Boston, MA
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"if you mandated that the entire population had to wear a mask when they went out, all those asymptomatic carriers that are now transmitting it through respiratory droplets it would be much harder for them to transmit it."
Former FDA Commissioner Dr. Scott Gottlieb talks about the effectiveness of protective masks during the coronavirus outbreak #wsjhealth
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biorxiv.org/content/10.1101/…
Yay! Finally a human genome. Congratulations to this "right-stuff" team!!! Next we want routine, diploid & free for all. (a 92% diploid genome is now $300, but could be <$0 as costs saved via genetic counseling are >$30k when community-averaged)
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Given Fauci masking into 2022 (& beyond + next wave + next pandemic), shouldn't we have better masks? Better seals at the edges, full face visible, food & drink without mask removal. microclimate.com/
arep.med.harvard.edu/gmc/DIY…
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Species-defining differences (governmental and scientific) include a mixture of physical & physiological measures, breeding/food/ecosystem preferences, and DNA. There is no magic number of changes in any of these categories. A single genetic change can cause speciation ... while millions of DNA differences between individuals in a population generally do not affect species-specific phenotypes -- much less speciation. Our new, healthy dire wolves with twenty precise, simultaneous edits -- yielding key phenotypes distinguishing them from gray wolves signify milestones that will surely be surpassed soon given the exponential rate of biotech, but for now, we can pause and enjoy the moment.
Examples of single gene speciation:
science.org/doi/10.1126/scie…
nature.com/articles/425679a
Beth Shapiro (@bonesandbugs), @BenLamm , @colossal
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I just published “How we Benefit from Getting our Genomes Sequenced” medium.com/p/how-we-benefit-…
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Steve Wozniak vs. George Church: The original homebrew computer club meets DIYBio - Epic fireside chat at #SynBioBeta2018 synbiobeta.com/news/steve-wo… @geochurch @stevewoz #synbio
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Walking along chromosomes with super-resolution imaging, contact maps, and integrative modeling
journals.plos.org/plosgeneti…
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If you like home science (gardening, weather, photo, computers, stars, psychotropics, nutrition, ancestry, birding...) &/or you're one of 2 billion global video-gamers, then check this out: molecular.tv
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2013 resistance to many viruses.
2022 resistance to all natural viruses.
The method should work for any host.
biorxiv.org/content/10.1101/…
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Excellent initiative. Thank you. Keep at it.
vox.com/future-perfect/2023/…
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Over 4 decades of Sharon Begley' strikingly clear prose will live on. For half that time, read her work from afar, until our first chat in 2007, then working with her on 48 more stories. I join many who miss her greatly already. statnews.com/2021/01/17/shar… @sxbegle
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Transcription Factors, TFome: aging forward & reverse
hms.harvard.edu/news/vision-…
hms.harvard.edu/news/custom-…
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exciting to see my new #bioscience company @ItIsColossal in the @nytimes. Thank you @federallamm and the entire Colossal team for making this possible. #ItIsColossal Read more: nyti.ms/3CE1W88
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clinicalomics.com/news-and-f…
Congratulations Hesaam and team!
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endpts.com/george-church-his… free and open, student-led, enabling the next generation of biotech leaders
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papers.ssrn.com/sol3/papers.…
Two SARS CoV-2 clade 20C infections of same patient (no virus or symptoms between): 3/25 & 5/26/2020. The 2nd time hypoxic & required oxygen support. 11 mutational differences.
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link.medium.com/7zL63vauY3 Thanks Ed. Rapid response capabilities needed: molecular diagnostics, vaccines, neutralizing antibodies, and homes easily converted to off-the-grid full-recycling quarantine-biospheres. Not just for this epidemic, but the next one.
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"...computers became toys, ... then the industry really took off. And that has to happen with biotech.” molecularreality.com
#Desci #synbio #citizenscience #biotech #FreemanDyson #MolecularReality
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3D super-resolution imaging of human genome via barcode in situ sequencing.
nature.com/articles/s41592-0…
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CDC: for medical professionals: "unvalved N95 respirator may be used with a faceshield to help block high velocity streams of blood". For the rest of us: try to do better than a tissue for every breath (not just coughs).
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As therapeutics become more complex with more functional domains, the role of AI in development will become critical. businesswire.com/news/home/2…
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Please don't go out. If you must, then wear a mask. CDC: "covering your cough or sneeze with a tissue". Talking/breathing releases comparable rates of 10-200 micron droplets -- trapped more reliably via tube-bandana than tissue. instagram.com/p/B-GeikpjHCA
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Molecular electronics sensors on a scalable semiconductor chip: A platform for single-molecule measurement of binding kinetics and enzyme activity pnas.org/content/119/5/e2112…
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How "perma" is the permafrost? Threshold breached for heavy snowfall, floods too.
nationalgeographic.com/envir…
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Decision-makers at the federal, state and provincial levels around the globe: Immediate lockdown for reducing spread of COVID-19 - Sign the Petition! chng.it/HBwm922P via @Change
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SwabSeq: 10k samples/day/technician, $1/sample, detect 1-6 molecules, quantitative over 3-4 logs.
notion.so/Octant-SwabSeq-Tes… #Cov2
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Excited to be an advisor for Neurona Health -- whole genome sequencing & clinicians to help screen for early pediatric diseases in children. neuronahealth.com
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1000-fold higher viral load. Baisheng Li, Jing Lu, et al (Guangdong CDC) nature.com/articles/d41586-0…
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#GPWRITE2019 4th GP-Write & 8th Sc2.0 Nov 11-14 NYC. How build almost any genome. Only beings seeing this super secret tweet, email or web page are eligible. gpwrite2019.org
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theconversation.com/a-case-a… We have laws already (much stronger than moratoria). M can accelerate what they intend to moderate (e.g. ESCs & RDNA). Instead: surveillance, enforcement, whistleblower motivation, equitable access, & actual public health issues.
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drivendata.org/competitions/…
Your goal is to create an algorithm that identifies the most likely lab-of-origin for genetically engineered DNA.
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Buffers + catalysts in the water.
What’s in the Water at the George Church Lab? A conversation with my friend and co-founder @GeoChurch re: the past, present and future of #genomics, #CRISPR + #SynBio — and how his lab’s radical, transformative technologies become startups 🧙♂️🧬 a16z.com/2019/02/26/george-c…
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New method: alternative to plasmids for gene expression and genome editing
ncbi.nlm.nih.gov/pmc/article…
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genome.gov/leadership-initia…
Human Genome project Interviews
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scientificamerican.com/artic… A $20 million dollars per year for the past decade (spread over 31 countries). Should we increase that considerably to prevent recurrence of $2 trillion emergency-relief authorized (in one country, ours) last week.
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Molecular & Cellular Multiplexing in 8 minutes technologynetworks.com/genom…
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Genetics of memory & speed. Game-based study. Alzheimer’s & other cognitive decline issues wyss.harvard.edu/pgp-lumosit…
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Registration is live for the inaugural Nucleate summit! As a founding advisor, I'm keen to support Nucleate’s commitment to empower the next generation of biotech leaders
It's amazing what you can do virtually these days. But it's time to take it offline. 👇
Announcing Nucleate Summit, uniting our global life sciences community for the first time.
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advances.sciencemag.org/cont…
Plenty of room for science discoveries on even our most basic and effective strategies.
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bit.ly/prolactin-XL
A long-acting prolactin to combat lactation insufficiency
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medium.com/better-humans/wha…
Disposable is not the only option. Especially to prevent "Silent spreading" (asymptomatic Cov positive)
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Cell & molecular multiplexing. Well done team Ido.
Ab-initio discovery of tumoricidal oligonucleotides in a DNA sequencing machine biorxiv.org/content/10.1101/…
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cnn.com/2023/01/31/world/dod… @itiscolossal @federallamm
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Genetics Society of America (GSA) and the Personal Genetics Education Project (pgEd) of Harvard. "Emphasis on those who have been marginalized, economically disadvantaged, or otherwise excluded from conversations about science." genetics-gsa.org/career-deve…
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Morality, Foresight, and Human Flourishing: An Introduction to Existential Ri... amazon.com/dp/1634311426/ref… via @amazon @xriskology
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Eriona sampling one of 5 frozen mammoths. instagram.com/p/Bm1nV2IAIY3/…
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Particle detection and tracking with DNA
arxiv.org/pdf/2105.11949.pdf
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SURRO-seq for the simultaneous investigation of thousands of off-targets sites for therapeutic RNA-guided nucleases in cells. go.nature.com/3OaangA
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Join @geochurch, @EvolvingJuan, @siranushbb, @okaysteve, @BrianBergstein, @janemetcalfe for a virtual conversation on the future of our species, hosted by @NEOdotLIFE, @manifestbos, @ginkgo +@endlesswestco. Save April 9. RSVP: neo.life/manifestvisions/
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Whole genome sequence interpretation for the world champion free diver medium.com/neodotlife/decodi… piped.video/watch?v=Bed0ekFj… @RodrigoATCG
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Top U.S. Intelligence Official Calls Gene Editing a WMD Threat technologyreview.com/s/60077…
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academic.oup.com/bioinformat…
The record compression (using reference genome info) is to 2.5 Mbytes per diploid genome. & one can compress much more using family info, since children can have a hundred changes relative to parents, while two random people have 3-4 million differences.
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Check out the Roswell "Get Wired" contest bit.ly/3r1mSTk - propose your favorite molecule, & we'll pick the most interesting ones to wire into the Roswell ME Chip™, the first molecular electronics chip, as seen in our PNAS paper bit.ly/3vhFsIa
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Tour de force! Nice teamwork.
Walking along chromosomes with super-resolution imaging, contact maps, and integrative modeling. Our collaboration work is now on Biorxiv! @TingWu_Lab @erezaterez lab, @MarciusLab, Peng Yin Lab, @bruker biorxiv.org/content/early/20…
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Students & postdocs: Genome Project Write (NYC) abstract deadline for talk & travel award Sep 23
gpwrite2019.org/
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Congratulations all e you
My first paper is finally in (digital) print @naturemethods 🎉🦑! It's been a wild ride with @grigonomics and @SurgeBiswas. I'm immensely grateful to @geochurch and @MoAlQuraishi for taking a chance on a wacky idea and guiding us through the maze of academic publication. (1/4)
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never bored, often edgy.
A conversation with me (and/or @geochurch):
edge.org/conversation/george…
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MARC1: "Mouse For Actively Recording Cells!"
storing a terabytes of lineage data in vivo; distributed by NIH Mutant Mouse Resource:
mmrrc.org/catalog/sds.php?mm…
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forbes.com/sites/robtoews/20…
LLM protein/NA Heroes: @EthanAlley @SurgeBiswas @fran_anastas @glebkuz @ekelsic @MoAlQuraishi @mrprotein24 @lizbwood @julie_norville @laserson ... @patch_bio @nablabio @ManifoldBio @jura_bio @Dyno_Tx
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Testing, testing,... Bioweathermapping technologyreview.com/2020/04…
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Will we forget again as soon as this is over? Inside America’s Two-Decade Failure to Prepare for Coronavirus politico.com/news/magazine/2… via @politico
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pgEd tackles the CRISPRevolution
pged.org/lesson-plans/#CRISP…
map-ed.org/
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