
47
197
"It may seem ridiculously naïve to characterize something with the complexity & intricacy of a cell as a ‘bag of RNA’. I will argue that in fact it is a powerful & productive abstraction that is helping revolutionize our understanding of cell biology." loom.ly/tXlvMF8
7
28
185
The Tabula Sapiens maps nearly 500,000 cells from 24 tissues and organs. A great accomplishment for #singlecell biology in redefining how we understand human biology. Congrats team, @czbiohub. @ScienceMagazine science.org/doi/10.1126/scie…
56
200
Our Tabula Muris team set out to determine the cell types and molecular pathways which can be rejuvenated by parabiosis - an effort to reverse aging.
nature.com/articles/s41586-0…
2
59
191
Why I refer to the cell as a "bag of RNA" in my @sciencedirect article: loom.ly/tXlvMF8
#cellbiology #mRNA
2
47
174
It has been an exciting first week as @chanzuckerberg’s Head of Science. It has been great to meet the team and I am looking forward to all that is to come in this new role.
2
3
169
One of my hobbies outside of my work in science is reading. Here are a few of the top books I read last year.
What were some of your favorite books you read in 2022?
16
14
173
244,970
I’m thrilled to see this group of distinguished scientists come together to launch the @ChanZuckerberg Imaging Institute and build a new generation of electron microscopy technologies that will advance our understanding of human biology czi.co/3cHItLU
2
25
167
Excited to share that @AllenInstitute, @cziscience and @UWMedicine are joining forces to launch the Seattle Hub for Synthetic Biology. Led by Jay Shendure, the Seattle Hub aims to revolutionize how we understand cell history and gene functions czi.co/SeaSynBioLaunch #SeaSynBio
1
26
169
24,590
Tabula Sapiens 2.0, a reference atlas with >1.1 million cells from 28 human tissues, reveals insights into transcription factor expression, cell senescence, & sex-specific gene expression. Explore the findings: biorxiv.org/content/10.1101/…
1
41
167
18,918
We’re expanding the @czbiohub network by launching a new Biohub in NY. #CZBiohubNY will characterize immune cell states, and engineer new functions into immune cells to detect and treat diseases earlier. (1/5) bit.ly/3twNAqK
4
20
148
30,710
I'm excited to share the news of @ChanZuckerberg's reinvestment in our work @czbiohub. We will continue to keep making fundamental discoveries and developing new technologies that will help to cure, prevent or manage all diseases by the end of the century. prn.to/3ExTpoL
2
10
142
CZI plans to build the computing power needed to create predictive models of cells at scale. We’re at a critical moment where AI tools, in combination with annotated high-quality data, can help us accelerate our understanding of cell and systems biology.
3
26
141
20,228
“A Decade of Molecular Cell Atlases” details the history of cell atlas development, from the first cell cDNA libraries to more complex transcriptomics technologies. @sciencedirect @czbiohub @stanford #cellatlas #dna
sciencedirect.com/science/ar…
28
137
Exciting update on the work of the @czbiohub and the Tabula Sapiens Consortium to create the most extensive reference of human cells via @biorxiv bit.ly/3DlKg10
1
29
126
AI and large language models, harnessed for biomedicine, have the potential to unravel the mysteries of our cells. Today @cziscience announced it is building one of the largest computing clusters dedicated to life science research in the world. bit.ly/3LvgiP4
1
41
119
20,516
Cell type deconvolution of cell free RNA and potential clinical applications in recent work by @mira_moufarrej, @skayaneh, and me.
@NatureBiotech nature.com/articles/s41587-0…
1
34
123
Congrats to the teams at @MDAndersonNews, @UCIrvine, and others on publishing the first Human Breast Cell Atlas in @nature! This reference is an unprecedented effort that profiles 700,000+ cells and will aid in creating the @humancellatlas’s first draft. nature.com/articles/s41586-0…
3
27
116
14,845
Cell free RNA provides a window into preeclampsia risk and etiology, a disease which affects hundreds of thousands of pregnant women each year.
nature.com/articles/s41586-0…
1
23
98
There are big things in store for 2023. Here are my 4 predictions for science in the year ahead: 1. #PersonalizedMedicine has transformed the field of oncology. By understanding a patient’s individual biology, doctors are now able to predict which therapies will be most effective
4
25
85
45,637
This year we worked with scientists & #AIML experts to create a vision for the future of virtual cells. Now in @CellPressNews, the vision shares a roadmap for large-scale, collaborative research on AI-supported virtual cells. This is just the beginning bit.ly/4gzocUL
2
15
74
5,746
Thank you, Cori, for your incredible leadership over these past six years. I am excited to take on this new role as Head of Science at CZI and lead this next chapter in our science work.
I’m thankful to Priscilla and Mark for putting their trust in me, and to the entire team for everything they do to accelerate science. My time at CZI will forever be a career highlight and I’m grateful to have played a role in advancing this work. 7/
2
6
72
I'm so excited to be leading the newly formed @czbiohub Network.
The CZ Biohub Network will work with universities across the USA to create new Biohubs which will pursue and solve grand scientific challenges.
Learn more: chanzuckerberg.com/about/ann…
4
6
66
This was almost exactly a year in advance of the paper publishing, illustrating the value of preprints in accelerating science.
Access the paper here: science.org/doi/10.1126/scie… via @ScienceMagazine
11
61
Had a great time celebrating the launch of the Kempner Institute at @Harvard. It will be a one-of-a-kind center for the study of the basic biological mechanisms of intelligence that will help advance our understanding of both neuroscience and AI.
1
3
57
AI is unlocking a thrilling era for discovery! @cziscience is training AI models to help scientists better understand cells and their structures. Our first projects will focus on genomic and biological data to better understand life at the molecular level. czi.co/43jhBs9
1
12
61
8,876
Excited to share my work with @alinaisakovaSci and Norma Neff, published in @PNASNews.
pnas.org/content/118/51/e211…
11
59
Great work by @czbiohub researcher & @Stanford colleague Peter Kim, who developed a new Covid vaccine that is showing extraordinary preclinical results for protecting against Covid-19, including all known variants. Human clinical trials are expected to begin this spring.
Exciting news! Biohub researcher & @Stanford prof Peter Kim developed a promising new Covid #vaccine that, in experiments, shows robust protection against all Variants of Concern. Read the preprint &🧵on this work. biorxiv.org/content/10.1101/… 1/n
2
7
54
18,541
ICYMI, the Aging Fly Atlas, which maps single-nucleus transcriptomes at multiple time points to create an aging clock, was published in @ScienceMagazine. Congrats to the entire team that worked on this major milestone! bit.ly/3J3nQr3
18
52
9,824
What started as a worry for my wife and unborn child ultimately led to multiple breakthroughs in noninvasive medical testing using cell-free DNA and RNA.
czbiohub.org/life-science/in… via @czbiohub
10
52
2023 is shaping up to be a big year for science and technology — here are some of the things I'm most excited about this year.
1
11
50
10,268
Honored to help launch #CZBiohubNY alongside representatives from New York, czbiohub + @chanzuckerberg leadership! The team is programming immune cells to scout and treat disease
5
47
5,154
Combining transcriptomic and metabolomic data from urine holds promise for improving early disease detection, subtyping, and prognosis, as well as enhancing our understanding of disease mechanisms. Read the paper in Clinical Chemistry: lnkd.in/gcJYJkgc
4
5
46
6,619
Why we developed the Tabula Muris, a cell atlas of the mouse: see my @sciencedirect article in the link below.
@czbiohub @stanford #cellatlas #dna
sciencedirect.com/science/ar…
6
43
Great visit to @CZBiohub Chicago in their brand-new lab office and lab space and meeting with @ShanaOKelley’s (growing) team. Can’t wait to see more of their incredible research studying inflammation. #CZBiohubChi
4
41
3,973
We are recruiting a director for the @Stanford Microfluidics Foundry!
Duties include training people, maintaining equipment, helping teach a microfluidics lab class, and working with bioscience labs to help them design, fabricate, and test PDMS devices... (1/3)
1
23
38
Thrilled to see this article on our work on predicting pregnancy complications. This research is personal to me, as someone close to me has faced these challenges. Their journey fueled my determination to improve prenatal care for all. @KnowableMagazine bit.ly/3PssySE
1
4
38
6,360
Today is #RareDiseaseDay, a day to bring awareness about the 300 million people worldwide living with a rare disease, their families and caregivers. For the third year, @ChanZuckerberg is joining the global rare disease community to #LightUpForRare. (1/2)
1
3
32
2,744
Extremely proud of the entire @MirvieDx team for their work in redefining the future of pregnancy healthcare.
Read more on our latest funding announcement: bit.ly/3Nmfri4 via @forbes
1
8
33
Honored to be a keynote lecturer at the 2nd annual @Cornell Immunology Symposium. Join me on April 20th at 9 am as I discuss our work on molecular cell atlases.
@CornellCFI
centerforimmunology.cornell.…
9
32
Join me in Cambridge, MA, this Wednesday as I’ll be speaking about my work on the decade of molecular cell atlases at The Ray A. and Robert L. Kroc Lecture at @Harvard. The seminar will be at 12:30 EST. Thanks to Tom Kirchhausen for organizing this seminar.
7
35
Joe DeRisi has been busy! From SARS-1 identification to increasing the clinical utility of metagenomic tools, he’s being honored with the @StanfordMed Arthur Kornberg & Paul Berg Lifetime Achievement Award—well deserved! bit.ly/3VJcbUt
3
36
2,958
It was an honor to join brilliant minds from @AllenInstitute, @ChanZuckerberg, and @UofWA to celebrate #SeaSynBio and this cross-institutional effort to deliver new insights and technologies to record the history of cells over time.
1
4
34
4,960
Today is 'Read a Book Day,' and I recommend David Fajgenbaum’s 'Chasing My Cure.' As his journey from football player to medical student unfolds, he reveals his battle with Castleman Syndrome. It's a story of near-death experience, self-discovery, and a life-saving breakthrough.
2
5
35
4,030
All alpha cells are not equally impacted by disease; a subset of alpha cells defined by their maturation state may be key drivers of impaired glucagon responses in Type 2 Diabetes.
sciencedirect.com/science/ar… @sciencedirect
10
33
New @ScienceMagazine : #CZBiohubCHI's biosensor continuously measures proteins in vivo. In a diabetes model, it resets in under a minute, enabling real-time cytokine tracking. A breakthrough for inflammation-related diseases. czi.co/4giRO8v
1
4
31
3,115
Join me in welcoming @USCDornsife’s Scott Fraser to @cziscience as our Vice President of Science Grant Programs. I’m excited to have him on board to shape our grants program that funds world-class science and advances our understanding of the mysteries of cells.
2
30
3,383
"We’re the new kid on the block, and as we celebrate our fifth birthday, we’re just getting started. But when we look at what has been accomplished so far, our experiment shows promising results." @czbiohub #5YearsofCZBiohub
czbiohub.org/life-science/co…
1
4
30
I had a great time last night at the screening of @noc_film and hearing from #RareAsOne grantees. Collaboration between patient communities and scientists is essential in accelerating research, and I’m inspired by the progress these groups have made against their diseases.
2
2
28
3,190
To further advance our understanding of regeneration, stem cell dynamics, and many other fundamental biological processes @PhysPlanaria and colleagues developed a strategy to allow transgenes expression in planarians bit.ly/3Wr60Dy
6
29
13,462
I've been enjoying some springtime skiing in Tahoe recently and managed to get out in shorts one day!
It's been an awesome ski season. Many beautiful days up in Tahoe. (1/2)
2
31
7,634
"I wanted to find ways to automate biology and develop the equivalent of the integrated circuit of biology which led me into microfluidics..." hear more about the intersection of physics and biology in my talks with @bios_community
open.spotify.com/episode/70J…
1
8
31
I am deeply saddened by the passing of Lubert Stryer, a terrific friend and mentor. Our first recruit at #CZBiohubSF, he led the inaugural investigator competition and established a culture of scientific excellence and collegiality.
He was a remarkable scientist and human being.
3
27
3,235
Earlier this month, I spoke at @helmholtz_en’s @bioeng22 in Munich, Germany. Big thanks to @helmholtz_en for the invitation and the opportunity to meet with a terrific group of scientists and engineers.
1
1
29
American Disruptor, by @newsrolando
A biography of Leland Stanford, the robber baron who helped build the transcontinental railroad, founded @Stanford and became a California governor. An astonishing story of corruption and ill-gotten wealth.
1
28
13,577
I’m proud of the progress @cziscience made this year toward measuring human biology in action—from launching the Kempner Institute at @Harvard to our work to map all cells in the body with @czbiohub's Tabula Sapiens.
Read our annual letter to learn more: czi.co/AnnualLetter
1
24
#LungCancerAwarenessMonth may be coming to a close, but the work we're doing to provide better-targeted treatments never stops. Read about how members from the @czbiohub team are working to use scRNA-seq of metastatic NSCLC to improve clinical outcomes: bit.ly/3184G0A
2
4
26
The #NobelPrize celebrates what’s possible when curiosity meets perseverance. Congrats to all the laureates including @cziscience grantee David Baker of @UWMedicine who received the honor along with Demis Hassabis & John Jumper for advancing our understanding of protein structure
2
28
2,672
Thanks to Cornell University, where I just finished serving as A.D. White Professor at large. I was impressed with the university community and the great science going on in Ithaca! I stopped by Montana on the way home to visit friends and went mountain biking in some early snow.
1
1
22
2,427
This week in Munich, Germany, I’ll be joining some distinguished colleagues to speak at @helmholtz_en’s @bioeng22. Learn more and register for the event here: bioeng2022.helmholtz-muenche…
1
5
26
Last month, I had the pleasure of joining @TerasakiInst for their seminar series. You can watch the full webinar where I discuss in depth the cell as a bag of RNA by clicking the link below.
bit.ly/3jdY0U7
4
26
Biological data is being generated at a staggering rate. AI will be instrumental in making sense of it all. Looking forward to exploring this topic with @stephen_wolfram and @biotechnation at @synbiobeta on 5/7. #SynBioBeta2024 bit.ly/4cQNZ9E
5
24
6,488
Building AI-driven virtual cells requires #OpenScience and broad & long-term collaborations. A roadmap created with science + AI/ML experts through community discussions and a CZI-hosted workshop, our new preprint advances virtual cell models: arxiv.org/pdf/2409.11654
8
27
5,386
Had a great conversation with my student @sevahnv on the @myADLM podcast about work she led exploring cell-free RNA in urine as a path to avoid invasive biopsies for detecting diseases earlier in prostate, kidney and bladder tissues bit.ly/3B3MOFV
1
24
1,892
At CZI, we’re working to observe and analyze any biological process within the human body across spatial scales and in real time. We’re building and supporting advanced imaging hardware and software to help us get there. #ImagingTheFuture
It’s #ImagingTheFuture week at @ChanZuckerberg! We’re sharing how breakthroughs in imaging science can improve our understanding of biology and help cure, prevent, or manage all disease
Learn how scientists are #ImagingTheFuture with innovative tech: czi.co/3XKB5l8
24
3,279
CZI is building a strong foundation for enabling AI/ML for scientific research at scale. Welcome aboard, @Tkaraletsos and our newest AI Advisory Group members. Your collective expertise will be invaluable as we build virtual cells for biomedical research. czi.co/49OsC72
4
25
2,437
The convoluted language of cells is a ripe challenge for AI. With the extensive collection of biological data, the possibility of predictive models of cells and cell systems is on the horizon, and cell biologists will be key to bringing this to fruition. bit.ly/49ekSMd
2
3
25
2,535
Looking forward to speaking at the Francis Crick Institute in London today and learning more about the institute and its research.
1
23
From Tabula Muris to Tabula Sapiens... how a simple question from Priscilla Chan: "Why don't we just do human?" inspired @CZBiohub to create a first-draft human cell atlas of nearly 500,000 cells from 24 organs across 15 subjects.
Read more here: cell.com/trends/genetics/ful…
1
19
Scientific discovery is not linear, but it should not deter us from curiosity-driven research and pursuing bold ideas.
economist.com/science-and-te…
1
4
23
4,812
Proud to be an organizer w/ @max_diehn for this year's CNAPS conference at the @GrandHyattSF on May 16-18.
Delegates will report research on circulating and cell-free nucleic acids and their diverse applications to liquid biopsies.
Register here: cnaps2022.com/
1
5
24
Congratulations to @MirvieDx! Mirvie's Preeclampsia Test is the first for early identification of preeclampsia risk months before any clinical presentation of symptoms to receive @USA_FDA Breakthrough Device designation - looking forward to the next phase of developments
1
1
23
Thanks to Paul Karon from @InsidePhilanthr for covering my new role as Head of Science at @ChanZuckerberg. We spoke about my career, what the future of my work looks like, and our goals of understanding diseases and having an impact on them: bit.ly/3AFkUvQ
5
23
With @czbiohub growing into a national organization, I’m excited to share that we’re expanding the board and welcoming Paul Alivisatos, @UChicago president, as a new board member. Learn more about Paul and the Network: bit.ly/3P6U7kB
1
1
21
2,704
I’m excited to be speaking at the IQUIST Seminar at the @UofIllinois - Urbana-Campaign.
@IllinoisQuantum
Tune in to the seminar via bit.ly/3R75MxJ.
2
4
20
"Science is driven by discovery...Inventing the future for me means inventing those technologies and measurement tools that will enable the fundamental discoveries that open up the future in science"
@bios_community
open.spotify.com/episode/70J…
1
21
On US National Postdoc Appreciation Week, we celebrate postdocs' pivotal role in scientific advancement. I'm grateful to have mentored countless talented individuals, and have witnessed their incredible contributions to research and innovation. Your dedication is invaluable.
1
2
21
3,318
Being pregnant in the U.S. can be a scary experience. Maternal mortality rose 14% from 2019 to 2020 via @CDC.
(1/2)
1
2
20
Fun chat with @nightsciencepodcast on the nature of creativity in science, embracing failure and the unique collaborative model we’re cultivating at @cziscience. You can listen at: bit.ly/3tdPWuS
2
19
3,239
Great time on @DNApodcast with @euanashley discussing the evolution of human genome sequencing and how this technology can revolutionize patient care and treatment through precision medicine. Excited to see what the future holds for this approach...
🎧 On a recent episode of @DNApodcast, @euanashley and CZ Biohub’s @StephenQuake discuss their early work together in genome sequencing, significant advancements in the field over the last decade, and Ashley’s recent book, The Genome Odyssey. dnapodcast.com/episodes/2021…
6
21
The @czbiohub's #cellatlas development included collaboration with the @AllenInstitute and the Swedish consortium led by Mattias Uhlen.
Details in my @sciencedirect article sciencedirect.com/science/ar…
1
20
Looking forward to joining the Frontiers of Biophysics conference this week in Paros, Greece. Thanks to Rob Phillips @Caltech for organizing a great group of speakers.
20
If you are interested in learning more about @MirvieDx, check out this interview @DocElovitz had with @HealthITNews. healthcareitnews.com/news/us…
2
17
Excited to get ski season started this weekend. A bluebird day and spring conditions at Palisades!
1
21
1,582
I recently read Shadow of the Wind by Carlos Ruiz Zafón. It is a lovely novel set in Barcelona in the first part of the 20th century.
(1/2)
2
1
21
5,895
Honored to be named a #CitationLaureate by @Clarivate. This work was done in collaboration with the phenomenally talented students and postdocs who worked with me over the years, and it’s really an award for them and their efforts as well. bit.ly/3qVlNfb
1
1
19
Excited to share that I'll be speaking at @bioeng22 on July 6th in Munich, Germany - thanks to the @helmholtz_en for the invite.
Learn more and register for the event here: bit.ly/3Q3Ps19
3
18
Interesting read in @ScienceMagazine's special issue on #CellEngineering and its position in the treatments of certain cancers and diseases.
A burgeoning area of investigation is focused on how cells can be customized to perform certain functions, bringing us closer to realizing long-imagined medical and basic science applications.
Learn more in a special issue of Science on #CellEngineering: scim.ag/El
2
18
4,697
Honored to be part of the Local Organizing Committee at @MicroTas2021 this upcoming week in Palm Springs. Today's the last day to register for remote participation - click the link for more information.
bit.ly/3lplwzb
1
18
Had an insightful conversation with the team @EMBO about my work at @ChanZuckerberg and @cziscience. Check it out.
“The biologists were pretty darn good with their microscopes": new EMBO podcast with Stephen Quake @StephenQuake @Stanford @ChanZuckerberg discussing what a cell type is, #openscience, #preprints, role of #funders and much more.
🎧👇
embo.org/podcasts/the-biolog…
3
19
5,705
It’s #NationalInnovationDay, and I thought I’d share a few thoughts on the subject…
(1/7)
1
4
20
5,985
Fascinating study from @CZIScience grantee and @czbiohub Investigator Sergiu Pasca on how human brain organoids formed connections with developing rats’ neurons. This could unlock a new model for studying biology of the brain and neurological disorders.
nytimes.com/2022/10/12/scien…
1
16