Rhodes Chair of Experimental Therapeutics, University of Oxford. Chief Editor of the European Respiratory Journal. Tweets in a personal capacity
Oxford, England
- Tweets 6,352
- Following 2,464
- Followers 9,183
- Likes 28,627
For the record
Junior doctors are the unsung heroes of this pandemic. Working all across our hospitals (and in primary care). Constantly having to adapt to new wards, new situations, ever changing rotas and a new disease. Working incredibly hard.
Unbelievable professionalism 👏
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Working a 12 hour shift on the COVID ward tonight and was going to miss seeing my daughter for her 7th birthday 🥳
@robinlungs just turned up to cover end of my shift- her face when I walked through the door 😍
I hope you are lucky enough to have colleagues like mine 🙏
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Had my COVID vaccine last week.
I'm a little bit disappointed. They said Bill Gates would take over my brain, but its been a week and i still can't figure out Windows 10
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I am honoured and delighted to be appointed Chief Editor of the European Respiratory Journal.
With our brilliant editorial board and @ERSpublications team in Sheffield I look forward to serving the @EuroRespSoc members and our respiratory community.
Big ERS publications news: we're announcing the next editors of the ERJ and the ERS Monograph. Congratulations to @ProfJDChalmers and Prof Peter Calverley on their appointments.
ersnet.org/news-and-features…
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Highly relevant to discussions around vaccine safety
Systematic review of blood clots in COVID19
1 in 6 hospitalized patients with COVID suffer blood clots.
Vaccine recipients= 1 in 500,000
Worried about blood clots? Get the vaccine, don't get COVID-19
pubmed.ncbi.nlm.nih.gov/3321…
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My paper, my way at the ERJ
The European Respiratory Journal will now not require strict manuscript formatting at the initial submission stage
If we like the paper, we will ask for formatting during revision
Another way society journals can support authors
erj.ersjournals.com/authors/…
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In case anyone forgets them today, for me the real heroes are the tens of thousands of volunteers who agreed to take part in vaccine trials, as early as March.
These extraordinary people have made announcements like the Oxford/AZ announcement today possible
#nationalheroes
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It is impossible to spend the day listening to the devastating impact of #longcovid on young people in particular, and to think that 100,000 COVID cases per day is acceptable
Mitigation of COVID impact needs to include consideration of long-Covid
@Daltmann10 @EuropeanLung
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Told my 7 year old daughter i was going to work early because i have a lecture
She looks at me, puzzled, then says:
"I used to get lectures all the time, but i'm much less naughty these days"
"you'll get there daddy"
#ERSCongress
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We did it!
Absolutely thrilled to share the results of the ASPEN trial published today in @NEJM
Brensocatib(10mg and 25mg vs placebo) reduced exacerbations over 52 weeks and slowed lung function decline
A new treatment for bronchiectasis patients
nej.md/4lBHwUr
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Big news for bronchiectasis!
The phase 3 ASPEN trial of Brensocatib is POSITIVE with a reduction in exacerbations, and important effects on symptoms and slowing rate of lung function decline at the 25mg dose.
investor.insmed.com/2024-05-…
A new anti-inflammatory therapy 🧵
@Insmed
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Delighted to announce that the new European Respiratory Journal impact factor is 33.795
Sincere thanks to all of our editors, reviewers, authors and readers. Particular thanks to the @EuroRespSoc @ERSpublications editorial office in Sheffield
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We did it! The first approved medication for bronchiectasis
Brensocatib approved by the FDA in the United States. A great day for patients and the scientific community that made this happen. Thank you Insmed, all investigators and participants
multivu.com/insmed/9347351-e…
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Perspective:
March 20-Jan 21 I saw pulmonary emboli(PE) at the fastest rate I've ever seen in my career, because COVID is a PE risk factor
Since Jan we've seen a lot less because of the vaccine preventing COVID
Slowing down vaccine rollout because of a PE is not a risk free act
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Today I played golf and did nothing even remotely related to respiratory viruses
Beautiful 😀
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Whenever someone calls me on teams and leaves a message i get a transcript of the message to my e-mail. Teams transcription doesn't seem to recognise "bronchiectasis" so many of my messages say
"i am calling to discuss donkey exercise"
This will never not make me smile
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10 years. October 2012 Scottish Government funded my first study to set up a research group at @UoDMedicine
Everyone told me you could never sustain a research group focused on bronchiectasis and it would be crazy to try. They were right on second part, but wrong on the first.
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Wow. Thank you so much to the Lancet for this profile, it is a real honour.
Medicine and Science are team sports and i've had amazing mentors, collaborators, clinical colleagues and the best team in Dundee that anyone could ask for. I feel very lucky and very grateful
Thank you❤️
Read our new profile on Professor James Chalmers:
"A maverick making an impact in bronchiectasis"
tinyurl.com/ycxn5hs8
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Dr: I want my second vaccine dose on time
Me: if you could give the dose to your mum/dad, who are higher risk, would you?
Dr: *thinks*..yes, i would
Me: in that case, shouldn't you be willing to give it to someone elses mum or dad?
Dr: i'm happy to wait for my second dose
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We have known for many years that neutrophils are central to the pathophysiology of bronchiectasis, and neutrophil elastase predict worse outcomes. This trial shows for the first time that directly targeting inflammation may be a beneficial approach for bronchiectasis @nejm
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The 2020 journal impact factors have been announced and the European Respiratory Journal as risen to a new record high of 16.67 (previous 12.34)
Thanks to the editors, reviewers, authors and our amazing editorial team in Sheffield @ERSpublications @EuroRespSoc
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Another weekend seeing patients with #COVID19 and asking them to participate in clinical trials.
At one of the worst moments in their life, admitted to hospital with COVID, thousands of our patients have agreed to take part in research to help others.
Our patients are amazing
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New paper!
How effective are inhaled antibiotics in bronchiectasis?
Answer: 22% reduction in exacerbations. 52% reduction in hospitalization. Significant improvement in symptoms.
Data from >3000 patients enrolled in 20 trials
@hayoungcc @accpchest
journal.chestnet.org/article…
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Our new paper out today in @LancetRespirMed The sputum microbiome and clinical outcomes in bronchiectasis.
Hard work from Alison Dicker @KeirHolly @alexxhollysmith @SimonMFinch @UoDMedicine
Supported by @lunguk @EuroRespSoc @EMBARCnetwork
thelancet.com/journals/lanre…
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It’s a great day for science (with all the caveats of waiting for the full data) but amid all the congratulations to Pfizer I think we should take a moment to thank 43,500 AMAZING people that took an experimental vaccine to make this happen
👋👋👋👋👋👋👋
bbc.co.uk/news/health-548731…
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3 journalists this week asked me if the low hospitalization and mortality rate for current COVID19 cases meant the virus had "mutated" to milder strain. I gave boring (correct) answer below - not printed.
Do they keep asking different medics until they get the answer they want?
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Can't believe it! Thank you @HeraldEvents - truly honoured to win this award
I'm incredibly lucky to work with outstanding clinical colleagues and the best research team anyone could wish for. #teamwork
#COVID19 @dundeeuni @NHSTayside
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Strange claim that Downing Street were working on the vaccine programme in May 20 - long before any vaccines were available. If true, i'd love to know what they were doing.
I love the idea there is an adenovirus lab in the basement of Downing Street
'I know at that period we're talking about people working long hours, 18-19 hour days, absolutely exhausted, to deliver one of the best vaccine programmes in the world.'
Tory MP @Mike_Fabricant says Boris Johnson's weakness is his loyalty to people who work for him.
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New pre-print from the @NHSTayside @dundeeuni MATCH study shows antibodies from past infection with SARS-CoV-2 provides 85% protection against future infection.
Natural immunity provides similar % protection to vaccines
papers.ssrn.com/sol3/papers.…
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Join me for an upcoming interactive webinar on bronchiectasis
The role of inflammation in the vicious vortex of bronchiectasis – is it time to re-evaluate? Thursday 8thJune, 15:00 BST/16:00 CET
Register here:
us02web.zoom.us/webinar/regi…
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We did it!
More than 1000 participants joined us for the World Bronchiectasis Conference #WBC2024 hosted in Dundee.
Incredible breakthroughs for bronchiectasis patients, warm friendship and so many memories.
Thank you to everyone who worked so hard to make this possible
❤️❤️❤️
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Grant funded. A lovely way to end the week. There is nothing more exciting than having the opportunity to ask new questions, find new answers and benefit patients.
Lets go!
#science #celebrate
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Selected impact factors from respiratory journals announced today
Lancet Resp 102.6
ERJ 33.8
AJRCCM 30.5
CHEST 10.3
ERR 9.6
Pulmonology 9.2
Thorax 9.1
Ann ATS 8.8
AJRCMB 7.7
Resp Res 7.2
Also first impact factor for ERJ Open Research at 4.2 @ERSpublications
Delighted to announce that the new European Respiratory Journal impact factor is 33.795
Sincere thanks to all of our editors, reviewers, authors and readers. Particular thanks to the @EuroRespSoc @ERSpublications editorial office in Sheffield
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Just out 🔥🔥
Hydrocortisone in severe community acquired pneumonia - results from REMAP-CAP
7 day fixed dose hydrocortisone - Stopped for futility
15% mortality with HC vs 9.8% with standard care.
Unlikely that hydrocortisone substantially reduce mortality in CAP.
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Bronchiectasis in Europe- Data from the EMBARC registry. Just published in @LancetRespirMed our prospective study of 16963 patients from 28 countries describing characteristics and outcomes of bronchiectasis.
@EuroRespSoc @AlibertiStefano @EvaPolverino
thelancet.com/journals/lanre…
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Feeling very Scottish today.
Peer review of our latest paper included the following comment
"the introduction is very disjointed and i recommend you get it reviewed by a native English speaker"
It was written by me
chan eil fios agam dè a tha mi a ’dèanamh
#academicfail
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It’s my wedding anniversary today so what better way to spend the evening than having fun with Mrs C in Holyrood at the Royal Garden Party
King and Queen in attendance!
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In view of the risks of cross-infection, i have eaten all of the communal chocolates in the lab.
It was a difficult decision, but it seemed the most responsible thing to do
#safetyfirst #COVID19
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Message for the media - stop saying COVID19 is "only killing elderly patients with underlying conditions"
This so called "reassurance" is terrifying to the millions of older people with underlying conditions
Try saying that the vast majority are recovering, regardless of age
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The bronchiectasis community is incredibly friendly and collaborative which makes clinical and research work a joy
All together tonight for the EMBARC dinner celebrating our work together
@Lena_Group4Resp @Shoemelia @AriettaSpinou @Beika_Physio @SinganayagamLab @FionaMosgrove
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New paper!
How effective is Pseudomonas eradication treatment in people with bronchiectasis and new isolation of PA?
Answer: 40% will clear PA at 1 year.
Much more effective (48% vs 27%) if you include an inhaled antibiotic
Limitations: observational data only. We need RCTs
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Special day today- after 30 years on and off of playing terrible golf I got a hole in one on a 200 yard par 3
Miracles happen! And 30 years of pain for 30 seconds of glory was definitely worth it
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I work a lot and so have always assumed most people have a more exciting life than me.
But here i am on friday night in Tesco surrounded by people with trolleys full of toilet roll, paracetomol+ pasta, and my choice of a sticky toffee pudding and a DVD looks positively wild
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Congratulations to @DrHollyKeir receiving the @atscommunity rising star award for her work on precision medicine in #bronchiectasis
👏👏👏👏
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Very excited to welcome the World Bronchiectasis Conference to Scotland next year.
Look forward to sharing more about our exciting programme and opportunities for collaboration
Its a really exciting time for bronchiectasis science and clinical care. Come and join us in 2024!
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We are delighted to announce the new impact factor for the European Respiratory Journal is the highest ever at 12.339
Delighted for our editors, editorial staff and readers. The ERS society journal goes from strength to strength
@EuroRespSoc @ERSpublications @elinreeves
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On the day the AZ/Oxford vaccine is approved, remember this key research study
Scary-Anti-vaxers are more effective online than pro-vax views and are predicted to dominate in a decade.
If you do one thing today- post something supportive of vaccination
nature.com/articles/s41586-0…
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Congratulations Dr Holly Keir @KeirHolly who passed her PhD viva today
Deserved success and recognition for an amazing scientist and colleague
Thank you cosupervisor @Shoemelia
Examined by the legendary Peter Barnes @COPDUK , @ezpearson @drdavidc
#proud #simplythebest
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Thinking about "what happens next" after lockdown. We have used data from 67 countries COVID19 cases to estimate R0 and quantify how much easing of restrictions is possible.
Looks like resuming more than 10% of previous contacts would risk a second peak
medrxiv.org/content/10.1101/…
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I have awesome colleagues @NHSTayside @UoDMedicine
Taken today at a surprise (socially distanced) celebration of recent research success
I am very lucky and proud to work with this team
@DundeeChest @W1ll_Anderson @robinlungs @drdavidc @philipmshort @HelenLiddicoat
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If this is as good as advertised when the full data is released, this is a massive moment in the pandemic. Better than many expected and potentially the game changer we have been waiting for
theguardian.com/world/2020/n…
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Nov 9th- Pfizer vaccine 90% effective
Nov 12th- Sputnik 92% effective
Nov 16th- Moderna 94% effective
Nov 18th- Pfizer 95% effective
Oxford in no rush to get results by Christmas
No wonder- if they leave it till Jan it will be 120% effective! 🤪😜
bit.ly/3ff7ueC
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Whenever I stand up at the m + m meeting I feel guilty because I know I’m not the real slim shady
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COPD is massively overdiagnosed in people with bronchiectasis - many patients have the label and have no airflow obstruction or have never smoked
Almost half of COPD diagnoses do not meet objective criteria in nearly 1700 European patients in EMBARC
@EvaPolverino #ERSCongress
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Eosinophilic patients with bronchiectasis receiving inhaled steroid have a 30% reduction in exacerbations and 50% lower hospitalisations in the EMBARC bronchiectasis registry
Great work from the amazing @thephdproject_ Jennifer Pollock
#bronchiectasis #ERSCongress
#proud
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"Grief, I’ve learned, is really just love. It’s all the love you want to give, but cannot. All that unspent love gathers up in the corners of your eyes, the lump in your throat, and in that hollow part of your chest. Grief is just love with no place to go"
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Paper is "awaiting editor decision" - decision expected soon!
Trying to explain to non-medics/scientists what waiting for peer review is like.
Its like the night before Christmas when you were a kid, but with a 90% chance Santa will leave an insulting note rather than presents!
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Airway clearance is the key component of therapy in bronchiectasis. This new @EuroRespSoc statement provides the rationale and clinical evidence for different techniques, and future directions
Bravo @AriettaSpinou @Beika_Physio and team
@ERSpublications
erj.ersjournals.com/content/…
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Fascinating pre-print from colleagues in Edinburgh medrxiv.org/content/10.1101/…
Sharing a household with young children reduces risk of COVID19 and severe disease. Possible explanations include cross-reacting antibodies with circulating coronaviruses- i.e kids give you colds!
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We are delighted to publish the final results of the WILLOW trial of DPP1 inhibition in bronchiectasis in the @NEJM - thanks to all patients and investigators that made this possible
Results show a new anti-inflammatory approach may reduce exacerbations
nejm.org/doi/full/10.1056/NE…
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Presented last night at ATS, a novel drug targeting neutrophil proteases significant prolonged time to first exacerbation, reduced exacerbations and reduced lung inflammation in a trial of 256 patients with bronchiectasis. Full publication to follow soon #bronchiectasis @insmed
A drug which potentially reduces the risk of people living with a chronic lung disease from needing antibiotics or emergency hospital treatment could soon be a reality, according to the results of a clinical trial led by @ProfJDChalmers @UoDMedicine
buff.ly/2Yusnfi
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Exciting positive results announced today for interferon beta as a treatment for COVID19- press briefing later today. Smaller than some recent studies (n=101) but strong therapeutic effect (OR 0.21 for development of severe disease)
synairgen.com/wp-content/upl…
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Its World Bronchiectasis Day 2024!
Today we raise awareness of bronchiectasis as a COMMON and NEGLECTED chronic respiratory condition in urgent need of new treatments.
World Bronchiectasis is an initiative shared by Lung Health Organisations, Societies and Charities worldwide
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As of today, >400 hospitalized patients with severe COVID19 have participated in clinical trials of new treatments at Ninewells Hospital.
Thank you to our patients and their families for their key contribution to improving care.
@TASC_TCTU @UoDMedicine @TASC_Research @NHSTayside
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I have spent a bit of time recently thinking of the famous Professor who told me, in 2011, that i was wasting my career working on Respiratory Infections because there was no funding in it, and antibiotics and vaccines had solved all the problems.
How's that going?
Academia is an odd thing to be involved in.
Most of it is being told you can't do stuff or whatever you are doing isn't worth doing.
Sometimes they are right. Often wrong.Trick is to realise when,and who to listen to.
You need a thick skin and perseverance.
#AcademicTwitter
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Delighted to share this paper in @NatureMedicine in collaboration with @NTUsg
Integration of bacterial, fungal and viral data captures the complexity of bronchiectasis exacerbations
Congratulations @mmacaogain @KeirHolly
nature.com/articles/s41591-0…
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Dundee named top University in the UK for medicine
@dundeeuni @UoDMedicine
A great start to the weekend - we’ve jumped into the top 20 of The Guardian’s 2021 University Guide rankings!
theguardian.com/education/ng…
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Victory! Paper accepted after a personal record of 7 revisions
what's your record? Can anyone beat 7 resubmissions?
@AcademicChatter #peerreview #badatwriting
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Professor Andy Bush wins the @BTSrespiratory medal for his services to respiratory medicine
A true respiratory legend!!
#BTSWinter2022
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Biggest difference between COVID wave 1 and 2
1-
Them: We need this by next week
me: we are COVID frontline
them: sorry to hear that, take all the time you need
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Them: We need this by next week
me: we are COVID frontline
them: sorry to hear that, we need this by next week
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Setting out our ambition to transform the treatment of bronchiectasis - published today in @ERSpublications ERJ for #Worldbronchiectasisday
The @EuroRespSoc EMBARC3 research programme
Proud to be part of this amazing global community
erj.ersjournals.com/content/…
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If any of my students had given the kind of science presentation that Boris+ co delivered yesterday they would be getting urgent retraining on Monday.
Can someone not help them make decent slides and let them use the clicker so they don't have to keep saying "next slide"? #COVID
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Exciting day today as we are at @BTSrespiratory headquarters to plan the programme for the BTS winter meeting in November
What do you want to see on the programme?
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Very excited to share our latest paper from @EMBARCnetwork - Inflammatory molecular endotypes in bronchiectasis . Led by the brilliant @hayoungcc @ATSBlueEditor
Patients can be clustered by neutrophilic and T2 inflammation and this predicts exacerbations
atsjournals.org/doi/epdf/10.…
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This is a very frustrating headline. This is not a political statement but a public health one:
COVID restrictions are not a punishment - they are to protect the public. No one is being "hammered". These are really difficult decisions taken to save lives
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Honoured to be invited to give a talk at the PCD on the move conference on phenotypes and endotypes in bronchiectasis.
Bronchiectasis is a heterogenous disease and requires careful assessment and personalized treatment. The future is stratified trials using biomarkers
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I enjoyed this review on personalized medicine for bronchiectasis - just published from colleagues at the Royal Brompton Hospital
#precisionmedicine #treatabletraits
mdpi.com/2075-4426/13/1/133
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Airway clearance and physiotherapy are the key intervention in bronchiectasis. If we could do one thing to help our patients in Europe it would be to widen access to specialist physio
We have more patients
We need more specialist physios and resource for physiotherapy #simples
Dr @AriettaSpinou shows techniques for people with #bronchiectasis to clear mucus from their airways. #Bronchiectasis2022
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The European Respiratory Journals latest impact factor has risen to 24.9. Thanks to all of our editors and reviewers.
IF of the major respiratory journals
Lancet Resp Med 76.2
ERJ 24.9
AJRCCM 24.7
Pulmonology 11.7
Thorax 10
Chest 9.6
@ERSpublications @EuroRespSoc @donsin4
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Sat down with one of my students today to write their first paper today and was reminded of this absolute gem of a paper in Breathe
If you are thinking of writing your first paper- this contains fantastic advice #AcademicTwitter @ERSpublications
breathe.ersjournals.com/cont…
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The new European Respiratory Journal impact factor is 21. Ranked #2 across all resp journals
Thank you to the incredible @donsin4 , all authors, our outstanding editors and journal staff ♥️
@ERSpublications @EuroRespSoc
IF for selected respiratory journals below
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Reviewing a paper for a leading journal - about to submit my review and got to the conflicts of interest section. Decided to add the following disclosure
"no real COI, but i follow the lead author on twitter and i think they are pretty funny"
Full disclosure!
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Thank you to the wonderful colleagues from @atscommunity @ATS_Assemblies @ATS_PITB for the 2021 Mid Career Award. Very honoured and proud!
thoracic.org/members/assembl…
Great to see familiar faces from @atscommunity @ATS_Assemblies @ATS_PITB members for the Assembly meeting. Look forward to hearing about all the new initiatives!
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First patient enrolled today in the GREAT-2 trial- testing a novel antibody treatment against Pseudomonas infection in people with bronchiectasis.
So proud of our outstanding team working to find new treatments for BE @Shoemelia @MereteLong @emma_d_johnson @beccahull_ @TASC_TCTU
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Important take away from the World Bronchiectasis Conference #WBC2024
All conferences should have therapy dogs
This is the way
#EMBARK @erin_cant
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Flying home from an amazing #ERS2022 conference
I've loved every minute of it, but i can't wait to touch down in Scotland and feel COLD!
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Countries that have done well (mostly in Asia) have used effective test/trace/isolate and kept economies largely open.
We can do it in the UK- we do extensive asymptomatic testing to protect professional football, why not protect NHS patients and vulnerable groups the same way?
Good to hear @ProfJDChalmers Good Morning Scotland 7.10 emphasising those countries that have done well and kept economies open have been those that have gone for test trace isolate big time. And he cites testing of footballers as perfect example so not just those with symptoms !
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Does anyone know where I could get a T-shirt that says “I have allergic rhinitis- I sometimes blow my nose and it will not kill you”
Would make travelling by plane/train much less stressful at the moment #cornoravirus #COVID19
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I love that NHS Test and Protect sent a text message to my 6 year old daughter (to my wife's phone obviously) asking if she needed any support to self-isolate
She says she needs a teddy and a lego set.
Quite reasonable demands i'd say
#COVID19
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