Researching how exercise, nutrition and aging alter musculoskeletal function
California
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For PhD students, don't worry if the first draft of your first paper comes back to you like this. It is normal. This is a process. No one starts perfect.
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With @IAAFDoha2019 one week a away, I figured it might be interesting to look at why there might be hamstring pulls in the men's 200 and 400m sprints. Just a simple demonstration as to why increases in tendon stiffness (for the same muscle strength) cause muscle pulls/ruptures.
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A quick demonstration of stress shielding and stress relaxation and how they relate to tendon injury and repair. If you want to see how we use this to improve injured tendon check out this paper ncbi.nlm.nih.gov/m/pubmed/30…
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For all of those who think that the protein in tendons and ligaments doesn't turn over. Sorry, the evidence suggests that protein turnover in loaded tendons and ligaments is HIGHER than muscle: journals.plos.org/plosone/ar….
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Like everyone else, I am sheltering in place. At this time, it is important to remember that activity is important. This recent JAMA paper shows that walking 10,000 steps decreases all cause mortality 4-fold compared to walking 2,000 steps per day. Stay active my firends.
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Running stress-relaxation tests on patellar tendons in the lab today. Beautiful curves. Note that 80% of the relaxation happens in the first thirty seconds. That is why we hold isometrics for thirty seconds to try to fix an injured tendon.
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Comparative physiology is a great way to understand exercise physiology. I love looking at the flight muscles of birds (the way Holloszy did in his 1967 classic) to understand how basic muscle properties change with habitual exercise.
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One of my favorite graphics of muscle over age incorporates the fact that if you are in strongest 1/3 you live longer
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Really proud that @ucdavis is standing up to @ElsevierConnect on this issue. I am an Assoc. Editor of one of their journals, review tens of articles a year for them, and yet still have to pay huge fees to publish my articles. Meanwhile, they made > £900 million in 2018.
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Using all the toys today to try to understand how exercise increases collagen in ligaments.
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Athletes with the biggest energy deficiency have the highest body fat. Body weight is one thing. Body composition is another.
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That is why I always do comments for students in paper. Accept all is the enemy of actually learning
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Please RT & help me get the word out. I am actively looking for a postdoctoral fellow interested in working from humans to cell culture to understand how varying nutrition affects muscle growth and function. Come join a diverse group of scientists in a beautiful part of the world
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Following up on yesterday's tweet about decreasing non needed mass, it is important to realize why. Myers and Steudel (jeb.biologists.org/content/1…) showed that for every added kg at the waist the cost of running increased 1% and this increases as the mass moves away from the core.
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This figure shows that each load results in a different cellular response. Tensile loading increases aligned collagen I; compression increases proteoglycans (cartilage genes that bring water into the tissue); and shear loads increase lubricin at the surface
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Nice article by @sweatscience in the @globeandmail on our recent gelatin research theglobeandmail.com/life/hea…
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Reminder. 1 set to failure w/heavy weight (80% 1RM) as good as 3 sets for building strength jap.physiology.org/content/e…
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A great article from @sweatscience to start the new year (outsideonline.com/2259366/fo…?). Luc van Loon spends millions of Euros to prove his mom was right: eat 3 protein rich meals, exercise everyday, sit up, and chew your food if you want to grow your muscles.
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Really sad to hear that my long time mentor John Holloszy passed away this morning. He made such an impact on ExPhys. Don't just look to his papers, more important to look at the great scientists (present company excepted) that he produced. #Legendary
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Cogratulations to @dlisforrest, @JordanStrength and the rest of the group on this paper finally getting out. Collagen and Vitamin C Supplementation Increases Lower Limb Rate of Force Development journals.humankinetics.com/v…
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What I tell all postdocs: It is never the techniques that you know that we are looking for. We look for 1) curiosity (reading a lot of papers on different topics); 2) a passion for science (thinking critically and asking questions); and 3) the desire to help others (mentoring) nitter.app/hswaldman/status/94362…
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Twelve years ago, I carried this little girl into our lives and she took over our hearts like nothing we had ever known. Yesterday, I carried her to her last sleep. Thank you @ucdavisvetmed for helping us give our lovely girl a quite and gentle sendoff.
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A ketogenic diet preserves skeletal muscle mass and function with aging in mice. Nice work @Muscle_Wallace and team. onlinelibrary.wiley.com/doi/…
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Thanks to the generous person who donated their ruptured ACL and the remaining healthy tendon great to our research. From this one donation, we will be able to make more than 1000 engineered human ligaments.
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Muscle memory. Hypomethylation that occurs in response to training is maintained during a period of detraining. Exercise again and your muscle remembers resulting in even more muscle growth from the same training later. Great work @DrAdamPSharples
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If you are a member of @APSPhysiology or can get a hold of this paper (physiology.org/doi/full/10.1…) in this month's Physiology journal, you need to read it. It will help you really understand muscle contraction. You will then want to read everything Manny and Tom have ever written.
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For those who aren't sure that tendons play a role in performance, watch these mice jump. Those with a mutation in a single tendon gene jump way farther.
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One of the great studies of all time. Association between fitness and intelligence in Swedes. pnas.org/content/106/49/2090…
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Teaching one of the classics tomorrow. Passive stiffness and efficiency/economy. Passive stiffness makes you a better runner (more efficient). Great work by @AndyBeetroot
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One of the great things about what we do is getting letters like this. "As an active 90 year old...." Thanks @sweatscience for the article that brought this letter to me.
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If you are interested in tendon physiology, please take a look at this recent editorial I wrote on some of the problems in the field. I would love to hear comments of those who work in this area. onlinelibrary.wiley.com/doi/…
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Our newest paper on enhancing the interface between the bone and ligament is now online. In it, we discover a growth factor that turns ligament cells into the cartilage that forms the transition to bone onlinelibrary.wiley.com/jour…
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Alright folks, see how you do on the essay question from the midterm of my capstone exercise biology course "Physiology of Maximal Performance". Also, there is no truth (as far as the mutation, that I know of) in the example
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We have been able to isolate viable cells from human ACLs & PCLs up to 45 days post mortem. Will be trying to engineer ligaments from these cells in the next few weeks.
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Having trouble getting to sleep? Check out our new paper on nutritional ways to help you fall asleep (mdpi.com/2072-6643/12/9/2579…) and this poster with our key findings #SportsScience
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Start to #ihps2019 is in good hands with @mackinprof telling us the role of dietary protein in human performance
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If you are curious as to why I focused on the men's races, it is because estrogen decreases connective tissue stiffness and therefore decreases muscle pulls in women. For more info see this recent review frontiersin.org/articles/10.…
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Tendons are circadian tissues. We synthesize most new molecules at night. ncbi.nlm.nih.gov/pubmed/3023…. #BSMSAutumnSchool
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If you've ever wondered how inflammation affects tendons/ligaments, check this out.
Also, if you knew inflammation decreased ligament mechanics, did you know that inhibiting NFkB would make it worse?
sciencedirect.com/science/ar…
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Paper on response to resistance exercise in older individuals is out. In it, we show the initial response to exercise is similar, but the ability to prolong protein synthesis is diminished with age. Might be a little controversial. Welcome any feedback. frontiersin.org/article/10.3…
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Twenty years ago today, I donned some fly baggy pants and married @BarbMiltner1. What an amazing adventure we have shared. I'm in awe of her brain, spirit, empathy, and bravery. I could not imagine life without her.
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Super cool finding from Helge Amthor. Increases in muscle mass, and force correlates with ECM more than muscle fiber size. #paradigmshift? onlinelibrary.wiley.com/doi/…
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Really proud of my undergrad student Jed Obra for this cool video about his research. Check out his explanation on this award winning video and send along any questions piped.video/zIDJo2MLvG4
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Here's to the latest version of the lab and to all the former lab members around the world. Thank you for choosing to be a part of my family.
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Great to be able to cite the wonderful Michael Barany in my ExPhys class. You've got to check out this paper. He measured muscle function in everything from humans to tortoise and sloth and correlated it with ATPase activity. Faster your myosin breaks ATP the faster you move.
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Check out this podcast that I recently did on Tendon Health, Rehab and Elastic Power Performance. Take a listen to this Just Fly Performance Podcast #156 and let me know what you think. just-fly-sports.com/?p=14001 via @JustFlySports
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Stretching a muscle results in a change in titin mechanics. It no longer stretches through the whole range. Instead, this important spring is shortened, making the muscle passively stiffer. #BSMSAutumnSchool
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Testing human engineered ligaments today. The new @instron Is working beautifully.
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Ever wonder why your muscles grow after you lift? Here is a quick review as to the molecules you activate ncbi.nlm.nih.gov/m/pubmed/25…
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For those new to exercise physiology hearing about Dr. Holloszy for the first time at the end of his life, please allow me to give you some context.
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Please RT: We have started an exciting new journal. Translation Sports Medicine. From bench to clinic onlinelibrary.wiley.com/jour…
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Super cool data in the lab today. Change in nutrition resulted in a 2.5-fold increase in maximal tensile load in our ligaments. A lot of work to do on this before we would take this into practice, but a really exciting start.
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Hanging out backstage before my talk as part of the #WeNutritionConference. At least this way, you will know who's making the tracker if I get interrupted.
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Last, I made this one a little silly so that everyone would understand where gelatin and hydrolyzed collagen come from.
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Did a video for my ExPhys students on making infographics. Picked my first paper for the purpose. I had a little fun, take a look and let me know what you think.
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Signing his letter of intent. Alec Avey is now an official member of the lab. He will be studying the molecular mechanism of inflammatory tendinitis and developing loading and nutritional interventions to prevent it.
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My mission is "perform world class musculoskeletal research in a family environment".We all want our family to be healthy, happy, and successful. Expand your definition of family to include those who don't look and think like you and I can guarantee you will be successful.
A benefit of staying on your previous lab’s WattsApp tread is that you still learn about good #mentorship. In the photo below @MuscleScience is doing @MuscleScience things. If you are a #mentor, be more like 👇🏽. These small gestures make a big difference in your #mentees’ lives.
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A big welcome to Suraj Pathak. Today he signed his lab letter of intent. For his PhD, he will be studying how a ketogenic diet alters acetylation in muscle and the role this plays in the neurocognitive benefits of the diet.
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We are looking for a strong physiologist to join our group at the University of California Davis. Please RT widely.
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Does anyone know how to get a hold of Professor Kozaburo Hayashi formerly of Osaka University? I tried to send the attached message and am worried he has retired and won't get it. If you do know him, could you either forward the attached message or DM me a working email? Thanks
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It's the right decision, but it is still sad. Was hoping to welcome the exercise science world to San Fransisco and Davis. We will consider hosting or symposium on collagen protein as a virtual meeting. @mackinprof @dlisforrest @JenniferSygo and @CFlake_Esq (Luc van Loon)
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Unlike alcohol and ibuprofen, which blunt the anabolic response to strength training, CBD does not. Good job @HenningLanger and @agata_moss journals.humankinetics.com/v…
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Great paper! Scientific evidence that the strong survive better. More muscle = longer life!
Get & stay strong ⬆️ lifespan | Fantastic paper, seen via a tweet from @MuscleScience ages ago | Open access PDF via bmj.com/content/bmj/337/bmj.…
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Second paper submitted today, making it 4 for the week. On top of the major experiments, 2 grants and 10+ letters of recommendation I need to do for students, the next person who asks if I've had a relaxing summer holiday really better watch out
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How your tea or cocoa could alter endurance adaptation & fat burning, from our recent review journal.frontiersin.org/arti…
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Very few things in biology have r2 of 0.9 or above so we are doing a second independent (blinded) quantification of fiber size. Having said that, we might have some exciting news about a natural product cocktail that could increase load-induced muscle growth. Stay tuned.
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This is an interesting finding. Rapamycin prevents sarcopenia in rodents. There is no doubt that blocking mTORC1 can be good, increasing autophagy and mitophagy, the question is whether it is better to achieve this goal with diet and exercise or drugs. Important nuances.
Time to rethink the role of #mTORC1 in muscle aging? Read our latest research showing long-term #rapamycin treatment slows #sarcopenia. Great collaboration with @ZavolanLab and @c_handschin. Published with @SpringerNature in @NatureComms. Read more here: rdcu.be/b6X1m.
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Check out our newest article that contraction induced muscle injury in old individuals can be decreased by removing a single microRNA and increasing dystrophin protein. Great work @HughesDC_Muscle and team physoc.onlinelibrary.wiley.c…
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Women suffer fewer hamstring, groin, and ankle injuries but 2-3 times more ACL ruptures. Likely down to the stiffness of connective tissues as a result of a decrease in cross linking #FFMED ncbi.nlm.nih.gov/m/pubmed/25…
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Blood taken 1h after consuming increasing amounts VitC-enriched gelatin increases collagen in engineered ligaments.
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Another good article from @sweatscience on starting recovery from musculoskeletal injury ASAP theglobeandmail.com/life/hea…?. Good summary of Monica Bayer, @SPMagnuss, and Michael Kjaer's study
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Another wonderful talk from @mackinprof. Great to see scientists who are willing to change their minds as data develops
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Every time I go through this I remember what my dad said. I teach for free. I get paid my whole salary to grade. Grades submitted. Let the emails begin
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Great talk by @RogerEnoka on fatigue. Fatigue has both physiological and cognitive components. "The best way to know if someone is fatigued is to ask them"
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Rehabilitation and nutrition protocols for optimising return to play from traditional ACL reconstruction in elite rugby union players: A case study tandfonline.com/doi/full/10.…
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Great to be on the STEM-Talk podcast talking all things muscle. Check it out and feel free to send any feedback. ihmc.us/stemtalk/episode-62-…
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Congratulations to PhD student Alec Avey on his first paper "Muscle-tendon Crosstalk During Muscle Wasting" in @AJPCellPhys. A new area for the lab. Let me know what you think journals.physiology.org/doi/…
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An absolutely outstanding article that everyone should read comletely and slowly. Efficiency vs Living Creatively theguardian.com/technology/2…
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For all those who think they are the only ones who do stupid things, I give you today's dog walking injury. Got distracted and walked into a tree branch.
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If you increase the fluid in a muscle, you increase the passive stiffness of the muscle. rsbl.royalsocietypublishing.…. This means that as you exercise and deplete glycogen passive stiffness in the muscle should go down. #BSMSAutumnSchool
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Athletes on a HFLC burn incredible amounts of fat, but their economy good down (it takes more oxygen to go a certain speed) and economy is a key parameter in performance
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Our latest paper is out.
sciencedirect.com/science/ar…
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For those not familiar with Holloszy's 67 paper, it was the first paper showing exercise increased mitochondria m.jbc.org/content/242/9/2278…
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A first look at the world's only whole body human PET scanner developed here @ucdavis. Already planning to see what's happening in the liver, brain and muscles during and following exercise. Super exciting stuff
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For those suffering from, or working with athletes with, patellar tendinopathy, this case study might prove useful in not just decreasing pain but fixing the underlying pathology. Be interested to hear feedback or questions. journals.humankinetics.com/d…
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A measure of a great scientist. John Holloszy has made an incredible impact on exercise physiology
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Really happy to see this paper come out. It is only a case study, but the reversal of a central core tendinopathy in a professional athlete is significant. Thanks to the performance staff and the athlete for their work on this project journals.humankinetics.com/d…
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Endurance athletes, remember periodic sleeping with low glycogen improves performance. ncbi.nlm.nih.gov/pubmed/2674…
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