Serving the biotech industry since 1981. EIC @johnsterling4; publisher @liebertpub Subscribe to GEN: ow.ly/XOjEe
New Rochelle, NY
- Tweets 71,614
- Following 3,352
- Followers 89,485
- Likes 13,733
Magnesium Enables Immune Cells to Tackle Infections and Cancer
A new study has identified extracellular magnesium as a critical immune modulator of CD8+ T cells. Learn more: ow.ly/rgym50Hz6YY
8
116
420
Peptide-Guided Nanoparticles Deliver mRNA to Neurons
Engineers say they have modified lipid nanoparticles (LNPs) to not only cross the blood-brain barrier (BBB) but also to target specific types of cells, including neurons. hubs.li/Q0301f5z0
5
75
265
18,633
👀A sneak peek into the most anticipated #biotech event of the year! Don't miss your chance to hear Nobel laureate, Jennifer Doudna @doudna_lab discuss the evolution of #CRISPR over the years
FREE REGISTRATION: bit.ly/StateofBiotech22
3
51
216
CRISPR Technique Effectively Destroys Metastatic Cancer Cells in Living Animal. Read more: ow.ly/qnUl50CWjnq #cancer #oncology #CRISPR
3
53
188
CRISPR Pioneers Doudna and Charpentier win 2020 Nobel Prize for Chemistry. Read more: ow.ly/1gBk50BM7db #crispr #geneediting #nobelprize
2
36
176
Mechanisms Underlying SARS-CoV-2 Neuroinvasion Discovered.
Researchers at @YaleMed have discovered that SARS-CoV-2 can directly infect the central nervous system. Read more: ow.ly/9tmJ50D7sys #SARSCoV2 #COVID19 #neuroscience
2
83
173
Leukemia Immune Evasion Revealed, Antibody Restores T Cell Attack
#Leukemia cells evade immune attack via SLAMF6, and by blocking this protein with a new antibody, researchers restored #Tcell function in AML
@lunduniversity
#antibodies #immunotherapy
hubs.li/Q03MF2KC0
6
41
165
59,730
Researchers have modified E. coli to produce chondroitin sulfate, which has been used as a dietary supplement for treating osteoarthritis. Learn more: ow.ly/zBmY50DPvBg
3
49
152
Scientists in Japan say they have designed the first bottom-up peptides that can form artificial nanopores to identify and enable single molecule-sorting of genetic material in a lipid membrane. Read more: ow.ly/qWHt50GYq2Z #drugdiscovery #nanotechnology
5
32
142
CAR T Cells Generated In Vivo Reverse Fibrosis, Restore Cardiac Function in Mice with Heart Failure. Learn more: ow.ly/Xl6i50HpJKh
4
40
132
CRISPR Technique Effectively Destroys Metastatic Cancer Cells in Living Animal. Read more: ow.ly/qnUl50CWjnq #cancer #oncology #CRISPR
41
130
“This is the first study in the world to prove that the #CRISPR genome editing system can be used to treat #cancer effectively in a living animal...” Read more about @peer_lab's findings: ow.ly/t0C650Cqh9E
1
33
126
Can a bacterial toxin have a healing effect?
A team of researchers has found that the toxin α-hemolysin (Hla) from Staphylococcus aureus stimulates tissue regeneration. Learn more: ow.ly/sDbd50BUtT5 #tissueregeneration #drugdiscovery #staph #inflammation
3
43
121
Experimental Drug Boosts Brain Cell Cleaning to Reverse Alzheimer's Disease Symptoms
Oral drug therapy resulted in reduced levels of tau protein and protein clumps in two mouse models of Alzheimer’s disease. Read more: ow.ly/FLwN50Ew1j7 #neuroscience #alzheimers
4
35
120
Scientists offer a new answer to solve a 100-year-old cancer mystery: The Warburg Effect. Read more: ow.ly/ee3T50Di2I6 #cancer #warburgeffect
2
34
124
Researchers from Columbia Engineering have developed a system that temporarily disguises therapeutic bacteria from immune systems and allows them to deliver drugs to tumors and kill cancer cells in mice. Learn more: ow.ly/wnim50ImGXJ
7
39
113
Microwave Processing Isolates That Suppress Lung Cancer Metastasis
Scientists have developed a new microwave processing technology to isolate red ginseng compounds that effectively inhibit the metastasis of lung cancer. Read more: ow.ly/Wnr650DRiXO
1
28
114
A new study found that the #SARSCoV2 spike protein can cross the blood–brain barrier (BBB) in mice, strongly suggesting that it can enter the brain. Learn more: ow.ly/cL9P50CX8Ze #COVID19
6
49
123
Researchers Flip the Switch on Immune Response in IBD
Researchers at KU Leuven and Seoul National University developed a method that instructs immune system cells to help repair damaged tissues in the intestine. Learn more: ow.ly/ueq450DvxtX
4
40
114
.@umichmedicine researchers report that 6-gingerol, the main bioactive compound in ginger root, has therapeutic effects against certain autoimmune diseases, including lupus and antiphospholipid syndrome (APS), in mice. Learn more: ow.ly/aF5050D3PzO
4
40
111
RNA Editing Is Having a Moment
Although DNA editing has been celebrated for its potential to create new drugs, a relatively unsung alternative, RNA editing, may end up stealing the show. Read more: ow.ly/fnPZ50QmoG6
1
28
116
10,066
A team of researchers used CRISPR to convert white fat cells into “beige” fat cells and then implanted the cells in mice models of breast and pancreatic cancer. The engineered fat cells outcompeted tumors for nutrients and reduced cancer progression.
hubs.li/Q035W1ww0
4
40
117
5,709
Researchers discover what blocks the communication between the gut and the brain and causes insulin resistance in people with #diabetes by targeting the Enteric Nervous System. Learn more: ow.ly/u0AZ50BMJ6b
1
54
113
AAV Delivered NanoCas CRISPR System Edits Muscle in Non-Human Primates
Potent in vivo gene editing in skeletal muscle of non-human primates by a novel, ultracompact CRISPR system delivered via a single AAV vector.
hubs.li/Q0351q2j0
10
35
119
4,473
Tea compounds, ECG and EGCG, found in black and green tea have been found to relax blood vessels by activating ion channel proteins. These findings may lead to the development of new therapeutics for hypertension. Learn more: ow.ly/PdDT50DUcVH
5
35
105
Researchers investigating the DNA outside our genes (the “dark genome”) report that they have discovered recently evolved regions that code for proteins associated with schizophrenia and bipolar disorder. Learn more: ow.ly/IpOm50HjU1b
1
30
109
People with diabetes have a higher risk of developing Alzheimer's disease (AD) raising a possible link between the cells that are disordered in diabetes—pancreatic β cells—and AD. A study reveals these cells may secrete neuroprotective factors.
hubs.li/Q034tL-W0
8
43
110
6,368
Researchers discover what blocks the communication between the gut and the brain and causes insulin resistance in people with diabetes by targeting the Enteric Nervous System. Learn more: ow.ly/lijr50BMsK1
1
32
109
Researchers Reveal How Killer T Cells Are Blocked from Fighting Cancer Cells.
A new study by scientists at the @salkinstitute demonstrates how “bad fats” hinder killer T cells from fighting cancer cells. Learn how: ow.ly/Pdud50F8isP
3
28
102
Ribosomes Shown Translating mRNA from Maternally Inherited Mitochondrial Genome
Specialized mechanism for translation of the mitochondrial genome into proteins revealed. Learn more: ow.ly/jV0k50DHH7u
2
30
103
Researchers Uncover Protein That Helps Tumors Evade Immune System
Researchers identify a protein called secreted gelsolin that aids tumors in evading the immune system. Learn more: ow.ly/yyqn50F24h1
2
29
107
Epigenetic DNA Methylation Imaged Directly in the Brain Using New eMRI Technique. Learn more: ow.ly/6hoJ50I6ZlL
3
24
102
The 1st complete telomere-to-telomere sequence of a human autosome has been completed. The sequence of chromosome 8 not only fills in the gap of more than three million bases missing from the current reference genome, but...Read more: ow.ly/Yt1f50EkCcw #genomics #sequencing
1
32
105
Top Cancer Article of 2024: Readers' Choice—Tumors Have a Taste for Fructose, If It’s Transformed by the Liver
New research shows that fructose promotes tumor growth in multiple animal models of cancer after being converted by the liver.
hubs.li/Q030ZY4_0
4
39
96
8,542
Genetics May Play a Role in Our Immune Response to Cancer Treatment
Researchers find Inherited genetic variation plays a role in who is likely to benefit from checkpoint inhibitors. Read more: ow.ly/CW8a50DxNhE
1
23
101
Mark your calendars for Wednesday, March 16. Join us live at 2PM ET for our next episode of GEN Live "What COVID-19 Has Revealed about Science & Society"
@PeterHotez Talks Anti-Science and How to Prevent the Next Pandemic. Register today: ow.ly/tzHL50HX9pP #COVID19
7
37
80
New gene and cell therapies are on the horizon to modulate the brain activity that causes the characteristic motor symptoms associated with Parkinson’s disease, heal the damage done to the brain, and even regrow lost neurons.
hubs.li/Q02_Nzjg0
6
29
102
5,329
A team from @MIT describes a new CRISPR-Cas9 #genomeediting tool called PASTE, which delivered genes as long as 36,000 DNA base pairs to several types of human cells (as well as to liver cells in mice). Learn more: ow.ly/ZqkR50LOPiP #CRISPR
1
32
101
Structure of Key Parkinson's Disease Protein, PINK1, Seen for First Time
Researchers say structure reveals many new ways to change PINK1, essentially switching it on, which will be "life-changing" for people with Parkinson’s disease.
@WEHI_researc
hubs.li/Q03bYHLB0
2
26
103
4,229
“This is the first study in the world to prove that the #CRISPR genome editing system can be used to treat #cancer effectively in a living animal...” Read more about @peer_lab's findings: ow.ly/t0C650Cqh9E
1
25
98
Scientists at .@HopkinsMedicine say they have designed tiny, star-shaped microdevices that can latch onto intestinal mucosa and release drugs into the body. Learn more: ow.ly/cqw550CcnnA #drugdelivery
1
21
98
Scientists have uncovered a new cell type in the human brain. They also found non-tumor cells that are neuron-glia hybrids, suggesting that this cell population may contribute to healthy brain function. Read more: hubs.li/Q02NTNX30
2
34
85
4,546
Researchers have developed a new way to grow T cells in the lab that enables the cells to live longer and better destroy cancer cells in a mouse model of melanoma, compared with those cells grown using traditional growth media. @PittTweet @UPMCHillmanCC
hubs.li/Q034tQz60
6
37
104
6,343
#CRISPR Engineers a New Path for #Antibiotic Production
Scientists have discovered a new way of manipulating enzymes in bacteria, through #geneediting, which could create a new generation of antibiotics. Read more: ow.ly/x2NN50GZAV7
3
40
96
Personal Reflections on Five Years of COVID-19
Peter Hotez, MD, PhD, reflects on how it was the best of science and the worst of anti-science.
hubs.li/Q032JPH-0
5
27
101
23,304
Neural Stem Cells Decline During Aging.
"Much work remains to be done, but this study marks exciting progress towards our goal of identifying prescription drugs that could rejuvenate our brains as we grow older..." Read more: ow.ly/MLqX50EooGp #neuroscience #aging
1
34
95
#Omicron Infections, Without Vaccinations, Provide Little Immunity
Scientists found that without vaccination, infection with Omicron does not provide robust immunity against other #COVID19 variants. Learn more: ow.ly/BCvI50Jc1Rg
5
40
84
First Synthetic Eukaryotic Genome Completed
The completion of chromosome synXVI allows scientists to explore new possibilities in metabolic engineering and strain optimization.
hubs.li/Q033JvDr0
2
47
95
4,341
First Genetically Engineered Pig Kidney Transplanted into Living Patient
The kidney transplant marks historic milestone and opens new frontier in transplantation to address kidney shortage affecting millions globally. Read more: ow.ly/C7Ng50QYYWn
6
23
90
10,081
Cannabidiol’s Antibiotic Potential Extends to Gram-Negative Bacteria. Read more: ow.ly/9aih50Dhs8r
#cannabis #antibiotics #bacteria
1
29
91
Alzheimer's Pathology Linked to Herpes Virus
A new study adds more evidence to the link between Alzheimer's disease and the herpes simplex virus-1. The study also revealed how tau protein might initially protect the brain from the virus.
hubs.li/Q0313MsN0
1
35
89
4,493
Proteins That Shape DNA Are Able to Shift Gears
A study reveals the structural maintenance of chromosomes proteins that shape our DNA can switch directions.
hubs.li/Q032RkYG0
9
29
85
5,207
PASTE, Don’t Cut: Genome Editing Tool Looks Beyond #CRISPR and Prime
A recently patented #genomeediting tool called PASTE holds genuine promise for expanding the universe of treatable genetic diseases. Learn more: ow.ly/PE7W50NheO5
3
30
89
12,370
CRISPR-Based Cancer Cell Lineage Tracing Offers Insights into Drivers of Metastasis
Researchers hope that using CRISPR-based technology might enable them to progress from observing #cancer cells, to predicting their behavior. Learn more: ow.ly/Vxqg50Dfyy3 #CRISPR
19
83
Nanoimaging Gets Some Help from Graphene
Using a molecule called graphene, a single layer of carbon atoms arranged in a 2D honeycomb lattice, the researchers were able to coat cells and keep them alive and wet for much-improved imaging. Read more: ow.ly/jZPw50DDL0v
1
21
87
AI Accelerates Enzyme Engineering
A new ML-guided platform can design thousands of new enzymes, predict how they will behave in the real world, and test their performance.
hubs.ly/Q033Vf0K0
4
45
89
5,586
A new tool for mitochondrial DNA mutagenesis has emerged—the double-stranded DNA deaminase (DddA)-derived cytosine base editor (DdCBE). Learn more: ow.ly/brYU50HTpeG
4
29
82
The 1st complete telomere-to-telomere sequence of a human autosome has been completed. The sequence of chromosome 8 not only fills in the gap of more than three million bases missing from the current reference genome, but...Read more: ow.ly/Yt1f50EkCcw #genomics #sequencing
17
88
Epigenetic Memory Survives DNA Replication with Aid of Histone-Recycling Protein
Cell identity is preserved during DNA replication by a histone allocation mechanism that involves a replisome component called Mrc1. Read more: hubs.li/Q02LgrJ_0
1
34
86
5,042
Artificial Demonstrates AI Integration with @NVIDIA BioNeMo for Drug Discovery
The proof-of-concept demonstrates the power of pairing #AI with lab orchestration solutions to automate molecular screening for drug discovery.
hubs.li/Q033JGdS0
7
34
82
3,781
A new CRISPR-Cas9 #genomeediting tool called PASTE, which can insert large pieces of DNA into several types of human cells, may be able to replace genes in a safer and more efficient way. Learn more: ow.ly/ZqkR50LOPiP #CRISPR
2
34
90
CRISPR-Cas9 Screening Enables Phenotypic Development of Antibody Drugs
Antibody drugs may hit entirely new targets now that CRISPR-Cas9 facilitates phenotypic discovery. Learn more: ow.ly/m4cj50DSvlW #CRISPR
36
82
To restore vision in the blind, scientists have developed a wide-field, high-density and high-resolution photovoltaic prosthesis for the retina called POLYRETINA that can impart artificial vision. Learn more: ow.ly/BZRX50DSV7Y
1
31
79
.@YaleMed synthetic biologists report they were able to re-write the genetic code of E. coli using a cellular platform that they developed enabling the production of new classes of synthetic proteins.
hubs.li/Q035Qd8s0
1
23
80
4,486
🧬FREE VIRTUAL SUMMIT
Less than a week left before The State of #Biotech! Don't miss the opportunity to engage in conversations with world-renowned #scientists, entrepreneurs, inventors, and academics.
Save your seat here: lnkd.in/e3Ed5-RM
3
15
65
2025 Trends: Organoids
The organoid market is expected to grow. Several R&D experts share their expectations for the next few years. hubs.li/Q032JRCC0
2
27
84
5,224
Scientists at the University of California, Irvine (UCI), and the Italian Institute of Technology have developed a new molecule, ALY101, that shows promising anticancer activity against a wide range of tumor cell types and in mouse models. Read more: ow.ly/1L4r50Jj6pS
3
33
75
Cancer Cells Metabolize Lipids Not Just for Fuel, but for Immune Evasion
Cancer cells can use lipids not just as fuel, but as a means to obscure inflammatory signals, enabling immune evasion. Read more: hubs.li/Q02QlX_g0
40
77
4,086
Blood-Brain Barrier Control Mechanism Could Point to CNS Therapeutic Strategies
Results from a new study could inform on how the microenvironment is important for blood-brain barrier maintenance. Learn more: ow.ly/tuCx50IkKin
2
27
79
Experimental Drug Boosts Brain Cell Cleaning to Reverse Alzheimer's Disease Symptoms
Oral drug therapy resulted in reduced levels of tau protein and protein clumps in two mouse models of Alzheimer’s disease. Read more: ow.ly/FLwN50Ew1j7 #neuroscience #alzheimers
3
21
77
Improving CAR-T Cell Efficacy via New Manufacturing Process
A new bioprocessing technique developed by a team of researchers could improve a range of therapies based on CAR-T cells. Read more: hubs.li/Q02QvqrV0
1
27
73
3,296
At @PennMedicine CAR T cells have been developed that can kill tumor cells in mouse models of neuroendocrine tumors and gastrointestinal cancers. Even better, the CAR T cells show no toxicity toward healthy epithelial cells. Read more: ow.ly/MQli50Isf1t
31
78
In a first-in-human clinical trial involving four adult glioblastoma patients, an mRNA cancer vaccine developed at the University of Florida (UF) reprogrammed the immune system to attack the tumors. Learn more: ow.ly/HE2c50RuLw0
29
73
12,577
A new study by shows that up to 20% of #glioblastomas are powered by overactive #mitochondria and may be treatable with drugs currently in clinical trials. Learn more: ow.ly/Z0gC50D6pjF
1
25
76
Improving Cancer Immunotherapy by Blocking Glucose Supply
Memorial Sloan Kettering researchers report that immunotherapy may be improved by altering immune cells' access to sugar. Learn more: ow.ly/rVmh50DCwS9
3
25
72
Fanzor: First CRISPR-Like System Found in Eukaryotes
The first RNA-guided DNA-cutting enzyme found in eukaryotes, Fanzor could one day be harnessed to edit DNA more precisely than CRISPR/Cas systems. Learn more: ow.ly/mrxi50PGFje
23
74
9,238
Personal Reflections on Five Years of COVID-19
Peter Hotez, MD, PhD, reflects on how it was the best of science and the worst of anti-science.
hubs.li/Q032JQ5Z0
1
20
75
18,012
A new study reveals the presence of a fungus commonly found in foods like meat and cheese, preferentially localizes to injured and inflamed regions in the gut in patients with Crohn’s disease, preventing wound healing. Learn more: ow.ly/ZyfA50DZDOf
22
74
Scientists at @scrippsresearch and @disney_lab have developed a tool called Chem-CLIP-Fragment Mapping that bypasses "undruggable" proteins, and focuses on RNA to aid in drug discovery of incurable diseases. Read more: ow.ly/2YMT50CN44y #breastcancer #RNA
2
11
71
Researchers have solved the mysterious function of how MCM proteins protect the human cells against DNA instability, which can cause diseases including cancer. Learn more: Learn more: ow.ly/Hht450C1pzv
1
20
64
#mRNA #Cancer #Vaccine Elicits T Cell Response and Eliminates Tumors in Mice
An mRNA-based cancer vaccine, delivered directly into the lymphatic system for a more potent response, eliminates tumors and prevents recurrence in mice. Read more: ow.ly/MO4S50KlON0
1
27
66
Researchers develop a genome editing tool for the potential treatment of mitochondrial diseases: ow.ly/v98930lXQA8
1
42
71
Human Stem Cells Repair Retinas in Monkey Models of Macular Holes
Experiments in Japanese macaques showed that transplanting human embryonic stem cell organoid sheets resulted in successful hole closure.
hubs.li/Q02S8NRj0
22
72
14,493
A @Stanford study shows reprogramming myeloid immune cells can restore youthful bioenergetic metabolism and suppress inflammation in the brain. Learn more: ow.ly/ZK5850Dg8NC #aging
1
17
64
Researchers at @UofT and @nyugrossman developed a novel #artificialintelligence technology, called ZFDesign, that can design #zincfinger proteins to target any stretch of DNA in the human genome. Learn more: ow.ly/piIK50MC5ja #genetherapy #genetics #genomeediting
1
32
72
37,865
First Alzheimer's Disease #GeneSilencing Approach Lowers Tau Levels in Humans
Clinical trial results show promise for a new #genetic therapy for #Alzheimersdisease that lowers levels of the tau protein known to cause the disease. Learn more: ow.ly/Xv5L50NU7AE
27
62
9,216
Targeted Protein Degradation: A Promising Option for Cancer Drug Developers
Instead of inhibiting disease-causing proteins, targeted protein degraders consign them to proteosomal and endolysosomal pathways. Learn more: ow.ly/y9QR50NO7P8
15
65
8,067
.@Stanford study shows reprogramming myeloid immune cells can restore youthful bioenergetic metabolism and suppress inflammation in the brain. Learn more: ow.ly/98fx50DgQQJ
15
61
A new method combining sequencing and micro-imaging, developed by @MIT called in situ #genomesequencing, sequences DNA directly within intact biological samples and pinpoints where specific DNA sequences are located inside intact cells. Read more: ow.ly/IjuP50D0TOs
1
25
63
Researchers have now explained the mechanisms involved in the loss of smell (anosmia) in patients infected with #SARSCoV2 at different stages of the disease. Learn more about their findings: ow.ly/JHA250EGe64 #COVID19
2
24
70
Pin-point, a new base-editing system that uses RNA aptamers to localize DNA modifying effector enzymes at genome targets is adept in performing point-mutation edits and can enhance the therapeutic potential of #genomeediting, reported In @CRISPRjournal. ow.ly/ZQRW50DJ793
22
69
Nanoparticle Platform Delivers siRNA Across the Blood-Brain Barrier in Traumatic Brain Injury Mouse Model
The delivery system showed 3Xs more accumulation in the brain than conventional methods. Learn more: ow.ly/hDqq50CZOnL #drugdelivery #neuroscience
1
15
66
A team of researchers has succeeded in inhibiting the immune response induced by #AAV antibodies present as a result of natural immunity or following gene therapy. This result opens up new therapeutic prospects. Read more: ow.ly/L98050CVNSS #genetherapy
2
20
66
#GeneEditing Startups Cut Fine Therapeutic Figures
New companies are exploiting next-generation #CRISPR technologies and powerful #CRISPR alternatives to realize new therapeutic approaches. Read more: ow.ly/hR2950CXIqt
12
65
BindCraft AI Model Achieves One-Shot Functional Protein Design
The open-source pipeline designs #proteins with improved success rates for therapeutic targets, including gene editing proteins and allergens
@MartinPacesa @EPFL_en
#AI #drugdevelopment
hubs.li/Q03FR2X-0
15
70
3,232
Fructose is added to many of our foods and drinks. Unfortunately, excessive fructose in the brain may contribute to Alzheimer’s disease. Read more about .@CUAnschutz's findings : ow.ly/nFjT50BAjFf #alzheimers #diabetes
1
34
70
Mechanisms Underlying SARS-CoV-2 Neuroinvasion Discovered.
A new study from investigators at @YaleMed describes the mechanisms that allow the #coronavirus to directly infect the central nervous system.. Read more: ow.ly/IPgX50D7WM4 #SARSCoV2 #COVID19 #neuroscience
4
50
61
A novel tool has been developed to visualize the process of palmitoylation—the post-translational modification that allows peripheral membrane proteins (PMPs) to associate with cellular membranes—in living cells. Learn more: ow.ly/v6Fa50ISoLH
13
63
CRISPR’s Tricks: How Cas Enzymes Capture, Trim, and Integrate Foreign DNA
New work from Jennifer Doudna’s lab could be useful for CRISPR-based technologies that seek to repurpose Cas1–Cas2 for molecular recording and information storage. Learn more: ow.ly/owp450OQv5G
16
60
10,431
Researchers led by Imperial College London have uncovered new insights into how bacteria hook up to exchange DNA that helps them resist antibiotics. Learn more: ow.ly/2BSL50JypEr
2
23
65