The University of Michigan Department of Pathology is comprised of nearly 200 faculty and 1,100 staff, who provide the best patient care and research possible.
Congratulations to #UMichPath researchers, Drs. Jolanta Grembecka and Tomasz Cierpicki on their recent @US_FDA approval of the first once-daily oral therapy for relapsed/refractory NPM1-mutant acute myeloid leukemia.
“This transformative discovery, grounded in research conducted in the Department of Pathology, marks an important moment for our community. The work of Drs. Grembecka and Cierpicki, now recognized through FDA approval, reflect the strength of our scientific environment and our commitment to improving care for patients. It is meaningful to see U-M Pathology contribute to a therapy that is making a real difference for those with leukemia,” said Charles Parkos, Chair of the Department of Pathology.
Read about their work: michmed.org/qNYd4
ALT Tomasz Cierpicki, left, and Jolanta Grembecka, both professors of pathology, recently received FDA approval for a drug intended for patients with acute myeloid leukemia and an NPM1 genetic mutation. (Leisa Thompson, Michigan Photography).
What was your path to pathology?
In our new series #MyPath2Path we'd like to know when you realized that you wanted to be a pathologist.
Share a tweet or video and use #MyPath2Path and we'll share your story.
We begin the series today with the inimitable Dr. Henry Appelman:
Here is this week's #COTW!
Woman in her 20’s had painful lesion on her finger, present for several years. Reported pain on touching the lesion or when she did not wear gloves in the cold. Exam revealed 0.5 cm red-blue nodule on distal aspect of first finger.
What's your guess?
#Pathology Twitter: Let's try something new for #FollowFriday#FF
If you work in pathology and have less than 2000 friends/followers, reply to this and tell us who you are!
Let's follow ALL who reply to this tweet and support each other!
Ready for the #COTW from Dr. Katelyn Zebrowski?
A 60-year-old woman presents with a vulvar lesion which has been increasing in size. An excisional biopsy was performed. What is your diagnosis?
Are all pathologists introverted?
Do pathologist not like working with people?
Do pathologists only do autopsies?
Madelyn Lew, MD, sets the record straight on some misconceptions about pathologists. #realtalk#recuts#UMichPath
🔬 Genitourinary #Pathology, day 4
➡ What's your #dailydx of this testicular lesion?
➡ With what syndrome(s) is it associated?
➡ We’ll tweet the answers and some quick facts tomorrow! #UMichPath#GUPath
🔬 #DailyDx theme this week: Breast Pathology
➡️ Day 1: What’s your differential diagnosis of this breast lesion & what do you favor?
➡️ What diagnostic features do you look for to make this diagnosis?
➡️ We’ll tweet the answers and some quick facts tomorrow! #BreastPath
🔬 #DailyDx theme this week: Bone & Soft Tissue #Pathology
➡️ Day 1: What’s your diagnosis of this nodule?
➡️ In what anatomic location are these most commonly seen?
➡️ We’ll tweet the answers and some quick facts tomorrow!
#UMichPath#BSTPath
🔬 #DailyDx Dermato-#Pathology Day 5:
➡️ What’s your diagnosis of this face lesion in a 56-year-old woman?
➡️ We’ll tweet the answer and some quick facts on Monday! #UMichPath#DermPath
🔬 #DailyDx theme this week: Pediatric #Pathology
➡️ Day 1: What’s your diagnosis of this face lesion?
➡️ What is the most common age group affected and what is the typical disease course?
➡️ We’ll tweet the answer and some quick facts tomorrow!
#UMichPath#PediPath
Congratulations to #UMichPath resident @MeredithKHerman for being this year's runner-up for her piece, "The Lives We Hold", in the @RCPath Art of Pathology competition! This year's theme was pathologists and patients. michmed.org/RRx49
ALT Dr. Meredith Herman's oil on canvas, "The Lives We Hold", 18”x24”.
In regards #Melanoma, Dr. Lori Lowe is giving all types of excellent tips: when measuring Breslow thickness with associated nevus—measure only to invasive melanoma, NOT nevus; and the do’s and don’ts to indicate Tumor Mitotic Rate (TMR). #NFPath2019#UMichPath
#UMichPath is excited to welcome @KMirza to our team as the new Director of the Division of Education, Assistant Chair of Education, and professor of hematopathology. Read Dr. Mirza's story on his #Path2Path and how he came to Michigan. michmed.org/w8eYk
ALT Dr. Kamran Mirza sits at his microscope while smiling at the camera.
🔬This week’s #COTW from @WRPears:
The patient is a woman in her 60s: What is the anatomic site and the diagnosis?
Diagnosis and answers on Friday! #PathTwitter
🔬 #DailyDx theme this week: Bone & Soft Tissue #Pathology
➡️ Day 1: What’s your diagnosis of this nodule?
➡️ We’ll tweet the answer and some quick facts tomorrow!
#UMichPath#BSTPath
AMAZING!
In less than 24 hours Chase was able to raise over 15k for DIPG research!
Now @mohurstjr has joined in and challenge and will dye his hair orange if we raise 73K!
⬇️ Help #ChadTough raise money and awareness by giving now! ⬇️
🔬 Frozen #Pathology, Day 1
➡️ What’s you’re #DailyDx of this mandibular cyst submitted for frozen section?
➡️ What surgical management would you expect with your diagnosis?
➡️ We’ll tweet the answers and some quick facts tomorrow #UMichPath#FrozenPath
🔬 Sinonasal Pathology, Day 3:
➡️ What’s your #DailyDx of this lesion?
➡️ We’ll tweet the answers, some quick facts, and the next case tomorrow! #UMichPath#ENTPath
🔬This week’s theme: Gastrointestinal #pathology
➡️Day 1: What’s your #DailyDx of this liver mass? (Note the background liver on the right of the low-power)
➡️What are the key features of this entity?
➡️We’ll tweet the answers & some quick facts tomorrow! #GIPath#UMichPath
We are *really* excited to share a preview of our next video!
We recently invited a patient behind-the-scenes to see how #pathologists & #MedicalLaboratoryScientists diagnosed and monitored her leukemia.
Brenda's Story is set to premiere Fri, April 5: piped.video/watch?v=Rrp3PNfd…
Are you ready for this week's #CaseoftheWeek?
30 y/o female presents with a vesicular rash in her intertriginous areas. Some vesicles have progressed to bullae, ruptured, and formed a crust. Lesions are pruritic, burning, and malodourous.
What is your diagnosis?
🔬 Gastrointestinal #Pathology, Day 2
➡️ What’s your #DailyDx of this liver mass?
➡️ With what genetic abnormality is this associated, and with what other entity has a link been proposed?
➡️ We’ll tweet the answers & some quick facts tomorrow!
#GIPath#UMichPath
🔬 This week’s theme: Gynecologic #Pathology
➡️ Day 1: What’s your #DailyDx of this ovary? Similar findings were present in both ovaries.
➡️ What could be associated with this finding?
➡️ We’ll tweet the answers & some quick facts tomorrow!
#GYNPath
Check out the #COTW from Dr. Mark Rudolf!
This 0.2 cm yellow nodule in the renal cortex was discovered incidentally at autopsy. What is your diagnosis?
It's Wednesday, which means it's time for the #COTW!
Here is the case...
- A type of carcinoma commonly seen in children and young adults.
- What are the three different types of cells?
- What does complete surgical excision look like?
What's your diagnosis? Let us know!
🔬 Gynecologic #Pathology: Day 5
➡ What's your #DailyDx of this uterine lesion?
➡ We’ll tweet the answer and some quick facts tomorrow! #UMichPath#GYNPath
🔬 #DailyDx theme this week: Gastrointestinal & Liver #Pathology
➡️ Day 1: What’s your diagnosis of this liver?
➡️ What ancillary test(s) would you perform?
➡️ We’ll tweet the answers and some quick facts tomorrow!
#UMichPath#GIPath#LiverPath
🔬 Bone & Soft Tissue #Pathology, Day 2
➡️ What’s your #DailyDx of this soft tissue lesion from a child?
➡️ What genetic alteration 🧬 is associated with this entity?
➡️ Answers and quick facts tomorrow!
#UMichPath#BSTPath
🔬 This week's #DailyDx theme: Prostate #Pathology
➡️ One of these things is not like the other! Can you tell which image is different from the others?
➡️ We’ll tweet the answer and some quick facts tomorrow! #UMichPath#GUPath
🔬 This week’s theme: Breast #Pathology
➡️ Day 1: What’s your #DailyDx of this breast mass?
➡️ What genetic abnormality do these tumors demonstrate?
➡️ We’ll tweet the answers & some quick facts tomorrow!
#BreastPath#UMichPath
Day 5: Final day of our ovary series.
What’s your #DailyDx of this oophorectomy? Which gene mutations are typically present in these?
We’ll tweet answers, some quick facts, and the next case tomorrow! #umichpath#GYNPath
🔬 #DailyDx theme this week: Vulvovaginal #Pathology
➡️ What’s your diagnosis of these two lesions (from different patients)?
➡️ What can you predict about one patient versus the other?
➡️ We’ll tweet the answers, some quick facts, and the next case tomorrow! #UMichPath
🔬 #DailyDx theme this week: Pediatric #Pathology
➡️ Day 3: What’s your diagnosis of this breast mass in a 16-year-old?
➡️ We’ll tweet the answer and some quick facts tomorrow!
#UMichPath#PediPath
🔬 Gastrointestinal #Pathology, Day 3
➡️ What’s your #DailyDx of this pancreas mass?
➡️ What is the expected immunoprofile?
➡️ We’ll tweet the answers & some quick facts on Monday!
#GIPath#UMichPath
🔬 Pulmonary #Pathology, Day 2
➡️ What’s your #DailyDx of this lung finding?
➡️ What ➕stain would help confirm the diagnosis?
➡️ Answers & quick facts tomorrow!
#UMichPath#PulmPath
#UMichPath has launched new digital pathology technology! Glass slides are now digital images viewed on monitors and integrated with radiology in a unified platform, enhancing diagnostic precision and patient care. #DigitalPathology
ALT A group of fourteen people standing together in a laboratory next to the digital pathology scanners. The individuals are smiling and posing for the photo, reflecting their excitement about the digital transformation they achieved.
🔬#GYNPath Day, 1:
➡️What’s your #DailyDx of this tissue protruding from the cervix?
➡️We’ll tweet the answer, some quick facts, and the next case tomorrow! #GYNPath#umichpath
🔬 Thoracic #Pathology, Day 1:
➡️ What’s your #DailyDx of this lung wedge?
➡️ What is the expected immunoprofile?
➡️ We’ll tweet the answers and some quick facts tomorrow!
#UMichPath#PulmPath
🔬 Frozen #Pathology, Day 4
➡️ What’s your Frozen #DailyDX of this nasal mass?
➡️ We’ll tweet the answer and some quick facts tomorrow!
#UMichPath#FrozenPath
It is time for this week's #CaseOfTheWeek from @JasmineSaleh of #UMichPath
A solitary papule on the lip. A shave biopsy was performed.
What is your diagnosis?
🔬 #DailyDx theme this week: Gynecologic #Pathology
➡️ Day 1: What’s your diagnosis of this endometrial curettage?
➡️ What laboratory findings would you expect to see in this patient?
➡️ We’ll tweet the answer and some quick facts tomorrow! #UMichPath#GynPath
Here is this week's #CaseOfTheWeek from @JasmineSaleh of #UMichPath.
25 y.o. F presents with multiple tumors on her scalp. Shave biopsy performed.
What is your diagnosis?
What syndrome may it be associated with?
Answers to be shared on Friday!
#PathTwitter
🔬 This week’s theme: Genitourinary #Pathology
➡️ Day 1: What’s your #DailyDx of this bladder mass?
➡️ What anatomic location in the bladder wall is this most commonly found?
➡️ What ➕ and ➖ stains would support your Dx?
➡️ Answers & quick facts tomorrow!
#UMichPath#GUPath
Our #CaseoftheWeek!
35 M with hx of hypertension & Marfan syndrome with chest pain radiating to his neck becomes diaphoretic and collapses with no pulse and dies.
Postmortem exam consistent with the images. What is the histologic manifestation of the patient’s cause of death?
#WhatsYourDx: Children and adolescents can develop this, but occurs primarily in adults, w/ women and men equally affected. Not an infection and not contagious. Chronic inflammatory skin disorder that causes areas of thickened, inflamed, red skin, and scales: @cebulka26#COTW 🤔
🔬 Gynecologic #Pathology, Day 3
➡️ What is your #DailyDx of this uterine mass?
➡️ What stains would you expect to be positive to confirm the diagnosis?
➡️ We’ll tweet the answers and some quick facts on Monday!
#UMichPath#GYNPath
🔬 What is your This week's #DailyDx theme: #Neuropathology
➡️ What's your diagnosis of this dural lesion?
➡️ What other histologic patterns/features would convey a similar grade?
➡️ We’ll tweet the answer and some quick facts tomorrow! #UMichPath
🔬 Bone & Soft Tissue #Pathology, Day 3
➡What's your #DailyDx of this femur mass?
➡Mutations in what gene(s) are found in these tumors?
➡We’ll tweet the answers and some quick facts tomorrow!
#UMichPath#BSTPath
🔬Bone & Soft Tissue #Pathology, Day 2
➡️ What’s your #DifferentialDx and favored #DailyDx of this deep mass in an older patient?
➡️ What #IHC would help confirm the diagnosis?
➡️ We’ll tweet the answers and some quick facts tomorrow!
#UMichPath#BSTPath
🔬 Vulvovaginal Pathology, Day 3
➡️ What’s your #DailyDx of this vaginal lesion?
➡️ What genetic rearrangements might you see in this lesion?
➡️ We’ll tweet the answers, some quick facts, and the next case tomorrow! #UMichPath#GYNPath
🔬 Vulvovaginal #Pathology, Day 5
➡️ What’s your #DailyDx of this vaginal nodule?
➡️ What IHC stains would you consider?
➡️ We’ll tweet the answers, and some quick facts tomorrow! #UMichPath#GYNPath
🔬 Frozen #Pathology, Day 2
➡️ What’s your Frozen #DailyDX of this para-aortic mass?
➡️ We’ll tweet the answer and some quick facts tomorrow!
#UMichPath#FrozenPath
Holding the title of Chief Resident at Michigan Medicine Department of Pathology, one of the top academic pathology residency programs in the country, is a challenging yet exciting responsibility. For the 2022-2023 year, this honor and responsibility belong to Dr. Batoul Aoun.
🔬 This week's #DailyDx theme: Gynecologic #Pathology
➡ Day 1: What's your diagnosis of this endometrial curettage?
➡ What stains would you consider ordering to confirm?
➡ We’ll tweet the answer and some quick facts tomorrow! #UMichPath#GYNPath
🔬 Bone and Soft Tissue #Pathology, day 2
➡ What's your #DifferentialDiagnosis of this superficial soft tissue mass?
➡ What #DailyDx do you favor, and what confirmatory stain(s) would you order?
➡ We’ll tweet the answers and some quick facts tomorrow! #UMichPath#BSTPath
🧠 #Neuropathology - Day 2
➡️ What’s your #DailyDx of this intradural spinal mass?
➡️ What WHO grade is it?
➡️ What is a major factor for predicting survival?
🔬 We’ll tweet the answers and some quick facts tomorrow!
#UMichPath#NeuroPath
Check out @IMHolmes_DO's #COTW!
35-year-old female with a history of irritable bowel syndrome undergoes a small intestine biopsy which shows the following: What do you see? What’s your diagnosis?
🔬 #DailyDx theme this week: Head & Neck #Pathology
➡️ Day 1: What’s your diagnosis of this parotid mass?
➡️ We’ll tweet the answer and some quick facts tomorrow! #UMichPath#ENTPath
🔬 Pediatric #Pathology, Day 5
➡️ What’s your #DailyDX of this tibia mass?
➡️ In what age group is this entity most common what anatomical location within the bone is this most likely arising?
➡️ We’ll tweet the answers and some quick facts on Monday!
#UMichPath#PediPath
🔬 #Dermatopathology, Day 2
➡️ What’s your #DailyDx of this skin lesion?
➡️ In what anatomic location is this lesion most commonly found?
➡️ Answers & quick facts tomorrow!
#UMichPath#DermPath
🔬 Gastrointestinal & Liver #Pathology, Day 2
➡️ What’s your #DailyDx of this liver mass?
➡️ What’s the most common recurrent genetic alteration found in this entity?
➡️ Answers & quick facts tomorrow!
#UMichPath#GIPath#LiverPath
🔬 Genitourinary #Pathology, Day 2
➡️ What’s your #DailyDx of this nodule adjacent to the testis?
➡️ What ➕ stains would support your Dx?
➡️ What recurrent genetic alterations were recently described in this entity?
➡️ Answer & quick facts tomorrow!
#UMichPath#GUPath
🔬 Bone & Soft Tissue #Pathology, Day 2
➡What's your #DailyDx of this large bone mass?
➡How are these tumors graded?
➡We’ll tweet the answers and some quick facts tomorrow!
#UMichPath#BSTPath
🔬Head & Neck #Pathology, Day 2:
➡️What’s your #DailyDx of this nasal mass?
➡️What stain(s) do you predict would be ➕?
➡️Answers & quick facts tomorrow!
#UMichPath#ENTPath
🔬 This week’s theme: Pulmonary #Pathology
➡️ Day 1: What’s your #DailyDx of this central lung mass?
➡️ What is the predicted immunoprofile?
➡️ Answers & quick facts tomorrow!
#UMichPath#PulmPath
🔬Dermato-#Pathology, Day 2
➡️ What is your #DailyDx of this skin excision from a pediatric patient?
➡️ With what genetic alteration 🧬 are these associated?
➡️ Answers and quick facts tomorrow!
#UMichPath#DermPath
🔬 Breast #Pathology, Day 2
➡️ What’s your #DailyDx of this breast biopsy?
➡️ How would you “topline” the biopsy diagnosis?
➡️ What do you predict the receptor status will be?
➡️ We’ll tweet the answers & some quick facts tomorrow!
#BreastPath#UMichPath
🔬 This week’s theme: Head and Neck #Pathology
➡️ What’s your #DailyDx of this parotid mass?
➡️ What stains would you do to confirm your diagnosis?
We’ll tweet the answers & some quick facts tomorrow!
#ENTPath#UMichPath
We're back with another #CaseOfTheMonth!
51 y.o. F presents with vaginal bleeding and a mass protruding from her vagina. Imaging shows the mass arises from the posterior cervix. Clusters of cysts filled with clear fluid along the entirety of the mass.
What is your diagnosis?
🔬 #DailyDx Neuro #Pathology Day 4:
➡️ What’s your diagnosis of this CPA mass in a 1 y/o?
➡️ What molecular finding would you expect to find in this tumor?
➡️ We’ll tweet the answers and some quick facts on Monday! #UMichPath#NeuroPath
🔬 Gynecologic #Pathology, Day 2:
➡️ What’s your #DailyDx of this ovary?
➡️ What ➕ stain(s) would help confirm the Dx or narrow the differential?
➡️ We’ll tweet the answers & some quick facts tomorrow!
#UMichPath#GYNPath
🔬#DailyDx theme this week: #Neuropathology.
➡ What’s your diagnosis of this cerebellar mass?
➡ With what syndrome is this associated?
➡ We’ll tweet the answers and some quick facts tomorrow!
#UMichPath#NeuroPath
🔬 Ovary #Pathology, Day 5:
➡️ What’s your #DailyDx of this ovarian mass?
➡️ With what gene mutations are these associated?
➡️ We’ll tweet the answers, some quick facts, and the next case tomorrow! #UMichPath#GYNPath.
🔬 #DailyDx theme this week: Head & Neck #Pathology
➡️ Day 1: What’s your diagnosis of this parotid mass?
➡️ What is the expected immunoprofile?
➡️ We’ll tweet the answers and some quick facts tomorrow!
#UMichPath#ENTPath
🔬 #DailyDx theme this week: Head & Neck #Pathology
➡️ Day 1: What’s your diagnosis of this nasal mass?
➡️ What ➕ and ➖ stains would support your Dx?
➡️ Answers & quick facts tomorrow!
#UMichPath#ENTPath
🔬 #DailyDx, Gynecologic #Pathology, Day 2
➡️ What’s your #DifferentialDx and favored Dx of this fallopian tube lesion?
➡️ What stains would help resolve the Dx?
➡️ Answers & quick facts tomorrow!
#UMichPath#GYNPath
#BreastPath, Day 2.
What’s your #DailyDx of this breast core biopsy?
What stain is typically positive, and what recurrent genetic alteration is associated?
We’ll tweet the answers, some quick facts, and the next case tomorrow! #UMichPath
🔬 Soft Tissue #Pathology, Day 2
➡️ What’s your #DailyDx of this mass?
➡️ We’ll tweet the answer, some quick facts, and the next case tomorrow! #UMichPath#BSTPath
.@sarahnfarran shared this weeks #COTW!
18-year-old healthy female with a left medial arm 7 mm violaceous papule, tender to palpation. What is your diagnosis?
🔬 Genitourinary #Pathology, Day 3
➡️ What’s your #DailyDX of this penile lesion?
➡️ We’ll tweet the answer and some quick facts tomorrow!
#UMichPath#GUPath
🔬 Gynecologic #Pathology, Day 2
➡️ 2 endometrial samples, 2 findings.
➡️ What is present in 1? What is present in 2?
➡️ We’ll tweet the answers and some quick facts tomorrow!
#UMichPath#GYNPath
🔬 Frozen #Pathology, Day 3
➡️ What’s your Frozen #DailyDX of this parotid mass?
➡️ We’ll tweet the answer and some quick facts tomorrow!
#UMichPath#FrozenPath
🔬 Gynecologic #Pathology, Day 1
➡️ How would you 'topline' your #DailyDx of this vulvar cyst?
➡️ From what structure(s) did it most likely develop?
➡️ We’ll tweet the answers and some quick facts tomorrow!
#UMichPath#GYNPath
🔬 #DermPath, Day 2
➡️ What’s your #DailyDx of this skin lesion?
➡️ What stain(s) could you order to confirm?
➡️ We’ll tweet the answers and some quick facts tomorrow! #UMichPath