Researcher in vaccine & drug delivery infectious & autoimmune diseases & cancer. 🏳️🌈 Ally. Mom 2 boys. She/her. @kristy-ainslie-lab.bsky.social. My views.
Chapel Hill, NC
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I stepped down from NIH study section NANO this week. Between NANO & the 32 other study sections I have served ad hoc, I learned many things about how to construct a good grant.
Thus, I give you a song themed thread of potentially helpful grant tips!
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Pulled from r/Professors. Students are most productive with mid-career highly productive female advisors.
sciencedirect.com/science/ar…
Here's the reddit thread: teddit.net/r/Professors/comm…
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Decided to update my Nano/microparticle timeline. Let me know if anything looks off and feel free to use it.
You can download an editable PowerPoint Slide of it here: unc.live/37Lg9Cc
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I chaired a search committee for an open Asst/Assoc Prof. We did 15 zoom pre-interviews. We had 7 questions that lasted 25 mins, w/ an opportunity for the candidates to ask questions at the end. Here are my tips from that experience, themed around song lyrics! Enjoy!
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Submitted report for full prof promotion. Dwelling on lots of failures punctuated with limited success via data! For all grants (RO1 to $5K internal), my success rate is 13.3%. Each last author pub has been reviewed on average 1.7 times. #academiclife
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New FDA approved Micro- & Nano-technology Timeline!
Revised overall, synthetic & inorganic timeline to include silver NPs.
Silver NPs (1889) (PMID: 21218770)
Link to slide deck: ainslielab.web.unc.edu/wp-co…
Modified from: aiche.onlinelibrary.wiley.co…
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Reviewing a manuscript without figures in the text is painful enough, but having captions separate from the figures is just adding insult to injury.
In this digital age can't we just have figures and captions inline with text for manuscripts?
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I am dumbfounded! A 1.0 percentile! How does this happen? Thanks NANO! So excited to be working on vaccine formulations to fight pox viruses (e.g. monkey pox) with awesome collaborators like Herman Staats, Roland Tisch & @Heise_Lab. 🎉🎉
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Thanks for your kind words about my promotion. I was told I couldn't get into grad school, have kids as a professor, and many other things that I decided to not give an F about and just kept going. Now am a full professor and have awesome kids and husband! Focus on the good!
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Referenced & available for citation UPDATED Micro & Nanotechnology Timeline out today in @BioTM_Buzz
"Micro and nanotechnologies: The little formulations that could"
Older timelines tweeted out may have errors, please use this version.
Free: doi.org/10.1002/btm2.10421
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Happy to announce I no longer have any *required* adjectives in front of my professor title!
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First day as chair of @DPMP_UNC! First task to change email signature. ☑️Done. Wish me luck! 😃
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I am very honored to receive the 46th Sato Memorial International Award from the Pharmaceutical Society of Japan. Thank you for hosting me in Japan, inviting me to your meeting & allowing me to discuss my science with such a notable group of researchers.
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Would it be too passive aggressive to add the last line to my email signature? 🙂
Kristy M. Ainslie, PhD (she/hers)
Fred Eshelman Distinguished Professor and Chair
Division Pharmacoengineering & Molecular Pharmaceutics
Yo!! Kristy is spelled with a 'y' not an 'ie'
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Here is a link for free access until June 12, 2021 to our pub "Historical perspective of clinical nano and microparticle formulations for delivery of therapeutics"
Enjoy!
authors.elsevier.com/a/1cyTO…
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Have you seen these fantastic info graphics from @ZJAyres regarding grad student and Post Doc mental health and well-being? There is a whole series of amazing posters to check out! A great resource for faculty, students and post docs!
med.unc.edu/genetics/mental-…
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According to my CV, this is my 100th paper! 🥳
Congrats Ryan Woodring & team on the review "Drug Delivery Systems for Localized Cancer Combination Therapy" @ACS_ABM @UNCPharmacy @DPMP_UNC
doi.org/10.1021/acsabm.2c009…
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I mean who wouldn't want to be chair for faculty like @JulieNguyenLab, @Aaron_Anselmo, @HingtgenLab, @alkabanov, Mike Jay, and Leaf Huang? 😃
Thanks all for the kind words!
BIG NEWS just announced! 📢📢📢
@AinslieLab will be chair of DPMP starting July 1!
After 9 wonderful years of dedicated service, Dr. Mike Jay will be stepping down as chair June 30 and returning to the DPMP faculty. @UNCPharmacy
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Roses are red,
Violets are blue.
My lab needs a post doc,
Maybe its you!
#AcademicValentine
No, seriously we are looking for post docs: ainslielab.web.unc.edu/posit…
There are free cookies and these awesome people!
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I have over 60 published peer reviewed articles and maybe a dozen book chapters, yet my 9 & 12 yo still question and argue over every edit I suggest for their written homework. 🙄😒
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New LINKS!
New timelines: biologics, synthetic & inorganic carriers!
Added:
1992 Membrane Coated NPs (PMID: 1333772)
1955 Poly-drug conjugate (PMID: 20672864)
1912 Anti-drug conjugate (PMID: 26845587)
Modified from: aiche.onlinelibrary.wiley.co…
Download: ainslielab.web.unc.edu/wp-co…
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I've been sending this out to a lot of individuals lately, so thought I would re-post it. Here is a presentation I put together on how to put together a faculty packet. I updated it with a couple slides on a Diversity Statement. Enjoy!
ainslielab.web.unc.edu/wp-co…
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Excited to receive a NOA for a $3M RO1 to continue working with the amazing Ted Ross @ugavetmed towards development of broadly acting influenza vaccines. @UNCPharmacy @NIAIDFunding
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I just finished the 9th quilt for my PhD students! Each student gets a quilt around their defense.
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Happy New Year to my amazing collaborators and me!
Looking forward to continue working with Eric Bachelder, Herman Staats, Mark Heise & Roland Tisch!
Time to work on a vaccinia vaccine!
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Perhaps helpful for course planning. The most recent micro & nanotech timeline for therapeutics, vaccines & imaging!
OG source: tinyurl.com/4cbdp8sd
PPTX: tinyurl.com/yttx7j48
PDF: tinyurl.com/y3afemtu
Let me know if something is off, still sorting ADC!
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So honored to be part of @aimbe fellows for 2021. It is amazing to be part of such an influential group and wonderful that the amazing @TejalDesaiUCSF was able to announce me!
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After years of researching subunit vaccines and having a former student doing the scale up at Moderna's, I of course get the J&J vaccine. Happy to be vaccinated nonetheless!!!
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It's a great honor to receive the award and I can't wait to visit Japan in March!
Congratulations to @UNCPharmacy's very own Kristy Ainslie (@AinslieLab), the recipient of the 2023 Sato Memorial International Award! Learn more about this great honor in the story below: unc.live/3ihee1O
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Great job @colejbatty on your 1st author piece "Historical Perspective of Clinical Nano and Microparticle Formulations for Delivery of Therapeutics"
Check out this fantastic timeline of FDA approved NPs from it!
@TrendsMolecMed @DPMP_UNC @UNCPharmacy
sciencedirect.com/science/ar…
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Thank you so much @CRSScience for this amazing acknowledgement. It's such an honor to be recognized as a CRS fellow and to be part of such an outstanding group of inductees!
Congratulations to 2022 CRS College of Fellows inductee Kristy Ainslie, PhD (@UNC)! Elevation to ‘fellow’ recognizes an exceptional individual in the field of #controlledrelease who has made outstanding & sustained contributions to the field of #deliveryscience and technology! Dr
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Got a frame to make it official! Thanks @CRSScience, @BenBoyd_Monash, @alkabanov for nominating me & congrats fellow inductees!
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Thanks for all the great discussions! I have added Microvesicles, 3D printing, Janus particles, Cell backpacks & Heteromultivalent particles. The date for ADC was also updated.
OG Source: aiche.onlinelibrary.wiley.co…
Powerpoint:ainslielab.web.unc.edu/wp-co…
PDF: ainslielab.web.unc.edu/wp-co…
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Our COVID vaccine review in @ADDReditors is out! DYK a LNP wasn't the 1st mRNA vaccine in clinical trials? Or explosive powder is used in 1 vaccine? Or there is an oral vaccine in trials? Read all about it!!
@Heise_Lab @colejbatty @UNCPharmacy @UNC_SOM
sciencedirect.com/science/ar…
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Here's an updated timeline. Correction for carbon nanotubes (and re-colored lines). The previous date was for hollow graphitic fibers not nanotubes.
Take it, make it your own! TY for all the comments.
ainslielab.web.unc.edu/wp-co…
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Pls RT. We are hiring multiple post docs to work on multiple NIH funded projects related to development of drug carriers for influenza vaccines. Please see the full adds below!
Chemist: unc.live/2SBgtMO
Engineer or Closely Related Field: unc.live/2SDPfVV
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Just gave a talk on vaccines to prevent COVID-19 to a great group of post doc Fellows as part of @alkabanov T32 group. pharmacy.unc.edu/education/f…
I uploaded it to my website as a PDF. If you think you can use it in your lectures, feel free to download it.
ainslielab.web.unc.edu/wp-co…
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Just submitted two grants and wanted to do something creative. So I give you drug delivery 'Guess Who?'. Images taken from the nanomedicine timeline here: aiche.onlinelibrary.wiley.co…
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Great dinner as part of #NanoDDS! Wonderful celebration of @alkabanov and great job @JulieNguyenLab spearheading it with Jubina! 👏👏👏
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Pls. RT: Hiring post docs in drug delivery who can start <4 months (sry UNC = 6mos+ for J1/H1B visa). To work on modulating immune cell responses. Pls email CV to ainsliek @ email.unc.edu. More info: ainslielab.web.unc.edu/posit…
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Thanks. This did not come easy. It was submitted 5x since 2017. Uses prelim & published data from 3+ pubs. All work from the amazing Dr. Liz Gurysh who learned on @HingtgenLab R01 - to be awarded a @PhRMAfoundation post doc & @theNCI F32 fellowship to branch off for this effort.
Congrats @AinslieLab on a $1.7M @theNCI R01 "Tunable Temporal Drug Release for Optimized Synergistic Combination Therapy of Glioblastoma" in collaboration with @HingtgenLab, Dr. Zamboni @UNC_DPET, & Dr. Fecci @Dukeneurosurg.
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Simply the Best: Give quantitative proof your idea is > similar current clinical & preclinical approaches. Discuss similar 1s & why yours is >. Use clinical controls in prelim data, a table quantitatively summarizing the results of yours and others and/or highlight drawbacks.
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Here is an updated version, prob 1 of many, keep commenting! TY for all comments so far. I try to use the 1st instance of platforms (e.g. COVID vaccine is not listed because Onpattro is). The former link will download the updated version as well unc.live/37Lg9Cc
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Before Twitter burns, 1 last 🧵
Easy (& some inexpensive) ideas for a PI or chair to improve the environment for grad students, post docs, & staff. We understand the best idea is more $ but our hands are tied there by those above often regarding salary.
Please add to the list!
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I mean making two types of scones, two types of quick breads, biscotti and granola for the visiting PhD recruits is a representation of a normal baking habit, right?
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When you get paper acceptance with no major revisions on first review (as displayed by my 10 yo)!
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The first roll cake I have ever done. Made for my post doc's birthday tommorow. 🎉🎂 (Pumpkin w/ maple cream cheese frosting)
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Pls RT. Looking for a post doc w/ experience in viral animal models. For NIH funded projects on universal influenza vaccines.
Sorry, at this time I'm not looking for experience with formulations unless applied to virus infections models.
linkedin.com/jobs/view/20252…
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Want to be introduced to immunology in less than 150 pages? Check this book out. I always have copies available for new students to read when they start in my lab. Janeway is great too, but this will certainly you started faster!
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Last update for a while. TY for all the help including @alkabanov . I tried to focus on 1st report of the tech, not just for drug delivery.
Please use it, make it your own & happy teaching!
The former link will download the updated version as well unc.live/37Lg9Cc
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1 of my fav tools is a web plot digitizer which takes a picture of a graph & estimates data points. Perhaps you already use it, but if you don't here is my favorite one: apps.automeris.io/wpd/. My awesome post doc used it to compare our scaffold release rates to published ones.
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I could be your chair! 😀
We have an open rank tenure-track position focused on drug delivery related to neuroscience.
Our amazing faculty are chemists, engineers & other scientists who train equally diverse students & teach dozens of lectures in the PhD & PharmD curriculum.
unc.live/3nKeQwQ
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Thanks ACS Editors for recognizing my article "Distribution of Female & Male First & Last Authorship across Drug Delivery Related Journals w/ Respect to Year & JIF" in Molecular Pharmaceutics as an ACS Editors' Choice Article.
Open access: pubs.acs.org/doi/10.1021/acs…
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New review just out "Nano/microparticle Formulations for Universal Influenza Vaccines" @theaapsjournal
@niaidcivics @UNCPharmacy @DPMP_UNC
link.springer.com/article/10…
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I am organizing some of my grad students and a post doc together into a NIH F31 & F32 working group. "I could give 2 F's" is a perfectly acceptable title for that group, right? 😀
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When life gives you 🍋 make lemon bars (for the lab!). When life gives you a pinched nerve so you can't travel to GRC Biomaterials for a talk & conference you have been looking forward to for a long time, make brownies & Blondie bars to go with them! Hope you all have fun at GRC!
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New pub in @ACSBiomaterials "Development of an Intranasal Gel for the Delivery of a Broadly Acting Subunit Influenza Vaccine"
pubs.acs.org/doi/10.1021/acs…
@UNCPharmacy @DPMP_UNC @niaidcivics @ugacvi @devikamvarma @colejbatty @JohnRoqueIII @Kunyu_Qiu @Aaron_Anselmo
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Today is the first day back for the lab. Thought in addition to shifts, masks, social distancing, disinfectant and gloves my lab members needed some lasagna & stuffed shells to take home. Stay safe!
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Made some food for my labbies after a horrific last week & hopefully relaxing long weekend.
Sweet potato burrito bowl w/ spicy tahini sauce
Mushroom, spinach & tomato cavatappi
Southwest chicken burrito bowl
Jerk chicken w/ grilled asparagus and Caribbean red beans & rice
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It might get below freezing tonight in Chapel Hill! So some lasagna for the lab group to keep them warm & cupcakes for an undergrad's birthday! It's a two course lunch today for the lab. 😆
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Glioblastoma needs to calm down!
Come to my BMES talk on Saturday 10/14 at 1:30 where I'll discuss controlled release chemo and immunotherapy approaches to treat the cancer.
Thanks @dgpnanomedlab for the invitation!
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Thanks! This took 4+ yrs of prelim data on diabetes & ironically lots of cookies & brownies to happen. Baked good bribes for Roland Tisch's lab members since they had to take time away from their experiments to work on prelim data! Excited to be working with Roland on this!
Two days, two RO1's for DPMP Faculty!
Congrats @AinslieLab on the award of your @NIDDKgov R01 "Formulation to Generate Tolerance Towards Type 1 Diabetes" 🎉🎉
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Join me (if u can) at 3 today for @GordonConf Drug Carriers Power Hour! My amazing grad student Ryan Woodring helped me to put together infographics on Women & URM in Drug Delivery - but we'll focus on Examples of Inclusion & Actionable Points! unc.live/3PJIwp0
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Looking forward to this phenomenal drug delivery conference @JulieNguyenLab spearheaded with @BrudnoLab, @TheFentonLab, @alkabanov, and me. Can't wait to kick it off tonight by having dinner with all the speakers!
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Our paper is out in print today in @BioTM_Buzz! Immunogenicity of an adjuvanted broadly active influenza vaccine in immunocompromised and diverse populations
aiche.onlinelibrary.wiley.co… @DPMP_UNC @UNCPharmacy
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We’re hiring post docs, pls RT.
We offer paid extended parenteral leave, mentoring during & after your PD, skills from synthesis to in vivo models, wonderful colleagues, $ >NIH payscale, research triangle environment, collaboration abound & more (🧁).
ainslielab.web.unc.edu/posit…
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20 years ago, I gave a commencement speech with a friend. Which lead to 20 years of dating (5 years at different PhD schools) 14 years of marriage, 2 boys, and 10 years of running an academic lab together!
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ABC: We all use acronyms - limit them & define w/ 1st use. Use common 1s. Too many acronyms = poor readability. If u don’t use the acronym much, don’t define it. Ctrl-F to determine frequency. If you define it early & use it late, be cautious. If room put table in aims page.
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Decided to update my Timeline of Micro- & Nanotechnology for Therapeutic, Vaccine, and Imaging Applications (old one: unc.live/2Y25ixE) Anything I missed or got wrong?
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One of my undergrads just turned 21 so I made Irish Trinity cupcakes to bring into lab tomorrow. Guinness chocolate cake, Irish Whiskey chocolate ganache & Bailey's cream frosting with a whiskey chocolate on top. 🍻
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This is what happens when you have group meeting the day after your birthday. My group is amazing! 🤩
Check out those awesome brain cupcakes Ryan made. They have scaffolds to mimic our glioblastoma work. 🥰
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Arrived in Sapporo Japan & was able to walk around the lovely @HokkaidoUni campus this morning with my family. Looking forward to the Sato Memorial award ceremony tonight at The Pharmaceutical Society of Japan Conference!
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