We've uploaded a fruit fly. We took the @FlyWireNews connectome of the fruit fly brain, applied a simple neuron model (@Philip_Shiu Nature 2024) and used it to control a MuJoCo physics-simulated body, closing the loop from neural activation to action. A few things I want to say about what this means and where we're going at @eonsys. 🧵

“Mind uploading has been a science fiction, but now mind uploading — for a fly, at least — is becoming mainstream science,” -@SebastianSeung nytimes.com/2024/10/02/scien…

GO SEE PANTHEON brillant new fiction on netflix. It follows the first 3 uploaded humans, how they escape onto the internet and nuke each other's data centers from space.

Why not faster drug approvals with clear risk labels: 'Experimental' (Risk Level 10), 'Moderate', 'Established'? Right now, we only get 'Established'. Knowing the level of experimentalness and risk category lets you choose your own path—more freedom to take risks and access treatments sooner. Seems useful for all drugs.

It covers some of the difficult philosophical issues like copies, backups, and how it feels to have a family member that's 'dead' but also not dead. It covers speed superintelligence, they can run thousands of times faster or more, with some limitations. It's also just a beautiful story. It's at the top of my list for best movies/shows. Several people I've shared it with have said it's the best show they've seen as well, or right near the top. If you liked the matrix, inception, san junipero, contact, oblivion, avatar. Pantheon - Netflix

This is going to be a great conference on how to stay alive and thrive before AGI! I'll be speaking on our progress toward human emulation

Want to predict the future? Sometimes it's hard because of 'failure of imagination'. Arthur C. Clarke's list of inventions/discoveries that were completely unexpected (left) and expected (right). [from 1972 book: Profiles of the Future]

AI ethics needs more than pointing out downsides. It requires nuanced weighing of pros, cons and alternatives. #AIEthics Love this article from @AmandaAskell askell.io/posts/2020/12/bad-…

wow--modeling brain circuits using newly released @FlyWireNews fruitfly connectome and predicted neurotransmitter identity yielded 91% accurate model biorxiv.org/content/10.1101/…

I love looking back over scanned documents. something beautiful about analog documents that have been digitized. They will never fade, now forever searchable, copyable to live in multiple places, findable, accessible, tiny, to travel at the speed of light

onenote and i are more clever than i

"Furthermore, the model does not account for the possibility of gap junctions, non-spiking neurons, internal state, or long-range neuropeptides, and assumes that the basal firing of each neuron is 0"

nextbigfuture.com/2016/03/ho… from @peterxing

To Combat Radical Violence in America, We Need Radical Medicine motherboard.vice.com/read/to… via @motherboard

Favorite conference of the year. Meet thoughtful people who care about doing great good in the present, near term, and far future.

"Once you get to an individual income of around $40,000, other factors, such as health, relationships and a sense of purpose, seem far more important than income. So [don't] focus on earning more than this." I agree with this (after adjusting for bay area) 80000hours.org/articles/mone…

This is so cool. One of the previous versions felt like touching any kind of object made of down feathers. Congrats guys! @slyjacklee @ICastroGarcia #Metaverse #vr #touch #humanconnection venturebeat.com/2022/01/28/e…

What model are you running that needs a petabyte of ram?

I wanted the same thing, but ended up just getting a Chrysler Pacifica Hybrid. Way more space than X or Y and daily it almost never uses the ICE

Arlo ultra 2 is pretty good for night cam, also battery poweredfor a couple of weeks. What distance?

What an awesome system for donating, love the causes, too! Thanks @Effect_Altruism and @open_phil

this but for humans

Been using Pocket, can I get an invite to @getupnext ?

Except replace 'aging' with 'mortality'

it's literally on netflix now, with season 2 coming

Actually, @jeffreycider, @Philip_Shiu's Nature paper emulated the flywire brain, reproducing behaviors like feeding and grooming with 95% accuracy, and it ran on his laptop with leaky-integrate-and-fire neurorns. Really depends on what your neuron model is and it's not known yet what's required to get 99.9%. Full mammalian brains are definitely a much bigger challenge, but total op/s of a human scale brain emulation run efficiently could run on 1-500 H100's.

Agree we need something better than leaky-integrate-and-fire but I think the astonishing thing was that it worked so well, which suggests that we don't need to go all the way to mollecular level

Have you looked into m-disc? They estimate 1000 years for a blu-ray disc. 100GB so fairly small, but there are lots of these drives available on the used market. Why reinvent data storage, if it already exists? How long are you trying to store for? mdisc.com/technology.html

I love pixels! 8k? Physical dimensions? How is the latency? Nice wood on your desk

Interested in reverse engineering the brain? #carboncopies online workshop going on right now: carboncopies.org/livestream and discussion: goo.gl/slides/h67s4a Speakers: Ted Berger, @tonyzador, Randal Koene, Ken Kayworth, @adammarblestone, Diana Deca, Shawn Mikula @brainmaps

@elonmusk good comparison, although neither make the top 10 ways living people in the US die: cdc.gov/nchs/fastats/deaths.… #1 is heart disease

I saw their booth at @SfNtweets 2024 this week. It was pretty impressive, though I didn't see great connectome level stuff. They charge $10k for it though. Bluebrain had a version with ~10 neurons in it from MICRONS but their app wasn't available yet. I saw both on metaquest 3

Looking forward to Scaled Machine Learning #scaledml at Stanford on Saturday scaledml.org Tickets are sold out, but they are usually pretty ok with a few extras joining in. Discussing GPUs, TPUs, CPUs and scaling machine learning algorithms.