The Ensembl project seeks to enable genomic science by providing high quality, integrated annotation.

Hinxton, UK
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Ensembl 116 + Ensembl Genomes 63 are out! Explore new pig, cattle, and oat genomes, updated alignments and new VEP plugins It’s a milestone! Our last on the current platform. New data from here on is via beta.ensembl.org More info on our blog: zurl.co/MrJ2A
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ATGGAGAGGAGGTACTGCCACAGGATCAGCACCATGGCCAGCGCCAACGACGCCCACGCCCCCCCCTACAACGAGTGGTACGAGGCCAGG from everyone at @ensembl
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ATGGAGAGGAGGTACTGCCACAGGATCAGCACCATGGCCAGCGCCAACGACGCCCACGCCCCCCCCTACAACGAGTGGTACGAGGCCAGG from everyone at Ensembl! buff.ly/1Izo5qL
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1/ You’ve sequenced your samples and identified variants. Great! 🙌 Now, here's how you can use @ensembl to find out the effect of your variants on #protein structures and interactions. A thread...🧵 #genomics #bioinformatics #tweetorial #Ensembltraining 🧬
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1/ My favourite gene has 15 transcripts, which one should I use for further analysis? To report the position of variants? To design primers for? 🤯 This #tweetorial will show you how to filter and prioritise transcripts… 🧵 #genomics #bioinformatics #Ensembltraining 🧬
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1/ Do you need to download sequences from #Ensembl? We’ve put together a #tweetorial to guide you in the right direction whether you need the sequence for a single exon or a whole #genome… 🧵 #genomics #bioinformatics #Ensembltraining 🧬
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1/ Want to learn about a gene, but there’s no functional data for that species? Or maybe you're looking for a homologue of your favourite gene in a model organism? Here's how you can find orthologues in @ensembl. A thread…🧵 #genomics #bioinformatics #Ensembltraining🧬
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Hip hip, hooray! Ensembl is 22 years old! 🎉🥳🎊🍾🎁🎈🎂 Here's a baby pic of 6 months old @ensembl 👶 look how far we've come. #genomics #bioinformatics
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1/ Do you want to get the promoter sequence of your favourite gene from @ensembl? The answer might be more complicated than you first thought, but we’re here to walk you through it. A thread...🧵 #genomics #bioinformatics #epigenomics #epigenetics #tweetorial #Ensembltraining🧬
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Want to learn about a gene function, but there’s no functional data in your species of interest? Or maybe looking for a homologue of your fav gene in a model organism to carry out functional work? Look no further! This #tweetorial will show you how to find orthologues in @ensembl
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1/ Do you want to know if a variant will affect the structure and function of a protein? We’ve got lots of tools and #data in @ensembl to help you investigate and we’re here to show you how! A thread...🧵 #genomics #bioinformatics # #tweetorial #Ensembltraining🧬
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1/ Do you want to get the promoter sequence of your favourite gene from @ensembl? The answer might be more complicated than you first thought, but we’re here to walk you through it. A thread...🧵 #genomics #bioinformatics #epigenomics #epigenetics #tweetorial #Ensembltraining🧬
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ATGGAGAGGAGGTACTGCCACAGGATCAGCACCATGGCCAGCGCCAACGACGCCCACGCCCCCCCCTACAACGAGTGGTACGAGGCCAGG from everyone at @ensembl
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1/ Do you need reference sequence files from #Ensembl? All of the different files available can be confusing. Here’s a thread to help you decide which files you need…🧵 #genomics #bioinformatics #tweetorial #Ensembltraining🧬
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1/12 Thursday is #tutorial day! This week, we want to show you how to find out which biological pathways a gene is involved in!
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🎄✨ 🎄✨ We have a Christmas riddle for you today! 🎄✨🎄✨ TGGCACGCCACCATCAGCAGCGCCAACACCGCCAGCAACATCAACACCCACAGGGAGATCAACGACGAGGAGAGGTGCGCCCTGCTGGAGGAC
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1/ There are so many bioinformatics databases 🤯 How do we find the corresponding genes and other related #data? This #tweetorial will show you how to find the links from Ensembl to those other databases… 🧵 #genomics #bioinformatics #Ensembltraining 🧬
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1/8 In this week’s #tweetorial, we are showing you how to find out if a variant is associated with any phenotypes 🧬 #EnsemblTraining #genomics #bioinf
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ATGGAGAGGAGGTACTGCCACAGGATCAGCACCATGGCCAGCGCCAACGACGCCCACGCCCCCCCCTACAACGAGTGGTACGAGGCCAGG from everyone at @ensembl
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Ensembl is 20 years old 🎂! We're celebrating our #birthday by trawling through the archives to bring you a blast from the past- here is @ewanbirney's announcement e-mail from 2000! (Even the @emblebi logo has changed quite a lot)
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1/ Do you have a list of @ensembl IDs that you want to convert to IDs from other databases? Here's how you can retrieve the @NCBI gene IDs from a list of #Ensembl IDs. A thread...🧵 #genomics #bioinformatics #tweetorial #Ensembltraining 🧬
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1/ Do you have a list of gene symbols or IDs that you want to convert? Here's how you can retrieve the @ensembl gene IDs from a list of gene names. A thread...🧵 #genomics #bioinformatics #tweetorial #Ensembltraining 🧬
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EZH2 protein products are involved in gene regulation via chromatin remodelling and histone modification buff.ly/1iYwnGS
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agcaccgcgtatagcgcgtttgaaacccatattagcccggcgaacgatgaaatgatttgctgccatcgcattagcaccatggcgagc buff.ly/2HHmHXH We hope you all have a safe and enjoyable Christmas
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1/ From ~20,000 coding genes in humans, biological complexity is also the result of gene/transcript expression levels in different tissues 📈 Want to see the expression of a #gene using @ensembl? A thread...🧵 #genomics #bioinformatics #tweetorial #Ensembltraining 🧬
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The genome sequence of a man has been published - despite having no genetic material. Hans Jonatan, born 236 years ago, had his genome reconstructed using information from 182 of his descendants @ScienceNordic buff.ly/2obcXds
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Ensembl is 23 years old 🎂! Check out @ewanbirney's e-mail from 2000 announcing Ensembl and different ways to access our data. We have added lots more routes to access our data now (buff.ly/3wvSUZU).
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1/ Are you designing #CRISPR experiments in human cell lines or in mouse?🧑‍🤝‍🧑🐭 Just a few clicks in @ensembl can help you design your gRNA sequence and this #tweetorial will show you how… 🧵 #genomics #bioinformatics 🧬
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1/ Do you want to know if a variant will affect the structure and function of a protein? We’ve got lots of tools and #data in @ensembl to help you investigate and we’re here to show you how! A thread...🧵 #genomics #bioinformatics #tweetorial #Ensembltraining🧬
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1/14 Have a genetic #variant? Want to know its effect? Use Ensembl's Variant Effect Predictor (VEP) tool! This #tweetorial will give you some tips on how to use #VEP 👨🏼‍🏫 #tweetorial #genomics #EnsemblTraining
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Ensembl 99 and @ensemblgenomes 46 have now been released! 🔸 38 new vertebrate species, 2 dog breeds and 4 updated #genomes including #data from @genomeark 🔸 New #plant species 🌾🌱🌿 🔸 Updated human variation data 👫 Read more in our latest blog post: buff.ly/35ZTf7s
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The #basmati #rice genome has been sequenced! It brings new insights into the evolutionary history of the circum-basmati group of #OryzaSativa. @biorxivpreprint buff.ly/2P6DhFc #plantsci #cropsci #NGS
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🎄✨ 🎄✨ We have a Christmas riddle for you today! 🎄✨🎄✨ TGGCACGCCACCATCAGCAGCGCCAACACCGCCAGCAACATCAACACCCACAGGGAGATCAACGACGAGGAGAGGTGCGCCCTGCTGGAGGAC
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1/9 Do you want to know what #biological processes a gene is involved in? Let us show you how you can use Ensembl to find #GOterms for a gene in this tweetorial! 🤓 #bioinf #genomics #genome #EnsemblTraining #EMBL #EBI
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Ensembl version 94 has been released! Check out our blog post to explore what exciting new data you can find now in Ensembl, including updates to 👫, 🐁 and loads more 🐟🐠🐡! #Ensembl94 Perhaps you can try #FindingNemo...? buff.ly/2RmV8Fd
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It’s not always ‘AUG’! @nature study reveals how alternative start sites for protein synthesis are chosen buff.ly/2mpCpKA #Genetics #Transcriptomics
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Did you know that you can use the Ensembl Variant Effect Predictor to visualise variants on #Alphafold predicted 3D protein structures? Find out more in our latest blog post: 👉ensembl.info/2022/08/26/cool… #genomics #bioinformatics #VEP
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Happy #NationalDNADay 🧬 It's been 18 years since the completion of the #HumanGenomeProject and 68 years since James Watson, Francis Crick, Maurice Wilkins, Rosalind Franklin and colleagues published papers on the structure of #DNA in @nature.
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Hi #ChatGPT 👋 can you make a rap about the #Ensembl genome browser? A story in 5 parts... 🧵 😂 #genomics #bioinformatics 🧬
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1/8 Have you got a #phenotype and you want to find out any associated genomic information about it? Did you know you can use #Ensembl to do so? We’ll show you how in this week’s #tweetorial! 🧬 #bioinf #genomics #EnsemblTraining
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1/ It’s another Thursday, and that means it’s time for another #tweetorial! Today, we want to show you how you can view RefSeq #annotations on Ensembl 🥳 #bioinf #genomics #assembly #EnsemblTraining
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1/9 You might know that you can add custom tracks on #Ensembl, but did you know you can visualise Ensembl features in the #Karyotype view? Let us show you how in this week’s #tweetorial! #bioinf #EnsemblTraining #genomics
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1/ Did you know that #Ensembl houses annotation for over 35,000 genomes (a number which is only going to continue growing!) organised across different websites? This thread is here to help you find the species you are looking for...🧵 #genomics #bioinformatics #tweetorial 🧬
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Happy International DNA Day 🎉 🎊 We're commemorating the completion of the Human #Genome Project in 2003 and the discovery of DNA's double #helix in 1953. Have a look at our #DNA guide! #DNADay
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1/ Do you have a list of @ensembl IDs that you want to convert to IDs from other databases? Here's how you can retrieve the @NCBI gene IDs from a list of #Ensembl IDs. A thread...🧵 #genomics #bioinformatics #tweetorial #Ensembltraining 🧬
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1/ There is so much #data in Ensembl! How do I find what I’m looking for? 😱 Here's a quick-start guide to searching the @ensembl genome browser. A thread...🧵 #genomics #bioinformatics #tweetorial #Ensembltraining 🧬
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1/ Knowing the frequency for alleles of genomic variants in populations around the world helps us understand phenotypes and disease 🌎🌍🌏 We’re here to take you through the data in @ensembl step-by-step. A thread…🧵 #genomics #bioinformatics #tweetorial #Ensembltraining🧬
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1/ Are you working with human variation data? 🧑‍🤝‍🧑Are you interested in phenotypes and disease? Here's how you can find the clinical significance of variants using #Ensembl. A thread...🧵 #genomics #bioinformatics #tweetorial #Ensembltraining 🧬
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Replying to @BioMickWatson
Looks like the sequences have gone on the lamb. Just for ewe, we'll ram this to the top of our to-do list.
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1/ From ~20,000 coding genes in humans, biological complexity is also the result of gene/transcript expression levels in different tissues 📈 Want to see the expression of a #gene using @ensembl? A thread...🧵 #genomics #bioinformatics #tweetorial #Ensembltraining 🧬
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Ensembl 106 and Ensembl Genomes 53 have now been released, including #AlphafoldDB data for human, mouse, zebrafish, maize and soybean 🧑‍🤝‍🧑🐭🐟🌽🌱 Find out more on our blog: 👉 ensembl.info/2022/04/12/ense… #genomics #bioinformatics
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1/ Are you ready for 🎄🎅Chirstmas #Tweetorial? Whether you need the sequence for a single exon or whole #genome we got you covered! In the spirit of #Christmas, we will use Vitis vinifera 🍇 🍷in our example #genomics #bioinformatics #Ensembltraining
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We're going to be busy
Genomes of all known UK species to be sequenced bit.ly/2PODb48
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We are excited to announce the launch of our #COVID19 resource! You can find our #SARSCoV2 browser and related resources at: buff.ly/2T8cmbD Check the #Ensemblblog for all details: buff.ly/36g8qej #coronavirus #OpenData
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Looking for online #Ensembltraining? Look no further! 🎓💻 Our six courses @emblebi @EBItraining got a new look and several updates. We’ll introduce all of them here👇this week, so stay tuned. #bioinformatics #genomics 1/7
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One genome's #junk is another genome's #treasure! A new @NatureEcoEvo study, using related #rice #genomes, shows that random sections of non-coding DNA can quickly evolve to produce novel proteins. The first direct evidence of #denovo genes. @rapdbjp buff.ly/2Hlr6jo
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How to measure differential gene expression? New paper evaluates 36 methods for assessing single-cell RNA-seq (#scRNA) data. Also provide public scRNA-seq datasets for method testing! #CitedEnsembl @naturemethods #bioinformatics #funcgen buff.ly/2I3vctt
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📢 @GoogleDeepMind’s new AI tool, #AlphaMissense, has catalogued 89% of all 71 million possible missense #variants, predicting their potential to cause disease 🧬 Best part? It is freely available and now integrated as an #Ensembl #VEP plugin! 🥳 ➡️ buff.ly/3WSLpbA
Uncovering the causes of disease is one of the greatest challenges in genetics. 🧬 To help advance this, we created AlphaMissense: an AI model classifying missense variants - or genetic changes affecting proteins. Here's how it can help scientists. 🧵 dpmd.ai/alphamissense-blog
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Did you know you can view pathways your gene is involved in in Ensembl? We have a new display from @reactome for this! buff.ly/2vhAPBO #Ensembltraining
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1/8 In this week’s #tweetorial we are finding out how to view #phenotype associations within a #variation dataset on Ensembl 🔎 #EnsemblTraining #genomics #bioinf
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#Codons matter! New in vivo study in 🐁 finds that codons ending in a G or C have higher #protein lifetimes & abundance, mRNA abundance, & translation rates than those ending in A/U! A hidden impact of #synonymous variants? #CitedEnsembl @euforna buff.ly/2PHLj7E
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📢 We are thrilled to announce that Ensembl 110 / Ensembl Genomes 57 is out! The new #release features updates across many Ensembl sites and the addition of many genomes! 🐁🧍🏾🐖🐜🪲🌿 Read more in our new blog post ➡️ buff.ly/3PWsAD9
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1/ How similar is the human genome sequence to other species? Here's a thread to show you how to find highly conserved regions across genomes using the @ensembl browser....🧵 #genomics #bioinformatics #tweetorial #Ensembltraining #evolution 🧬
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1/6 My favourite gene has 15 transcripts, which one should I use for further analysis? To report the position of variants? To design primers for? Find out more in today’s #Tweetorial. #Ensembltraining #genomics #bioinformatics ensembl.org/Homo_sapiens/Gen…
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Did you know that #Ensembl and @ensemblgenomes are part of the @ELIXIREurope Core Data Resources? These #openaccess resources collectively form an integrated life sciences data infrastructure. #FAIRdata #OpenData #CitedEnsembl Read all about it: buff.ly/2G3Vgpy
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Is the end of the linear reference in sight? vg toolkit for variation graphs at human genome scale brings us one step closer! @erikgarrison @richard_durbin @NatureBiotech buff.ly/2PvgQpu #genomics #bioinformatics #compbio
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Happy DNA day! Join us to celebrate the worldwide movement to empower communities to innovate, collaborate and discover genomics knowledge. Today marks the completion of Human Genome Project in 2003 and the discovery of the double helix of DNA in 1953 buff.ly/3JWzfGI
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1/ In today’s #Tweetorial we are going to look at how to find specific #exons and #introns in your gene of interest. This may be helpful for selecting sequence to design #primers.
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1/6 Its Thursday #Tweetorial time! Let’s look at how to visualise gene expression data in different tissue types using RNASeq gene models in @ensembl.
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Today marks International Day of Women and Girls in Science. The world needs science, and science needs women and girls! Let's celebrate by recognising #WomenInScience who are leading us to a safer future #WellcomeGenomeWomen
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Our #Ensembl 2018 paper is out: 100 genomes, REST archive, VEP update, browser improvements, new training website @NAR_Open academic.oup.com/nar/advance… training.ensembl.org
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Ancient #Rome was a melting pot - culturally and genetically! Genome #sequencing of #ancientDNA study shed light on #ancestry and shifts over time. @sciencemagazine @jkpritch buff.ly/2Q1KG7I
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#Elephants are known to have very low rates of #cancer for their size. New research finds a '#zombie gene' unique to elephants in the LIF gene family that fights cells w/ damaged #DNA. So LIF is our #GeneOfTheWeek! News: buff.ly/2vKbm1P / buff.ly/2P9C7Vz
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Would you like to attend free virtual Ensembl Browser #workshop 9th-10th Nov? Sign up here: buff.ly/3moN2KW 9am-1pm (Pacific Time): Day 1 Viewing #genes, transcripts, variation data and the #VEP Day 2 Data export with #BioMart, comparative #genomics and #gene regulation
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We have 29 new genomes in our latest release: 🦁 3 mammals 🐟 7 fish 🐧 6 birds 🐢 4 reptiles 🌿 8 plants 🦟 1 mosquito Find all details in the #Ensemblblog: buff.ly/2W86sbn #Ensembl100 💯
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#Ensembl98 has been released. We have 🐷 breed genomes, lots of new 🐟 genomes and a new tool for analysing your GWAS. Check out our #Ensemblblog to know more: ensembl.info/2019/09/26/ense…
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#DNA from two mammoths that lived 1.2 million years ago revealed a new #mammoth lineage and has set a new record for the oldest DNA yet sequenced, pushing the study of ancient DNA closer to its theoretical limit. @nature @love_dalen buff.ly/3dpRack #aDNA #evolution
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This year's #NobelPrize in Chemistry was awarded for the development of a method for #genome editing. Did you know that you can use #Ensembl to design #CRISPR gRNAs by turning on the CRISPR spCAS9 track, showing NGG CRISPR sites identified by the WGE resource? #genomics
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1/ In today’s #tweetorial, we are showing you how to find gene trees in Ensembl! 👨🏿‍🔬🐒🐟🐅🐼🐦🐀 #bioinf #genomics #comparativegenomics #EnsemblTraining @EBITraining @emblebi
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Its been 70 years since the discovery of the double helix and we cannot imagine life without it. We @emblebi are lucky to be located near @Cambridge_Uni ’s Cavendish lab and of course @TheEagleGK pub that first heard about the "discovery of the secret of life". #DNADay23 #DNADay
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Oh no the #ElfOnAShelf has gotten into #Ensembl. He's messing with the exons.
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New tool: #python script 'GTFtools' allows comparison of gene models & quick access of gene exon, intron, length, TSS and more! Output to .bed format #CitedEnsembl paper: @biorxivpreprint | documentation: buff.ly/2oaPclz
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Our ever popular #Ensembltraining online course has had a revamp. Check it out: ebi.ac.uk/training/online/co…
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cncRNAdb: a new #database for ‘dual-function’ RNA with coding and noncoding functions #CitedEnsembl @NAR_Open buff.ly/3luiQ0s Web: buff.ly/2GMZFji #bioinformatics #compbio
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#Ensembl100 💯 is out, along with #EnsemblGenomes47! 🎉🎂 They bring you: - GENCODE 34🚶& GENCODE M25 🐁 - gnomAD version 3 allele frequencies - 29 new & 3 updated genomes - New interface to configure multidimensional track hubs More in the #Ensemblblog: buff.ly/2W86sbn
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Analysis of 200 #insect transcriptomes reveals that light environment drives #evolution of colour vision genes in #butterflies and #moths 🦋 #UsingEnsembl @Mothyash @Dr_Akito @KawaharaLab @biorxivpreprint buff.ly/2TAVMlo
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Our latest #webinar using the brand-new #Ensembl100 💯 is now available in the @EBItraining online course! @AstridGAGall presented Comparative #Genomics yesterday. Find the recording, all course materials and exercises here: buff.ly/3f89IMw #evolution #phylogenetics
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Got six minutes? Why not watch how a single cell develops into an organism in this cool timelapse video! aeon.co/videos/watch-a-singl… #EvoDevo #Imaging #Microscopy
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A person has ~70 de novo mutations that are not in their parent’s #genome - and this number is affected by parental age - finds an @eLife study buff.ly/2OVLlH8 #genomics
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This international Women's Day we will celebrate the contributions of the amazing women in our team @ensembl @embl @emblebi #WomeninScience #WomensDay
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1/12 Do you need to find a position of your variants in a transcript, coding sequence or protein? This #tweetorial will show you how to do it using the @ensembl Variant Effect Predictor #VEP #Ensembltraining #genomics #bioinformatics
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Lab shutdown due to #COVID19? #WFH? 💻🎓 Why not take an online #Ensembltraining course, e.g buff.ly/2MHsRth (Browser) buff.ly/2EqjPx2 (REST API) buff.ly/2U7otqt (Gene annotation for clinical genomics) #PhDChat #ECRchat #AcademicTwitter
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"Ensemble" means to bring together. That's what we do here at Ensembl, we bring together datasets, such as genes, genetic variation and gene regulation into a single source, integrating them to learn more, and we can only do that because those datasets are #openaccess. #OAWeek
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Our free online #Ensembltraining starts in exactly two weeks time. #bioinformatics #training #genomics Sign up here: ensembl.info/2018/07/24/free…
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Want to know which pathways your gene is involved in? Check out the ‘Pathway’ display from @reactome in our latest release! buff.ly/2GDKMLh #Ensembl92
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1/9 Exciting news from #Ensembl! A major update in the latest Ensembl 110 release includes the addition of new #regulation data. This #tweetorial will show you how you can view these on the browser 👨🏿‍💻 #bioinf #genomics #EnsemblTraining #annotation
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Coding is red Non-coding is blue Merged transcripts are golden #Ensembltraining for you #AcademicValentine
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Need to do #RNAseq analysis & don't know where to start? Check out the #hitchhikers guide to expression analysis - not clear whether a #towel is required... #DouglasAdams #phdchat #methods #training #bioinformatics #CitedEnsembl buff.ly/2ADcuqO
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#CRISPR knockouts of 20,000 genes, in 300 lab-grown #tumors from 30 #cancer types identifies novel drug targets. A huge effort from a @DepMapSanger #collaboration between @sangerinstitute, @GSK_bio, & @emblebi @opentargets. buff.ly/2UwLWDd
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